Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation

Retrovirology

Volumn 9, Issue , 2012, Pages

  Bonnet, Amandine ^a,b,c   Randrianarison Huetz, Voahangy ^a,b,c   Nzounza, Patrycja ^a,b,c   Nedelec, Martine ^a,b,c   Chazal, Maxime ^a,b,c   Waast, Laetitia ^a,b,c   Pene, Sabrina ^a,b,c   Bazarbachi, Ali ^d   Mahieux, Renaud ^e   Bénit, Laurence ^a,b,c   Pique, Claudine ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^e UNIVERSITÉ DE LYON   (France)

Author keywords

Leukemia; NF kappaB; Nuclear speckles; Retrovirus; SUMO; Ubiquitin

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TAX PROTEIN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CD4+ T LYMPHOCYTE; CELL NUCLEUS; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CYTOPLASM; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; PROMOTER REGION; SUMOYLATION; UBIQUITINATION;

AMINO ACID SUBSTITUTION; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE PRODUCTS, TAX; GENES, REPORTER; HOST-PATHOGEN INTERACTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; I-KAPPA B KINASE; INTRANUCLEAR SPACE; LUCIFERASES, RENILLA; MICROSCOPY, CONFOCAL; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUMO-1 PROTEIN; SUMOYLATION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UBIQUITINATION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 84866538111     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-9-77     Document Type: Article

References (41)

1. Journo C, Douceron E, Mahieux R. HTLV gene regulation: because size matters, transcription is not enough. Future Microbiol 2009, 4:425-440. 10.2217/fmb.09.13, 19416012.
2. Taylor JM, Nicot C. HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. Apoptosis 2008, 13:733-747. 10.1007/s10495-008-0208-7, 2633601, 18421579.
3. Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. The HTLV-1 tax interactome. Retrovirology 2008, 5:76. 10.1186/1742-4690-5-76, 2533353, 18702816.
4. Peloponese JM, Kinjo T, Jeang KT. Human T-cell leukemia virus type 1 tax and cellular transformation. Int J Hematol 2007, 86:101-106. 10.1532/IJH97.07087, 17875521.
5. Robek MD, Ratner L. Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 tax mutants expressed in a functional molecular clone. J Virol 1999, 73:4856-4865. 112529, 10233947.
6. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009, 27:693-733. 10.1146/annurev.immunol.021908.132641, 19302050.
7. Harhaj EW, Sun SC. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus tax protein. J Biol Chem 1999, 274:22911-22914. 10.1074/jbc.274.33.22911, 10438454.
8. Shembade N, Ma A, Harhaj EW. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010, 327:1135-1139. 10.1126/science.1182364, 3025292, 20185725.
9. Journo C, Filipe J, About F, Chevalier SA, Afonso PV, Brady JN, Flynn D, Tangy F, Israel A, Vidalain PO, et al. NRP/Optineurin cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. PLoS Pathog 2009, 5:e1000521. 10.1371/journal.ppat.1000521, 2706988, 19609363.
10. Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol 2008, 9:254-262. 10.1038/ni1563, 18246070.
11. Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G. HTLV-1 tax-mediated TAK1 activation involves TAB2 adapter protein. Biochem Biophys Res Commun 2008, 365:189-194. 10.1016/j.bbrc.2007.10.172, 17986383.
12. Sun SC, Yamaoka S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 2005, 24:5952-5964. 10.1038/sj.onc.1208969, 16155602.
13. Petropoulos L, Lin R, Hiscott J. Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein. Virology 1996, 225:52-64. 10.1006/viro.1996.0574, 8918533.
14. Suzuki T, Hirai H, Yoshida M. Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription. Oncogene 1994, 9:3099-3105.
15. Baydoun H, Duc-Dodon M, Lebrun S, Gazzolo L, Bex F. Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins tax, Rex and p30II in specific nuclear subdomains. Gene 2007, 386:191-201. 10.1016/j.gene.2006.09.008, 17071021.
16. Bex F, McDowall A, Burny A, Gaynor R. The human T-cell leukemia virus type 1 transactivator protein tax colocalizes in unique nuclear structures with NF-kappaB proteins. J Virol 1997, 71:3484-3497. 191495, 9094620.
17. Semmes OJ, Jeang KT. Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles. J Virol 1996, 70:6347-6357. 190661, 8709263.
18. Fryrear KA, Durkin SS, Gupta SK, Tiedebohl JB, Semmes OJ. Dimerization and a novel Tax speckled structure localization signal are required for tax nuclear localization. J Virol 2009, 83:5339-5352. 10.1128/JVI.00232-09, 2681966, 19321601.
19. Kfoury Y, Setterblad N, El-Sabban M, Zamborlini A, Dassouki Z, El Hajj H, Hermine O, Pique C, de The H, Saib A, Bazarbachi A. Tax ubiquitylation and SUMOylation control the dynamic shuttling of tax and NEMO between Ubc9 nuclear bodies and the centrosome. Blood 2011, 117:190-199. 10.1182/blood-2010-05-285742, 20959607.
20. Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F. Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol Cell Biol 2005, 25:10391-10406. 10.1128/MCB.25.23.10391-10406.2005, 1291224, 16287853.
21. Chin KT, Chun AC, Ching YP, Jeang KT, Jin DY. Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res 2007, 67:1072-1081. 10.1158/0008-5472.CAN-06-3053, 17283140.
22. Durkin SS, Guo X, Fryrear KA, Mihaylova VT, Gupta SK, Belgnaoui SM, Haoudi A, Kupfer GM, Semmes OJ. HTLV-1 tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. J Biol Chem 2008, 283:36311-36320. 10.1074/jbc.M804931200, 2605996, 18957425.
23. Lodewick J, Lamsoul I, Bex F. Move or die: the fate of the tax oncoprotein of HTLV-1. Viruses 2011, 3:829-857. 10.3390/v3060829, 3185767, 21994756.
24. Nasr R, Chiari E, El-Sabban M, Mahieux R, Kfoury Y, Abdulhay M, Yazbeck V, Hermine O, de The H, Pique C, Bazarbachi A. Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation. Blood 2006, 107:4021-4029. 10.1182/blood-2005-09-3572, 16424386.
25. Peloponese JM, Iha H, Yedavalli VR, Miyazato A, Li Y, Haller K, Benkirane M, Jeang KT. Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity. J Virol 2004, 78:11686-11695. 10.1128/JVI.78.21.11686-11695.2004, 523283, 15479810.
26. Chiari E, Lamsoul I, Lodewick J, Chopin C, Bex F, Pique C. Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding. J Virol 2004, 78:11823-11832. 10.1128/JVI.78.21.11823-11832.2004, 523289, 15479824.
27. Fryrear KA, Guo X, Kerscher O, Semmes OJ. The SUMO-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein tax. Blood 2012, 119:1173-1178. 10.1182/blood-2011-06-358564, 22106342.
28. Lavorgna A, Harhaj EW. An RNA interference screen identifies the deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-kappaB activation. J Virol 2012, 86:3357-3369. 10.1128/JVI.06456-11, 3302326, 22258247.
29. Yasunaga J, Lin FC, Lu X, Jeang KT. Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling. J Virol 2011, 85:6212-6219. 10.1128/JVI.00079-11, 3126525, 21525354.
30. Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW. The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol 2007, 81:13735-13742. 10.1128/JVI.01790-07, 2168884, 17942533.
31. Shibata Y, Tanaka Y, Gohda J, Inoue J. Activation of the IkappaB kinase complex by HTLV-1 tax requires cytosolic factors involved in tax-induced polyubiquitination. J Biochem 2011, 150:679-686. 10.1093/jb/mvr106, 21862596.
32. Kfoury Y, Nasr R, Favre-Bonvin A, El-Sabban M, Renault N, Giron ML, Setterblad N, Hajj HE, Chiari E, Mikati AG, et al. Ubiquitylated tax targets and binds the IKK signalosome at the centrosome. Oncogene 2008, 27:1665-1676. 10.1038/sj.onc.1210804, 17891179.
33. Harhaj NS, Sun SC, Harhaj EW. Activation of NF-kappa B by the human T cell leukemia virus type I tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem 2007, 282:4185-4192.
34. Gatza ML, Dayaram T, Marriott SJ. Ubiquitination of HTLV-I tax in response to DNA damage regulates nuclear complex formation and nuclear export. Retrovirology 2007, 4:95. 10.1186/1742-4690-4-95, 2234431, 18081936.
35. Au PY, Yeh WC. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol 2007, 597:32-47. 10.1007/978-0-387-70630-6_3, 17633015.
36. Ye H, Park YC, Kreishman M, Kieff E, Wu H. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell 1999, 4:321-330. 10.1016/S1097-2765(00)80334-2, 10518213.
37. Garcia-Mata R, Bebok Z, Sorscher EJ, Sztul ES. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J Cell Biol 1999, 146:1239-1254. 10.1083/jcb.146.6.1239, 2156127, 10491388.
38. Bhat NK, Adachi Y, Samuel KP, Derse D. HTLV-1 gene expression by defective proviruses in an infected T-cell line. Virology 1993, 196:15-24. 10.1006/viro.1993.1450, 8356792.
39. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980, 77:7415-7419. 10.1073/pnas.77.12.7415, 350514, 6261256.
40. Wang YT, Yang WB, Chang WC, Hung JJ. Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression. J Mol Biol 2011, 414:1-14. 10.1016/j.jmb.2011.09.027, 21983342.
41. Sun Y. Targeting E3 ubiquitin ligases for cancer therapy. Cancer Biol Ther 2003, 2:623-629.