The kringle-like domain facilitates post-endoplasmic reticulum changes to premelanosome protein (PMEL) oligomerization and disulfide bond configuration and promotes amyloid formation

Journal of Biological Chemistry

Volumn 291, Issue 7, 2016, Pages 3595-3612

  Ho, Tina ^a,b   Watt, Brenda ^a,b   Spruce, Lynn A ^a   Seeholzer, Steven H ^a   Marks, Michael S ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; COVALENT BONDS; DIMERS; GLYCOPROTEINS; MASS SPECTROMETRY; SIZE EXCLUSION CHROMATOGRAPHY; SULFUR COMPOUNDS;

AMYLOID FORMATION; CYSTEINE RESIDUES; ENDOPLASMIC RETICULUM; POST-GOLGI COMPARTMENTS; PULSE-CHASE ANALYSIS; SECRETORY PATHWAYS; SEDIMENTATION VELOCITIES; SMALL MOLECULE INHIBITOR;

PROTEINS;

AMYLOID; CELL PROTEIN; CYSTEINE; DIMER; ISOPROTEIN; MONOMER; PREMELANOSOME PROTEIN; UNCLASSIFIED DRUG; CYSTINE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MELANOCYTE PROTEIN PMEL 17; PMEL PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MELANOMA CELL LINE; OLIGOMERIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS; SIZE EXCLUSION CHROMATOGRAPHY; TWO DIMENSIONAL GEL ELECTROPHORESIS; AMINO ACID SUBSTITUTION; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; GENETICS; KRINGLE DOMAIN; METABOLISM; MOLECULAR MODEL; MOLECULAR WEIGHT; MULTIVESICULAR BODY; POINT MUTATION; PROTEIN FOLDING; PROTEIN PROCESSING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

AMINO ACID SUBSTITUTION; AMYLOID; CELL LINE, TUMOR; CYSTEINE; CYSTINE; DIMERIZATION; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; GP100 MELANOMA ANTIGEN; GREEN FLUORESCENT PROTEINS; HUMANS; KRINGLES; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR WEIGHT; MULTIVESICULAR BODIES; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; RECOMBINANT PROTEINS;

EID: 84964653569     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.692442     Document Type: Article

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