Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Liu, Bingbing ^a   Huang, Weihua ^a   Xiao, Xiaoshan ^a   Xu, Yao ^a,b   Ma, Songmei ^a,c   Xia, Zhengyuan ^d,e  

^a GUANGDONG SECOND PROVINCIAL GENERAL HOSPITAL   (China)

^b HUIZHOU MUNICIPAL CENTRAL HOSPITAL   (China)

^c FIRST PEOPLE S HOSPITAL OF SHANGQIU   (China)

^d GUANGDONG MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; PROTEINS;

ANTIAPOPTOTIC PROPERTIES; APOPTOTIC CELL DEATH; BIOCHEMICAL ANALYSIS; CONCOMITANT REDUCTION; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL ISCHEMIA-REPERFUSION INJURIES; NEUROPROTECTIVE EFFECTS; PROTEIN EXPRESSIONS;

DRUG PRODUCTS;

CASPASE 3; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; ULINASTATIN; GLYCOPROTEIN; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCHEMICAL ANALYSIS; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXPERIMENTAL RABBIT; IMMUNOHISTOCHEMISTRY; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD ISCHEMIA; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ANIMAL; METABOLISM; NERVE CELL; PATHOLOGY; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MALONDIALDEHYDE; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD ISCHEMIA; SUPEROXIDE DISMUTASE;

EID: 84934301342     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/624819     Document Type: Article

References (40)

1. C. B-Rao and J. Stewart, "Inverse analysis of empirical matrices of idiotypic network interactions", Bulletin of Mathematical Biology, vol. 58, no. 6, pp. 1123-1153, 1996.
2. P. D. Smith, F. Puskas, X. Meng et al., "The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury", Circulation, vol. 126, pp. S110-S117, 2012.
3. M. Kakinohana, K. Kida, S. Minamishima et al., "Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice", Stroke, vol. 42, no. 8, pp. 2302-2307, 2011.
4. L. Lang-Lazdunski, K. Matsushita, L. Hirt, C. Waeber, J.-P. G. Vonsattel, and M. A. Moskowitz, "Spinal cord ischemia: development of a model in the mouse", Stroke, vol. 31, no. 1, pp. 208-213, 2000.
5. M. F. Conrad, J. Y. Ye, T. K. Chung, J. K. Davison, and R. P. Cambria, "Spinal cord complications after thoracic aortic surgery: long-term survival and functional status varies with deficit severity", Journal of Vascular Surgery, vol. 48, no. 1, pp. 47-53, 2008.
6. T. Hayashi, M. Sakurai, K. Abe, M. Sadahiro, K. Tabayashi, and Y. Itoyama, "Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia", Stroke, vol. 29, no. 5, pp. 1007-1013, 1998.
7. S. Zong, G. Zeng, Y. Fang et al., "The role of IL-17 promotes spinal cord neuroinflammation via activation of the transcription factor STAT3 after spinal cord injury in the rat", Mediators of Inflammation, vol. 2014, Article ID 786947, 10 pages, 2014.
8. J. Oda, K. Yamashita, T. Inoue et al., "Resuscitation fluid volume and abdominal compartment syndrome in patients with major burns", Burns, vol. 32, no. 2, pp. 151-154, 2006.
9. S. Endo, K. Inada, K. Taki, S. Hoshi, and M. Yoshida, "Inhibitory effects of ulinastatin on the production of cytokines: implications for the prevention of septicemic shock", Clinical Therapeutics, vol. 12, no. 4, pp. 323-326, 1990.
10. Y.-Z. Cao, Y.-Y. Tu, X. Chen, B.-L. Wang, Y.-X. Zhong, and M.-H. Liu, "Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13", Experimental and Toxicologic Pathology, vol. 64, no. 6, pp. 543-547, 2012.
11. Q.-L. He, F. Zhong, F. Ye et al., "Does intraoperative ulinastatin improve postoperative clinical outcomes in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials", Bio Med Research International, vol. 2014, Article ID 630835, 15 pages, 2014.
12. H.-M. Luo, M.-H. Du, Z.-L. Lin et al., "Ulinastatin suppresses burn-induced lipid peroxidation and reduces fluid requirements in a swine model", Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 904370, 8 pages, 2013.
13. Z.-L. Cao, Y. Okazaki, K. Naito, T. Ueno, M. Natsuaki, and T. Itoh, "Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart", Annals of Thoracic Surgery, vol. 69, no. 4, pp. 1121-1126, 2000.
14. O. A. R. Binns, N. F. De Lima, S. A. Buchanan et al., "Neutrophil endopeptidase inhibitor improves pulmonary function during reperfusion after eighteen-hour preservation", The Journal of Thoracic and Cardiovascular Surgery, vol. 112, no. 3, pp. 607-613, 1996.
15. Y. Kudo, T. Egashira, and Y. Yamanaka, "Protective effect of ulinastatin against liver injury caused by ischemia-reperfusion in rats", Japanese Journal of Pharmacology, vol. 60, no. 3, pp. 239-245, 1992.
16. H. Nakahama, K. Obata, and M. Sugita, "Ulinastatin ameliorates acute ischemic renal injury in rats", Renal Failure, vol. 18, no. 6, pp. 893-898, 1996.
17. T. Yano, S. Anraku, R. Nakayama, and K. Ushijima, "Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats", Anesthesiology, vol. 98, no. 2, pp. 465-473, 2003.
18. W. Yao, G. Luo, G. Zhu et al., "Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model", Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 258567, 9 pages, 2014.
19. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, "Protein measurement with the Folin phenol reagent", The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265-275, 1951.
20. T. Luo, Z. Xia, D. M. Ansley et al., "Propofol dose-dependently reduces tumor necrosis factor-α-induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and bax expression and nitric oxide generation", Anesthesia and Analgesia, vol. 100, no. 6, pp. 1653-1659, 2005.
21. M. Liu, B. Zhou, Z.-Y. Xia et al., "Hyperglycemia-induced inhibition of DJ-1 expression compromised the effectiveness of ischemic postconditioning cardioprotection in rats", Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 564902, 8 pages, 2013.
22. H. Li, Z. Liu, J. Wang et al., "Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats", Cardiovascular Diabetology, vol. 12, no. 1, article 133, 2013.
23. N. T. Kouchoukos, J. R. Scharff, and C. F. Castner, "Repair of primary or complicated aortic coarctation in the adult with cardiopulmonary bypass and hypothermic circulatory arrest", The Journal of Thoracic and Cardiovascular Surgery, 2014.
24. H. Kertmen, B. Gürer, E. R. Yilmaz et al., "The protective effect of low-dosemethotrexate on ischemia-reperfusion injury of the rabbit spinal cord", European Journal of Pharmacology, vol. 714, no. 1-3, pp. 148-156, 2013.
25. E. D. Hall and J. E. Springer, "Neuroprotection and acute spinal cord injury: a reappraisal", Neuro Rx, vol. 1, no. 1, pp. 80-100, 2004.
26. C. A. Oyinbo, "Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade", Acta Neurobiologiae Experimentalis, vol. 71, no. 2, pp. 281-299, 2011.
27. R. D. Azbill, X. Mu, A. J. Bruce-Keller, M. P. Mattson, and J. E. Springer, "Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury", Brain Research, vol. 765, no. 2, pp. 283-290, 1997.
28. Q. Fan, X.-C. Yang, Y. Liu et al., "Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans", Clinical Science, vol. 120, no. 6, pp. 251-261, 2011.
29. S. Lei, H. Li, J. Xu et al., "Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/e NOS signaling", Diabetes, vol. 62, no. 7, pp. 2318-2328, 2013.
30. E. R. Yilmaz, H. Kertmen, H. Dolgun et al., "Effects of darbepoetin-alpha in spinal cord ischemia-reperfusion injury in the rabbit", Acta Neurochirurgica, vol. 154, no. 6, pp. 1037-1044, 2012.
31. A. Diaz-Ruiz, C. Rios, I. Duarte et al., "Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone", Neuro Report, vol. 11, no. 8, pp. 1765-1767, 2000.
32. Y. Yamauchi, Y. Izumi, M. Inoue et al., "Safety of postoperative administration of human urinary trypsin inhibitor in lung cancer patients with idiopathic pulmonary fibrosis", PLoS ONE, vol. 6, no. 12, Article ID e29053, 2011.
33. Y. Koga, M. Fujita, R. Tsuruta et al., "Urinary trypsin inhibitor suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats", Neurological Research, vol. 32, no. 9, pp. 925-932, 2010.
34. L. Xu, B. Ren, M. Li, F. Jiang, Z. Zhanng, and J. Hu, "Ulinastatin suppresses systemic inflammatory response following lung ischemia-reperfusion injury in rats", Transplantation Proceedings, vol. 40, no. 5, pp. 1310-1311, 2008.
35. K. Kannan and S. K. Jain, "Oxidative stress and apoptosis", Pathophysiology, vol. 7, no. 3, pp. 153-163, 2000.
36. B. Antonsson and J. C. Martinou, "The Bcl-2 protein family", Experimental Cell Research, vol. 256, no. 1, pp. 50-57, 2000.
37. D. R. Green and J. C. Reed, "Mitochondria and apoptosis", Science, vol. 281, no. 5381, pp. 1309-1312, 1998.
38. C.-C. Chen, Z.-M. Liu, H.-H. Wang, W. He, Y. Wang, and W.-D. Wu, "Effects of ulinastatin on renal ischemia-reperfusion injury in rats", Acta Pharmacologica Sinica, vol. 25, no. 10, pp. 1334-1340, 2004.
39. Y. Wang, X. Liu, D. Zhang, J. Chen, S. Liu, and M. Berk, "The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction", BMC Medicine, vol. 11, no. 1, article 32, 2013.
40. G. M. Cohen, "Caspase: the executioners of apoptosis", Biochemical Journal, vol. 326, no. 1, pp. 1-16, 1997.