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Volumn 115, Issue 1, 2016, Pages 5-11

Targeting cell death signalling in cancer: Minimising 'Collateral damage'

Author keywords

adverse effects; BCL 2 family; cancer; cell death; IAPs; SMAC mimetics; targeted therapies; TRAIL

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DEATH PROTEIN; CELL PROTEIN; UNCLASSIFIED DRUG; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84965034325     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2016.111     Document Type: Article
Times cited : (55)

References (54)
  • 2
    • 84918821230 scopus 로고    scopus 로고
    • Small molecule Mcl-1 inhibitors for the treatment of cancer
    • Belmar J, Fesik SW. (2015). Small molecule Mcl-1 inhibitors for the treatment of cancer. Pharmacol Ther 145: 76-84
    • (2015) Pharmacol Ther , vol.145 , pp. 76-84
    • Belmar, J.1    Fesik, S.W.2
  • 3
    • 84878990701 scopus 로고    scopus 로고
    • Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax
    • Berger A, Quast SA, Plotz M, Kammermeier A, Eberle J. (2013). Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. Cell Death Dis 4: e477
    • (2013) Cell Death Dis , vol.4 , pp. e477
    • Berger, A.1    Quast, S.A.2    Plotz, M.3    Kammermeier, A.4    Eberle, J.5
  • 6
    • 84925763790 scopus 로고    scopus 로고
    • Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins
    • Colin DJ, Hain KO, Allan LA, Clarke PR. (2015). Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol 5(3): 140156
    • (2015) Open Biol , vol.5 , Issue.3 , pp. 140156
    • Colin, D.J.1    Hain, K.O.2    Allan, L.A.3    Clarke, P.R.4
  • 8
    • 84861653411 scopus 로고    scopus 로고
    • The complexities of life and death: Death receptor signalling platforms
    • Dickens LS, Powley IR, Hughes MA, MacFarlane M. (2012). The complexities of life and death: death receptor signalling platforms. Exp Cell Res 318(11): 1269-1277
    • (2012) Exp Cell Res , vol.318 , Issue.11 , pp. 1269-1277
    • Dickens, L.S.1    Powley, I.R.2    Hughes, M.A.3    MacFarlane, M.4
  • 9
    • 35348877298 scopus 로고    scopus 로고
    • Barriers to effective TRAIL-Targeted therapy of malignancy
    • Dyer MJ, MacFarlane M, Cohen GM. (2007). Barriers to effective TRAIL-Targeted therapy of malignancy. J Clin Oncol 25(28): 4505-4506
    • (2007) J Clin Oncol , vol.25 , Issue.28 , pp. 4505-4506
    • Dyer, M.J.1    MacFarlane, M.2    Cohen, G.M.3
  • 11
    • 84941686309 scopus 로고    scopus 로고
    • BMX negatively regulates BAK function, thereby increasing apoptotic resistance to chemotherapeutic drugs
    • Fox JL, Storey A. (2015). BMX negatively regulates BAK function, thereby increasing apoptotic resistance to chemotherapeutic drugs. Cancer Res 75(7): 1345-1355
    • (2015) Cancer Res , vol.75 , Issue.7 , pp. 1345-1355
    • Fox, J.L.1    Storey, A.2
  • 12
    • 84903647814 scopus 로고    scopus 로고
    • Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
    • Fresquet V, Rieger M, Carolis C, Garcia-Barchino MJ, Martinez-Climent JA. (2014). Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood 123(26): 4111-4119
    • (2014) Blood , vol.123 , Issue.26 , pp. 4111-4119
    • Fresquet, V.1    Rieger, M.2    Carolis, C.3    Garcia-Barchino, M.J.4    Martinez-Climent, J.A.5
  • 15
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. (2011). Hallmarks of cancer: the next generation. Cell 144(5): 646-674
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 17
    • 68349154339 scopus 로고    scopus 로고
    • Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival
    • Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M. (2009). Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol Cell 35(3): 265-279
    • (2009) Mol Cell , vol.35 , Issue.3 , pp. 265-279
    • Hughes, M.A.1    Harper, N.2    Butterworth, M.3    Cain, K.4    Cohen, G.M.5    MacFarlane, M.6
  • 20
    • 84907883684 scopus 로고    scopus 로고
    • Phase i dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors
    • Infante JR, Dees EC, Olszanski AJ, Dhuria SV, Sen S, Cameron S, Cohen RB. (2014). Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors. J Clin Oncol 32(28): 3103-3110
    • (2014) J Clin Oncol , vol.32 , Issue.28 , pp. 3103-3110
    • Infante, J.R.1    Dees, E.C.2    Olszanski, A.J.3    Dhuria, S.V.4    Sen, S.5    Cameron, S.6    Cohen, R.B.7
  • 22
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR, Strom SC. (2000). Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 6(5): 564-567
    • (2000) Nat Med , vol.6 , Issue.5 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6    Strom, S.C.7
  • 23
    • 84873632857 scopus 로고    scopus 로고
    • Rare somatic mutation of pro-Apoptotic BAX and BAK genes in common human cancers
    • Kim MS, Kim SS, Yoo NJ, Lee SH. (2012). Rare somatic mutation of pro-Apoptotic BAX and BAK genes in common human cancers. Tumori 98(6): 149e-151e
    • (2012) Tumori , vol.98 , Issue.6 , pp. 149e-151e
    • Kim, M.S.1    Kim, S.S.2    Yoo, N.J.3    Lee, S.H.4
  • 24
    • 84918813211 scopus 로고    scopus 로고
    • HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells
    • Lee DH, Sung KS, Bartlett DL, Kwon YT, Lee YJ. (2015). HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cell Signal 27(2): 293-305
    • (2015) Cell Signal , vol.27 , Issue.2 , pp. 293-305
    • Lee, D.H.1    Sung, K.S.2    Bartlett, D.L.3    Kwon, Y.T.4    Lee, Y.J.5
  • 26
    • 0033975513 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor-related apoptosisinducing ligand sensitivity in primary and transformed human keratinocytes
    • Leverkus M, Neumann M, Mengling T, Rauch CT, Brocker EB, Krammer PH, Walczak H. (2000). Regulation of tumor necrosis factor-related apoptosisinducing ligand sensitivity in primary and transformed human keratinocytes. Cancer Res 60(3): 553-559
    • (2000) Cancer Res , vol.60 , Issue.3 , pp. 553-559
    • Leverkus, M.1    Neumann, M.2    Mengling, T.3    Rauch, C.T.4    Brocker, E.B.5    Krammer, P.H.6    Walczak, H.7
  • 29
    • 77956630795 scopus 로고    scopus 로고
    • TRAIL treatment provokes mutations in surviving cells
    • Lovric MM, Hawkins CJ. (2010). TRAIL treatment provokes mutations in surviving cells. Oncogene 29(36): 5048-5060
    • (2010) Oncogene , vol.29 , Issue.36 , pp. 5048-5060
    • Lovric, M.M.1    Hawkins, C.J.2
  • 30
    • 29244483111 scopus 로고    scopus 로고
    • TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies
    • MacFarlane M, Kohlhaas SL, Sutcliffe MJ, Dyer MJ, Cohen GM. (2005). TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies. Cancer Res 65(24): 11265-11270
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11265-11270
    • MacFarlane, M.1    Kohlhaas, S.L.2    Sutcliffe, M.J.3    Dyer, M.J.4    Cohen, G.M.5
  • 31
    • 84869445913 scopus 로고    scopus 로고
    • Glucose-A sweet way to die: Metabolic switching modulates tumor cell death
    • MacFarlane M, Robinson GL, Cain K. (2012). Glucose-A sweet way to die: metabolic switching modulates tumor cell death. Cell Cycle 11(21): 3919-3925
    • (2012) Cell Cycle , vol.11 , Issue.21 , pp. 3919-3925
    • MacFarlane, M.1    Robinson, G.L.2    Cain, K.3
  • 32
    • 84860738218 scopus 로고    scopus 로고
    • Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis
    • Meynet O, Beneteau M, Jacquin MA, Pradelli LA, Cornille A, Carles M, Ricci JE. (2012). Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis. Leukemia 26(5): 1145-1147
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 1145-1147
    • Meynet, O.1    Beneteau, M.2    Jacquin, M.A.3    Pradelli, L.A.4    Cornille, A.5    Carles, M.6    Ricci, J.E.7
  • 37
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    • Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. (2007). Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12(5): 445-456
    • (2007) Cancer Cell , vol.12 , Issue.5 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6    Harran, P.7    Wang, X.8
  • 39
    • 84870564122 scopus 로고    scopus 로고
    • Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL
    • Robinson GL, Dinsdale D, MacFarlane M, Cain K. (2012). Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL. Oncogene 31(48): 4996-5006
    • (2012) Oncogene , vol.31 , Issue.48 , pp. 4996-5006
    • Robinson, G.L.1    Dinsdale, D.2    MacFarlane, M.3    Cain, K.4
  • 40
    • 79959886892 scopus 로고    scopus 로고
    • Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL
    • Shi J, Zhou Y, Huang HC, Mitchison TJ. (2011). Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res 71(13): 4518-4526
    • (2011) Cancer Res , vol.71 , Issue.13 , pp. 4518-4526
    • Shi, J.1    Zhou, Y.2    Huang, H.C.3    Mitchison, T.J.4
  • 41
    • 84923856052 scopus 로고    scopus 로고
    • Lessons from gain-And loss-of-function models of pro-survival Bcl2 family proteins: Implications for targeted therapy
    • Sochalska M, Tuzlak S, Egle A, Villunger A. (2015). Lessons from gain-And loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy. FEBS J 282(5): 834-849
    • (2015) FEBS J , vol.282 , Issue.5 , pp. 834-849
    • Sochalska, M.1    Tuzlak, S.2    Egle, A.3    Villunger, A.4
  • 43
    • 84875877848 scopus 로고    scopus 로고
    • Identification of non-canonical NF-kappaB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
    • Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S. (2013). Identification of non-canonical NF-kappaB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. Cell Death Dis 4: e564
    • (2013) Cell Death Dis , vol.4 , pp. e564
    • Tchoghandjian, A.1    Jennewein, C.2    Eckhardt, I.3    Rajalingam, K.4    Fulda, S.5
  • 45
    • 84877047169 scopus 로고    scopus 로고
    • Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis
    • Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM. (2013). Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. Neoplasia 15(5): 568-578
    • (2013) Neoplasia , vol.15 , Issue.5 , pp. 568-578
    • Varadarajan, S.1    Butterworth, M.2    Wei, J.3    Pellecchia, M.4    Dinsdale, D.5    Cohen, G.M.6
  • 47
    • 84931292235 scopus 로고    scopus 로고
    • Bcl-2 family of proteins as drug targets for cancer chemotherapy: The long way of BH3 mimetics from bench to bedside
    • Vela L, Marzo I. (2015). Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside. Curr Opin Pharmacol 23: 74-81
    • (2015) Curr Opin Pharmacol , vol.23 , pp. 74-81
    • Vela, L.1    Marzo, I.2
  • 53
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. (1956). On respiratory impairment in cancer cells. Science 124(3215): 269-270
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 54
    • 84887616429 scopus 로고    scopus 로고
    • Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics
    • Pt B
    • Yu L, Liu S. (2013). Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics. Semin Cancer Biol 23(6 Pt B): 553-560
    • (2013) Semin Cancer Biol , vol.23 , Issue.6 , pp. 553-560
    • Yu, L.1    Liu, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.