Geraniol improves the impaired vascular reactivity in diabetes and metabolic syndrome through calcium channel blocking effect

Journal of Diabetes and its Complications

Volumn 30, Issue 6, 2016, Pages 1008-1016

  El Bassossy, Hany M ^a,b   Elberry, Ahmed A ^a,c   Ghareib, Salah A ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Zagazig University   (Egypt)

^c BENI SUEF UNIVERSITY   (Egypt)

Author keywords

Advanced glycation end products; Calcium channels; Diabetes; Geraniol; Nitric oxide; Vascular reactivity

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CALCIUM CHLORIDE; GERANIOL; INDOMETACIN; METHYLGLYOXAL; N(G) NITROARGININE METHYL ESTER; POTASSIUM CHLORIDE; TETRYLAMMONIUM CHLORIDE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; TERPENE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; IN VITRO STUDY; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; RAT; VASOCONSTRICTION; VASODILATATION; ANIMAL; AORTA; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; AORTA; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; IN VITRO TECHNIQUES; MALE; METABOLIC SYNDROME; RATS; RATS, WISTAR; TERPENES; VASODILATION; VASODILATOR AGENTS;

EID: 84964626553     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2016.04.006     Document Type: Article

References (40)

1. Abebe, W., Harris, K.H., Macleod, K.M., Enhanced contractile responses of arteries from diabetic rats to α1-adrenoceptor stimulation in the absence and presence of extracellular calcium. Journal of Cardiovascular Pharmacology 16 (1990), 239–248.
2. Ajay, M., Gilani, A.H., Mustafa, M.R., Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sciences 74 (2003), 603–612.
3. Akinyemi, A.J., Ademiluyi, A.O., Oboh, G., Inhibition of angiotensin-1-converting enzyme activity by two varieties of ginger (Zingiber officinale) in rats fed a high cholesterol diet. Journal of Medicinal Food 17:3 (2014), 317–323.
4. Bard, M., Albrecht, M.R., Gupta, N., Guynn, C.J., Stillwell, W., Geraniol interferes with membrane functions in strains of Candida and Saccharomyces. Lipids 23 (1988), 534–538.
5. Baynes, J.W., Role of oxidative stress in development of complications in diabetes. Diabetes 40 (1991), 405–412.
6. Bedoukian, P.Z., Geraniol & nerol Perfumery and flavoring synthetics. 1986, Allured Publishing Corporation, Weaton.
7. Brayden, J.E., Potassium channels in vascular smooth muscle. Clinical and Experimental Pharmacology and Physiology 23 (1996), 1069–1076.
8. Carnesecchi, S., Bradaia, A., Fischer, B., Coelho, D., Scholler-Guinard, M., Perturbation by Geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. Journal of Pharmacology and Experimental Therapeutics 303 (2002), 711–715.
9. Cinar, M.G., Ulker, S., Alper, G., Evinc, A., Effect of dietaryvitamin E supplementation on vascular reactivity of thoracic aorta in streptozotocin-diabetic rats. Pharmacology 62 (2001), 56–64.
10. Edris, A.E., Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review. Phytotherapy Research 21 (2007), 308–323.
11. El-Bassossy, H.M., Dsokey, N., Fahmy, A., Characterization of vascular complications in experimental model of fructose-induced metabolic syndrome. Toxicology Mechanisms and Methods 24:8 (2014), 536–543.
12. El-Bassossy, H.M., El-Fawal, R., Fahmy, A., Watson, M.L., Arginase inhibition alleviates hypertension in the metabolic syndrome. British Journal of Pharmacology 169 (2013), 693–703.
13. El-Bassossy, H.M., El-Moselhy, M.A., Mahmoud, M.F., Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-alpha inhibition. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (2011), 277–285.
14. Ghayur, M.N., Gilani, A.H., Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology 45:1 (2005), 74–80.
15. Ibrahim, S.M., El-Denshary, E.S., Abdallah, D.M., Geraniol, alone and in combination with pioglitazone, ameliorates fructose-induced metabolic syndrome in rats via the modulation of both inflammatory and oxidative stress status. PloS one, 10(2), 2015, e0117516, 10.1371/journal.pone.0117516.
16. Jayachandran, M., Chandrasekaran, B., Namasivayam, N., Effect of Geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamsters. Molecular and Cellular Biochemistry 398 (2015), 39–53.
17. Kahn, B.B., Flier, J.S., Obesity and insulin resistance. The Journal of Clinical Investigation 106:4 (2000), 473–481.
18. Karaki, H., Ozaki, H., Hori, M., Calcium movements, distribution, and functions in smooth muscle. Pharmacology Review 49 (1997), 157–230.
19. Kazeem, M.I., Akanji, M.A., Yakubu, M.T., Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome. Pathophysiology, 2015, 10.1016/j.pathophys.2015.08.004.
20. Khan, A.Q., Khan, R., Qamar, W., Lateef, A., Rehman, M.U., Tahir, M.,.. Sultana, S., Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: Possible role of p38 MAP kinase and NF-kappaB. Experimental and Molecular Pathology 94 (2013), 419–429.
21. Kowalski, J., Sliwczyńska-Rodziewicz, D., Ciećwierz, J., Kowalczyk, E., Pawlicki, L., Irzmański, R.,.. Barylski, M., Vascular complications in patients with metabolic syndrome. Polski Merkuriusz Lekarski 30:178 (2011), 241–245.
22. Kshirsagar, R., Reddy, G.B., Bakshi, V., Diwan, P., Geraniol a major component of essential oil ameliorates endothelial dysfunction induced by high-fat diet fed rats. Atherosclerosis 241:1 (2015), E154–E155.
23. Lahlou, S., Magalhães, P.J.C., Siqueira, R.J.B., Figueiredo, A.F., Interaminense, L.F.L., Maia, J.G.S., Cardiovascular effects of the essential oil of Aniba canelilla bark in normotensive rats. Journal of Cardiovascular Pharmacology 46 (2005), 412–421.
24. Lapczynski, A., Bhatia, S.P., Foxenberg, R.J., Letizia, C.S., Api, A.M., Fragrance material review on Geraniol. Food and Chemical Toxicology 46:11 (2008), 160–170.
25. Mahmoud, M.F., Hassan, N.A., El Bassossy, H.M., Fahmy, A., Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: Effect on low grade inflammation. PloS one, 8, 2013, e63784.
26. Mukohda, M., Okada, M., Hara, Y., Yamawaki, H., Exploring mechanisms of diabetes-related macrovascular complications: Role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility. Journal of Pharmacological Sciences 118 (2012), 303–310.
27. Novakovic, A., Bukarica, L.G., Kanjuh, V., Heinle, H., Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol. Basic and Clinical Pharmacology and Toxicology 99 (2006), 360–364.
28. Orie, N.N., Aloamaka, C.P., Iyawe, V.I., Duration-dependent attenuation of acetylcholine-but not histamine - Induced relaxation of the aorta in diabetes mellitus. General Pharmacology 24 (1993), 329–332.
29. Qu, Z., Zhang, J., Gao, W., Chen, H., Guo, H., Wang, T.,.. Liu, C., Vasorelaxant effects of Cerebralcare Granule® are mediated by NO/cGMP pathway, potassium channel opening and calcium channel blockade in isolated rat thoracic aorta. J Ethnopharmacol 155:1 (2014), 572–579.
30. Shidfar, F., Rajab, A., Rahideh, T., Khandouzi, N., Hosseini, S., Shidfar, S., The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal complementary integrative medicine 12:2 (2015), 165–170.
31. Shiina, Y., Funabashi, N., Lee, K., Toyoda, T., Sekine, T., Honjo, S.,.. Komuro, I, Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transtho-racic Doppler echocardiography. International Journal of Cardiology 129 (2008), 193–197.
32. Soubh, A.A., Abdallah, D.M., El-Abhar, H.S., Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways. Life Sciences 136 (2015), 142–150.
33. Spedding, M., Cavero, I., Calcium antagonists: A class of drugs with a bright future. Part II. Determination of basic pharmacological properties. Life Sciences 35 (1984), 575–587.
34. Thornalley, P.J., Langborg, A., Minhas, H.S., Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemical Journal 344:Pt. 1 (1999), 109–116.
35. van Dieren, S., Beulens, J.W., van der Schouw, Y.T., Grobbee, D.E., Neal, B., The global burden of diabetes and its complications: An emerging pandemic. European Journal of Cardiovascular Prevention and Rehabilitation 17:1 (2010), S3–S8.
36. Vlassara, H., Fuh, H., Makita, Z., Krungkrai, S., Cerami, A., Bucala, R., Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: A model for diabetic and aging complications. Proceedings of the National Academy of Sciences of the United States of America 89:24 (1992), 12043–12047.
37. Webb, R.C., Smooth muscle contraction and relaxation. Advances in Physiology Education 27 (2003), 201–206.
38. Xu, B., Ji, Y., Yao, K., Cao, Y.X., Ferro, A., Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: Relevance to diabetes. Clinical Science (London) 109:5 (2005), 439–446.
39. Zhang, N., Zou, H., Jin, L., Wang, J., Zhong, M.F., Huang, P.,.. Chen, H., Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacologica Sinica 31 (2010), 421–428.
40. Zhu, B.H., Guan, Y.Y., Min, J., He, H., Contractile responses of diabetic rat aorta to phenylephrine at different stages of diabetic duration. Acta Pharmacologica Sinica 22 (2001), 445–449.