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Volumn 75, Issue 7, 2015, Pages 1345-1355

BMX negatively regulates BAK function, thereby increasing apoptotic resistance to chemotherapeutic drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BMX PROTEIN; CAMPTOTHECIN; DOCETAXEL; ETOPOSIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 21; PROTEIN BAK; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; BAK1 PROTEIN, HUMAN; BMX PROTEIN, HUMAN; PTPN21 PROTEIN, HUMAN;

EID: 84941686309     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1340     Document Type: Article
Times cited : (31)

References (48)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006;25:4798-811.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 4
    • 0035500410 scopus 로고    scopus 로고
    • Apoptosis and cancer chemotherapy
    • Makin G, Dive C. Apoptosis and cancer chemotherapy. Trends Cell Biol 2001;11:S22-6.
    • (2001) Trends Cell Biol , vol.11 , pp. S22-S26
    • Makin, G.1    Dive, C.2
  • 5
    • 0033927677 scopus 로고    scopus 로고
    • Apoptosis and cancer chemotherapy
    • Makin G, Hickman JA. Apoptosis and cancer chemotherapy. Cell Tissue Res 2000;301:143-52.
    • (2000) Cell Tissue Res , vol.301 , pp. 143-152
    • Makin, G.1    Hickman, J.A.2
  • 6
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003;22:8590-607.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 8
    • 77956095537 scopus 로고    scopus 로고
    • Mitochondria and cell death: Outer membrane permeabilization and beyond
    • Tait SW, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 2010;11:621-32.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 621-632
    • Tait, S.W.1    Green, D.R.2
  • 9
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008;9:47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 10
    • 41149152733 scopus 로고    scopus 로고
    • How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
    • Chipuk JE, Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 2008;18:157-64.
    • (2008) Trends Cell Biol , vol.18 , pp. 157-164
    • Chipuk, J.E.1    Green, D.R.2
  • 11
    • 79551620159 scopus 로고    scopus 로고
    • Apoptosis and oncogenesis: Give and take in the BCL-2 family
    • Llambi F, Green DR. Apoptosis and oncogenesis: give and take in the BCL-2 family. Curr Opin Genet Dev 2011;21:12-20.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 12-20
    • Llambi, F.1    Green, D.R.2
  • 13
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001;292:727-30.
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3    Lindsten, T.4    Panoutsakopoulou, V.5    Ross, A.J.6
  • 14
    • 84870003427 scopus 로고    scopus 로고
    • Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis
    • Azad A, Fox J, Leverrier S, Storey A. Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. PLoS ONE 2012;7:e49601.
    • (2012) PLoS ONE , vol.7
    • Azad, A.1    Fox, J.2    Leverrier, S.3    Storey, A.4
  • 15
    • 79951909056 scopus 로고    scopus 로고
    • "Licensed to kill": Tyrosine dephosphorylation and Bak activation
    • Fox J, Azad A, Ismail F, Storey A. "Licensed to kill": tyrosine dephosphorylation and Bak activation. Cell Cycle 2011;10:598-603.
    • (2011) Cell Cycle , vol.10 , pp. 598-603
    • Fox, J.1    Azad, A.2    Ismail, F.3    Storey, A.4
  • 16
  • 17
    • 34247381115 scopus 로고    scopus 로고
    • Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    • Haffty BG, Yang Q, Reiss M, Kearney T, Higgins SA, Weidhaas J, et al. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 2006;24:5652-7.
    • (2006) J Clin Oncol , vol.24 , pp. 5652-5657
    • Haffty, B.G.1    Yang, Q.2    Reiss, M.3    Kearney, T.4    Higgins, S.A.5    Weidhaas, J.6
  • 19
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750-67.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6
  • 20
    • 0033535347 scopus 로고    scopus 로고
    • Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
    • Griffiths GJ, Dubrez L, Morgan CP, Jones NA, Whitehouse J, Corfe BM, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol 1999;144:903-14.
    • (1999) J Cell Biol , vol.144 , pp. 903-914
    • Griffiths, G.J.1    Dubrez, L.2    Morgan, C.P.3    Jones, N.A.4    Whitehouse, J.5    Corfe, B.M.6
  • 21
    • 0037817848 scopus 로고    scopus 로고
    • A new quantitative assay for cytochrome c release in apoptotic cells
    • Waterhouse NJ, Trapani JA. A new quantitative assay for cytochrome c release in apoptotic cells. Cell Death Differ 2003;10:853-5.
    • (2003) Cell Death Differ , vol.10 , pp. 853-855
    • Waterhouse, N.J.1    Trapani, J.A.2
  • 22
    • 33748071774 scopus 로고    scopus 로고
    • Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
    • Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, et al. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer Res 2006;66:8058-64.
    • (2006) Cancer Res , vol.66 , pp. 8058-8064
    • Dai, B.1    Kim, O.2    Xie, Y.3    Guo, Z.4    Xu, K.5    Wang, B.6
  • 23
    • 34848917292 scopus 로고    scopus 로고
    • In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method
    • Jarvius M, Paulsson J, Weibrecht I, Leuchowius KJ, ersson AC, Wahlby C, et al. In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method. Mol Cell Proteomics 2007;6:1500-9.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 1500-1509
    • Jarvius, M.1    Paulsson, J.2    Weibrecht, I.3    Leuchowius, K.J.4    Ersson, A.C.5    Wahlby, C.6
  • 24
    • 79952358749 scopus 로고    scopus 로고
    • Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy
    • Guo S, Sun F, Guo Z, Li W, Alfano A, Chen H, et al. Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. PLoS One 2011;6:e17778.
    • (2011) PLoS One , vol.6
    • Guo, S.1    Sun, F.2    Guo, Z.3    Li, W.4    Alfano, A.5    Chen, H.6
  • 26
    • 4344568204 scopus 로고    scopus 로고
    • Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing
    • Paavonen K, Ekman N, Wirzenius M, Rajantie I, Poutanen M, Alitalo K. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Mol Biol Cell 2004;15:4226-33.
    • (2004) Mol Biol Cell , vol.15 , pp. 4226-4233
    • Paavonen, K.1    Ekman, N.2    Wirzenius, M.3    Rajantie, I.4    Poutanen, M.5    Alitalo, K.6
  • 27
    • 84898782348 scopus 로고    scopus 로고
    • The expression and role of tyrosine kinase ETK/BMX in renal cell carcinoma
    • Zhuang J, Tu X, Cao K, Guo S, Mao X, Pan J, et al. The expression and role of tyrosine kinase ETK/BMX in renal cell carcinoma. J Exp Clin Cancer Res 2014;33:25.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 25
    • Zhuang, J.1    Tu, X.2    Cao, K.3    Guo, S.4    Mao, X.5    Pan, J.6
  • 28
    • 77954370361 scopus 로고    scopus 로고
    • Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells
    • Dai B, Chen H, Guo S, Yang X, Linn DE, Sun F, et al. Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells. Cancer Res 2010;70:5587-96.
    • (2010) Cancer Res , vol.70 , pp. 5587-5596
    • Dai, B.1    Chen, H.2    Guo, S.3    Yang, X.4    De Linn5    Sun, F.6
  • 29
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Cancer Genome Atlas Network1
  • 32
  • 34
    • 0034002476 scopus 로고    scopus 로고
    • Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation
    • Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, et al. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol 2000;20:2043-54.
    • (2000) Mol Cell Biol , vol.20 , pp. 2043-2054
    • Tsai, Y.T.1    Su, Y.H.2    Fang, S.S.3    Huang, T.N.4    Qiu, Y.5    Jou, Y.S.6
  • 35
    • 0034731509 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases
    • Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, et al. Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases. J Biol Chem 2000;275:41124-32.
    • (2000) J Biol Chem , vol.275 , pp. 41124-41132
    • Jui, H.Y.1    Tseng, R.J.2    Wen, X.3    Fang, H.I.4    Huang, L.M.5    Chen, K.Y.6
  • 36
    • 58249138122 scopus 로고    scopus 로고
    • Large-scale structural analysis of the classical human protein tyrosine phosphatome
    • Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, et al. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 2009;136:352-63.
    • (2009) Cell , vol.136 , pp. 352-363
    • Barr, A.J.1    Ugochukwu, E.2    Lee, W.H.3    King, O.N.4    Filippakopoulos, P.5    Alfano, I.6
  • 37
    • 2442717798 scopus 로고    scopus 로고
    • Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling
    • Cardone L, Carlucci A, Affaitati A, Livigni A, DeCristofaro T, Garbi C, et al. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Mol Cell Biol 2004;24:4613-26.
    • (2004) Mol Cell Biol , vol.24 , pp. 4613-4626
    • Cardone, L.1    Carlucci, A.2    Affaitati, A.3    Livigni, A.4    DeCristofaro, T.5    Garbi, C.6
  • 38
    • 0032544921 scopus 로고    scopus 로고
    • Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins
    • Hobbs S, Jitrapakdee S, Wallace JC. Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins. Biochem Biophys Res Commun 1998;252:368-72.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 368-372
    • Hobbs, S.1    Jitrapakdee, S.2    Wallace, J.C.3
  • 40
    • 0033519688 scopus 로고    scopus 로고
    • Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin
    • Xue LY, Qiu Y, He J, Kung HJ, Oleinick NL. Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin. Oncogene 1999;18:3391-8.
    • (1999) Oncogene , vol.18 , pp. 3391-3398
    • Xue, L.Y.1    Qiu, Y.2    He, J.3    Kung, H.J.4    Oleinick, N.L.5
  • 41
    • 1842429920 scopus 로고    scopus 로고
    • Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells
    • Kim O, Jiang T, Xie Y, Guo Z, Chen H, Qiu Y. Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene 2004;23:1838-44.
    • (2004) Oncogene , vol.23 , pp. 1838-1844
    • Kim, O.1    Jiang, T.2    Xie, Y.3    Guo, Z.4    Chen, H.5    Qiu, Y.6
  • 42
    • 79953757100 scopus 로고    scopus 로고
    • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    • Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011;19:498-511.
    • (2011) Cancer Cell , vol.19 , pp. 498-511
    • Guryanova, O.A.1    Wu, Q.2    Cheng, L.3    Lathia, J.D.4    Huang, Z.5    Yang, J.6
  • 43
    • 36349003312 scopus 로고    scopus 로고
    • Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells
    • Jiang X, Borgesi RA, McKnight NC, Kaur R, Carpenter CL, Balk SP. Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells. J Biol Chemi 2007;282:32689-98.
    • (2007) J Biol Chemi , vol.282 , pp. 32689-32698
    • Jiang, X.1    Borgesi, R.A.2    McKnight, N.C.3    Kaur, R.4    Carpenter, C.L.5    Balk, S.P.6
  • 44
    • 84866019998 scopus 로고    scopus 로고
    • PI3K and STAT3: A new alliance
    • Vogt PK, Hart JR. PI3K and STAT3: a new alliance. Cancer Discov 2011;1:481-86.
    • (2011) Cancer Discov , vol.1 , pp. 481-486
    • Vogt, P.K.1    Hart, J.R.2
  • 45
    • 75149168360 scopus 로고    scopus 로고
    • Non-receptor tyrosine kinase Etk regulation of drug resistance in small-cell lung cancer
    • Guo L, Zhou Y, Sun Y, Zhang F. Non-receptor tyrosine kinase Etk regulation of drug resistance in small-cell lung cancer. Eur J Cancer 2010;46:636-41.
    • (2010) Eur J Cancer , vol.46 , pp. 636-641
    • Guo, L.1    Zhou, Y.2    Sun, Y.3    Zhang, F.4
  • 46
    • 79953313816 scopus 로고    scopus 로고
    • Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation
    • Zhang Z, Zhu W, Zhang J, Guo L. Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Cancer Biol Ther 2011;11:690-8.
    • (2011) Cancer Biol Ther , vol.11 , pp. 690-698
    • Zhang, Z.1    Zhu, W.2    Zhang, J.3    Guo, L.4
  • 47
    • 0037069931 scopus 로고    scopus 로고
    • Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
    • Chau CH, Chen KY, Deng HT, Kim KJ, Hosoya K, Terasaki T, et al. Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation. Oncogene 2002;21:8817-29.
    • (2002) Oncogene , vol.21 , pp. 8817-8829
    • Chau, C.H.1    Chen, K.Y.2    Deng, H.T.3    Kim, K.J.4    Hosoya, K.5    Terasaki, T.6


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