Corticostriatal circuitry in regulating diseases characterized by intrusive thinking

Dialogues in Clinical Neuroscience

Volumn 18, Issue 1, 2016, Pages 65-76

  Kalivas, Benjamin C ^a   Kalivas, Peter W ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Addiction; Corticostriatal; Glutamate; Intrusive thinking; N acetylcysteine; Synaptic plasticity

Indexed keywords

ARTICLE; ASSOCIATION; CORPUS STRIATUM; HUMAN; INTRUSIVE THINKING; MENTAL DISEASE; NEUROBIOLOGY; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PREFRONTAL CORTEX; SYNAPSE; THINKING; BRAIN CORTEX; DRUG DEPENDENCE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

CEREBRAL CORTEX; HUMANS; MENTAL DISORDERS; NERVE NET; NEURONAL PLASTICITY; SUBSTANCE-RELATED DISORDERS; THINKING;

EID: 84964612020     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (98)

1. Julian D., O'Connor KP., Aardema F. Intrusive thoughts, obsessions, and appraisals in obsessive-compulsive disorder: a critical review. Clin Psychol Rev. 2007;27(3):366-383
2. Moss AC., Erskine JA., Albery IP., Allen JR., Georgiou GJ. To suppress, or not to suppress? That is repression: controlling intrusive thoughts in addictive behaviour. Addict Behav. 2015;44:65-70
3. Pittenger C. Disorders of memory and plasticity in psychiatric disease. Dialogues Clin Neurosci. 2013;15(4):455-463
4. Bortolon C., Laroi F., Stephan Y., et al Further insight into the role of metacognitive beliefs in schizophrenia and OCD patients: testing a mediation model. Psychiatry Res. 2014;220(1-2):698-701
5. Peterson RD., Klein J., Donnelly R., Renk K. Predicting psychological symptoms: the role of perceived thought control ability. Cogn Behav Ther. 2009;38(1):16-28
6. Leckman JF., Denys D., Simpson HB., et al Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V. Depress Anxiety. 2010;27(6):507-527
7. Reuven-Magril O., Dar R., Liberman N. Illusion of control and behavioral control attempts in obsessive-compulsive disorder. J Abnorm Psychol. 2008;117(2):334-341
8. Schultz W. Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology. Curr Opin Neurobiol. 2004;14(2):139-147
9. Kalivas PW., O'Brien C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology. 2008;33(1):166-180
10. Wise RA. Dopamine, learning and motivation. Nat Rev Neurosci. 2004;5(6):483-494
11. Marsh R., Maia TV., Peterson BS. Functional disturbances within front ostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 2009;66(6):664-674
12. Goldstein RZ., Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci. 2011;12(11):652-669
13. Val-Laillet D., Aarts E., Weber B., et al Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin. 2015;8:1-31
14. Ahmari SE., Dougherty DD. Dissecting OCD circuits: from animal models to targeted treatments. Depress Anxiety. 2015;328(8):550-562
15. Greenberg T., Chase HW., Almeida JR., et al Moderation of the relationship between reward expectancy and prediction error-related ventral striatal reactivity by anhedonia in unmedicated major depressive disorder: findings From the EMBARC study. Am J Psychiatry. 2015;172(9):881-891
16. Hughes KC., Shin LM. Functional neuroimaging studies of post-traumatic stress disorder. Expert Rev Neurother. 2011;11(2):275-285
17. Shin LM., Lasko NB., MackLin ML., et al Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder. Arch Gen Psychiatry. 2009;6(10):1099-1107
18. Bremner JD., Elzinga B., Schmahl C., Vermetten E. Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog Brain Res. 2008;167:171-186
19. Yin HH., Mulcare SP., Hilario MR., et al Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nat Neurosci. 2009;12(3):333-341
20. Hart G., Leung BK., Balleine BW. Dorsal and ventral streams: the distinct role of striatal subregions in the acquisition and performance of goal-directed actions. Neurobiol Learn Mem. 2014;108:104-118
21. Lüscher C., Malenka RC. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron. 2011;69(4):650-663
22. Dong Y., Nestler EJ. The neural rejuvenation hypothesis of cocaine addiction. Trends Pharmacol Sci. 2014;35(8):374-383
23. Pierce RC., Wolf ME. Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission. Cold Spring Harb Perspect Med. 2013;3(2):a012021
24. Kalivas PW., Volkow ND. New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry. 2011;16(10):974-986
25. Yin HH., Knowlton BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006;7(6):464-476
26. Shifleft MW., Balleine BW. Molecular substrates of action control in cortico-striatal circuits. Prog Neurobiol. 2011;95(1):1-13
27. Robbins TW., Everitt BJ. Limbic-striatal memory systems and drug addiction. Neurobiol Learn Mem. 2002;78(3):625-636
28. Kelley AE. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev. 2004;27(8):765-776
29. Crombag HS., Bossert JM., Koya E., Shaham Y. Review. Context-induced relapse to drug seeking: a review. Philos Trans R Soc Lond B Biol Sci. 2008;63(1507):3233-3243
30. Shaham Y., Shalev U., Lu L., De Wit H., Stewart J. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl). 2003;168(1-2):3-20
31. Everitt BJ., Wolf ME. Psychomotor stimulant addiction: a neural systems perspective. J Neurosci. 2002;22(9):3312-3320
32. Everitt BJ., Belin D., Economidou D., Pelloux Y., Dalley JW., Robbins TW. Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3125-3135
33. Haber SN. The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat. 2003;26(4):317-330
34. Chen BT., Yau HJ., Hatch C., et al Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 2013;496(7445):359-362
35. Kasanetz F., Deroche-Gamonet V., Berson N., et al Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science. 2010;328(5986):1709-1712
36. Piazza PV., Deroche-Gamonet V. A multistep general theory of transition to addiction. Psychopharmacology (Berl). 2013;229(3):387-413
37. Pelloux Y., Everitt BJ., Dickinson A. Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology (Berl). 2007;94(1):27-137
38. Wolf ME. The Bermuda Triangle of cocaine-induced neuroadaptations. Trends Neurosci. 2010;33(9):391-398
39. Robinson TE., Kolb B. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology. 2004;47(suppl 1):33-46
40. Russo SJ., Dietz DM., Dumitriu D., Morrison JH., Malenka RC., Nestler EJ. The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci. 2010;33(6):267-276
41. Robinson TE., Kolb B. Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats. Synapse. 1999;33(2):160-162
42. Shen H., Moussawi K., Zhou W., Toda S., Kalivas PW. Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proc Natl Acad Sci U S A. 2011;108(48):19407-19412
43. Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 2009;10(8):561-572
44. Gipson CD., Kupchik YM., Kalivas PW. Rapid, transient synaptic plasticity in addiction. Neuropharmacology. 2014;76(pt B):276-286
45. Gass JT., Sinclair CM., Cleva RM., Widholm JJ., Olive MF. Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. Addict Biol. 2011;16(2):215-228
46. La Lumiere RT., Kalivas PW. Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J Neurosci. 2008;28(12):3170-3177
47. McFarland K., Lapish CC., Kalivas PW. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci. 2003;23(8):3531-3537
48. Gipson CD., Reissner KJ., Kupchik YM., et al Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A. 2013;110(22):9124-9129
49. Parsegian A., See RE. Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. Neuropsychopharmacology. 2014;39(4):811-822
50. Peterson YK., Bernard ML., Ma H., Hazard S 3rd., Graber SG., Lanier SM. Stabilization of the GDP-bound conformation of Gia by a peptide derived from the G-protein regulatory motif of AGS3. J Biol Chem. 2000;275(43):33193-33196
51. Alhaddad H., Das SC., Sari Y. Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats. Psychopharmacology (Berl). 2014;231(20):4049-4057
52. Moussawi K., Kalivas PW. Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. Eur J Pharmacol. 2010;639(1-3):115-122
53. Moussawi K., Zhou W., Shen H., et al Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A. 2011;108(1):385-390
54. Shen HW., Scofield MD., Boger H., Hensley M., Kalivas PW. Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse. J Neurosci. 2014;34(16):5649-5657
55. Bowers MS., McFarland K., Lake RW., et al Activator of G-protein signaling 3: a gatekeeper of cocaine sensitization and drug-seeking. Neuron. 2004;42(2):269-281
56. Bowers MS., Hopf FW., Chou JK., et al Nucleus accumbens AGS3 expression drives ethanol seeking through Gß γ Proc Natl Acad Sci U S A. 2008;105(34):12533-12538
57. Garcia-Keller C., Kupchik YM., Roberts-Wolfe D., et al Glutamatergic mechanisms of comorbidity between stress disorders and cocaine addiction. Mol Psychiatry. In press
58. Lehre KP., Danbolt NC. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci. 1998;18(21):8751-8757
59. Olive MF., Cleva RM., Kalivas PW., Malcolm RJ. Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav. 2012;100(4):801-810
60. Wang X., Moussawi K., Knackstedt L., Shen H., Kalivas PW. Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol. 2013;18(1):40-49
61. Schmidt HD., Schassburger RL., Guercio LA., Pierce RC. Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma. J Neurosci. 2013;33(35):14160-14169
62. Smith AC., Kupchik YM., Scofield MD., et al Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nat Neurosci. 2014;17(12):1655-1657
63. Lee DK., Koh WC., Shim YB., Shim I., Choe ES. Repeated cocaine administration increases nitric oxide efflux in the rat dorsal striatum. Psychopharmacology (Berl). 2010;208(2):245-256
64. Selvakumar B., Campbell PW., Milovanovic M., et al AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin. Neuropharmacology. 2014;77:28-38
65. Gipson CD., Kupchik YM., Shen H., Reissner KJ., Thomas CA., Kalivas PW. Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron. 2013;77(5):867-872
66. Stankeviciute NM., Scofield MD., Kalivas PW., Gipson CD. Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking. Addict Biol. 2014;19(6):972-974
67. Chen Q., Zhu X., Zhang Y., Wetsel WC., Lee TH., Zhang X. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. J Mol Neurosci. 2010;40(3):284-294
68. Wiggins A., Smith RJ., Shen HW., Kalivas PW. Integrins modulate relapse to cocaine-seeking. J Neurosci. 2011;31(45):16177-16184
69. Rao PS., Sari Y. Glutamate transporter 1: target for the treatment of alcohol dependence. Curr Med Chem. 2012;19(30):5148-5156
70. Trantham-Davidson H., LaLumiere RT., Reissner KJ., Kalivas PW., Knackstedt LA. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. J Neurosci. 2012;32(36):12406-12410
71. Martin-Fardon R., Baptista MA., Dayas CV., Weiss F. Dissociation of the effects of MTEP [3-[(2-methyl-1, 3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer. J Pharmacol Exp Ther. 2009;329(3):1084-1090
72. Baptista MA., Martin-Fardon R., Weiss F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci. 2004;24(20):4723-4727
73. Kinon BJ., Millen BA., Zhang L., McKinzie DL. Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionil in schizophrenia. Biol Psychiatry. 2015;78(11):754-762
74. Berry-Kravis E., Hessl D., Coffey S., et al A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet. 2009;46(4):266-271
75. Zucker S., Cao J. Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: ready for prime time? Cancer Biol Ther. 2009;8(24):2371-2373
76. Knackstedt LA., Melendez RL., Kalivas PW. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry. 2010;67(1):81-84
77. Reissner KJ., Gipson CD., Tran PK., Knackstedt LA., Scofield MD., Kalivas PW. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol. 2015;20(2):316-323
78. Knackstedt LA., LaRowe S., Mardikian P., et al The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiatry. 2009;65(10):841-845
79. Gray KM., Watson NL., Carpenter MJ., Larowe SD. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. Am J Addict. 2010;19(2):187-189
80. Larowe SD., Kalivas PW., Nicholas JS., Randall PK., Mardikian PN., Malcolm RJ. A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict. 2013;22(5):443-452
81. Amen SL., Piacentine LB., Ahmad ME., et al Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology. 2011;36(4):871-878
82. Grant JE., Kim SW., Odlaug BL. N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study. Biol Psychiatry. 2007;62(6):652-657
83. Grant JE., Odlaug BL., Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 2009;66(7):756-763
84. Berk M., Dean OM., Cotton SM., et al The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2014;75(6):628-636
85. Afshar H., Roohafza H., Mohammad-Beigi H., et al N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2012;32(6):797-803
86. Froeliger B., McConnell PA., Stankeviciute N., McClure EA., Kalivas PW., Gray KM. The effects of N-acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: a double-blind, placebo-controlled fMRI pilot study. Drug Alcohol Depend. 2015;156:234-242
87. Sutherland MT., Carroll AJ., Salmeron BJ., Ross TJ., Hong LE., Stein EA. Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. Biol Psychiatry. 2013;74(7):538-546
88. Phillips ML., Chase HW., SheLine YL., et al Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. Am J Psychiatry. 2015;172(2):124-138
89. Millea PJ. N-acetylcysteine: multiple clinical applications. Am Fam Physician. 2009;80(3):265-269
90. Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet. 1991;20(2):123-134
91. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med. 1999;27(9-10):922-935
92. Rothstein JD., Patel S., Regan MR., et al ß-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature. 2005;433(7021):73-77
93. Soni N., Reddy BV., Kumar P. GLT-1 transporter: an effective pharmacological target for various neurological disorders. Pharmacol Biochem Behav. 2014;127:70-81
94. Hota SK., Barhwal K., Ray K., Singh SB., Ilavazhagan G. Ceftriaxone rescues hippocampal neurons from excitotoxicrty and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiol Learn Mem. 2008;89(4):522-532
95. Lai PC., Huang YT., Wu CC., Lai CJ., Wang PJ., Chiu TH. Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats. J Biomed Sci. 2011;18:69
96. Sari Y., Sakai M., Weedman JM., Rebec GV., Bell RL. Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. Alcohol Alcohol. 2011;46(3):239-246
97. Reissner KJ., Brown RM., Spencer S., Tran PK., Thomas CA., Kalivas PW. Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. Neuropsychopharmacology. 2014;39(2):499-506
98. Koya E., Golden SA., Harvey BK., et al Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. Nat Neurosci. 2009;12(8):1069-1073