-
1
-
-
84871530214
-
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
-
Foley EA, Kapoor TM. 2013 Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat. Rev. Mol. Cell Biol. 14, 25-37. (doi:10.1038/nrm3494)
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 25-37
-
-
Foley, E.A.1
Kapoor, T.M.2
-
2
-
-
34247232176
-
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
-
Allan LA, Clarke PR. 2007 Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol. Cell 26, 301-310. (doi:10.1016/j.molcel. 2007.03.019)
-
(2007)
Mol. Cell
, vol.26
, pp. 301-310
-
-
Allan, L.A.1
Clarke, P.R.2
-
3
-
-
67649362238
-
Length of mitotic arrest induced by microtubulestabilizing drugs determines cell death after mitotic exit
-
Bekier ME, Fischbach R, Lee J, Taylor WR. 2009 Length of mitotic arrest induced by microtubulestabilizing drugs determines cell death after mitotic exit. Mol. Cancer Ther. 8, 1646-1654. (doi:10.1158/1535-7163. MCT-08-1084)
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 1646-1654
-
-
Bekier, M.E.1
Fischbach, R.2
Lee, J.3
Taylor, W.R.4
-
4
-
-
70349452101
-
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly
-
Huang HC, Shi J, Orth JD, Mitchison TJ. 2009 Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 16, 347-358. (doi:10.1016/j.ccr.2009.08.020)
-
(2009)
Cancer Cell
, vol.16
, pp. 347-358
-
-
Huang, H.C.1
Shi, J.2
Orth, J.D.3
Mitchison, T.J.4
-
5
-
-
33744996707
-
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint
-
Brito DA, Rieder CL. 2006 Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr. Biol. 16, 1194-1200. (doi:10.1016/j.cub.2006.04.043)
-
(2006)
Curr. Biol.
, vol.16
, pp. 1194-1200
-
-
Brito, D.A.1
Rieder, C.L.2
-
6
-
-
48449098623
-
Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
-
Gascoigne KE, Taylor SS. 2008 Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14, 111-122. (doi:10.1016/j.ccr.2008.07.002)
-
(2008)
Cancer Cell
, vol.14
, pp. 111-122
-
-
Gascoigne, K.E.1
Taylor, S.S.2
-
7
-
-
7744233719
-
Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
-
Rieder CL, Maiato H. 2004 Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev. Cell 7, 637-651. (doi:10.1016/j.devcel.2004.09.002)
-
(2004)
Dev. Cell
, vol.7
, pp. 637-651
-
-
Rieder, C.L.1
Maiato, H.2
-
8
-
-
44849127993
-
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5
-
Shi J, Orth JD, Mitchison T. 2008 Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 68, 3269-3276. (doi:10.1158/0008-5472. CAN-07-6699)
-
(2008)
Cancer Res.
, vol.68
, pp. 3269-3276
-
-
Shi, J.1
Orth, J.D.2
Mitchison, T.3
-
9
-
-
78650004841
-
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α, δ phosphatase
-
Manchado E et al. 2010 Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55α, δ phosphatase. Cancer Cell 18, 641-654. (doi:10.1016/j.ccr.2010.10.028)
-
(2010)
Cancer Cell
, vol.18
, pp. 641-654
-
-
Manchado, E.1
-
10
-
-
61749102378
-
Cell-cycle control in the face of damage: A matter of life or death
-
Clarke PR, Allan LA. 2009 Cell-cycle control in the face of damage: a matter of life or death. Trends Cell Biol. 19, 89-98. (doi:10.1016/j.tcb.2008. 12.003)
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 89-98
-
-
Clarke, P.R.1
Allan, L.A.2
-
11
-
-
77954884045
-
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest
-
Harley ME, Allan LA, Sanderson HS, Clarke PR. 2010 Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J. 29, 2407-2420. (doi:10. 1038/emboj.2010.112)
-
(2010)
EMBO J.
, vol.29
, pp. 2407-2420
-
-
Harley, M.E.1
Allan, L.A.2
Sanderson, H.S.3
Clarke, P.R.4
-
12
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz IE et al. 2011 Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471, 110-114. (doi:10.1038/nature09779)
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
-
13
-
-
75149132946
-
Cyclindependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis
-
Terrano DT, Upreti M, Chambers TC. 2010 Cyclindependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Mol. Cell. Biol. 30, 640-656. (doi:10.1128/MCB.00882-09)
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 640-656
-
-
Terrano, D.T.1
Upreti, M.2
Chambers, T.C.3
-
14
-
-
77957219796
-
Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis
-
Uetake Y, Sluder G. 2010 Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis. Curr. Biol. 20, 1666-1671. (doi:10.1016/j.cub.2010.08.018)
-
(2010)
Curr. Biol.
, vol.20
, pp. 1666-1671
-
-
Uetake, Y.1
Sluder, G.2
-
15
-
-
84861308305
-
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest
-
Hayashi MT, Cesare AJ, Fitzpatrick JA, Lazzerini-Denchi E, Karlseder J. 2012 A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat. Struct. Mol. Biol. 19, 387-394. (doi:10.1038/nsmb.2245)
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 387-394
-
-
Hayashi, M.T.1
Cesare, A.J.2
Fitzpatrick, J.A.3
Lazzerini-Denchi, E.4
Karlseder, J.5
-
16
-
-
80053966362
-
Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis
-
Imreh G, Norberg HV, Imreh S, Zhivotovsky B. 2011 Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. J. Cell Sci. 124, 2951-2963. (doi:10.1242/jcs.081612)
-
(2011)
J. Cell Sci.
, vol.124
, pp. 2951-2963
-
-
Imreh, G.1
Norberg, H.V.2
Imreh, S.3
Zhivotovsky, B.4
-
17
-
-
84855391980
-
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
-
Orth JD, Loewer A, Lahav G, Mitchison TJ. 2012 Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol. Biol. Cell 23, 567-576. (doi:10. 1091/mbc. E11-09-0781)
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 567-576
-
-
Orth, J.D.1
Loewer, A.2
Lahav, G.3
Mitchison, T.J.4
-
18
-
-
34249056243
-
P73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
-
Crighton D, O'Prey J, Bell HS, Ryan KM. 2007 p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ. 14, 1071-1079. (doi:10.1038/sj.cdd. 4402108)
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1071-1079
-
-
Crighton, D.1
O'Prey, J.2
Bell, H.S.3
Ryan, K.M.4
-
19
-
-
33749334018
-
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
-
Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. 2006 A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20, 2687-2700. (doi:10.1101/gad.1447006)
-
(2006)
Genes Dev.
, vol.20
, pp. 2687-2700
-
-
Aylon, Y.1
Michael, D.2
Shmueli, A.3
Yabuta, N.4
Nojima, H.5
Oren, M.6
-
20
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
Chou TC. 2010 Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 70, 440-446. (doi:10.1158/0008-5472. CAN-09-1947)
-
(2010)
Cancer Res.
, vol.70
, pp. 440-446
-
-
Chou, T.C.1
-
21
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J. 2009 The DNA-damage response in human biology and disease. Nature 461, 1071-1078. (doi:10.1038/nature08467)
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
22
-
-
76149146422
-
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
-
So S, Davis AJ, Chen DJ. 2009 Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J. Cell Biol. 187, 977-990. (doi:10.1083/jcb. 200906064)
-
(2009)
J. Cell Biol.
, vol.187
, pp. 977-990
-
-
So, S.1
Davis, A.J.2
Chen, D.J.3
-
23
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M et al. 2007 Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc. Natl Acad. Sci. USA 104, 19 512-19 517. (doi:10.1073/pnas. 0709443104)
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
-
24
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson I et al. 2004 Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64, 9152-9159. (doi:10.1158/0008-5472. CAN-04-2727)
-
(2004)
Cancer Res.
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
-
25
-
-
79960834396
-
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
-
Peasland A et al. 2011 Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br. J. Cancer 105, 372-381. (doi:10.1038/bjc.2011.243)
-
(2011)
Br. J. Cancer
, vol.105
, pp. 372-381
-
-
Peasland, A.1
-
26
-
-
8844254050
-
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
-
Leahy JJ, Golding BT, Griffin RJ, Hardcastle IR, Richardson C, Rigoreau L, Smith GC. 2004 Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg. Med. Chem. Lett. 14, 6083-6087. (doi:10. 1016/j.bmcl.2004.09.060)
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 6083-6087
-
-
Leahy, J.J.1
Golding, B.T.2
Griffin, R.J.3
Hardcastle, I.R.4
Richardson, C.5
Rigoreau, L.6
Smith, G.C.7
-
27
-
-
33744924482
-
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
-
Zhao Y et al. 2006 Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 66, 5354-5362. (doi:10.1158/0008-5472. CAN-05-4275)
-
(2006)
Cancer Res.
, vol.66
, pp. 5354-5362
-
-
Zhao, Y.1
-
28
-
-
79958865837
-
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
-
Toledo LI et al. 2011 A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat. Struct. Mol. Biol. 18, 721-727. (doi:10.1038/nsmb.2076)
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 721-727
-
-
Toledo, L.I.1
-
29
-
-
0033975054
-
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
-
Jackson JR, Gilmartin A, Imburgia C, Winkler JD, Marshall LA, Roshak A. 2000 An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 60, 566-572.
-
(2000)
Cancer Res.
, vol.60
, pp. 566-572
-
-
Jackson, J.R.1
Gilmartin, A.2
Imburgia, C.3
Winkler, J.D.4
Marshall, L.A.5
Roshak, A.6
-
30
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C et al. 2008 ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68, 3421-3428. (doi:10.1158/0008-5472. CAN-07-5836)
-
(2008)
Cancer Res.
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
-
31
-
-
79959886892
-
Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL
-
Shi J, Zhou Y, Huang HC, Mitchison TJ. 2011 Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res. 71, 4518-4526. (doi:10.1158/0008-5472. CAN-10-4336)
-
(2011)
Cancer Res.
, vol.71
, pp. 4518-4526
-
-
Shi, J.1
Zhou, Y.2
Huang, H.C.3
Mitchison, T.J.4
-
32
-
-
70350347735
-
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
-
Andersen JL et al. 2009 Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J. 28, 3216-3227. (doi:10.1038/emboj.2009.253)
-
(2009)
EMBO J.
, vol.28
, pp. 3216-3227
-
-
Andersen, J.L.1
-
33
-
-
77952909686
-
Resistance to caspase-independent cell death requires persistence of intact mitochondria
-
Tait SW, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, Munoz-Pinedo C, Green DR. 2010 Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev. Cell 18, 802-813. (doi:10.1016/j.devcel.2010.03.014)
-
(2010)
Dev. Cell
, vol.18
, pp. 802-813
-
-
Tait, S.W.1
Parsons, M.J.2
Llambi, F.3
Bouchier-Hayes, L.4
Connell, S.5
Munoz-Pinedo, C.6
Green, D.R.7
-
34
-
-
0031888955
-
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
-
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. 1998 A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50. (doi:10.1038/34112)
-
(1998)
Nature
, vol.391
, pp. 43-50
-
-
Enari, M.1
Sakahira, H.2
Yokoyama, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
35
-
-
84898052474
-
Mitosis inhibits DNA doublestrand break repair to guard against telomere fusions
-
Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D. 2014 Mitosis inhibits DNA doublestrand break repair to guard against telomere fusions. Science 344, 189-193. (doi:10.1126/science.1248024)
-
(2014)
Science
, vol.344
, pp. 189-193
-
-
Orthwein, A.1
Fradet-Turcotte, A.2
Noordermeer, S.M.3
Canny, M.D.4
Brun, C.M.5
Strecker, J.6
Escribano-Diaz, C.7
Durocher, D.8
-
36
-
-
77954997032
-
DNA damage signaling in response to double-strand breaks during mitosis
-
Giunta S, Belotserkovskaya R, Jackson SP. 2010 DNA damage signaling in response to double-strand breaks during mitosis. J. Cell Biol. 190, 197-207. (doi:10.1083/jcb.200911156)
-
(2010)
J. Cell Biol.
, vol.190
, pp. 197-207
-
-
Giunta, S.1
Belotserkovskaya, R.2
Jackson, S.P.3
-
37
-
-
80053364894
-
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
-
Janssen A, Van Der Burg M, Szuhai K, Kops GJ, Medema RH. 2011 Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 333, 1895-1898. (doi:10.1126/science.1210214)
-
(2011)
Science
, vol.333
, pp. 1895-1898
-
-
Janssen, A.1
Van Der Burg, M.2
Szuhai, K.3
Kops, G.J.4
Medema, R.H.5
-
38
-
-
84856424908
-
DNA breaks and chromosome pulverization from errors in mitosis
-
Crasta K et al. 2012 DNA breaks and chromosome pulverization from errors in mitosis. Nature 482, 53-58. (doi:10.1038/nature10802)
-
(2012)
Nature
, vol.482
, pp. 53-58
-
-
Crasta, K.1
-
39
-
-
84879956366
-
Catastrophic nuclear envelope collapse in cancer cell micronuclei
-
Hatch EM, Fischer AH, Deerinck TJ, Hetzer MW. 2013 Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154, 47-60. (doi:10.1016/j.cell. 2013.06.007)
-
(2013)
Cell
, vol.154
, pp. 47-60
-
-
Hatch, E.M.1
Fischer, A.H.2
Deerinck, T.J.3
Hetzer, M.W.4
-
40
-
-
84903977636
-
Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
-
Loughery J, Cox M, Smith LM, Meek DW. 2014 Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters. Nucleic Acid Res. 42, 7666-7680. (doi:10.1093/nar/gku501)
-
(2014)
Nucleic Acid Res.
, vol.42
, pp. 7666-7680
-
-
Loughery, J.1
Cox, M.2
Smith, L.M.3
Meek, D.W.4
-
41
-
-
44649126775
-
Extra centrosomes and/or chromosomes prolong mitosis in human cells
-
Yang Z, Loncarek J, Khodjakov A, Rieder CL. 2008 Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat. Cell Biol. 10, 748-751. (doi:10.1038/ncb1738)
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 748-751
-
-
Yang, Z.1
Loncarek, J.2
Khodjakov, A.3
Rieder, C.L.4
-
42
-
-
0036211680
-
Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
-
Park YB, Park MJ, Kimura K, Shimizu K, Lee SH, Yokota J. 2002 Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. Cancer Genet. Cytogenet. 133, 105-111. (doi:10.1016/S0165-4608 (01) 00575-1)
-
(2002)
Cancer Genet. Cytogenet.
, vol.133
, pp. 105-111
-
-
Park, Y.B.1
Park, M.J.2
Kimura, K.3
Shimizu, K.4
Lee, S.H.5
Yokota, J.6
|