Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 2, 2002, Pages 711-715

  Carnesecchi, S ^a   Bradaia, A ^b   Fischer, B ^c   Coelho, D ^a   Scholler Guinard M ^a   Gosse, F ^b   Raul, F ^b  

^a INSERM   (France)

^b Laboratory of Molecular Oncology   (France)

^c IRCAD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GERANIOL; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C;

ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE PERMEABILITY; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEMBRANE STEADY POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CACO-2 CELLS; CELL DIVISION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; ELECTROPHYSIOLOGY; HUMANS; MEMBRANE POTENTIALS; MEVALONIC ACID; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TERPENES;

EID: 0036827604     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.039263     Document Type: Article

References (26)

1. Bard M, Albrecht MR, Gupta N, Guynn CJ, and Stillwell W (1998) Geraniol interferes with membrane functions in strains of candida and saccharomyces. Lipids 23:534-538.
2. Butler PJ, Tsou TC, Li JY, Usami S, and Chien S (2002) Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: A role for membrane perturbation in shear-induced MAPK activation. FASEB J 16:216-218.
3. Carnesecchi S, Langley K, Exinger F, Gosse F, and Raul F (2002) Geraniol, a component of plant essential oils, sensitizes human colonic cancer cell to 5-fluorouracil treatment. J Pharmacol Exp Ther 301:1-6.
4. Carnesecchi S, Schneider Y, Ceraline J, Duranton B, Gosse F, Seiler N, and Raul F (2001) Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 298:197-200.
5. Cass A, Finkelstein A, and Krespi VJ (1970) The ion permeability induced in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B. Gen Physiol 56:100-124.
6. Clarke S (1992) Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu Rev Biochem 61:355-386.
7. Clegg RJ, Middleton B, Bell GD, and White DA (1980) Inhibition of hepatic cholesterol synthesis and S-3-hydroxy-3-methylglutaryl-CoA reductase by mono and bicyclic monoterpenes administered in vivo. Biochem Pharmacol 29:2125-2127.
8. Clegg RJ, Middleton B, Bell GD, and White DA (1982) The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat. J Biol Chem 257:2294-2299.
9. Cuthbert JA and Lipsky PE (1995) Suppression of the proliferation of Rastransformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. Cancer Res 15:1732-1740.
10. Elson CE (1995) Suppression of mevalonate pathway activities by dietary isoprenoids: Protective roles in cancer and cardiovascular disease. J Nutr 125:1666S-1672S.
11. Elson CE, Underbakke GL, Hanson P, Shrago E, Wainberg RH, and Qureshi AA (1989) Impact of lemongrass oil, an essential oil, on serum cholesterol. Lipids 24:677-679.
12. Elson CE and Yu SG (1994) The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables. J Nutr 124:607-614.
13. Flach J, Antoni I, Villemin P, Craig L, Bentzen L, and Niesor EJ (2000) The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. Biochem Biophys Res Commun 270:240-246.
14. Holz R and Finkelstein A (1970) The water and nonelectrolyte permeability induced in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B. J Gen Physiol 92:145-159.
15. Huang HW, Goldberg EM, and Zidovetzki R (1999) Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J 77:1489-1497.
16. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
17. Goldstein JL and Brown MS (1990) Regulation of the mevalonate pathway. Nature (Lond) 343:425-430.
18. McKemy DD, Neuhausser WM, and Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (Lond) 416:52-58.
19. Maltese WA (1990) Posttranslational modification of proteins by isoprenoids in mammalian cells. FASEB J 4:3319 -3328.
20. Rae J, Cooper K, Gates P, and Watsky M (1991) Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods 37:15-26.
21. Sanders D and Bethke P (2000) Membrane transport, in Biochemistry and Molecular Biology of Plants (Gruissem W and Jones R eds) pp 110-159, American society of Plant Physiologists, Rockville.
22. Shoff SM, Grummer M, Yatvin MB, and Elson CE (1991) Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol. Cancer Res 51:37-42.
23. Tsavaler L, Shapero MH, Morkowski S, and Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-3769.
24. Tsuchiya H (2001) Biphasic membrane effects of eapsaicin, an active component in capsicum species. J Ethno-Pharmacol 75:295-299.
25. Warber S (1998) Modes of Action at Target Sites (Kaufman PB, Leland JC, Warber S, Duke JA, and Brielmann HL eds) pp 157-182, CRC Press, Boca Raton, FL.
26. Yu SG, Hildebrandt LA, and Elson CE (1995) Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J Nutr 125:2763-2767.