HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

PLoS Pathogens

Volumn 12, Issue 4, 2016, Pages

  Wang, Chong ^a   Long, Wenying ^a   Peng, Chao ^b,c   Hu, Lin ^a   Zhang, Qiong ^a   Wu, Ailing ^a   Zhang, Xiaoqing ^a   Duan, Xiaotao ^d   Wong, Catherine C L ^b,c   Tanaka, Yuetsu ^e   Xia, Zongping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^e UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GREEN FLOUROSCENCE PROTEIN; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; LYSINE; LYSINE 63; POLYUBIQUITIN; PROTEIN S 100; TAX PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN CONJUGATING ENZYME 13; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TAX PROTEIN, HUMAN T-LYMPHOTROPHIC VIRUS 1; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN T-LYMPHOTROPIC VIRUS 1; IMMUNOBLOTTING; IN VITRO STUDY; JURKAT CELL LINE; LUCIFERASE ASSAY; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; BIOSYNTHESIS; ENZYME ACTIVATION; GENE INACTIVATION; GENETIC TRANSFECTION; HTLV-1 INFECTION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; GENE KNOCKOUT TECHNIQUES; GENE PRODUCTS, TAX; HEK293 CELLS; HTLV-I INFECTIONS; HUMANS; I-KAPPA B KINASE; IMMUNOBLOTTING; JURKAT CELLS; NF-KAPPA B; POLYUBIQUITIN; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84964827742     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005584     Document Type: Article

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