Comparative Evaluation of the Chemical Stability of 4 Well-Defined Immunoglobulin G1-Fc Glycoforms

Journal of Pharmaceutical Sciences

Volumn 105, Issue 2, 2016, Pages 575-587

  Mozziconacci, Olivier ^a   Okbazghi, Solomon ^a   More, Apurva S ^a   Volkin, David B ^a   Tolbert, Thomas ^a   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

antibody; biosimilar; glycoform; H2O2; metal; oxidation; peroxide; stability; UV light

Indexed keywords

IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; METHIONINE SULFOXIDE; SUCROSE; GLYCOPROTEIN; IMMUNOGLOBULIN G;

AMINO ACID SEQUENCE; ARTICLE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; DEAMINATION; GLYCATION; MASS SPECTROMETRY; OXIDATION; PEPTIDE MAPPING; PROTEIN STABILITY; TEMPERATURE; THERMOSTABILITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION; CHEMISTRY; COMPARATIVE STUDY; DRUG STABILITY; GLYCOSYLATION; METABOLISM; PRECLINICAL STUDY; PROCEDURES;

DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; GLYCOPROTEINS; GLYCOSYLATION; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G;

EID: 84964522978     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2015.10.024     Document Type: Article

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