Ulinastatin attenuates LPS-induced human endothelial cells oxidative damage through suppressing JNK/c-Jun signaling pathway

Biochemical and Biophysical Research Communications

Volumn 474, Issue 3, 2016, Pages 572-578

  Li, Chunping ^a   Ma, Dandan ^a   Chen, Man ^a   Zhang, Linlin ^b   Zhang, Lin ^a   Zhang, Jicheng ^a   Qu, Xin ^a   Wang, Chunting ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

HUVECs; JNK c Jun signaling pathways; Lipopolysaccharide; Oxidative stress; ROS; Ulinastatin

Indexed keywords

ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; ULINASTATIN; GLYCOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TRYPSIN INHIBITOR;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; GENE REPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CULTURE; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; GLYCOPROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MAP KINASE KINASE 4; OXIDATIVE STRESS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRYPSIN INHIBITORS;

EID: 84964664631     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.04.104     Document Type: Article

References (35)

1. H. Matsumoto, K. Yamakawa, H. Ogura, T. Koh, N. Matsumoto, and T. Shimazu Enhanced expression of cell-specific surface antigens on endothelial microparticles in sepsis-induced disseminated intravascular coagulation Shock 43 2015 443 449 10.1097/shk.0000000000000331
2. D. Dixit, R. Ghildiyal, N.P. Anto, and E. Sen Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism Cell. Death Dis. 5 2014 e1212 10.1038/cddis.2014.179
3. H. Tang, H. Ge, Z.B. Chen, X.M. Luo, F.J. Su, Y.B. Liang, Z.Y. Li, J.G. Wu, and Q. Yang Micrometam C protects against oxidative stress in inflammation models in Zebrafish and RAW264.7 macrophages Mar. Drugs 13 2015 5593 5605 10.3390/md13095593
4. M. Zhang, A. Wang, W. He, P. He, B. Xu, T. Xia, X. Chen, and K. Yang Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons Toxicology 236 2007 208 216 10.1016/j.tox.2007.04.007
5. J. Wang, C. He, W.Y. Wu, F. Chen, Y.Y. Wu, W.Z. Li, H.Q. Chen, and Y.Y. Yin Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage and oxidative stress in a rat model of Parkinson's disease Pharmacol. Biochem. Behav. 138 2015 96 103 10.1016/j.pbb.2015.09.013
6. J. Zhao, J. Wei, N. Weathington, A.M. Jacko, H. Huang, A. Tsung, and Y. Zhao Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis Transl. Res. 166 2015 80 88 10.1016/j.trsl.2015.01.008
7. W. Jiang, F. Luo, Q. Lu, J. Liu, P. Li, X. Wang, Y. Fu, K. Hao, T. Yan, and X. Ding The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state Chem. Biol. Interact. 2015 10.1016/j.cbi.2015.09.010
8. W.Q. Liao, Y.L. Qi, L. Wang, X.M. Dong, T. Xu, C.D. Ding, R. Liu, W.C. Liang, L.T. Lu, W.F. Li, G.B. Luo, and X.C. Lu Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice World J. Gastroenterol. 21 2015 10375 10384 10.3748/wjg.v21.i36.10375
9. G. Wang, J. Wen, R.R. Wilbur, P. Wen, S.F. Zhou, and X. Xiao The effect of somatostatin, ulinastatin and Salvia mycorrhiza on severe acute pancreatitis treatment Am. J. Med. Sci. 346 2013 371 376 10.1097/MAJ.0b013e31827aa2bc
10. H. Lum, and K.A. Roebuck Oxidant stress and endothelial cell dysfunction Am. J. Physiol. Cell. Physiol. 280 2001 C719 C741
11. C.L. Kao, L.K. Chen, Y.L. Chang, M.C. Yung, C.C. Hsu, Y.C. Chen, S.J. Chen, H.H. Ku, and S.J. Hwang Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation J. Atheroscler. Thromb. 17 2010 970 979
12. I. Aytekin, H. Aksit, A. Sait, F. Kaya, D. Aksit, M. Gokmen, and A.U. Baca Evaluation of oxidative stress via total antioxidant status, sialic acid, malondialdehyde and RT-PCR findings in sheep affected with bluetongue Vet. Rec. Open 2 2015 10.1136/vetreco-2014-000054
13. H.B. Bae, C.W. Jeong, M. Li, H.S. Kim, and S.H. Kwak Effects of urinary trypsin inhibitor on lipopolysaccharide-induced acute lung injury in rabbits Inflammation 35 2012 176 182 10.1007/s10753-011-9303-y
14. N. Wang, X. Liu, X. Zheng, H. Cao, G. Wei, Y. Zhu, S. Fan, H. Zhou, and J. Zheng Ulinastatin is a novel candidate drug for sepsis and secondary acute lung injury, evidence from an optimized CLP rat model Int. Immunopharmacol. 17 2013 799 807 10.1016/j.intimp.2013.09.00417
15. K. Inoue, and H. Takano Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders Expert Opin. Investig. Drugs 19 2010 513 520 10.1517/13543781003649533
16. K. Ito, A. Mizutani, S. Kira, M. Mori, H. Iwasaka, and T. Noguchi Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes Injury 36 2005 387 394 10.1016/j.injury.2004.06.018
17. S.Y. Wang, Z.J. Li, X. Wang, W.F. Li, and Z.F. Lin Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis Genet. Mol. Res. 14 2015 4344 4353 10.4238/2015.April.30.7
18. B. Liu, W. Huang, X. Xiao, Y. Xu, S. Ma, and Z. Xia Neuroprotective effect of ulinastatin on spinal cord ischemia-reperfusion injury in rabbits Oxid. Med. Cell. Longev. 2015 2015 624819 10.1155/2015/624819
19. H. Guo, J. Chen, and D. Suo Clinical efficacy and safety of ulinastatin plus octreotide for patients with severe acute pancreatitis Zhonghua Yi Xue Za Zhi 95 2015 1471 1474
20. G.B. Zhou, Q.L. Xu, Y.A. Liu, Z.L. Wang, L. Su, and X.H. Guo Protective effects of ulinastatin against acute lung injury induced by heatstroke in mice Nan Fang. Yi Ke Da Xue Xue Bao 35 2015 1277 1282
21. Y. Koga, M. Fujita, R. Tsuruta, Y. Koda, T. Nakahara, M. Yagi T,Yuasa, and T. Maekawa Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats Neurol. Res. 32 2010 925 932 10.1179/016164110x12645013515133
22. N. Huang, F. Wang, Y. Wang, J. Hou, J. Li, and X. Deng Ulinastatin improves survival of septic mice by suppressing inflammatory response and lymphocyte apoptosis J. Surg. Res. 182 2013 296 302 10.1016/j.jss.2012.10.043
23. D.R. Karnad, R. Bhadade, P.K. Verma, N.D. Moulick, M.K. Daga, N.D. Chafekar, and S. Iyer Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study Intensive Care Med. 40 2014 830 838 10.1007/s00134-014-3278-8
24. E. Zhao, M. Amir, Y. Lin, and M.J. Czaja Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK PLoS One 9 2014 10.1371/journal.pone.0109750
25. C. Dong, D.D. Yang, M. Wysk, A.J. Whitmarsh, R.J. Davis, and R.A. Flavell Defective T cell differentiation in the absence of Jnk1 Science 282 1998 2092 2095
26. J. Ma, L. Zhang, W. Han, T. Shen, C. Ma, X. Nie, Y. Ran, and D. Zhu Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells J. Lipid Res. 53 2012 1093 1105 10.1194/jlr.M024398
27. P. Rockwell, J. Martinez, L. Papa, and E. Gomes Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium Cell. Signal 16 2004 343 353
28. C.H. Lee, S.D. Lee, H.C. Ou, and Y.J. Cheng Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK/eNOS pathway Int. J. Mol. Sci. 15 2014 10334 10349 10.3390/ijms150610334
29. H. Wang, X. Sun, F. Gao, B. Zhong, Y. Zhang, and Z. Sun Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB J. Exp. Clin. Cancer Res. 31 2012 2 10.1186/1756-9966-31-2
30. C.S. Goldsmith, and D. Bell-Pedersen Diverse roles for MAPK signaling in circadian clocks Adv. Genet. 84 2013 1 39 10.1016/b978-0-12-407703-4.00001-3
31. A. Chang, Y. Chen, W. Shen, R. Gao, W. Zhou, S. Yang, Y. Liu, Y. Luo, T.H. Chuang, and P. Sun Ifit1 protects against lipopolysaccharide and D-galactosamine-induced fatal hepatitis by inhibiting activation of the JNK pathway J. Infect. Dis. 212 2015 1509 1520 10.1093/infdis/jiv221
32. J.A. McCubrey, M.M. Lahair, and R.A. Franklin Reactive oxygen species-induced activation of the MAP kinase signaling pathways Antioxid. Redox Signal 8 2006 1775 1789 10.1089/ars.2006.8.1775
33. J.M. Van Raamsdonk, and S. Hekimi Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans PLoS Genet. 5 2009 10.1371/journal.pgen.1000361
34. H. Cai, P. Gehrig, T.M. Scott, R. Zimmermann, R. Schlapbach, and A.H. Zisch MnSOD marks cord blood late outgrowth endothelial cells and accompanies robust resistance to oxidative stress Biochem. Biophys. Res. Commun. 350 2006 364 369 10.1016/j.bbrc.2006.09.046
35. T. He, T.E. Peterson, E.L. Holmuhamedov, A. Terzic, N.M. Caplice, L.W. Oberley, and Z.S. Katusic Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase Arterioscler. Thromb. Vasc. Biol. 24 2004 2021 2027 10.1161/01.ATV.0000142810.27849.8f