Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats

Neurological Research

Volumn 32, Issue 9, 2010, Pages 925-932

  Koga, Yasutaka ^a   Fujita, Motoki ^a   Tsuruta, Ryosuke ^a   Koda, Yoichi ^a   Nakahara, Takashi ^a   Yagi, Takeshi ^a   Aoki, Tetsuya ^b   Kobayashi, Chihiro ^b   Izumi, Tomonori ^a   Kasaoka, Shunji ^a   Yuasa, Makoto ^b   Maekawa, Tsuyoshi ^a  

^a YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Forebrain ischemia; High mobility group box 1; Reperfusion; Superoxide; Ulinastatin

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; SUPEROXIDE; ULINASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFECT; ELECTROCHEMISTRY; ENDOTHELIUM INJURY; FOREBRAIN; INFLAMMATION; JUGULAR VEIN; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SENSOR; TREATMENT RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GAS ANALYSIS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ENDOTHELIUM; GLYCOPROTEINS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PROSENCEPHALON; RATS; RATS, WISTAR; REPERFUSION; SUPEROXIDES; TRYPSIN INHIBITORS;

EID: 77957583751     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164110X12645013515133     Document Type: Article

References (25)

1. Kontos HA. Oxygen radicals in cerebral ischemia: the 2001 Willis Lecture. Stroke. 2001;32: 2712-6.
2. Krause GS, White BC, Aust SD, Nayini NR, Kumar K. Brain cell death following ischemia and reperfusion: a proposed biochemical sequence. Crit Care Med. 1988;16: 714-26.
3. Warner DS, Sheng H, Batinić-Haberle I. Oxidants, antiox-idants and the ischemia brain. J Exp Biol 2004;207: 3221-31.
4. Fujita M, Tsuruta R, Kasaoka S, Fujimoto K, Tanaka R, Oda Y, et al. In vivo real-time measurement of superoxide anion radical with a novel electrochemical sensor. Free Radic Biol Med. 2009;47: 1039-48.
5. Yuasa M, Oyaizu K, Yamaguchi A, Ishikawa M, Eguchi K, Kobayashi T, et al. Electrochemical sensor for superoxide anion radical using polymeric iron porphyrin complexes containing axial 1-methylimidazole ligand as cytochrome c mimics. Polym Adv Technol. 2005;16: 287-92.
6. Yuasa M, Oyaizu K, Yamaguchi A, Ishikawa M, Eguchi K, Kobayashi T, et al. Electropolymerized iron meso-tetrakis(3-thienyl)porphyrin film as a sensing element for superoxide anion radical. Polym Adv Technol. 2005;16: 616-21.
7. Yuasa M, Oyaizu K. Electrochemical detection and sensing of reactive oxygen species. Curr Org Chem. 2005;9: 1685-97.
8. Aki HS, Fujita M, Yamashita S, Fujimoto K, Kumagai K, Tsuruta R, et al. Elevation ofjugular venous superoxide anion radical is associated with early inflammation, oxidative stress, and endothelial injury in forebrain ischemia-reperfusion rats. Brain Res. 2009;1292: 180-90.
9. Qiu J, Nishimura M, Wang Y, Sims JR, Qiu S, Savitz SI, et al. Early release ofHMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab. 2008;28: 927-38.
10. Ono T, Tsuruta R, Fujita M, Aki HS, Kutsuna S, Kawamura Y, et al. Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia-reperfusion. Brain Res. 2009;1305: 158-67.
11. Kudo Y, Egashira T, Yamanaka Y. Protective effect of ulinastatin against liver injury caused by ischemia-reperfusion in rats. Japan J Pharmacol. 1992;60: 239-45.
12. Yu JR, Yan S, Liu XS, Wu YJ, Fu PF, Wu LH, et al. Attenuation of graft ischemia-reperfusion injury by urinary trypsin inhibitor in mouse intestinal transplantation. World J Gastroenterol. 2005;11: 1605-9.
13. Xiaoqiao Z, Rong M, Zhigang Y, Yong D, Xihong F, Jingzhong S. Protective effect of ulinastatin against ischemia-reperfusion injury in rat small bowel transplantation. Transplant Proc. 2004;36: 1564-6.
14. Yano T, Anraku S, Nakayama R, Ushijima K. Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats. Anesthesiology. 2003;98: 465-73.
15. Inoue KI, Hirohisa T, Yanagisawa R, Sakurai M, Shimada A, Sato H, et al. Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide. Int J Mol Med. 2005;16: 1029-33.
16. Abramov AY, Scorziello A, Duchen M. Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci. 2007;27: 1129-38.
17. Chen H, Song YS, Chan PH. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab. 2009;29: 1262-72.
18. Parks DA, Granger DN. Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol Scand Suppl. 1986;548: 87-99.
19. Sims NR, Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem Int. 2002;40: 511-26.
20. Nishijima J, Hiraoka N, Murata A, Oka Y, Kitagawa K, Tanaka N, et al. Protease inhibitors (gebexate mesylate and ulinastatin) stimulate intracellular chemiluminescence in human neutrophils. J Leukoc Biol. 1992;52: 262-8.
21. Kitagawa S, Takaku F, Sakamoto S. Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes. J Clin Invest. 1980;65: 74-81.
22. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, et al. Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol. 2003;285: H2290-7.
23. Polidori MC, Cherubini A, Stahl W, Senin U, Sies H, Mecocci P. Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free Radic Res. 2002;36: 265-8.
24. Supinski GS, Callahan LA. Polyethyleneglycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction. Am J Respir Crit Care Med. 2006;173: 1240-7.
25. Hagiwara S, Iwasaka H, Uchino T, Noguchi T. High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study. Circ J. 2008;72: 1012-7.