Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse

Journal of Neuroscience

Volumn 34, Issue 16, 2014, Pages 5649-5657

  Shen, Hao Wei ^a   Scofield, Michael D ^b   Boger, Heather ^b   Hensley, Megan ^b   Kalivas, Peter W ^b  

^a PEKING UNIVERSITY   (China)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Extrasynaptic glutamate receptor; Glutamate spillover; Glutamate uptake; Heroin self administration; Nucleus accumbens; Relapse

Indexed keywords

CEFTRIAXONE; DIAMORPHINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; VESICULAR GLUTAMATE TRANSPORTER 1;

ARTICLE; BIOTINYLATION; BRAIN FUNCTION; BRAIN SLICE; CENTRAL NERVOUS SYSTEM FUNCTION; CLINICAL ASSESSMENT; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; ENZYME ACTIVITY; HUMAN; MICRODIALYSIS; NEUROMUSCULAR ELECTRICAL STIMULATION; NUCLEUS ACCUMBENS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RELAPSE; SIGNAL TRANSDUCTION; SYNAPTIC POTENTIAL; WHOLE CELL PATCH CLAMP;

EXTRASYNAPTIC GLUTAMATE RECEPTOR; GLUTAMATE SPILLOVER; GLUTAMATE UPTAKE; HEROIN SELF-ADMINISTRATION; NUCLEUS ACCUMBENS; RELAPSE;

ANIMALS; ASPARTIC ACID; CEFTRIAXONE; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG-SEEKING BEHAVIOR; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HEROIN; HEROIN DEPENDENCE; MALE; MORPHOLINOS; NEURONS; NUCLEUS ACCUMBENS; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; RECURRENCE; SYNAPSES;

EID: 84899479128     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4564-13.2014     Document Type: Article

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