Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus

Biomedicine and Pharmacotherapy

Volumn 81, Issue , 2016, Pages 439-452

  Adam, Siti Hajar ^a   Giribabu, Nelli ^a   Kassim, Normadiah ^a   Kumar, Kilari Eswar ^b   Brahmayya, Manuri ^c   Arya, Aditya ^a   Salleh, Naguib ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b ANDHRA UNIVERSITY   (India)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Diabetes mellitus; Pancreas; V.vinifera seed aqueous extract

Indexed keywords

CASPASE 3; CATALASE; GLUCOSE TRANSPORTER 2; GLUTATHIONE PEROXIDASE; GRAPE SEED EXTRACT; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; I KAPPA B KINASE BETA; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; INSULIN; LIPID; PLANT EXTRACT; PROTECTIVE AGENT; WATER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG SYNTHESIS; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GRAPE; HISTOPATHOLOGY; IC50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT DURATION; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRINKING BEHAVIOR; DRUG EFFECTS; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; LIPID PEROXIDATION; MASS FRAGMENTOGRAPHY; METABOLISM; PANCREAS; PATHOLOGY; PLANT SEED; VITIS; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; DRINKING BEHAVIOR; FASTING; FEEDING BEHAVIOR; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION REGULATION; GLUTATHIONE PEROXIDASE; HEMOGLOBIN A, GLYCOSYLATED; INFLAMMATION; INSULIN; LIPID PEROXIDATION; LIPIDS; MALE; OXIDATIVE STRESS; PANCREAS; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS, WISTAR; RNA, MESSENGER; SEEDS; SUPEROXIDE DISMUTASE; VITIS; WATER;

EID: 84964434651     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.04.032     Document Type: Article

References (38)

1. Muoio D.M., Newgard C.B. Molecular and metabolic mechanisms of insulin resistance and [beta]-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9(3):193-205.
2. Grodsky G.M., et al. Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Am. J. Physiol-Legacy Content 1963, 205:638-644.
3. Macfarlane W.M., et al. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic β-cells. J. Biol. Chem. 1997, 272(33):20936-20944.
4. Leibiger I.B., et al. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol. Cell 1998, 1(6):933-938.
5. Waeber G., et al. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol. Endocrinol. 1996, 10(11):1327-1334.
6. Poitout V., Olson L.K., Robertson R.P. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J. Clin. Invest. 1996, 97(4):1041.
7. Yin W., et al. Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas. Food Funct. 2015, 6(9):3065-3071.
8. Babu P.V.A., Liu D., Gilbert E.R. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J. Nutr. Biochem. 2013, 24(11):1777-1789.
9. Elosta A., Ghous T., Ahmed N. Natural products as anti-glycation agents: possible therapeutic potential for diabetic complications. Curr. Diabetes Rev. 2012, 8(2):92-108.
10. Coskun O., et al. Quercetin: a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol. Res. 2005, 51(2):117-123.
11. Rashid K., Sil P.C. Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats. Toxicol. Appl. Pharmacol. 2015, 282(3):297-310.
12. Choudhury S., et al. Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2-NF-κB and SAPK/JNK pathway. Free Radic. Res. 2016, 2015(0):1-41.
13. Casoli T., et al. Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer's disease neurodegeneration. Front. Aging Neurosci. 2015, 7:142.
14. Satyam S.M., et al. Grape seed extract and zinc containing nutritional food supplement delays onset and progression of streptozocin-induced diabetic cataract in Wistar rats. J. Food Sci. Technol. 2015, 52(5):2824-2832.
15. Giribabu N., et al. Vitis vinifera (Muscat variety) seed ethanolic extract preserves activity levels of enzymes and histology of the liver in adult male rats with diabetes. Evidence-Based Complement. Altern. Med. 2015, 2015:p8.
16. Güçlü A., et al. The effects of grape seed on apoptosis-related gene expression and oxidative stress in streptozotocin-induced diabetic rats. Ren. Fail. 2015, 37(2):192-197.
17. Yonguc G.N., et al. Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats. Gene 2015, 555(2):119-126.
18. Badavi M., et al. Co-administration of grape seed extract and exercise training improves endothelial dysfunction of coronary vascular bed of STZ-Induced diabetic rats. Iran. Red. Crescent Med. J. 2013, 15(10):e7624.
19. Katalinic V., et al. Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols. Food Chem. 2006, 94(4):550-557.
20. Stewart R.R., Bewley J.D. Lipid peroxidation associated with accelerated aging of soybean axes. Plant Physiol. 1980, 65(2):245-258.
21. Halliwell B., Gutteridge J.M., Aruoma O.I. The deoxyribose method: a simple test-tube assay for determination of rate constants for reactions of hydroxyl radicals. Anal. Biochem. 1987, 165(1):215-219.
22. Ruch R.J., Cheng S.J., Klaunig J.E. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 1989, 10(6):1003-1008.
23. Nelli G.B., Kilari E.K. Antidiabetic effect of alpha-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats. Syst. Biol. Reprod. Med. 2013, 59(6):319-328.
24. Giribabu N., et al. Chlorophytum borivilianum root extract maintains near normal blood glucose, insulin and lipid profile levels and prevents oxidative stress in the pancreas of streptozotocin-induced adult male diabetic rats. Int. J. Med. Sci. 2014, 11(11):1172.
25. Walawalkar P.S., Serai P.S., Iyer K. Isolation and catalytic competence of different animal liver microsomal fractions prepared by calcium-aggregation method. Indian J. Pharm. Sci. 2006, 68(2):262.
26. Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods in Enzymology 1990, 407-421. Academic Press. A.N.G. Lester Packer (Ed.).
27. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 1972, 247(10):3170-3175.
28. Bonaventura J., Schroeder W., Fang S. Human erythrocyte catalase: an improved method of isolation and a reevaluation of reported properties. Arch. Biochem. Biophys. 1972, 150(2):606-617.
29. Rotruck J.T., Pope A., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179(4073):588-590.
30. Guillam M.-T., et al. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat. Genet. 1997, 17(3):327-330.
31. Maritim A.C., Sanders R.A., Watkins R.J.B. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 2003, 17(2438.26).
32. Ramanathan M., Jaiswal A.K., Bhattacharya S.K. Superoxide dismutase, catalase and glutathione peroxidase activities in the brain of streptozotocin induced diabetic rats. Indian J. Exp. Biol. 1999, 37:182-183.
33. Yao D., Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 2010, 59(1):249-255.
34. Chung M.C., et al. Prodrugs for the treatment of neglected diseases. Molecules 2008, 13(3):616-677.
35. Harini S.T., et al. Novel 2, 6-bis (4-methoxyphenyl)-1-methylpiperidin-4-one oxime esters: synthesis and a new insight into their antioxidant and antimicrobial potential. Med. Chem. Res. 2014, 23(4):1887-1898.
36. Manoj G., Manohar S.H., Murthy H.N. Chemical constituents: antioxidant and antimocrobial activity of essential oil of Pogostemon paniculatus (Willd.). Nat. Prod. Res. 2012, 26(22):2152-2154.
37. Emonds-Ai, X., et al. Administrering for treatment of neutrogenic inflammation of the respiratory trart. Google Patents, (1993).
38. Irshad M., et al. Phytochemical composition of Cassia fistula fruit extracts and its anticancer activity against human cancer cell lines. J. Biolog. Active Prod. Nat. 2014, 4(3):158-170.