Fragrance material review on geraniol

Food and Chemical Toxicology

Volumn 46, Issue 11 SUPPL., 2008, Pages

  Lapczynski, A ^a   Bhatia, S P ^a   Foxenberg, R J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Fragrance material; Geraniol; Review

Indexed keywords

COSMETIC; FRAGRANCE; GERANIOL;

ACUTE TOXICITY; ARTICLE; HUMAN; MATERIALS TESTING; NONHUMAN; SKIN IRRITATION; TOXICITY TESTING;

ANIMALS; DRUG ADMINISTRATION ROUTES; HUMANS; MICE; MOLECULAR STRUCTURE; PERFUME; RABBITS; RATS; TERPENES;

EID: 55649117515     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.06.048     Document Type: Article

References (92)

1. Addo H.A., Ferguson J., Johnson B.E., and Frain-Bell W. The relationship between exposure to fragrance materials and persistent light reaction in the photosensitivity dermatitis with actinic reticuloid syndrome. British Journal of Dermatology 107 (1982) 261-274
2. Bar V.F., and Griepentrog F. Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel (where we stand concerning the evaluation of flavoring substances from the viewpoint of health). Medizinische Ernahrungs 8 (1967) 244-251
3. Basketter D.A., York M., McFadden G.P., and Robinson M.K. Determination of skin irritation potential in the human 4-h patch test. Contact Dermatitis 51 (2004) 1-4
4. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., and Tagami H. A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients. Food and Chemical Toxicology 46 11S (2008) S1-S71
5. Benke G.M., and Larsen W.G. Safety evaluation of perfumed shampoos: dose/response relationships for product use testing by presensitized subjects. Journal of Toxicology: Cutaneous and Ocular Toxicology 3 (1984) 65-67
6. Boyd E.M., and Sheppard E.P. The effect of inhalation of citral and geraniol on the output and composition of respiratory tract fluid. Archives of International Pharmacodyn 188 (1970) 5-13
7. Brites M.M., Goncalo M., and Figueiredo A. Contact allergy to fragrance mix - a 10-year study. Contact Dermatitis 43 (2000) 181-182
8. Buchbauer G., Jirovetz L., Jager W., Plank C., and Dietrich H. Fragrance compounds and essential oils with sedative effects upon inhalation. Journal of Pharmaceutical Science 82 (1993) 660-664
9. Buckley D.A., Rycroft R.J.G., White I.R., and McFadden J.P. Contact allergy to individual fragrance mix constituents in relation to primary site of dermatitis. Contact Dermatitis 43 (2000) 304-305
10. Calnan C.D., Cronin E., and Rycroft R.J.G. Allergy to perfume ingredients. Contact Dermatitis 6 (1980) 500-501
11. Chadha A., and Madyastha K.M. Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. Xenobiotica 14 (1984) 365-374
12. Cronin, E., 1985. Allergy to Cosmetics. Acta Dermato-Venereologica, Stockh 134, 77-82.
13. De Groot A.C., Liem D.H., Nater J.P., and van Ketal W.G. Patch tests with fragrance materials and preservatives. Contact Dermatitis 12 (1985) 87-92
14. De Groot A.C., Bruynzeel D.P., Bos J.D., van der Meeren H.L.M., van Joost Th., Jagtman B.A., and Weyland J.W. The allergens in cosmetics. Archives of Dermatology 124 (1988) 1525-1529
15. DeGroot A.C., VanDerKley A.M.J., Bruynzeel D.P., Meinardi M.H., Smeenk G., VanJoost T., and Pavel S. Frequency of false-negative reactions to the fragrance mix. Contact Dermatitis 28 (1993) 139-140
16. Eder E., Neudecker T., Lutz D., and Henschler D. Mutagenic potential of allyl and allylic compounds. Structure-activity relationship as determined by alkylating and direct in vitro mutagenic properties. Biochemical Pharmacology 29 (1980) 993-998
17. Enders F., Przybilla B., and Ring J. Patch testing with fragrance mix at 16% and 8%, and its individual constituents. Contact Dermatitis 20 (1989) 237-238
18. FEMA (Flavor and Extract Manufacturers Association), 1965. Recent progress in the consideration of flavoring ingredients under the food additives amendment 3. GRAS Substances. Food Technology 19(2 part 2), 151-197.
19. Ferguson J., and Sharma S. Cinnamic aldehyde test concentrations [Letter to the Editor]. Contact Dermatitis 10 (1984) 191-192
20. Florin I., Rutberg L., Curvall M., and Enzell C.R. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 18 (1980) 219-232
21. Food and Drug Administration, Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
22. Frosch P.J., Pilz B., Burrows D., Camarasa J.G., Lachapelle J.M., Lahti A., Menne T., and Wilkinson J.D. Testing with fragrance mix. Is the addition of sorbitan sesquioleate to the constituents useful?. Contact Dermatitis 32 (1995) 266-272
23. Fujii T., Furukawa S., and Suzuki S. Studies on compounded perfumes for toilet goods. On the non-irritative compounded perfumes for soaps. Yukugaku 21 (1972) 904-908
24. Gerberick G.F., Robinson M.K., Ryan C.A., Dearman R.J., Kimber I., Basketter D.A., Wright Z., and Marks J.G. Contact allergenic potency: correlation of human and local lymph node assay data. American Journal of Contact Dermatitis 12 (2001) 156-161
25. Grief, N. 1967. Cutaneous safety of fragrance material as measured by the maximization test. American Perfumer and Cosmetics 82, 54-57.
26. Haba Y., Itoh M., Morita C., and Tsuyuki S. Results of patch tests on cosmetic ingredients conducted in 1990 and 1991. Hifu [Skin Research] 35 Suppl. 16 (1993) 65-74
27. Hagan E.C., Hansen W.H., Fitzhugh O.G., Jenner P.M., Jones W.I., Taylor J.M., Long E.L., Nelson A.M., and Brouwer J.B. Food flavorings and compounds of related structure. II. Subacute and chronic toxicity. Food and Cosmetics Toxicology 5 (1967) 141-157
28. Hayakawa R., Ohiwa K., Ukei C., and Matsunaga K. Melanoisis faciei feminae in 1982. Skin Research 25 (1983) 690-695
29. Hendriks S.A., and Van Ginkel C.J.w. Evaluation of the fragrance mix in the European standard series. Contact Dermatitis 41 (1999) 161-162
30. Hirose O., Arima Y., Hosokawa K., Suzuki M., Matsunaga K., and Hayakawa R. Patch test results of cosmetic allergens during recent 30 months. Skin Research 29 3 (1987) 95-100
31. Heydorn S., Johansen J.D., Andersen K.E., Basketter D., Bruze M., Karlberg A.T., White I., and Menne T. Identification of fragrances relevant to hand eczema. Contact Dermatitis 46 Suppl. 4 (2002) 21-22
32. Heydorn S., Johansen J.D., Andersen K.E., Bruze M., Svedman C., White I.R., Basketter D.A., and Menne T. Fragrance allergy in patients with hand eczema - a clinical study. Contact Dermatitis 48 (2003) 317-323
33. IFRA (International Fragrance Association), 2003. Use Level Survey.
34. IFRA (International Fragrance Association), 2007. Code of Practice, Standard on Geraniol. Brussels.
35. Ishidate Jr. M., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., and Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food and Chemical Toxicology 22 (1984) 623-636
36. Ishihara M., Itoh S., Hayashi S., and Satake T. Methods of diagnosis in cases of cosmetic dermatitis and facial melanosis in females. Nishinihon Journal of Dermatology 41 (1979) 426-439
37. Ishihara M., Itoh M., Nishimura M., Kinoshita M., Kantoh H., Nogami T., and Yamada K. Closed epicutaneous test. Skin Research 28 Suppl. 2 (1986) 230-240
38. Isola D., and Lalko J. Vehicle effects in the murine local lymph node assay (LLNA). International Journal of Toxicology 20 (2001) 401
39. Itoh M. Sensitization potency of some phenolic compounds - with special emphasis on the relationship between chemical structure and allergenicity. Journal of Dermatology 9 (1982) 223-233
40. Itoh M., Ishihara M., Hosono K., Kantoh H., Kinoshita M., Yamada K., and Nishimura M. Results of patch tests conducted between 1978 and 1985 using cosmetic ingredients. Skin Research 28 Suppl. 2 (1986) 110-119
41. Jenner P.M., Hagan E.G., Taylor J.M., Cook E.L., and Fitzhugh O.G. Food flavorings and compounds of related structure. I. Acute oral toxicity. Food and Cosmetics Toxicology 2 (1964) 327-343
42. Joint Expert Committee on Food Additives, 2004. Safety Evaluation of Certain Food Additives. Who Food Additives Series: 54 Prepared by the 63rd Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), World Health Organization, Geneva 2000.
43. Kiec-Swierczynska M., and Krecisz B. Occupational skin diseases among the nurses in the region of Lodz. International Journal of Occupational Medicine and Environmental Health 13 (2000) 179-184
44. Klecak G., Geleick H., and Frey J.R. Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. Journal of the Society of Cosmetic Chemists Japan 28 (1977) 53-64
45. Klecak, G., 1979. The open epicutaneous test (OET), a predictive test procedure in the guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations. International Federation Societies Cosmetic Chemists, 9/18/79.
46. Klecak G. The freund's complete adjuvant test and the open epicutaneous test. Current Problems in Dermatology 14 (1985) 152-171
47. Lalko J., and Api A.M. Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay. Food and Chemical Toxicology 44 (2006) 739-746
48. Larsen W., Nakayama H., Lindberg M., Fischer T., Elsner P., Burrows D., Jordan W., Shaw S., Wilkinson J., Marks Jr. J., Sugawara M., and Nethercott J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part 1). American Journal of Contact Dermatitis 7 (1996) 77-83
49. Magnusson B., and Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. Journal of Investigative Dermatology 52 (1969) 268-276
50. Marzulli F.N., and Maibach H.I. Contact allergy: predictive testing of fragrance ingredients in humans by Draize and maximization methods. Journal of Environmental Pathology and Toxicology 3 (1980) 235-245
51. Malten K.E., Van Ketel V.G., Nater J.P., and Leim D.H. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis 11 (1984) 1-10
52. Motoyoshi K., Toyoshima Y., Sato M., and Yoshimura M. Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man. Cosmetics and Toiletries 94 (1979) 41-48
53. Nagareda T., Sugai T., Shouji A., Katoh J., Mita T., Utsumi M., and Nakanishi T. Incidence of positive reactions to cosmetic products and their ingredients in patch tests and representative cases with cosmetic dermatitis in 1991. Skin Research 34 Suppl. 14 (1992) 176-182
54. Nishimura M., Ishihara M., Itoh M., Hosono K., and Kantoh H. Results of patch tests on cosmetic ingredients conducted between 1979 and 1982. Skin Research 26 (1984) 945-954
55. Northover B.J., and Verghese J. The pharmacology of certain terpene alcohols & oxides. Journal of Scientific and Industrial Research 21C (1962) 342-345
56. Nozawa, Y., 1952. A report on studies of anthelmintic actions of principles of volatile oils. III. Toxicity for mice and the efficacy against pig ascaria and earthworm muscles. Sapporo Igaku Zasshi 3, 73-77.
57. Oda, Y., Hamano, Y., Inoue, K., Yamamoto, H., Niihara, T., Kunita, N., 1978. Mutagenicity of food flavours in bacteria (1st Report). Osaka-furitsu Koshu Eisei Kenkyu Hokoku Shokuhin Eisei Hen, 9, 177-181.
58. Ohela K., and Saramies J. Perfume sensitivity. Duodecim 99 (1983) 215-220
59. QRA Expert Group, Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients, Technical Dossier, revised June 22, 2006.
60. Remaut K. Contact dermatitis due to cosmetic ingredients. Journal of Applied Cosmetology 10 (1992) 73-80
61. RIFM (Research Institute for Fragrance Materials, Inc.), 1954. Pathological changes in rats from feeding of various flavoring agents. RIFM Report Number 4850, RIFM, Woodcliff Lake, NJ, USA.
62. RIFM (Research Institute for Fragrance Materials, Inc.), 1963. Eye irritation study of geraniol in rabbits. Unpublished report from IFF. RIFM Report Number 14093, RIFM, Woodcliff Lake, NJ, USA.
63. RIFM (Research Institute for Fragrance Materials, Inc.), 1963a. Eye irritation study of geraniol in rabbits. Unpublished report from IFF. RIFM Report Number 51136, November 29, RIFM, Woodcliff Lake, NJ, USA.
64. RIFM (Research Institute for Fragrance Materials, Inc.), 1964. Repeated insult patch test with geraniol. Unpublished report from IFF. RIFM Report Number 51135, April 30, RIFM, Woodcliff Lake, NJ, USA.
65. RIFM (Research Institute for Fragrance Materials, Inc.), 1964a. Repeated insult patch test with geraniol. Unpublished report from IFF. RIFM Report Number 14094, RIFM, Woodcliff Lake, NJ, USA.
66. RIFM (Research Institute for Fragrance Materials, Inc.), 1972. Acute toxicity studies in mice, rats and rabbits. RIFM Report Number 2536, November 1, RIFM, Woodcliff Lake, NJ, USA.
67. RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Skin irritation and capacity of allergenic sensitization of geraniol on guinea pigs. Unpublished report from Givaudan. RIFM Report Number 9473, RIFM, Woodcliff Lake, NJ, USA.
68. RIFM (Research Institute for Fragrance Materials, Inc.), 1979. Report on human maximization studies. RIFM Report Number 1697, June 18, RIFM, Woodcliff Lake, NJ, USA.
69. RIFM (Research Institute for Fragrance Materials, Inc.), 1979a. Report on human maximization studies. RIFM Report Number 1697, July 6, RIFM, Woodcliff Lake, NJ, USA.
70. RIFM (Research Institute for Fragrance Materials, Inc.), 1980. Rat open application skin irritation test with allyl phenoxyacetate and 2-heptylidenecyclopentan-1-one. Unpublished report from Quest Inc. RIFM Report Number 45420, RIFM, Woodcliff Lake, NJ, USA.
71. RIFM (Research Institute for Fragrance Materials, Inc.), 1984. Primary irritation test in rabbits. RIFM Report Number 1795, RIFM, Woodcliff Lake, NJ, USA.
72. RIFM (Research Institute for Fragrance Materials, Inc.), 1985. Acute dermal irritation study in rabbits. RIFM Report Number 3099, RIFM, Woodcliff Lake, NJ, USA.
73. RIFM (Research Institute for Fragrance Materials, Inc.), 1986. Acute dermal irritation study in rabbits. RIFM Report Number 5664, June 1, RIFM, Woodcliff Lake, NJ, USA.
74. RIFM (Research Institute for Fragrance Materials, Inc.), 1987. Acute dermal irritation/corrosion test of geraniol in the rabbit. Unpublished report from BBA. RIFM Report Number 15427, August 5, RIFM, Woodcliff Lake, NJ, USA.
75. RIFM (Research Institute for Fragrance Materials, Inc.), 1987a. Acute dermal irritation/corrosion test of geraniol in the rabbit. Unpublished report from BBA. RIFM Report Number 15428, July 17, RIFM, Woodcliff Lake, NJ, USA.
76. RIFM (Research Institute for Fragrance Materials, Inc.), 1989. The sensitization potential of geraniol in guinea pigs. Unpublished report from Quest Inc. RIFM Report Number 15429, December 1, RIFM, Woodcliff Lake, NJ, USA.
77. RIFM (Research Institute for Fragrance Materials, Inc.), 1992. Delayed contact hypersensitivity study of geraniol in guinea pigs (Buehler Technique). RIFM Report Number 17636, RIFM, Woodcliff Lake, NJ, USA.
78. RIFM (Research Institute for Fragrance Materials, Inc.), 2000. Repeated insult patch test of geraniol in humans. RIFM Report Number 36679, RIFM, Woodcliff Lake, NJ, USA.
79. RIFM (Research Institute for Fragrance Materials, Inc.), 2000a. Geraniol: Acute eye irritation/corrosion study in the rabbit. RIFM Report Number 36136, December 30, RIFM, Woodcliff Lake, NJ, USA.
80. RIFM (Research Institute for Fragrance Materials, Inc.), 2002. Repeated insult patch test (RIPT) with geraniol. RIFM Report Number 44248, August 12, RIFM, Woodcliff Lake, NJ, USA.
81. RIFM (Research Institute for Fragrance Materials, Inc.), 2004. Human repeated insult patch test with geraniol (Modified Draize procedure). RIFM Report Number 46888, August 9, RIFM, Woodcliff Lake, NJ, USA.
82. Santucci B., Cristaudo A., Cannistraci C., and Picardo M. Contact dermatitis to fragrances. Contact Dermatitis 16 (1987) 93-95
83. Sasaki Y.F., Imanishi H., Phta T., and Shirasu Y. Modifying effects of components of plant essence on the induction of sister-chromatid exchanges in cultured Chinese hamster ovary cells. Mutation Research 226 (1989) 103-110
84. Schauder S., and Ippen H. Contact and photocontact sensitivity to suncreens. Review of a 15-year experience and of the literature. Contact Dermatitis 37 (1997) 221-232
85. Sharp D.W. The sensitization potential of some perfume ingredients tested using a modified Draize procedure. Toxicology 9 (1978) 261-271
86. Sugai, T., 1982. Contact dermatatis due to household products. In: Proceedings of the 11th Annual Meeting, Japanese Society Cutaneous Health, 15-18.
87. Troy, W.R., 1977. Doctoral Dissertation: The Comparative Respiratory Irritation Potential of 14 Fragrance Raw Materials. Private Communication to RIFM. Report number 9011.
88. Van Joost T.H., Stolz D., Van Der Hoek J.S.V., and Prens E.P. Sensitivity to woodtar. Contact Dermatitis 11 (1984) 248
89. Van Joost T.H., Stolz E., and Van Der Hoek J.C.S. Simultaneous allergy to perfume ingredients. Contact Dermatitis 12 (1985) 115-116
90. Wohrl S., Hemmer W., Focke M., Gotz M., and Jarisch R. The significance of fragrance mix, balsam of Peru, colophony and propolis as screening tools in the detection of fragrance allergy. British Journal of Dermatology 145 (2001) 268-273
91. Yamawaki T. Pharmacological effects of geraniol. Nippon Yakurigaku Zasshi 58 (1962) 394-400
92. York M., Griffiths H.A., Whittle W., and Basketter D.A. Evaluation of a human patch test for the identification and classification of skin irritation potential. Contact Dermatitis 34 (1996) 204-212