Vasorelaxant effects of Cerebralcare Granule® are mediated by NO/cGMP pathway, potassium channel opening and calcium channel blockade in isolated rat thoracic aorta

Journal of Ethnopharmacology

Volumn 155, Issue 1, 2014, Pages 572-579

  Qu, Zhuo ^a   Zhang, Jingze ^b   Gao, Wenyuan ^a   Chen, Hong ^b   Guo, Huimin ^a   Wang, Tingting ^a   Li, Hongfa ^a   Liu, Changxiao ^c  

^a TIANJIN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^c State Key Laboratories of Pharmacodynamics and Pharmacokinetics   (China)

Author keywords

Aortic rings; Nitric oxide; Traditional Chinese medicine; Vasorelaxation

Indexed keywords

ALOE EMODIN; ATROPINE; CAFFEIC ACID; CALCIUM; CALCIUM CHLORIDE; CEREBRALCARE GRANULE; CHEMICAL COMPOUND; CHLOROGENIC ACID; CHRYSOPHANIC ACID; CYCLIC GMP; EMODIN; FERULIC ACID; GLIBENCLAMIDE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PAEONIFLORIN; PLANT MEDICINAL PRODUCT; POTASSIUM CHLORIDE; POTASSIUM ION; RHEIN; TETRYLAMMONIUM CHLORIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CEREBRALCARE PREPARATION; HERBACEOUS AGENT; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CHINESE HERB; CONTROLLED STUDY; DRUG ANALYSIS; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; NONHUMAN; RAT; THORACIC AORTA; VASCULAR RING; VASODILATATION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; AORTA, THORACIC; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENDOTHELIUM, VASCULAR; KATP CHANNELS; MALE; NITRIC OXIDE; POTASSIUM CHANNELS; RATS; RATS, WISTAR; VASODILATION; VASODILATOR AGENTS;

EID: 84905031024     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.05.062     Document Type: Article

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