Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations

ACS Medicinal Chemistry Letters

Volumn 7, Issue 4, 2016, Pages 418-423

  Sabbavarapu, Narayana Murthy ^a   Shavit, Michal ^a   Degani, Yarden ^a   Smolkin, Boris ^a   Belakhov, Valery ^a   Baasov, Timor ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Aminoglycosides; cystic fibrosis; genetic diseases; nonsense mutations; translational readthrough

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; ANTIBIOTIC G 418; DNA; GENTAMICIN; PAROMOMYCIN; RIBOSOME RNA;

ARTICLE; CYSTIC FIBROSIS; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EUKARYOTIC CYTOPLASMIC RIBOSOME; HURLER SYNDROME; IC50; MINIMUM INHIBITORY CONCENTRATION; NONSENSE MUTATION; PRIORITY JOURNAL; RIBOSOME; STEREOCHEMISTRY; STOP CODON; STRUCTURE ACTIVITY RELATION; USHER SYNDROME;

EID: 84965035945     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00006     Document Type: Article

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