Mitigation of NADPH oxidase 2 activity as a strategy to inhibit peroxynitrite formation

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 7029-7044

  Zielonka, Jacek ^a   Zielonka, Monika ^a   Verplank, Lynn ^b   Cheng, Gang ^a   Hardy, Micael ^c   Ouari, Olivier ^c   Ayhan, Mehmet Menaf ^c   Podsiadły, Radosław ^a   Sikora, Adam ^d   Lambeth, J David ^e   Kalyanaraman, Balaraman ^a  

^a FREE RADICAL RESEARCH CENTER   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c AIX MARSEILLE UNIV   (France)

^d LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; NITRIC OXIDE; OXIDATION; OXYGEN; PEROXIDES; THROUGHPUT;

ACTIVATED MACROPHAGES; BIOACTIVE COMPOUNDS; DIAGNOSTIC MARKERS; HIGH THROUGHPUT SCREENING; NITRIC-OXIDE SYNTHASE; OXYGEN SPECIES; POTENTIAL INHIBITORS; REDOX CHEMISTRY;

DIAGNOSTIC PRODUCTS;

CETYLPYRIDINIUM SALT; ENZYME INHIBITOR; HYDROGEN PEROXIDE; MEFLOQUINE; MITOXANTRONE; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2 INHIBITOR; SULCONAZOLE; SUPEROXIDE; UNCLASSIFIED DRUG; AMPLEX RED REAGENT; COUMARIN DERIVATIVE; CYBB PROTEIN, HUMAN; HYDROETHIDINE; HYDROPROPIDINE; MEMBRANE PROTEIN; MOLECULAR LIBRARY; MOLECULAR PROBE; OXAZINE DERIVATIVE; PEROXYNITROUS ACID; PHENANTHRIDINE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; QUATERNARY AMMONIUM DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HL 60 CELL LINE; HUMAN; HUMAN CELL; IC50; MACROPHAGE ACTIVATION; NITRATION; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; FLUOROMETRY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HL-60 CELL LINE; METABOLISM; MOLECULAR LIBRARY; MOLECULAR PROBE; OXIDATION REDUCTION REACTION; PHARMACOLOGY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; ENZYME INHIBITORS; FLUOROMETRY; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; MACROPHAGE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR PROBES; NADPH OXIDASE; OXAZINES; OXIDATION-REDUCTION; PEROXYNITROUS ACID; PHENANTHRIDINES; QUATERNARY AMMONIUM COMPOUNDS; SMALL MOLECULE LIBRARIES; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 84964907042     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.702787     Document Type: Article

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