Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms

Oncotarget

Volumn 7, Issue 16, 2016, Pages 21156-21167

  Zhai, Kui ^a   Yang, Zhiguang ^a   Zhu, Xiaofei ^b   Nyirimigabo, Eric ^a   Mi, Yue ^c   Wang, Yan ^c   Liu, Qinghua ^d   Man, Libo ^b   Wu, Shiliang ^c   Jin, Jie ^c   Ji, Guangju ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b Beijing Jishuitan Hospital   (China)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

^d SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

Bitter taste receptors; Chloroquine; Detrusor smooth muscle; Gerotarget; Human; Mouse; Overactive bladder

Indexed keywords

BITTER TASTE RECEPTOR; CARBACHOL; CHLOROQUINE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; POTASSIUM CHLORIDE; QUININE; UNCLASSIFIED DRUG; ANTIRHEUMATIC AGENT; CARDIOTONIC AGENT; TASTE RECEPTORS, TYPE 2;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; BLADDER FUNCTION; BLADDER OBSTRUCTION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYSTOMETRY; DETRUSOR MUSCLE; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; OVERACTIVE BLADDER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTION; ANIMAL; C57BL MOUSE; METABOLISM; PATHOLOGY; SMOOTH MUSCLE;

AGED; ANIMALS; ANTIRHEUMATIC AGENTS; CARBACHOL; CARDIOTONIC AGENTS; CHLOROQUINE; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH; RECEPTORS, G-PROTEIN-COUPLED; URINARY BLADDER, OVERACTIVE;

EID: 84965038798     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8549     Document Type: Article

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