Is the sense of agency in schizophrenia influenced by resting-state variation in self-referential regions of the brain?

Schizophrenia Bulletin

Volumn 42, Issue 2, 2016, Pages 270-276

  Robinson, Jeffrey D ^a,b   Wagner, Nils Frederic ^b   Northoff, Georg ^a,c,d,e,f  

^a ROYAL OTTAWA HEALTH CARE GROUP   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL CHENGCHI UNIVERSITY   (Taiwan)

^f Hangzhou Normal College   (China)

Author keywords

Agency; Default mode network; Resting state activity; Schizophrenia; Self; Source monitoring hypothesis

Indexed keywords

ARTICLE; BRAIN REGION; CONCEPTUAL FRAMEWORK; DEFAULT MODE NETWORK; ELECTROENCEPHALOGRAM; HUMAN; NEUROBIOLOGY; NEUROIMAGING; NEUROSCIENCE; PHENOMENOLOGY; PRIORITY JOURNAL; RESTING STATE NETWORK; SCHIZOPHRENIA; STIMULATION; THEORY; BRAIN; PATHOPHYSIOLOGY; SELF CONCEPT;

BRAIN; HUMANS; SCHIZOPHRENIA; SELF CONCEPT;

EID: 84964898429     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbv102     Document Type: Article

References (66)

1. Carruthers G. What makes us conscious of our own agency? And why the conscious versus unconscious representation distinction matters. Front Hum Neurosci. 2014;8:434.
2. Gallagher S. Philosophical conceptions of the self: implications for cognitive science. Trends Cogn Sci. 2000;4:14-21.
3. Gallagher S. Multiple aspects in the sense of agency. New Ideas Psychol. 2012;30:15-31.
4. Jeannerod M, Pacherie E. Agency, simulation and self-identification. Mind Lang. 2004;19:113-146.
5. Moore JW, Fletcher PC. Sense of agency in health and disease: A review of cue integration approaches. Conscious Cogn. 2012;21:59-68.
6. Wegner DM. The mind's best trick: how we experience conscious will. Trends Cogn Sci. 2003;7:65-69.
7. Nahmias E. Agency, authorship, and illusion. Conscious Cogn. 2005;14:771-785.
8. David N, Newen A, Vogeley K. The "sense of agency" and its underlying cognitive and neural mechanisms. Conscious Cogn. 2008;17:523-534.
9. Pacherie E. The sense of control and the sense of agency. Psyche (Stuttg). 2007;13:1-30. http://jeannicod.ccsd.cnrs.fr/ijn-00352565.
10. Pacherie E. The phenomenology of action: A conceptual framework. Cognition. 2008;107:179-217.
11. Pacherie E. Self- Agency. In: Gallagher S, ed. The Oxford Handbook of the Self. Vol 1. Oxford: Oxford University Press; 2011:442-464. http://hdl.handle.net/2299/14075.
12. Sass LA, Parnas J. Schizophrenia, consciousness, and the self. Schizophr Bull. 2003;29:427-444.
13. Parnas J, Handest P. Phenomenology of anomalous selfexperience in early schizophrenia. Compr Psychiatry. 2003;44:121-134.
14. Nelson B, Fornito A, Harrison BJ, et al. A disturbed sense of self in the psychosis prodrome: linking phenomenology and neurobiology. Neurosci Biobehav Rev. 2009;33:807-817.
15. Nelson B, Thompson A, Yung AR. Basic self-disturbance predicts psychosis onset in the ultra high risk for psychosis "prodromal" population. Schizophr Bull. 2012;38:1277-1287.
16. Schultze-Lutter F. Subjective symptoms of schizophrenia in research and the clinic: The basic symptom concept. Schizophr Bull. 2009;35:5-8.
17. Moe AM, Docherty NM. Schizophrenia and the sense of self. Schizophr Bull. 2014;40:161-168.
18. Frith CD, Done DJ. Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action. Psychol Med. 1989;19:359-363.
19. Frith C. The self in action: lessons from delusions of control. Conscious Cogn. 2005;14:752-770.
20. Frith C. The Cognitive Neuropsychology of Schizophrenia. Hove, East Sussex: Lawrence Erlblaum Associates; 1992.
21. Keefe RSE, Courtney M, McEvoy JM. Self-monitoring deficits in schizophrenia: Autonoetic agnosia. Schizophr Res. 2015;24:110.
22. Frith CD, Blakemore S, Wolpert DM. Explaining the symptoms of schizophrenia: Abnormalities in the awareness of action. Brain Res Brain Res Rev. 2000;31:357-363.
23. Gaweda L, Woodward TS, Moritz S, Kokoszka A. Impaired action self-monitoring in schizophrenia patients with auditory hallucinations. Schizophr Res. 2013;144:72-79.
24. Stephan KE, Friston KJ, Frith CD. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of selfmonitoring. Schizophr Bull. 2009;35:509-527.
25. Waters F, Woodward T, Allen P, Aleman A, Sommer I. Selfrecognition deficits in schizophrenia patients with auditory hallucinations: A meta- Analysis of the literature. Schizophr Bull. 2012;38:741-750.
26. Mingoia G, Wagner G, Langbein K, et al. Default mode network activity in schizophrenia studied at resting state using probabilistic ICA. Schizophr Res. 2012;138:143-149.
27. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124:1-38.
28. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: Anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124:1-38.
29. Buckner RL. The serendipitous discovery of the brain's default network. Neuroimage. 2012;62:1137-1145.
30. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A. 2001;98:676-682.
31. Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ. Default-mode brain dysfunction in mental disorders: A systematic review. Neurosci Biobehav Rev. 2009;33:279-296.
32. Kühn S, Gallinat J. Resting-state brain activity in schizophrenia and major depression: A quantitative meta- Analysis. Schizophr Bull. 2013;39:358-365.
33. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen, DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 2005;102:9673-9678.
34. Van Der Meer, L, Costafreda S, Aleman A, David AS. Selfreflection and the brain: A theoretical review and meta- Analysis of neuroimaging studies with implications for schizophrenia. Neurosci Biobehav Rev. 2010;34:935-946.
35. Vanhaudenhuyse A, Demertzi A, Schabus M, et al. Two distinct neuronal networks mediate the awareness of environment and of self. J Cogn Neurosci. 2011;23:570-578.
36. Sridharan D, Levitin DJ, Menon V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A. 2008;105:12569-12574.
37. Alonso-Solís A, Corripio I, de Castro-Manglano P, et al. Altered default network resting state functional connectivity in patients with a first episode of psychosis. Schizophr Res. 2012;139:13-18.
38. Nakao T, Bai Y, Nashiwa H, Northoff G. Resting-state EEG power predicts conflict-related brain activity in internally guided but not in externally guided decision-making. Neuroimage. 2013;66:9-21.
39. Haggard P, Tsakiris M. The experience of agency. Curr Dir Psychol Sci. 2009;18:242-246.
40. Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002;6:237-242.
41. Wolpert DM, Flanagan JR. Motor prediction. Curr Biol. 2001;11:R729-R732.
42. Synofzik M, Vosgerau G, Newen A. Beyond the comparator model: A multifactorial two-step account of agency. Conscious Cogn. 2008;17:219-239.
43. Moore JW, Middleton D, Haggard P, Fletcher PC. Exploring implicit and explicit aspects of sense of agency. Conscious Cogn. 2012;21:1748-1753.
44. Dijksterhuis A, Preston J, Wegner DM, Aarts H. Effects of subliminal priming of self and God on self- Attribution of authorship for events. J Exp Soc Psychol. 2008;44:2-9.
45. Vosgerau G, Synofzik M. Weighting models and weighting factors. Conscious Cogn. 2012;21:55-58.
46. Corlett PR, Taylor JR, Wang XJ, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Prog Neurobiol. 2010;92:345-369.
47. Fletcher PC, Frith CD. Perceiving is believing: A Bayesian approach to explaining the positive symptoms of schizophrenia. Nat Rev Neurosci. 2009;10:48-58.
48. Lindner A, Thier P, Kircher TT, Haarmeier T, Leube DT. Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Curr Biol. 2005;15:1119-1124.
49. Shergill SS, Samson G, Bays PM, Frith CD, Wolpert DM. Evidence for sensory prediction deficits in schizophrenia. Am J Psychiatry. 2005;162:2384-2386.
50. Christoff K, Cosmelli D, Legrand D, Thompson E. Specifying the self for cognitive neuroscience. Trends Cogn Sci. 2011;15:104-112.
51. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry. 2007;164:450-457.
52. Horn A, Ostwald D, Reisert M, Blankenburg F. The structural- functional connectome and the default mode network of the human brain. Neuroimage. 2014;102(pt 1):142-151.
53. Nakao T, Ohira H, Northoff G. Distinction between externally vs. Internally guided decision-making: Operational differences, meta- Analytical comparisons and their theoretical implications. Front Neurosci. 2012;6:1-26.
54. Northoff G. Resting state activity and the stream of consciousness in schizophrenia-neurophenomenal hypotheses. 2014;41:280-290.
55. Wiebking C, Duncan NW, Tiret B, et al. GABA in the insula - A predictor of the neural response to interoceptive awareness. Neuroimage. 2014;86:10-18.
56. Northoff G. Is schizophrenia a spatiotemporal disorder of the brain's resting state? World Psychiatry. 2015;14:17-18.
57. Carhart-Harris RL, Erritzoe D, Williams T, et al. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. 2012;109:1-6.
58. Hill K, Mann L, Laws KR, Stephenson CM, Nimmo-Smith I, McKenna PJ. Hypofrontality in schizophrenia: A metaanalysis of functional imaging studies. Acta Psychiatr Scand. 2004;110:243-256.
59. Enzi B, Duncan NW, Kaufmann J, Tempelmann C, Wiebking C, Northoff G. Glutamate modulates resting state activity in the perigenual anterior cingulate cortex - A combined fMRIMRS study. Neuroscience. 2012;227:102-109.
60. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain- A meta- Analysis of imaging studies on the self. Neuroimage. 2006;31:440-457.
61. Northoff G. Are auditory hallucinations related to the brain's resting state activity ? A "neurophenomenal resting state hypothesis.Clin Psychopharmacol Neurosci. 2014:1-7.
62. Lipsman N, Nakao T, Kanayama N, et al. Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. Cortex. 2014;60:6-11.
63. Wotruba D, Michels L, Buechler R, et al. Aberrant coupling within and across the default mode, task-positive, and salience network in subjects at risk for psychosis. Schizophr Bull. 2013;40:1-10.
64. Whitfield-Gabrieli S, Thermenos HW, Milanovic S, et al. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A. 2009;106:1279-1284.
65. Northoff G. Spatiotemporal psychopathology I: No rest for the brain's resting state activity in depression? spatiotemporal psychopathology of depressive symptoms [published online ahead of print May 14, 2015]. J Affect Disord. doi:10.1016/j.jad.2015.05.007.
66. Northoff G. Spatiotemporal psychopathology II: How does a psychopathology of the brain's resting state look like? spatiotemporal approach and the history of psychopathology [published online ahead of print May 19, 2015]. J Affect Disord. doi:10.1016/j.jad.2015.05.008.