A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells

ACS Chemical Biology

Volumn 5, Issue 10, 2010, Pages 981-993

  Gianni, Davide ^a   Taulet, Nicolas ^a   Zhang, Hui ^b   Dermardirossian, Celine ^a   Kister, Jeremy ^c   Martinez, Luis ^c   Roush, William R ^c   Brown, Steven J ^a   Bokoch, Gary M ^a   Rosen, Hugh ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (TRIFLUOROMETHYL) PHENOTHIAZINE; 2 ACETYLPHENOTHIAZINE; CHLORPROMAZINE; CORTACTIN; ENZYME INHIBITOR; G PROTEIN COUPLED RECEPTOR; ML 171; PHENOTHIAZINE DERIVATIVE; PROTEIN NOXA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL STRAIN HEK293; CELL STRAIN HT29; CELL ULTRASTRUCTURE; COLON CANCER; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; EPIFLUORESCENCE MICROSCOPY; EXTRACELLULAR MATRIX; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; INVADOPODIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NADH, NADPH OXIDOREDUCTASES; NEOPLASM INVASIVENESS; PHENOTHIAZINES; REACTIVE OXYGEN SPECIES; SMALL MOLECULE LIBRARIES;

EID: 77958098686     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100219n     Document Type: Article

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