-
1
-
-
33744486308
-
Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria
-
Hotez, P.J.; Molyneux, D.H.; Fenwick, A.; Ottesen, E.; Ehrlich, S.S.; Sachs, J.D. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria, PLoS Med. 2006, 3, e102.
-
(2006)
PLoS Med
, vol.3
-
-
Hotez, P.J.1
Molyneux, D.H.2
Fenwick, A.3
Ottesen, E.4
Ehrlich, S.S.5
Sachs, J.D.6
-
2
-
-
34547916456
-
Neglected diseases, civil conflicts, and the right to health
-
Beyrer, C.; Villar, J.D.; Suwanvanichkij, V.; Singh, S.; Baral S.D.; Mills, E.J. Neglected diseases, civil conflicts, and the right to health. Lancet 2007, 370, 619-627.
-
(2007)
Lancet
, vol.370
, pp. 619-627
-
-
Beyrer, C.1
Villar, J.D.2
Suwanvanichkij, V.3
Singh, S.4
Baral, S.D.5
Mills, E.J.6
-
3
-
-
0037157590
-
Drug development for neglected diseases: A deficient market and a public-health policy failure
-
Trouiller, P.; Olliaro, P.; Torreele, E.; Orbinski, J.; Laing, R.; Ford, N. Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet 2002, 359, 2188-2194.
-
(2002)
Lancet
, vol.359
, pp. 2188-2194
-
-
Trouiller, P.1
Olliaro, P.2
Torreele, E.3
Orbinski, J.4
Laing, R.5
Ford, N.6
-
4
-
-
29244444503
-
Neglected diseases of neglected populations: Thinking to reshape the determinants of health in Latin America and the Caribbean
-
Ehrenberg, J.P.; Ault, S.K. Neglected diseases of neglected populations: thinking to reshape the determinants of health in Latin America and the Caribbean, BMC Public Health 2005, 5, 119-132.
-
(2005)
BMC Public Health
, vol.5
, pp. 119-132
-
-
Ehrenberg, J.P.1
Ault, S.K.2
-
5
-
-
41649116768
-
-
Medecins Sans Frontieres. Drugs for Neglected Diseases Initiative: Teaming up to address neglect (12 March, 2003). Accessed from www.accessmed.msf.org in Nov. 2007.
-
Medecins Sans Frontieres. Drugs for Neglected Diseases Initiative: Teaming up to address neglect (12 March, 2003). Accessed from www.accessmed.msf.org in Nov. 2007.
-
-
-
-
6
-
-
15744367388
-
New drugs for neglected diseases: From pipeline to patients
-
Pécoul, B. New drugs for neglected diseases: from pipeline to patients. PloS Med. 2004, 1, 19-22.
-
(2004)
PloS Med
, vol.1
, pp. 19-22
-
-
Pécoul, B.1
-
7
-
-
26044468809
-
Opportunities and challenges in antiparasitic drug discovery
-
Pink, R.; Hudson, A.; Mouriès, M.A.; Bendig, M. Opportunities and challenges in antiparasitic drug discovery. Nature Rev. Drug Disc. 2005, 4, 727-740.
-
(2005)
Nature Rev. Drug Disc
, vol.4
, pp. 727-740
-
-
Pink, R.1
Hudson, A.2
Mouriès, M.A.3
Bendig, M.4
-
8
-
-
0036545413
-
Prodrug and antedrug: Two diametrical approaches in designing safer drugs
-
Lee, H. J.; Cooperwood, J. S.; You, Z.; Ko, D. H... Prodrug and antedrug: two diametrical approaches in designing safer drugs. Arch. Pharm. Res. 2002, 25, 111-136.
-
(2002)
Arch. Pharm. Res
, vol.25
, pp. 111-136
-
-
Lee, H.J.1
Cooperwood, J.S.2
You, Z.3
Ko, D.H.4
-
9
-
-
24944549193
-
Advances in prodrug design
-
Silva, A.T.A.; Castro, L.F.; Guido, R.V.C.; Chung, M. C.; Ferreira, E.I. Advances in prodrug design. Mini-Rev. Med. Chem. 2005, 5, 893-914.
-
(2005)
Mini-Rev. Med. Chem
, vol.5
, pp. 893-914
-
-
Silva, A.T.A.1
Castro, L.F.2
Guido, R.V.C.3
Chung, M.C.4
Ferreira, E.I.5
-
10
-
-
0347493809
-
A descoberta
-
Brener, Z. A descoberta. Mem. Inst. Oswaldo Cruz 1989, 84 (supl II), 1-6.
-
(1989)
Mem. Inst. Oswaldo Cruz
, vol.84
, Issue.SUPL II
, pp. 1-6
-
-
Brener, Z.1
-
11
-
-
41649086228
-
-
Acessed from /chagas/ in Dec
-
World Health Organization. Chagas Disease: TDR Acessed from http://www.who.int/tdr/diseases/chagas/ in Dec. 2007.
-
(2007)
Chagas Disease: TDR
-
-
-
12
-
-
0033256630
-
Parasitological cure of Chagas disease: Is it possible? Is it relevant?
-
Urbina JA. Parasitological cure of Chagas disease: Is it possible? Is it relevant? Mem. Inst. Oswaldo Cruz. 1999, 94, 349-355.
-
(1999)
Mem. Inst. Oswaldo Cruz
, vol.94
, pp. 349-355
-
-
Urbina, J.A.1
-
14
-
-
33749258363
-
Identification of novel inhibitors of UDP-Glc 40-epimerase, a validated drug target for african sleeping sickness
-
Urbaniak, M.D.; Tabudravu, J.N.; Msaki, A.; Matera, K.M.; Brenk, R.; Jaspars, M.; Ferguson, M.A.J. Identification of novel inhibitors of UDP-Glc 40-epimerase, a validated drug target for african sleeping sickness. Bioorg. Med. Chem. Lett. 2006, 16, 5744-5747.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 5744-5747
-
-
Urbaniak, M.D.1
Tabudravu, J.N.2
Msaki, A.3
Matera, K.M.4
Brenk, R.5
Jaspars, M.6
Ferguson, M.A.J.7
-
15
-
-
0042090138
-
Improved trypanocidal activities of cathepsin L inhibitors
-
Nkemngu, N.J.; Grande, R.; Hansell, E.; McKerrow, J.H.; Caffrey, C.R.; Steverding, D. Improved trypanocidal activities of cathepsin L inhibitors. Int. J. Antimicrob. Agents 2003, 22, 155-159.
-
(2003)
Int. J. Antimicrob. Agents
, vol.22
, pp. 155-159
-
-
Nkemngu, N.J.1
Grande, R.2
Hansell, E.3
McKerrow, J.H.4
Caffrey, C.R.5
Steverding, D.6
-
16
-
-
0025775041
-
Perspectives in research on and control of African trypanosomiasis
-
Kuzoe FAS, Perspectives in research on and control of African trypanosomiasis. Ann. Trop. Med. Parasitol. 1991, 85, 33-41.
-
(1991)
Ann. Trop. Med. Parasitol
, vol.85
, pp. 33-41
-
-
Kuzoe, F.A.S.1
-
17
-
-
0033519070
-
P.The fall and rise of sleeping sickness
-
Barrett M.P.The fall and rise of sleeping sickness. Lancet 1999, 353, 1113-1114.
-
(1999)
Lancet
, vol.353
, pp. 1113-1114
-
-
Barrett, M.1
-
19
-
-
3042555141
-
Leishmaniasis: Current situation and new perspectives
-
Desjeux, P. Leishmaniasis: current situation and new perspectives. Comp. Immunol. Microbiol. Inf. Dis. 2004, 27, 305-318.
-
(2004)
Comp. Immunol. Microbiol. Inf. Dis
, vol.27
, pp. 305-318
-
-
Desjeux, P.1
-
20
-
-
33646515328
-
The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells
-
Szyniarowski, P.; Bettendorff, L.; Schweingruber, M.E. The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells. Cell Biol. Toxicol. 2006, 22, 183-187.
-
(2006)
Cell Biol. Toxicol
, vol.22
, pp. 183-187
-
-
Szyniarowski, P.1
Bettendorff, L.2
Schweingruber, M.E.3
-
21
-
-
3042699341
-
-
WHO: Geneva, accessed June 12, 2007
-
WHO. The world health report 2004. Changing history. WHO: Geneva, 2004; http://www.who.int/whr/2004/en/index.html (accessed June 12, 2007).
-
(2004)
The world health report 2004. Changing history
-
-
-
22
-
-
0033540012
-
Miltefosine: The long-awaited therapy for visceral leishmaniasis?
-
Herwaldt, B. L. Miltefosine: The long-awaited therapy for visceral leishmaniasis? N. Engl. J. Med. 1999, 341, 1840-1842.
-
(1999)
N. Engl. J. Med
, vol.341
, pp. 1840-1842
-
-
Herwaldt, B.L.1
-
23
-
-
0142043920
-
Current treatment approaches to leishmaniasis
-
Berman, J. Current treatment approaches to leishmaniasis. Curr. Opin. Infect. Dis. 2003, 16, 397-401.
-
(2003)
Curr. Opin. Infect. Dis
, vol.16
, pp. 397-401
-
-
Berman, J.1
-
24
-
-
0142258171
-
Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs
-
Croft, S.L.; Coombs, G.H. Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol. 2003, 19, 502-508.
-
(2003)
Trends Parasitol
, vol.19
, pp. 502-508
-
-
Croft, S.L.1
Coombs, G.H.2
-
25
-
-
1642432131
-
Drugs against leishmaniasis: A synergy of technology and partnerships
-
Davis, A.J., Murray, H.W., Handman, E. Drugs against leishmaniasis: a synergy of technology and partnerships. Trends Parasitol. 2004, 20, 73-76.
-
(2004)
Trends Parasitol
, vol.20
, pp. 73-76
-
-
Davis, A.J.1
Murray, H.W.2
Handman, E.3
-
26
-
-
7944237421
-
Leishmaniasis: Drugs in the clinic, resistance and new developments
-
Ouellette, M.; Drummelsmith, J.; Papadopoulou, B. Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist. Updat. 2004, 7, 257-266.
-
(2004)
Drug Resist. Updat
, vol.7
, pp. 257-266
-
-
Ouellette, M.1
Drummelsmith, J.2
Papadopoulou, B.3
-
28
-
-
33745109939
-
Novel Approaches to Antimalarial Drug Discovery
-
Biot, C.; Chibale, K. Novel Approaches to Antimalarial Drug Discovery. Infect. Disord. Drug Targets 2006, 6, 173-204.
-
(2006)
Infect. Disord. Drug Targets
, vol.6
, pp. 173-204
-
-
Biot, C.1
Chibale, K.2
-
29
-
-
23944488852
-
-
Menezes, C.M.S.; Ferreira, E.I. Modulating agents in resistant malaria. Drug Design Rev. Online 2005, 2, 409-418.
-
Menezes, C.M.S.; Ferreira, E.I. Modulating agents in resistant malaria. Drug Design Rev. Online 2005, 2, 409-418.
-
-
-
-
31
-
-
33748367860
-
Schistosomiasis - a century searching for chemotherapeutic drugs
-
Ribeiro-dos-Santos, G.; Verjovski-Almeida, S.; Leite, L.C.C. Schistosomiasis - a century searching for chemotherapeutic drugs. Parasitol. Res. 2006, 99, 505-521.
-
(2006)
Parasitol. Res
, vol.99
, pp. 505-521
-
-
Ribeiro-dos-Santos, G.1
Verjovski-Almeida, S.2
Leite, L.C.C.3
-
33
-
-
0011523808
-
Global tuberculosis control: Surveillance, planning, financing
-
World Health Organization
-
World Health Organization. Global tuberculosis control: surveillance, planning, financing. WHO Report 2007.
-
(2007)
WHO Report
-
-
-
34
-
-
0022412887
-
Immunopathogenesis of the acquired immunodeficiency syndrome
-
Bower, D. L.; Lane, H. C.; Fauci, A. S. Immunopathogenesis of the acquired immunodeficiency syndrome. Ann. Intern. Med. 1985, 103, 704-709.
-
(1985)
Ann. Intern. Med
, vol.103
, pp. 704-709
-
-
Bower, D.L.1
Lane, H.C.2
Fauci, A.S.3
-
35
-
-
0024443788
-
Epidemiology of tuberculosis in the United States
-
Reider, H. L.; Cauthen, G. M.; Comstock, G. W; Snider, D. E. Jr. Epidemiology of tuberculosis in the United States. Epidemiol. Rev. 1989, 11, 79-98.
-
(1989)
Epidemiol. Rev
, vol.11
, pp. 79-98
-
-
Reider, H.L.1
Cauthen, G.M.2
Comstock, G.W.3
Snider Jr., D.E.4
-
36
-
-
6944221116
-
Multiple drug resistance: A threat for tuberculosis control
-
Cardoso, E. M. Multiple drug resistance: a threat for tuberculosis control. Rev. Panam. Salud Publica 2004, 16, 68-73.
-
(2004)
Rev. Panam. Salud Publica
, vol.16
, pp. 68-73
-
-
Cardoso, E.M.1
-
37
-
-
34047205100
-
Genetic polymorphisms associated with priapism in sickle cell disease
-
Elliott, L.; Ashley-Koch, A. E.; De Castro, L.; Jonassaint, J.; Price, J.; Ataga, K. I.; Levesque, M.C.; Weinberg, J.B.; Eckman, J.R.; Orringer, E.P.; Vance, J.M.; Telen, M.J. Genetic polymorphisms associated with priapism in sickle cell disease. Br. J. Haematol. 2007, 137, 262-267.
-
(2007)
Br. J. Haematol
, vol.137
, pp. 262-267
-
-
Elliott, L.1
Ashley-Koch, A.E.2
De Castro, L.3
Jonassaint, J.4
Price, J.5
Ataga, K.I.6
Levesque, M.C.7
Weinberg, J.B.8
Eckman, J.R.9
Orringer, E.P.10
Vance, J.M.11
Telen, M.J.12
-
38
-
-
10244263604
-
Special issue of microcirculation: Examination of the vascular pathobiology of sickle cell anemia
-
Hebbel, R.P. Special issue of microcirculation: Examination of the vascular pathobiology of sickle cell anemia. Microcirculation 2004, 11, 99-100.
-
(2004)
Microcirculation
, vol.11
, pp. 99-100
-
-
Hebbel, R.P.1
-
39
-
-
19844379671
-
Multiorgan dysfunction syndrome in sickle cell disease
-
Hiran, S. Multiorgan dysfunction syndrome in sickle cell disease. J. Assoc. Physicians India 2005, 53, 19-22.
-
(2005)
J. Assoc. Physicians India
, vol.53
, pp. 19-22
-
-
Hiran, S.1
-
40
-
-
12944287077
-
Sickle cell disease
-
Buchanan, G.R.; Debaun, M.R.; Quinn, C.T.; Steinberg, M.H. Sickle cell disease. Hematology 2004, 1, 35-47.
-
(2004)
Hematology
, vol.1
, pp. 35-47
-
-
Buchanan, G.R.1
Debaun, M.R.2
Quinn, C.T.3
Steinberg, M.H.4
-
41
-
-
5044239523
-
Sickel-cell disease
-
Stuart, M.J.; Nagel, R.L. Sickel-cell disease. Lancet 2004, 364, 1343-1360.
-
(2004)
Lancet
, vol.364
, pp. 1343-1360
-
-
Stuart, M.J.1
Nagel, R.L.2
-
42
-
-
0027078611
-
A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders
-
Perrine, S.P.; Ginder, G.D.; Faller, D.V.; Dover, G.H.; Ikuta, T.; Witkowska, H.E.; Cai, S.P.; Vichinsky, E.; Olivieri, N.F. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N. Engl. J. Med. 1993, 328, 81-86.
-
(1993)
N. Engl. J. Med
, vol.328
, pp. 81-86
-
-
Perrine, S.P.1
Ginder, G.D.2
Faller, D.V.3
Dover, G.H.4
Ikuta, T.5
Witkowska, H.E.6
Cai, S.P.7
Vichinsky, E.8
Olivieri, N.F.9
-
43
-
-
0028291736
-
Mortality in sickle cell disease. Life expectancy and risk factors for early death
-
Platt, O.S.; Brambilla, D.J.; Rosse, W.F.; Milner, P.F.; Castro, O.; Steinberg, M.H.; Klug, P.P. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N. Engl. J. Med. 1994, 330, 1639-1644.
-
(1994)
N. Engl. J. Med
, vol.330
, pp. 1639-1644
-
-
Platt, O.S.1
Brambilla, D.J.2
Rosse, W.F.3
Milner, P.F.4
Castro, O.5
Steinberg, M.H.6
Klug, P.P.7
-
44
-
-
0021343093
-
Is there a threshold level of fetal hemoglobin that ameliorates morbidity on sickle cell anaemia?
-
Powars, D.R.; Weiss, J.N.; Chan, L.S.; Schroeder, W.A. Is there a threshold level of fetal hemoglobin that ameliorates morbidity on sickle cell anaemia? Blood 1983, 63, 921-926.
-
(1983)
Blood
, vol.63
, pp. 921-926
-
-
Powars, D.R.1
Weiss, J.N.2
Chan, L.S.3
Schroeder, W.A.4
-
45
-
-
26244457606
-
Latenciação e formas avançadas de transporte de fármacos.
-
Chung, M-C.; Silva, A. T de A.; Castro, L. F.; Güido, R. V C.; Nassute, J. C.; Ferreira, E. I. Latenciação e formas avançadas de transporte de fármacos. Rev. Bras. Cienc. Farm/Braz. J. Pharm Sci. 2005, 41, 155-179.
-
(2005)
Rev. Bras. Cienc. Farm/Braz. J. Pharm Sci
, vol.41
, pp. 155-179
-
-
Chung, M.-C.1
Silva, A.T.D.A.2
Castro, L.F.3
Güido, R.V.C.4
Nassute, J.C.5
Ferreira, E.I.6
-
46
-
-
0029045156
-
The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design
-
McKerrow, J.H.; McGrath, M.E.; Engel, J.C. The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design. Parasitol. Today, 1995, 11, 272-82.
-
(1995)
Parasitol. Today
, vol.11
, pp. 272-282
-
-
McKerrow, J.H.1
McGrath, M.E.2
Engel, J.C.3
-
47
-
-
33748233963
-
Disulfide-reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria
-
Schirmer, R. H.; Müller, J. G.; Krauth-Siegel, L. Disulfide-reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria. Angew. Chem., Int. Ed. Engl. 1995, 34, 141-154
-
(1995)
Angew. Chem., Int. Ed. Engl
, vol.34
, pp. 141-154
-
-
Schirmer, R.H.1
Müller, J.G.2
Krauth-Siegel, L.3
-
48
-
-
0030885357
-
Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine
-
Chung, M-C.; Gonçalves, M. F.; Colli, W.; Ferreira, E. I.; Miranda, M. T. Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine. J. Pharm. Sci. 1997, 86, 1127-1131.
-
(1997)
J. Pharm. Sci
, vol.86
, pp. 1127-1131
-
-
Chung, M.-C.1
Gonçalves, M.F.2
Colli, W.3
Ferreira, E.I.4
Miranda, M.T.5
-
49
-
-
0141974478
-
-
Bundgaard, H, Ed, Elsevier: Amsterdam
-
Bundgaard, H., Ed. Prodrug Design; Elsevier: Amsterdam, 1985
-
(1985)
Prodrug Design
-
-
-
50
-
-
10744230611
-
-
Chung, M. C.; Guido, R..V.; Martinelli, T. F.; Goncalves, M. F.; Polli, M. C.; Botelho, K. C.; Varanda, E. A.; Colli, W.; Miranda, M. T.; Ferreira, E. I. Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug. Bioorg. Med. Chem., 2003, 11, 4779-4783.
-
Chung, M. C.; Guido, R..V.; Martinelli, T. F.; Goncalves, M. F.; Polli, M. C.; Botelho, K. C.; Varanda, E. A.; Colli, W.; Miranda, M. T.; Ferreira, E. I. Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug. Bioorg. Med. Chem., 2003, 11, 4779-4783.
-
-
-
-
51
-
-
41649090279
-
-
Trossini, G. H. G.; Ferreira, E. I. ; Menezes, C. M. S. A substrate-specificity evaluation of cruzain by the AM1 semi-empirical method. In: The International Chemical Congress of Pacific Basin Societies - PACIFCHEM 2005, Honolulu, 2005: The International Chemical Congress of Pacific Basin Societies - PACIFCHEM 2005, Abstract Book, 2005.
-
Trossini, G. H. G.; Ferreira, E. I. ; Menezes, C. M. S. A substrate-specificity evaluation of cruzain by the AM1 semi-empirical method. In: The International Chemical Congress of Pacific Basin Societies - PACIFCHEM 2005, Honolulu, 2005: The International Chemical Congress of Pacific Basin Societies - PACIFCHEM 2005, Abstract Book, 2005.
-
-
-
-
52
-
-
41649103376
-
-
Menezes, C. M. S.; Trossini, G. H. G.; Chung, Mc ; Ferreira, E. I. A semi-empirical evaluation of mutual dipeptide prodrugs of primaquine and nitrofurazone toward antichagasic leads. In: Molecular helminthology & drugs against protozoan parasites. Keystone Symposia - Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry, Silverthone, 2005.
-
Menezes, C. M. S.; Trossini, G. H. G.; Chung, Mc ; Ferreira, E. I. A semi-empirical evaluation of mutual dipeptide prodrugs of primaquine and nitrofurazone toward antichagasic leads. In: Molecular helminthology & drugs against protozoan parasites. Keystone Symposia - Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry, Silverthone, 2005.
-
-
-
-
53
-
-
24044533228
-
Voltammetric behavior of nitrofurazone and its hydroxymethyl prodrug with potential anti-Chagas' activity
-
Scalea, M. A. L.; Juliao, M. S. S.; Chung, M. C.; Serrano, S. H. P.; Ferreira, E. I. Voltammetric behavior of nitrofurazone and its hydroxymethyl prodrug with potential anti-Chagas' activity. J. Braz. Chem Soc. 2005, 16, 774-782.
-
(2005)
J. Braz. Chem Soc
, vol.16
, pp. 774-782
-
-
Scalea, M.A.L.1
Juliao, M.S.S.2
Chung, M.C.3
Serrano, S.H.P.4
Ferreira, E.I.5
-
54
-
-
0017091023
-
Actividad hidroxiácido-dehidrogenasa en Trypanosoma cruzi.
-
Gerez de Burgos, N.M.; Burgos, C.; Blanco, A.; Paulone, I.; Segura, E.L. Actividad hidroxiácido-dehidrogenasa en Trypanosoma cruzi. Acta. Physiol. Latinoam. 1976, 26, 10-19.
-
(1976)
Acta. Physiol. Latinoam
, vol.26
, pp. 10-19
-
-
Gerez de Burgos, N.M.1
Burgos, C.2
Blanco, A.3
Paulone, I.4
Segura, E.L.5
-
55
-
-
0037819555
-
Separación y propiedades catalíticas de las izo enzimas de la α-hidroxiácido deshidrogenasa de Trypanosoma cruzi.
-
Coronel, C.; Gerez de Burgos, N.M.; Burgos, C.; Blanco, A. Separación y propiedades catalíticas de las izo enzimas de la α-hidroxiácido deshidrogenasa de Trypanosoma cruzi. Medicina (Buenos Aires) 1980, 40, 159-164
-
(1980)
Medicina (Buenos Aires)
, vol.40
, pp. 159-164
-
-
Coronel, C.1
Gerez de Burgos, N.M.2
Burgos, C.3
Blanco, A.4
-
56
-
-
0019644359
-
Properties of α-hydroxyacid dehydrogenase isozymes from Trypanosoma cruzi
-
Coronel, C.E.; Rovai, L.E.; Gerez de Burgos, N.M.; Burgos, C.; Blanco, A. Properties of α-hydroxyacid dehydrogenase isozymes from Trypanosoma cruzi. Mol. Biochem. Parasitol. 1981, 4, 29-38.
-
(1981)
Mol. Biochem. Parasitol
, vol.4
, pp. 29-38
-
-
Coronel, C.E.1
Rovai, L.E.2
Gerez de Burgos, N.M.3
Burgos, C.4
Blanco, A.5
-
57
-
-
0023103912
-
Subcellular localization of leucine aminotransferase and a-hydroxiacid dehydrogenase in Trypanosoma cruzi
-
Montamat, E.E.; Arauzo, S.S.; Blanco, A. Subcellular localization of leucine aminotransferase and a-hydroxiacid dehydrogenase in Trypanosoma cruzi. Mol. Biochem. Parasitol. 1987, 22, 185-193.
-
(1987)
Mol. Biochem. Parasitol
, vol.22
, pp. 185-193
-
-
Montamat, E.E.1
Arauzo, S.S.2
Blanco, A.3
-
58
-
-
0038351812
-
Inhibition of Trypanosoma cruzi α-Hydroxyacid Dehydrogenase-isozyme II by N-Isopropyl Oxamate and its Effect on Intact Epimastigotes
-
Elizondo, S.; Chena, M.A, ; Rodríguez-Páez, L. ; Nogueda, B.; Baeza, I.; Wong, C. Inhibition of Trypanosoma cruzi α-Hydroxyacid Dehydrogenase-isozyme II by N-Isopropyl Oxamate and its Effect on Intact Epimastigotes. J. Enz. Inhib. Med. Chem. 2003, 18, 265-271.
-
(2003)
J. Enz. Inhib. Med. Chem
, vol.18
, pp. 265-271
-
-
Elizondo, S.1
Chena, M.A.2
Rodríguez-Páez, L.3
Nogueda, B.4
Baeza, I.5
Wong, C.6
-
59
-
-
0023083934
-
The carboxyl esterases of Trypanosoma cruzi epimastigotes
-
Aldunate, J.; Repetto, Y.; Letelier, M.E.; Morello, A. The carboxyl esterases of Trypanosoma cruzi epimastigotes. Comp. Biochem. Physiol. 1987, 86, 67-71.
-
(1987)
Comp. Biochem. Physiol
, vol.86
, pp. 67-71
-
-
Aldunate, J.1
Repetto, Y.2
Letelier, M.E.3
Morello, A.4
-
60
-
-
18444405242
-
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains
-
Chena, M.A, ; Elizondo, S.; Rodríguez-Páez, L. ; Nogueda, B. ; Baeza, I. ; Wong, C. Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains. J. Enz. Inhib. Med. Chem. 2005, 2, 189-197.
-
(2005)
J. Enz. Inhib. Med. Chem
, vol.2
, pp. 189-197
-
-
Chena, M.A.1
Elizondo, S.2
Rodríguez-Páez, L.3
Nogueda, B.4
Baeza, I.5
Wong, C.6
-
61
-
-
0000428307
-
Recent advances in the chemotherapy of Chagas' disease
-
Brener, Z. Recent advances in the chemotherapy of Chagas' disease. Mem. Inst. Oswaldo. Cruz. 1984, 79, 149-155.
-
(1984)
Mem. Inst. Oswaldo. Cruz
, vol.79
, pp. 149-155
-
-
Brener, Z.1
-
62
-
-
4644332709
-
-
Lanteri, C. A.; Trumpower, B. L.; Tidwell, R. R.; Meshnick,S, R. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob. Agents Chemoter. 2004, 48, 3968-3974.
-
Lanteri, C. A.; Trumpower, B. L.; Tidwell, R. R.; Meshnick,S, R. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob. Agents Chemoter. 2004, 48, 3968-3974.
-
-
-
-
63
-
-
84985265278
-
Trypanocidal diamidine with three isolated ring systems
-
Dann, O.; Fick, H.; Pietzner, B.; Walkenhorst, E.; Fernbach, R.; Zeh, D. Trypanocidal diamidine with three isolated ring systems. Justus Liebigs. Ann. Chem. 1975, 160-194.
-
(1975)
Justus Liebigs. Ann. Chem
, pp. 160-194
-
-
Dann, O.1
Fick, H.2
Pietzner, B.3
Walkenhorst, E.4
Fernbach, R.5
Zeh, D.6
-
64
-
-
0017576850
-
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans
-
Das, B. P.; Boykin, D. W. Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans. J. Med. Chem. 1977, 20, 531-536.
-
(1977)
J. Med. Chem
, vol.20
, pp. 531-536
-
-
Das, B.P.1
Boykin, D.W.2
-
65
-
-
0032897384
-
Antibody directed enzyme prodrug therapy (ADEPT): A review of the experimental and clinical considerations
-
Syrigos, K. N; Epenetos, A. A. Antibody directed enzyme prodrug therapy (ADEPT): a review of the experimental and clinical considerations. Anticancer Res. 1999, 19, 605-614.
-
(1999)
Anticancer Res
, vol.19
, pp. 605-614
-
-
Syrigos, K.N.1
Epenetos, A.A.2
-
66
-
-
0022481301
-
Direct observation by proton NMR of cephalosporoate intermediates in aqueous solution during the hydrazinolysis and .beta.-lactamase-catalyzed hydrolysis of cephalosporins with 3′ leaving groups: Kinetics and equilibria of the 3′ elimination reaction
-
Pratt, R. F.; Faraci, W. S. Direct observation by proton NMR of cephalosporoate intermediates in aqueous solution during the hydrazinolysis and .beta.-lactamase-catalyzed hydrolysis of cephalosporins with 3′ leaving groups: kinetics and equilibria of the 3′ elimination reaction. J. Am. Chem. Soc. 1986, 108, 5328-5333.
-
(1986)
J. Am. Chem. Soc
, vol.108
, pp. 5328-5333
-
-
Pratt, R.F.1
Faraci, W.S.2
-
67
-
-
0034755438
-
Functional heavy-chain antibodies in Camelidae
-
Nguyen, V. K.; Desmyter, A.; Muyldermans, S. Functional heavy-chain antibodies in Camelidae. Adv. Immunol. 2001, 79, 261-296.
-
(2001)
Adv. Immunol
, vol.79
, pp. 261-296
-
-
Nguyen, V.K.1
Desmyter, A.2
Muyldermans, S.3
-
68
-
-
0344447084
-
-
Lauwereys, M.; Arbabi, Ghahroudi, M.; Desmyter, A.; Kinne, J.; Holzer, W.; De Genst, E.; Wyns, L.; Muyldermans, S. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J. 1998, 17, 3512-3520.
-
Lauwereys, M.; Arbabi, Ghahroudi, M.; Desmyter, A.; Kinne, J.; Holzer, W.; De Genst, E.; Wyns, L.; Muyldermans, S. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J. 1998, 17, 3512-3520.
-
-
-
-
69
-
-
9144220168
-
Efficient targeting of conserved cryptic epitopes of infectious agents by a single domain antibodies
-
Stijlemans, B.; Conrath, K.; Cortez-Retamozo, V.; Xong, H. V.; Wyns, L.; Senter, P.; Revets, H.; De Baetselier, P.; Muyldermans, S.; Magez, S. Efficient targeting of conserved cryptic epitopes of infectious agents by a single domain antibodies. J. Biol. Chem. 2004, 279, 1256-1261.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 1256-1261
-
-
Stijlemans, B.1
Conrath, K.2
Cortez-Retamozo, V.3
Xong, H.V.4
Wyns, L.5
Senter, P.6
Revets, H.7
De Baetselier, P.8
Muyldermans, S.9
Magez, S.10
-
70
-
-
0027310612
-
Naturally occurring antibodies devoid of light chains
-
Hamers-Casterman, C.; Atarhouch, T.; Muyldermans, S.; Robison, G.; Hamers, C.; Songa, E. B.; Bendahman, N.; Hamers, R. Naturally occurring antibodies devoid of light chains. Nature. 1993, 363, 446-448.
-
(1993)
Nature
, vol.363
, pp. 446-448
-
-
Hamers-Casterman, C.1
Atarhouch, T.2
Muyldermans, S.3
Robison, G.4
Hamers, C.5
Songa, E.B.6
Bendahman, N.7
Hamers, R.8
-
71
-
-
0017290546
-
The effect of normal human serum on trypanosomes of distinct antigenic type (ETat 1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense
-
Van Meirvenne, N.; Maginus, E.; Janssens, P. G. The effect of normal human serum on trypanosomes of distinct antigenic type (ETat 1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense. Ann. Soc. Belg. Med. Trop. 1976, 56, 55-63.
-
(1976)
Ann. Soc. Belg. Med. Trop
, vol.56
, pp. 55-63
-
-
Van Meirvenne, N.1
Maginus, E.2
Janssens, P.G.3
-
72
-
-
3042660680
-
The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness
-
Vanhamme, L; Pays, E. The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness. Int. J. Parasitol. 2004, 34, 887-898.
-
(2004)
Int. J. Parasitol
, vol.34
, pp. 887-898
-
-
Vanhamme, L.1
Pays, E.2
-
73
-
-
0037422045
-
Apolipoprotein L-I is the trypanosome lytic factor of human serum
-
Vanhamme, L.; Paturiaux-Hanocq, F.; Poelvoorde, P.; Nolan, D. P.; Lins, L.; Abbeele, J. V. D.; Pays, A.; Tebabi, P.; Xong, H. V.; Jacquet, A.; Moguilevsky, N.; Dieu, M.; Kane, J. P.; De Baetselier, P.; Brasseur, R.; Pays, E. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 2003, 422, 83-87.
-
(2003)
Nature
, vol.422
, pp. 83-87
-
-
Vanhamme, L.1
Paturiaux-Hanocq, F.2
Poelvoorde, P.3
Nolan, D.P.4
Lins, L.5
Abbeele, J.V.D.6
Pays, A.7
Tebabi, P.8
Xong, H.V.9
Jacquet, A.10
Moguilevsky, N.11
Dieu, M.12
Kane, J.P.13
De Baetselier, P.14
Brasseur, R.15
Pays, E.16
-
74
-
-
0032423741
-
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense
-
Xong, H. V.; Vanhamme, L.; Chamekh, M.; Chimfwembe, C. E. A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell. 1998, 95, 839-846.
-
(1998)
Cell
, vol.95
, pp. 839-846
-
-
Xong, H.V.1
Vanhamme, L.2
Chamekh, M.3
Chimfwembe, C.E.4
-
75
-
-
33646545070
-
Experimental therapy of African trypanosomiasis with a nanobody-conjugated Human Trypanolitic Factor
-
Baral, T. N.; Magez, S.; Stijlemans, B.; Conrath, K.; Vanhollebeke, B.; Pays, E.; Muyldermans, S.; De Baetselier, P. Experimental therapy of African trypanosomiasis with a nanobody-conjugated Human Trypanolitic Factor. Nat. Med. 2006, 12, 580-584.
-
(2006)
Nat. Med
, vol.12
, pp. 580-584
-
-
Baral, T.N.1
Magez, S.2
Stijlemans, B.3
Conrath, K.4
Vanhollebeke, B.5
Pays, E.6
Muyldermans, S.7
De Baetselier, P.8
-
76
-
-
4143141923
-
Antigenic variation in Trypanosoma brucei: Facts, challenges and mysteries
-
Pays, E.; Vanhamme, L.; Perez-Morga, D.Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries. Curr. Opin. Microbiol. 2004, 7, 369-374.
-
(2004)
Curr. Opin. Microbiol
, vol.7
, pp. 369-374
-
-
Pays, E.1
Vanhamme, L.2
Perez-Morga, D.3
-
77
-
-
4444367744
-
The molecular control of antigenic variation in Trypanosoma brucei
-
Horn, D. The molecular control of antigenic variation in Trypanosoma brucei. Curr. Mol. Med. 2004, 4, 563-576.
-
(2004)
Curr. Mol. Med
, vol.4
, pp. 563-576
-
-
Horn, D.1
-
78
-
-
0034117242
-
Structure-Activity Study on the in Vitro Antiprotozoal Activity of Glutathione Derivatives
-
D'Silva, C.; Daunes, S. Structure-Activity Study on the in Vitro Antiprotozoal Activity of Glutathione Derivatives. J. Med. Chem. 2000, 43, 2072-2078.
-
(2000)
J. Med. Chem
, vol.43
, pp. 2072-2078
-
-
D'Silva, C.1
Daunes, S.2
-
79
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg, A. M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 2006, 5, 471-484.
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
80
-
-
0033179892
-
Immune recognition of foreign DNA: A cure for bioterrorism?
-
Klinman, D. M.; Verthelyi, D.; Takeshita, F.; Ishii, K. J. Immune recognition of foreign DNA: a cure for bioterrorism? Immunity, 1999, 11, 123-129.
-
(1999)
Immunity
, vol.11
, pp. 123-129
-
-
Klinman, D.M.1
Verthelyi, D.2
Takeshita, F.3
Ishii, K.J.4
-
81
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman, D. M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 2004, 4, 249-258.
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
82
-
-
11144282529
-
Antisense and siRNA as agonists to Toll-like receptors
-
Agrawal, S.; Kandimalla, E. R. Antisense and siRNA as agonists to Toll-like receptors. Nat. Biotechnol. 2004, 22, 1533-1537.
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1533-1537
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
83
-
-
21344471386
-
Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs
-
Grajkowski, A.; Pedras-Vasconcelos, J.; Wang, V.; Ausín, C.; Hess, S.; Verthelvi, D.; Beaucage, S. L. Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs. Nucleic Acids Res. 2005, 33, 3550-3560.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3550-3560
-
-
Grajkowski, A.1
Pedras-Vasconcelos, J.2
Wang, V.3
Ausín, C.4
Hess, S.5
Verthelvi, D.6
Beaucage, S.L.7
-
84
-
-
0035865054
-
Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
-
Verthelyi, D.; Ishii, K. J.; Gursel, M.; Takeshita, F.; Klinman, D. M. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 2001, 166, 2372-2377
-
(2001)
J. Immunol
, vol.166
, pp. 2372-2377
-
-
Verthelyi, D.1
Ishii, K.J.2
Gursel, M.3
Takeshita, F.4
Klinman, D.M.5
-
85
-
-
0037083664
-
CpG oligodeoxynucleotides as vaccine adjuvants in primates
-
Verthelyi, D.; Kenney, R. T.; Seder, R. A.; Gam, A. A.; Friedag, B.; Klinman, D. M. CpG oligodeoxynucleotides as vaccine adjuvants in primates. J. Immunol. 2002, 168, 1659-1663.
-
(2002)
J. Immunol
, vol.168
, pp. 1659-1663
-
-
Verthelyi, D.1
Kenney, R.T.2
Seder, R.A.3
Gam, A.A.4
Friedag, B.5
Klinman, D.M.6
-
86
-
-
0037407856
-
-
Verthelyi, D.; Gursel, M.; Kenney, R. T.; Lifson, J. D.; Shuying, L.; Mican, J.; Klinman, D. M. CpG Oligodeoxynucleotides protect normal and SIV infected macaques from Leishmania infection. J. Immunol. 2003, 170, 4717-4723.
-
Verthelyi, D.; Gursel, M.; Kenney, R. T.; Lifson, J. D.; Shuying, L.; Mican, J.; Klinman, D. M. CpG Oligodeoxynucleotides protect normal and SIV infected macaques from Leishmania infection. J. Immunol. 2003, 170, 4717-4723.
-
-
-
-
87
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci, C.; Ott, G.; Chan, J. H.; Damon, E.; Calacsan, C.; Matray, T.; Lee, K. D.; Coffman, R. L.; Barrat, F. J. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 2006, 203, 1999-2008.
-
(2006)
J. Exp. Med
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
Ott, G.2
Chan, J.H.3
Damon, E.4
Calacsan, C.5
Matray, T.6
Lee, K.D.7
Coffman, R.L.8
Barrat, F.J.9
-
88
-
-
4043065769
-
Necessity of oligonucleotide aggregation for Toll-like receptor 9 activation
-
Wu, C. C. N.; Lee, J.; Raz, E.; Corr, M.; Carson, D. Necessity of oligonucleotide aggregation for Toll-like receptor 9 activation. J. Biol. Chem. 2004, 279, 33071-33078.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 33071-33078
-
-
Wu, C.C.N.1
Lee, J.2
Raz, E.3
Corr, M.4
Carson, D.5
-
89
-
-
20244367698
-
Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-{alpha} induction by CpG-A in plasmacytoid dendritic cells
-
Kerkmann, M.; Costa, L. T.; Richter, C.; Rothenfusser, S.; Battiany, J.; Hornung, V.; Johnson, J.; Englert, S.; Ketterer, T.; Heckl, W.; Thalhammer, S.; Endres, S.; Hartmann, G. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-{alpha} induction by CpG-A in plasmacytoid dendritic cells. J. Biol. Chem. 2005, 280, 8086-8093.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 8086-8093
-
-
Kerkmann, M.1
Costa, L.T.2
Richter, C.3
Rothenfusser, S.4
Battiany, J.5
Hornung, V.6
Johnson, J.7
Englert, S.8
Ketterer, T.9
Heckl, W.10
Thalhammer, S.11
Endres, S.12
Hartmann, G.13
-
90
-
-
33845871431
-
Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: Structural studies and immunomodulatory activity in primates
-
Puig, M.; Grajkowski, A.; Bockowska, M.; Ausín, C.; Beaucage, S. L.; Verthelvi, D. Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates. Nucleics Acid Res. 2006, 34, 6488-6495.
-
(2006)
Nucleics Acid Res
, vol.34
, pp. 6488-6495
-
-
Puig, M.1
Grajkowski, A.2
Bockowska, M.3
Ausín, C.4
Beaucage, S.L.5
Verthelvi, D.6
-
91
-
-
0013891721
-
Leishmaniasis in the Sudan Republic 27. Lack of effect of chloroquine and pyrimethamine on visceral Leishmaniasis in the hamster
-
Mansour, N. S.; Mcconnel, E. Leishmaniasis in the Sudan Republic 27. Lack of effect of chloroquine and pyrimethamine on visceral Leishmaniasis in the hamster. Am. J. Trop. Med. Hyg. 1966, 15, 146-148.
-
(1966)
Am. J. Trop. Med. Hyg
, vol.15
, pp. 146-148
-
-
Mansour, N.S.1
Mcconnel, E.2
-
92
-
-
0027996240
-
PTR1: A reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
-
Bello, A. R.; Nare. B.; Freedman, D.; Hardy, L.; Beverley, S. M. PTR1: A reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc. Natl. Acad. Sci. USA. 1994, 9, 11442-11446.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.9
, pp. 11442-11446
-
-
Bello, A.R.1
Nare, B.2
Freedman, D.3
Hardy, L.4
Beverley, S.M.5
-
93
-
-
0030946111
-
The roles of pteridine reductase 1 and dihydrofolate reductasethymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
-
Nare, B.; Hardy, L. W.; Beverley, S. M. The roles of pteridine reductase 1 and dihydrofolate reductasethymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J. Biol. Chem. 1997, 272, 13883-13891.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 13883-13891
-
-
Nare, B.1
Hardy, L.W.2
Beverley, S.M.3
-
94
-
-
0141731261
-
Synthesis and in vitro evaluation of potential anti-leishmanial targeted drugs of pyrimethamine
-
De Carvalho, P. B.; Ramos, D. C. C.; Cotrim, P. C.; Ferreira, E. I. Synthesis and in vitro evaluation of potential anti-leishmanial targeted drugs of pyrimethamine. J. Pharm. Sci. 2003, 92, 2109-2116.
-
(2003)
J. Pharm. Sci
, vol.92
, pp. 2109-2116
-
-
De Carvalho, P.B.1
Ramos, D.C.C.2
Cotrim, P.C.3
Ferreira, E.I.4
-
95
-
-
0003595252
-
-
Molyneux, D. H, Ashford, R. W, Eds, International Publications: New York
-
Molyneux, D. H.; Ashford, R. W., Eds. The biology of Trypanosoma and Leishmania, parasites of man and domestic animals. International Publications: New York, 1983; pp. 211-249.
-
(1983)
The biology of Trypanosoma and Leishmania, parasites of man and domestic animals
, pp. 211-249
-
-
-
96
-
-
0031789888
-
Macrophage mannosyl fucosyl receptor: Its role in invasion of virulent and avirulent L. donovani promastigotes
-
Chakraborty, R.; Chakraborty, P.; Basu, M. K. Macrophage mannosyl fucosyl receptor: Its role in invasion of virulent and avirulent L. donovani promastigotes. Biosci. Rep. 1998, 18, 129-142.
-
(1998)
Biosci. Rep
, vol.18
, pp. 129-142
-
-
Chakraborty, R.1
Chakraborty, P.2
Basu, M.K.3
-
97
-
-
0027056550
-
The activity of hydroxynaphthoquinones against Leishmania donovani
-
Croft, S. L.; Hogg, J.; Gutteridge, W. E.; Hudson, A. T.; Randall, A. W. The activity of hydroxynaphthoquinones against Leishmania donovani. J. Antimicrob. Chem. 1992, 30, 827-832.
-
(1992)
J. Antimicrob. Chem
, vol.30
, pp. 827-832
-
-
Croft, S.L.1
Hogg, J.2
Gutteridge, W.E.3
Hudson, A.T.4
Randall, A.W.5
-
98
-
-
0347361636
-
Synthesis, in vitro evaluation and antileishmanial activity of water-soluble prodrugs of buparvaquone
-
Mäntylä, A.; Garnier, T.; Rautio, J.; Nevalainen, T.; Vepsälainen, J.; Koskinen, A.; Croft, S. L.; Järvinen, T. Synthesis, in vitro evaluation and antileishmanial activity of water-soluble prodrugs of buparvaquone. J. Med. Chem. 2003, 47, 188-195.
-
(2003)
J. Med. Chem
, vol.47
, pp. 188-195
-
-
Mäntylä, A.1
Garnier, T.2
Rautio, J.3
Nevalainen, T.4
Vepsälainen, J.5
Koskinen, A.6
Croft, S.L.7
Järvinen, T.8
-
99
-
-
2942601915
-
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
-
Mäntylä, A.; Rautio, J.; Nevalainen, T.; Vepsälainen, J.; Juvonen, R.; Kendrick, H.; Garnier, T.; Croft, S.L.; Järvinen, T. Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives. Bioorg. Med. Chem. 2004, 12, 3497-3502.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 3497-3502
-
-
Mäntylä, A.1
Rautio, J.2
Nevalainen, T.3
Vepsälainen, J.4
Juvonen, R.5
Kendrick, H.6
Garnier, T.7
Croft, S.L.8
Järvinen, T.9
-
100
-
-
0347361636
-
Synthesis, in Vitro Evaluation, and Antileishmanial Activity of Water-Soluble Prodrugs of Buparvaquone
-
Mäntylä, A.; Garnier, T.; Rautio, J.; Nevalainen, T.; Vepsälainen, J.; Koskinen, A.; Croft, S. L.; Järvinent, T. Synthesis, in Vitro Evaluation, and Antileishmanial Activity of Water-Soluble Prodrugs of Buparvaquone. J. Med. Chem. 2004, 47, 188-195.
-
(2004)
J. Med. Chem
, vol.47
, pp. 188-195
-
-
Mäntylä, A.1
Garnier, T.2
Rautio, J.3
Nevalainen, T.4
Vepsälainen, J.5
Koskinen, A.6
Croft, S.L.7
Järvinent, T.8
-
101
-
-
0342832999
-
Improved oral drug delivery: Solubility limitations overcome by the use of prodrugs
-
Fleisher, D.; Bong, R.; Stewart, B. H. Improved oral drug delivery: solubility limitations overcome by the use of prodrugs. Adv. Drug Delivery Rev. 1996, 19, 115-130.
-
(1996)
Adv. Drug Delivery Rev
, vol.19
, pp. 115-130
-
-
Fleisher, D.1
Bong, R.2
Stewart, B.H.3
-
102
-
-
0021185679
-
Phenytoin prodrugs III: Water-soluble prodrugs for oral and/or parenteral use
-
Varia, S. A.; Schuller, S.; Sloan, K. B.; Stella, V. J. Phenytoin prodrugs III: water-soluble prodrugs for oral and/or parenteral use. J. Pharm. Sci. 1984, 73, 1068-1073.
-
(1984)
J. Pharm. Sci
, vol.73
, pp. 1068-1073
-
-
Varia, S.A.1
Schuller, S.2
Sloan, K.B.3
Stella, V.J.4
-
103
-
-
0033549849
-
Novel prodrug approach for tertiary amines: Synthesis and preliminary evaluation of n-phosphonooxymethyl prodrugs
-
Krise, J. P.; Zygmunt, J.; Georg, G. I.; Stella, V. J. Novel prodrug approach for tertiary amines: synthesis and preliminary evaluation of n-phosphonooxymethyl prodrugs. J. Med. Chem. 1999, 42, 3094-3100.
-
(1999)
J. Med. Chem
, vol.42
, pp. 3094-3100
-
-
Krise, J.P.1
Zygmunt, J.2
Georg, G.I.3
Stella, V.J.4
-
104
-
-
34548783789
-
In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs
-
Garnier, T.; Mäntylä, A.; Järvinen, T.; Lawrence, J.; Brown, M.; Croft, S. In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs. J. Antimicrob. Chemother. 2007, 60, 802-810.
-
(2007)
J. Antimicrob. Chemother
, vol.60
, pp. 802-810
-
-
Garnier, T.1
Mäntylä, A.2
Järvinen, T.3
Lawrence, J.4
Brown, M.5
Croft, S.6
-
105
-
-
16644373945
-
Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone
-
Mäntylä, A.; Rautio, J.; Nevalainen, T.; Keski-Rahkonen, P.; Vepsälainen, J.; Järvinen, T. Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone. Eur. J. Pharm. Sci. 2004, 23, 151-158.
-
(2004)
Eur. J. Pharm. Sci
, vol.23
, pp. 151-158
-
-
Mäntylä, A.1
Rautio, J.2
Nevalainen, T.3
Keski-Rahkonen, P.4
Vepsälainen, J.5
Järvinen, T.6
-
106
-
-
0032497909
-
Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: Mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides
-
Jousserandot, A.; Boucher, J. L.; Henry, Y.; Niklaus, B.; Clement, B.; Mansuy, D. Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides. Biochemistry 1998, 37, 17179-17191.
-
(1998)
Biochemistry
, vol.37
, pp. 17179-17191
-
-
Jousserandot, A.1
Boucher, J.L.2
Henry, Y.3
Niklaus, B.4
Clement, B.5
Mansuy, D.6
-
107
-
-
35348944028
-
Assessment of safety of the major antimalarial drugs
-
Chattopadhyay, R.; Mahajan, B.; Kumar, S. Assessment of safety of the major antimalarial drugs. Expert Opin Drug Saf. 2007, 6, 505-21.
-
(2007)
Expert Opin Drug Saf
, vol.6
, pp. 505-521
-
-
Chattopadhyay, R.1
Mahajan, B.2
Kumar, S.3
-
108
-
-
84989030561
-
Latentiation of chemotherapeutic agents. Part 1: Synthesis of oxidized starch imine derivatives and antimalarials
-
Ferreira, E. I.; Cruz, M. L.; Korolkovas, A. Latentiation of chemotherapeutic agents. Part 1: synthesis of oxidized starch imine derivatives and antimalarials. Starch/starke 1992, 44, 21-24.
-
(1992)
Starch/starke
, vol.44
, pp. 21-24
-
-
Ferreira, E.I.1
Cruz, M.L.2
Korolkovas, A.3
-
109
-
-
0028840763
-
Antimalarial Activity Of Imine Oxidized Starch And Cellulose Derivatives
-
Ohara, M. T.; Sakuda, T. M.; Cruz, M. L.; Ferreira, E. I.; Korolkovas, A. Antimalarial Activity Of Imine Oxidized Starch And Cellulose Derivatives. Boll. Chim. Farm. 1995, 9, 522-527.
-
(1995)
Boll. Chim. Farm
, vol.9
, pp. 522-527
-
-
Ohara, M.T.1
Sakuda, T.M.2
Cruz, M.L.3
Ferreira, E.I.4
Korolkovas, A.5
-
110
-
-
0346527137
-
Latentiation of chemotherapeutic agents. Part 2: Synthesis of oxidized cellulose imine derivatives and antimalarials
-
Cruz, M. L.; Ferreira, E. I.; Korolkovas, A. Latentiation of chemotherapeutic agents. Part 2: synthesis of oxidized cellulose imine derivatives and antimalarials. Starch/Stärke 1997, 49, 66-70.
-
(1997)
Starch/Stärke
, vol.49
, pp. 66-70
-
-
Cruz, M.L.1
Ferreira, E.I.2
Korolkovas, A.3
-
111
-
-
0000734067
-
Lipids of the red cell membrane
-
Surgenor, G, ed, Academic Press, Inc, New York, N.Y
-
Van Deenen, L. L. M.; De Gier, J. Lipids of the red cell membrane. In The red blood cell. Surgenor, G., (ed.); Academic Press, Inc.: New York, N.Y., 1975; pp. 147-211.
-
(1975)
The red blood cell
, pp. 147-211
-
-
Van Deenen, L.L.M.1
De Gier, J.2
-
112
-
-
24144440791
-
Pharmacological Properties of a New Antimalarial Bisthiazolium Salt, T3, and a Corresponding Prodrug, TE3
-
Nicolas, O.; Margout, N. T.; Wein, S.; Calas, M.; Vial, H. J.; Bressollei, F. M. Pharmacological Properties of a New Antimalarial Bisthiazolium Salt, T3, and a Corresponding Prodrug, TE3. Antimicrob. Agents Chemother. 2005, 49, 3631-3639.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 3631-3639
-
-
Nicolas, O.1
Margout, N.T.2
Wein, S.3
Calas, M.4
Vial, H.J.5
Bressollei, F.M.6
-
113
-
-
7444260721
-
Prodrugs of bisthiazolium salts are orally potent antimalarials
-
Vial, H.J.; Wein, S.; Farenc, C.; Kocken, C.; Nicolas, O.; Ancelin, M. L.; Bressolles, F.; Thomas, A.; Calas, M. Prodrugs of bisthiazolium salts are orally potent antimalarials. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 15458-15463.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 15458-15463
-
-
Vial, H.J.1
Wein, S.2
Farenc, C.3
Kocken, C.4
Nicolas, O.5
Ancelin, M.L.6
Bressolles, F.7
Thomas, A.8
Calas, M.9
-
114
-
-
0034628578
-
Antimalarial Activity of Compounds Interfering with Plasmodium falciparum Phospholipid Metabolism: Comparison between Mono- and Bisquaternary Ammonium Salts
-
Calas, M..; Ancelin, M. L.; Cordina, G.; Portefaix, P.; Piquet, G.; Vidal-Sailhan, V.; Vial, H. Antimalarial Activity of Compounds Interfering with Plasmodium falciparum Phospholipid Metabolism: Comparison between Mono- and Bisquaternary Ammonium Salts. J. Med. Chem., 2000, 43, 505-516.
-
(2000)
J. Med. Chem
, vol.43
, pp. 505-516
-
-
Calas, M.1
Ancelin, M.L.2
Cordina, G.3
Portefaix, P.4
Piquet, G.5
Vidal-Sailhan, V.6
Vial, H.7
-
115
-
-
0034522796
-
Plasmodium falciparum: Detection of the Deoxyxylulose 5-Phosphate Reductoisomerase Activity
-
Wiesner, J.; Hintz, M.; Altincicek, B.; Sanderbrand, S.; Weidemeyer, C.; Beck, E.; Jomaa, H. Plasmodium falciparum: Detection of the Deoxyxylulose 5-Phosphate Reductoisomerase Activity. Exp. Parasitol. 2000, 96, 182-186.
-
(2000)
Exp. Parasitol
, vol.96
, pp. 182-186
-
-
Wiesner, J.1
Hintz, M.2
Altincicek, B.3
Sanderbrand, S.4
Weidemeyer, C.5
Beck, E.6
Jomaa, H.7
-
116
-
-
0037308581
-
Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria
-
Lell, B.; Ruangweerayut, R.; Wiesner, J.; Missinou, M. A.; Schindler, A.; Baranek, T.; Hintz, M.; Hutchinson, D.; Jomaa, H.; Kremsner, P. G. Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria. Antimicrob. Agents Chemother. 2003, 47, 735-738.
-
(2003)
Antimicrob. Agents Chemother
, vol.47
, pp. 735-738
-
-
Lell, B.1
Ruangweerayut, R.2
Wiesner, J.3
Missinou, M.A.4
Schindler, A.5
Baranek, T.6
Hintz, M.7
Hutchinson, D.8
Jomaa, H.9
Kremsner, P.G.10
-
117
-
-
0033520336
-
Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs
-
Jomaa, H.; Wiesner, J.; Sanderbrand, S.; Altincicek, B.; Weidemeyer, C.; Hintz, M.; Turbachova, I.; Eberl, M.; Zeidler, J.; Lichtenthaler, H. K.; Soldati, D.; Beck, E. Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs. Science. 1999, 285, 1573-1576.
-
(1999)
Science
, vol.285
, pp. 1573-1576
-
-
Jomaa, H.1
Wiesner, J.2
Sanderbrand, S.3
Altincicek, B.4
Weidemeyer, C.5
Hintz, M.6
Turbachova, I.7
Eberl, M.8
Zeidler, J.9
Lichtenthaler, H.K.10
Soldati, D.11
Beck, E.12
-
118
-
-
0020043777
-
-
Tsuchiya, T.; Ishibashi, K.; Terakawa, M.; Nishiyama, M.; Itoh, N.; Noguchi, H. Eur. J. Drug Metab. Pharmacokinet. Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs. 1982, 7, 59-64.
-
Tsuchiya, T.; Ishibashi, K.; Terakawa, M.; Nishiyama, M.; Itoh, N.; Noguchi, H. Eur. J. Drug Metab. Pharmacokinet. Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs. 1982, 7, 59-64.
-
-
-
-
119
-
-
0035953022
-
Diaryl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity
-
Reichenberg, A.; Wiesner, J.; Weidemeyer, C.; Dreiseidler, E.; Sanderbrand, S.; Altincicek, B.; Beck, E.; Schlitzer, M.; Jomaa, H. Diaryl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity. Bioorg. Med. Chem. Lett. 2001, 11, 833-835.
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 833-835
-
-
Reichenberg, A.1
Wiesner, J.2
Weidemeyer, C.3
Dreiseidler, E.4
Sanderbrand, S.5
Altincicek, B.6
Beck, E.7
Schlitzer, M.8
Jomaa, H.9
-
120
-
-
0037871840
-
Acyloxyalkyl ester prodrugs of fr900098 with improved in vivo anti-malarial activity
-
Ortmann, R.; Wiesner, J.; Reichenberg, A.; Henscker, D.; Beck, E.; Jomaa, H.; Schlitzer, M. Acyloxyalkyl ester prodrugs of fr900098 with improved in vivo anti-malarial activity. Bioorg. Med. Chem. Lett. 2003, 13, 2163-2166.
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, pp. 2163-2166
-
-
Ortmann, R.1
Wiesner, J.2
Reichenberg, A.3
Henscker, D.4
Beck, E.5
Jomaa, H.6
Schlitzer, M.7
-
121
-
-
22544446490
-
Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity
-
Ortmann, R.; Wiesner, J.; Reichenberg, A.; Henschker, E. B.; Jomaa, H.; Schlitzer, M. Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity. Arch. Pharm. Chem. Life. Sci. 2005, 338, 305-314.
-
(2005)
Arch. Pharm. Chem. Life. Sci
, vol.338
, pp. 305-314
-
-
Ortmann, R.1
Wiesner, J.2
Reichenberg, A.3
Henschker, E.B.4
Jomaa, H.5
Schlitzer, M.6
-
122
-
-
0037186497
-
Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of New Diamine Containing Analogues
-
Hindley, S.; Ward, S. A.; Storr, R. C.; Searle, N. L.; Bray, P. G.; Park, K.; Davies, J.; O'Neil, P. M. Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of New Diamine Containing Analogues J. Med. Chem. 2002, 45, 1052-1063.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1052-1063
-
-
Hindley, S.1
Ward, S.A.2
Storr, R.C.3
Searle, N.L.4
Bray, P.G.5
Park, K.6
Davies, J.7
O'Neil, P.M.8
-
123
-
-
2542640961
-
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides
-
O'Neil, P.; Posner, G. H. A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides. J. Med. Chem. 2004, 47, 2945-2964.
-
(2004)
J. Med. Chem
, vol.47
, pp. 2945-2964
-
-
O'Neil, P.1
Posner, G.H.2
-
124
-
-
0012808690
-
Malaria: New Chemotherapeutic Peroxide Drugs
-
Borstnik, K.; Paik, I-H.; Posner, G. H. Malaria: New Chemotherapeutic Peroxide Drugs. Mini Rev. Med. Chem. 2002, 2, 573-583.
-
(2002)
Mini Rev. Med. Chem
, vol.2
, pp. 573-583
-
-
Borstnik, K.1
Paik, I.-H.2
Posner, G.H.3
-
125
-
-
0001123285
-
Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action
-
Cumming, J. N.; Ploypradith, P.; Posner, G. H. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Adv. Pharmacol. 1997, 37, 253-297.
-
(1997)
Adv. Pharmacol
, vol.37
, pp. 253-297
-
-
Cumming, J.N.1
Ploypradith, P.2
Posner, G.H.3
-
126
-
-
4544263432
-
Design and Synthesis of Endoperoxide Antimalarial Prodrug Models
-
O'Neil, P.; Stocks, P. A.; Pugh, M. D.; Araujo, N. C.; Korshin, E.; Bickley, J. F.; Ward, S. A.; Bray, P. G.; Pasini, E.; Davies, J.; Verissimo, E.; Bach, M. D. Design and Synthesis of Endoperoxide Antimalarial Prodrug Models. Angew. Chem. 2004, 43, 4193-4197.
-
(2004)
Angew. Chem
, vol.43
, pp. 4193-4197
-
-
O'Neil, P.1
Stocks, P.A.2
Pugh, M.D.3
Araujo, N.C.4
Korshin, E.5
Bickley, J.F.6
Ward, S.A.7
Bray, P.G.8
Pasini, E.9
Davies, J.10
Verissimo, E.11
Bach, M.D.12
-
127
-
-
0035207181
-
Why Artemisinin and Certain Synthetic Peroxides are Potent Antimalarials. Implications for the Mode of Action
-
Jefford, A. W. Why Artemisinin and Certain Synthetic Peroxides are Potent Antimalarials. Implications for the Mode of Action. Curr. Med. Chem. 2001, 8, 1803-1826.
-
(2001)
Curr. Med. Chem
, vol.8
, pp. 1803-1826
-
-
Jefford, A.W.1
-
128
-
-
0042860063
-
Artemisinins target the SERCA of Plasmodium falciparum
-
Eckstein-Ludwig, U.; Webb, R. J.; van Goethem, I. D. A.; East, J. M.; Lee, A. G.; Kimura, M.; O'Neil, P. M.; Bray, P. G.; Ward, s. A.; Krishna S. Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003, 424, 957-961.
-
(2003)
Nature
, vol.424
, pp. 957-961
-
-
Eckstein-Ludwig, U.1
Webb, R.J.2
van Goethem, I.D.A.3
East, J.M.4
Lee, A.G.5
Kimura, M.6
O'Neil, P.M.7
Bray, P.G.8
Ward, S.A.9
Krishna, S.10
-
129
-
-
0029594562
-
In Vitro Antimalarial Activity of Chalcones and Their Derivatives
-
Li, R.; Kenyon, G. L.; Cohen, F. E.; Chen, X.; Gong, B.; Dominguez, J. N.; Davidson, E.; Kurzban, G.; Miller, R. E.; Nuzum, E. O.; Rosenthal, P. J.; McKerrol, J. H. In Vitro Antimalarial Activity of Chalcones and Their Derivatives. J. Med. Chem. 1995, 38, 5031-5037.
-
(1995)
J. Med. Chem
, vol.38
, pp. 5031-5037
-
-
Li, R.1
Kenyon, G.L.2
Cohen, F.E.3
Chen, X.4
Gong, B.5
Dominguez, J.N.6
Davidson, E.7
Kurzban, G.8
Miller, R.E.9
Nuzum, E.O.10
Rosenthal, P.J.11
McKerrol, J.H.12
-
130
-
-
0028828562
-
A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells
-
Atamna, H.; Ginsburg, H. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells J. Biol. Chem. 1995, 270, 24876-24883.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 24876-24883
-
-
Atamna, H.1
Ginsburg, H.2
-
131
-
-
33748233963
-
Disulfide reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria
-
Schirmer, R. H.; Müller, J. G.; Krauth-Siegel, R. L. Disulfide reductase inhibitors as chemotherapeutic agents: the design of drugs for trypanosomiasis and malaria Angew. Chem. Int. Edn. 1995, 34, 141-154.
-
(1995)
Angew. Chem. Int. Edn
, vol.34
, pp. 141-154
-
-
Schirmer, R.H.1
Müller, J.G.2
Krauth-Siegel, R.L.3
-
132
-
-
0035935690
-
A prodrug for of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline
-
Davioud-Charvet, E.; Delarue, S.; Biot, C.; Schwobel, B.; Boehme, C. C.; Mussigbrodt, A.; Maes, L.; Sergheraert, C., Grellier, P.; Schirmer, R. H., Becker K. A prodrug for of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J. Med. Chem. 2001, 44, 4268-4276.
-
(2001)
J. Med. Chem
, vol.44
, pp. 4268-4276
-
-
Davioud-Charvet, E.1
Delarue, S.2
Biot, C.3
Schwobel, B.4
Boehme, C.C.5
Mussigbrodt, A.6
Maes, L.7
Sergheraert, C.8
Grellier, P.9
Schirmer, R.H.10
Becker, K.11
-
133
-
-
0037115759
-
Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum
-
Meierjohann, S.; Walter, R. D.; Muller, S. Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. Biochem. J. 2002, 368, 761-768.
-
(2002)
Biochem. J
, vol.368
, pp. 761-768
-
-
Meierjohann, S.1
Walter, R.D.2
Muller, S.3
-
134
-
-
0346398299
-
Double-drug development against antioxidant enzymes from Plasmodium falciprurn
-
Biot, C.; Dessolin, J.; Grellier, P.; Davioud-Charvet, E. Double-drug development against antioxidant enzymes from Plasmodium falciprurn. Redox Rep. 2003, 8, 280-283.
-
(2003)
Redox Rep
, vol.8
, pp. 280-283
-
-
Biot, C.1
Dessolin, J.2
Grellier, P.3
Davioud-Charvet, E.4
-
135
-
-
2942564073
-
Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-dione derivatives of primaquine: Scope and limitations
-
Gomes, P.; Araujo, M. J.; Rodriguez, M.; Vale, N.; Azevedo, Z.; Iley, J.; Chambel, P.; Morais, J.; Moreira, R. Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-dione derivatives of primaquine: scope and limitations. Tetrahedron. 2004, 60, 5551-5562.
-
(2004)
Tetrahedron
, vol.60
, pp. 5551-5562
-
-
Gomes, P.1
Araujo, M.J.2
Rodriguez, M.3
Vale, N.4
Azevedo, Z.5
Iley, J.6
Chambel, P.7
Morais, J.8
Moreira, R.9
-
136
-
-
0042684770
-
-
Rosenthal, P. J, Ed, Humana: Totowa
-
Brueckner, R. P.; Ohrt, C.; Baird, J. K.; Milhous, W. K. In Antimalarial Chemotherapy; Rosenthal, P. J., Ed.; Humana: Totowa, 2001; pp. 123-151.
-
(2001)
Antimalarial Chemotherapy
, pp. 123-151
-
-
Brueckner, R.P.1
Ohrt, C.2
Baird, J.K.3
Milhous, W.K.4
-
137
-
-
0019858036
-
Development of new derivatives of primaquine by association with lysosomotropyc carriers
-
Trouet, A.; Pirson, P.; Steiger, R.; Masquelier, M.; Baurain, R.; Gillet, J. Development of new derivatives of primaquine by association with lysosomotropyc carriers. Bull. World Health Org. 1981, 59, 449-458.
-
(1981)
Bull. World Health Org
, vol.59
, pp. 449-458
-
-
Trouet, A.1
Pirson, P.2
Steiger, R.3
Masquelier, M.4
Baurain, R.5
Gillet, J.6
-
138
-
-
0023912390
-
Peptide Derivatives of Primaquine as Potential Antimalarial Agents
-
Philip, A.; Kepler, J A.; Johnson, B. H.; Carroll, F. I. Peptide Derivatives of Primaquine as Potential Antimalarial Agents. J. Med. Chem. 1988, 31, 870-874.
-
(1988)
J. Med. Chem
, vol.31
, pp. 870-874
-
-
Philip, A.1
Kepler, J.A.2
Johnson, B.H.3
Carroll, F.I.4
-
139
-
-
0342437513
-
Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
-
Pauletti, G. M.; Gangwar, S.; Siahaan, T. J.; Aube, J.; Borchardt, R. T. Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies. Adv. Drug. Del. Rev. 1997, 27, 235-256.
-
(1997)
Adv. Drug. Del. Rev
, vol.27
, pp. 235-256
-
-
Pauletti, G.M.1
Gangwar, S.2
Siahaan, T.J.3
Aube, J.4
Borchardt, R.T.5
-
140
-
-
0026500650
-
(C) Means to enhance penetration: (1) Prodrugs as a means to improve the delivery of peptide drugs
-
Bundgaard, H. (C) Means to enhance penetration: (1) Prodrugs as a means to improve the delivery of peptide drugs. Adv. Drug. Del. Rev. 1992, 8, 1-38.
-
(1992)
Adv. Drug. Del. Rev
, vol.8
, pp. 1-38
-
-
Bundgaard, H.1
-
141
-
-
0028870036
-
Biodegradable microspheres. 17. Lysosomal degradation of primaquine-peptide spacer arms
-
Borissova, R.; Stjarnkvist, P.; Karlsson, M. O.; Sjoholm, I. Biodegradable microspheres. 17. Lysosomal degradation of primaquine-peptide spacer arms. J. Pharm. Sci. 1995, 84, 256-262.
-
(1995)
J. Pharm. Sci
, vol.84
, pp. 256-262
-
-
Borissova, R.1
Stjarnkvist, P.2
Karlsson, M.O.3
Sjoholm, I.4
-
142
-
-
0033020951
-
Dipeptide Derivatives of Primaquine as Transmission-Blocking Antimalarials: Effect of Aliphatic Side-Chain Acylation on the Gametocytocidal Activity and on the Formation of Carboxyprimaquine in Rat Liver Homogenates
-
Portela, M. J.; Moreira, R.; Valente, E.; Constantino, L.; Iley, J.; Pinto, J.; Rosa, R.; Cravo, P.; do Rosario, V. E. Dipeptide Derivatives of Primaquine as Transmission-Blocking Antimalarials: Effect of Aliphatic Side-Chain Acylation on the Gametocytocidal Activity and on the Formation of Carboxyprimaquine in Rat Liver Homogenates. Pharm. Res. 1999, 16, 949-955.
-
(1999)
Pharm. Res
, vol.16
, pp. 949-955
-
-
Portela, M.J.1
Moreira, R.2
Valente, E.3
Constantino, L.4
Iley, J.5
Pinto, J.6
Rosa, R.7
Cravo, P.8
do Rosario, V.E.9
-
143
-
-
0033054737
-
N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: Synthesis, chemical and enzymatic stability studies
-
Bak, A.; Fich, M.; Larsen, B. D.; Frokjaer, S.; Friis, G. J. N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: synthesis, chemical and enzymatic stability studies. Eur. J. Pharm. Sci. 1999, 7, 317-323.
-
(1999)
Eur. J. Pharm. Sci
, vol.7
, pp. 317-323
-
-
Bak, A.1
Fich, M.2
Larsen, B.D.3
Frokjaer, S.4
Friis, G.J.5
-
144
-
-
13444269006
-
Imidazolidin-4-one Derivatives of Primaquine as Novel Transmission-Blocking Antimalarials
-
Araujo, M.. J.; Bom, J.; Capela, R.; Casimiro, C.; Chambel, P.; Gomes, P.; Iley, J.; Lopes, F.; Morais, J.; Moreira, R.; de Oliveira, E.; do Rosario, V.; Vale, N. Imidazolidin-4-one Derivatives of Primaquine as Novel Transmission-Blocking Antimalarials. J. Med. Chem. 2005, 48, 888-892.
-
(2005)
J. Med. Chem
, vol.48
, pp. 888-892
-
-
Araujo, M.J.1
Bom, J.2
Capela, R.3
Casimiro, C.4
Chambel, P.5
Gomes, P.6
Iley, J.7
Lopes, F.8
Morais, J.9
Moreira, R.10
de Oliveira, E.11
do Rosario, V.12
Vale, N.13
-
145
-
-
0141504172
-
8-Quinolinamines and Their Pro Prodrug Conjugates as Potent Blood-Schizontocidal Antimalarial Agents
-
Vagapandu, S.; Sachdeva, S.; Jain, M.; Singh, S.; Singh, P. P.; Kaul, C. L.; Jain, R. 8-Quinolinamines and Their Pro Prodrug Conjugates as Potent Blood-Schizontocidal Antimalarial Agents. Bioorg. Med. Chem. 2003, 11, 4557-4568.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 4557-4568
-
-
Vagapandu, S.1
Sachdeva, S.2
Jain, M.3
Singh, S.4
Singh, P.P.5
Kaul, C.L.6
Jain, R.7
-
146
-
-
0025754304
-
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: A catabolic pathway initiated by a specific aspartic protease
-
Goldberg, D. E.; Slater, A. F.; Beavis, R.; Chait, B.; Cerami, A.; Henderson, G. Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease. J. Exp. Med. 1991, 173, 961-969.
-
(1991)
J. Exp. Med
, vol.173
, pp. 961-969
-
-
Goldberg, D.E.1
Slater, A.F.2
Beavis, R.3
Chait, B.4
Cerami, A.5
Henderson, G.6
-
147
-
-
2342463719
-
Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'
-
Romeo, S.; Dell'Agli, M.; Parapini, S.; Rizzi, L.; Galli, G.; Mondani, M.; Sparatore, A.; Taramelli, D.; Bosisio, E. Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'. Bioorg. Med. Chem. Lett. 2004, 14, 2931-2934.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 2931-2934
-
-
Romeo, S.1
Dell'Agli, M.2
Parapini, S.3
Rizzi, L.4
Galli, G.5
Mondani, M.6
Sparatore, A.7
Taramelli, D.8
Bosisio, E.9
-
148
-
-
0036185240
-
Basis for antifolate action and resistance in malaria
-
Yuthavong, Y. Basis for antifolate action and resistance in malaria. Microbes Infect. 2002, 4, 175-182.
-
(2002)
Microbes Infect
, vol.4
, pp. 175-182
-
-
Yuthavong, Y.1
-
149
-
-
41649100596
-
-
Rieckmann, K. H. The in vitro activity of experimental antimalarial compounds against strains of Plasmodium falciparum with varying degrees of sensitivity to pyrimethamine and chloroquine. In Chemotherapy of malaria and resistance to antimalarials (World Health Organization Technical Report Series); World Health Organization: Geneva, Switzerland, 1973; p. 58.
-
Rieckmann, K. H. The in vitro activity of experimental antimalarial compounds against strains of Plasmodium falciparum with varying degrees of sensitivity to pyrimethamine and chloroquine. In Chemotherapy of malaria and resistance to antimalarials (World Health Organization Technical Report Series); World Health Organization: Geneva, Switzerland, 1973; p. 58.
-
-
-
-
150
-
-
0242501573
-
Insights into antifolate resistance from malarial DHFR-TS structures
-
Yuvaniyama, J.; Chitnumsub, P.; Kamchonwongpaisan, S.; Vanichtanankul, J.; Sirawaraporn, W.; Taylor, P.; Walkinshaw, M. D.; Yuthavong, Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat. Struct. Biol. 2003, 10, 357-365.
-
(2003)
Nat. Struct. Biol
, vol.10
, pp. 357-365
-
-
Yuvaniyama, J.1
Chitnumsub, P.2
Kamchonwongpaisan, S.3
Vanichtanankul, J.4
Sirawaraporn, W.5
Taylor, P.6
Walkinshaw, M.D.7
Yuthavong, Y.8
-
151
-
-
0029858680
-
Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model
-
Rieckmann, K. H.; Yeo, A. E.; Edstein, M. D. Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model. Trans. R. Soc. Trop. Med. Hyg. 1996, 90, 568-571.
-
(1996)
Trans. R. Soc. Trop. Med. Hyg
, vol.90
, pp. 568-571
-
-
Rieckmann, K.H.1
Yeo, A.E.2
Edstein, M.D.3
-
152
-
-
0027180074
-
PS-15: A potent, orally active antimalarial from a new class of folic acid antagonists
-
Canfield, C. J.; Milhous, W. K.; Ager, A. L.; Rossan, R. N.; Sweeney, T. R. Lewis, N. J.; Jacobus, D. P. PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists. Am. J. Trop. Med. Hyg. 1993, 49, 121-126.
-
(1993)
Am. J. Trop. Med. Hyg
, vol.49
, pp. 121-126
-
-
Canfield, C.J.1
Milhous, W.K.2
Ager, A.L.3
Rossan, R.N.4
Sweeney, T.R.5
Lewis, N.J.6
Jacobus, D.P.7
-
153
-
-
20944441296
-
In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
-
Shearer, T. W.; Kozar, M. P.; O'Neil, M. T.; Smith, P. L.; Schiehser, G. A.; Jacobus, D. P.; Diaz, D. S.; Yang, Y-S.; Milhous, W. k.; Skillman, D. R. In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines. J. Med. Chem. 2005, 48, 2805-2813.
-
(2005)
J. Med. Chem
, vol.48
, pp. 2805-2813
-
-
Shearer, T.W.1
Kozar, M.P.2
O'Neil, M.T.3
Smith, P.L.4
Schiehser, G.A.5
Jacobus, D.P.6
Diaz, D.S.7
Yang, Y.-S.8
Milhous, W.K.9
Skillman, D.R.10
-
154
-
-
9144236861
-
Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo
-
Wiesner, J.; Kettler, K.; Sakowski, J.; Ortmann, R.; Katzin, A. M.; Kimura, E. A.; Silber, K.; Klebe, G.; Jomaa, H.; Schlitzer, M. Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo. Angew. Chem., Int. Ed. 2004, 43, 251-254.
-
(2004)
Angew. Chem., Int. Ed
, vol.43
, pp. 251-254
-
-
Wiesner, J.1
Kettler, K.2
Sakowski, J.3
Ortmann, R.4
Katzin, A.M.5
Kimura, E.A.6
Silber, K.7
Klebe, G.8
Jomaa, H.9
Schlitzer, M.10
-
155
-
-
0029966304
-
Protein Prenyltransferases
-
Casey, P. J.; Seabra, M. C. Protein Prenyltransferases. J. Biol. Chem. 1996, 271, 5289-5292.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 5289-5292
-
-
Casey, P.J.1
Seabra, M.C.2
-
156
-
-
0035953020
-
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
-
Ohkanda, J.; Lockman, J. W.; Yokoyama, K.; Gelb, M. H.; Croft, S. L.; Kendrick, H.; Harrell, M. I.; Feagin, J. E.; Blaskovich, M. A.; Sebti, S. M.; Hamilton, A. D. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorg. Med. Chem. Lett. 2001, 11, 761-764.
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 761-764
-
-
Ohkanda, J.1
Lockman, J.W.2
Yokoyama, K.3
Gelb, M.H.4
Croft, S.L.5
Kendrick, H.6
Harrell, M.I.7
Feagin, J.E.8
Blaskovich, M.A.9
Sebti, S.M.10
Hamilton, A.D.11
-
157
-
-
20844437245
-
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
-
Carrico, D.; Ohkanda, J.; Kendrick, H.; Yokoyama, K.; Blasklovich, M. A.; Bucher, C. J.; Buckner, F. S.; van Voorhis, W. C.; Chakrabarti, D.; Croft, S.; Gelb, M. H.; Sebti, S. M.; Hamilton, A. D. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg. Med. Chem. 2004, 12, 6517-6526.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 6517-6526
-
-
Carrico, D.1
Ohkanda, J.2
Kendrick, H.3
Yokoyama, K.4
Blasklovich, M.A.5
Bucher, C.J.6
Buckner, F.S.7
van Voorhis, W.C.8
Chakrabarti, D.9
Croft, S.10
Gelb, M.H.11
Sebti, S.M.12
Hamilton, A.D.13
-
158
-
-
41649086637
-
-
Ledig, K. W. 7-(Substituted)-7H-pyrrolo[3,2,-f]quinazoline-1,3-diamines. U.S. Patent 4,118,561, 1978
-
Ledig, K. W. 7-(Substituted)-7H-pyrrolo[3,2,-f]quinazoline-1,3-diamines. U.S. Patent 4,118,561, 1978.
-
-
-
-
159
-
-
0015380294
-
Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic) methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease
-
Davoll, J.; Johnson, A. M.; Davies, H. J.; Bird, O. D.; Clarke, J.; Elslager,. E. F. Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic) methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease. J. Med. Chem. 1972, 15, 812-826.
-
(1972)
J. Med. Chem
, vol.15
, pp. 812-826
-
-
Davoll, J.1
Johnson, A.M.2
Davies, H.J.3
Bird, O.D.4
Clarke, J.5
Elslager, E.F.6
-
160
-
-
0015425062
-
Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects
-
Elslager, E. F.; Bird, O. D.; Clarke, J.; Perricone, S. C.; Worth, D. F. Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects. J. Med. Chem. 1972, 15, 1138-1146.
-
(1972)
J. Med. Chem
, vol.15
, pp. 1138-1146
-
-
Elslager, E.F.1
Bird, O.D.2
Clarke, J.3
Perricone, S.C.4
Worth, D.F.5
-
161
-
-
0036783048
-
A new pyrroloquinazoline alkaloid from Linaria vulgaris
-
Hua, H.; Cheng, M.; Li, X.; Pei, Y. A new pyrroloquinazoline alkaloid from Linaria vulgaris. Chem. Pharm. Bull. 2002, 50, 1393-1394.
-
(2002)
Chem. Pharm. Bull
, vol.50
, pp. 1393-1394
-
-
Hua, H.1
Cheng, M.2
Li, X.3
Pei, Y.4
-
162
-
-
28844474431
-
Antimalarial activity of new pyrrolo[3,2-f]Quinazoline-1,3-Diamine derivatives
-
Guan, J.; Zhang, Q.; O'Neil, M.; Obaldia III, N.; Ager, A.; Gerena, L.;
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 4928-4933
-
-
Guan, J.1
Zhang, Q.2
O'Neil, M.3
Obaldia III, N.4
Ager, A.5
Gerena, L.6
Lin, A.J.7
-
163
-
-
33646453477
-
New Potential Antimalarial Agents: Therapeutic-Index Evaluation of Pyrroloquinazolinediamine and Its Prodrugs in a Rat Model of Severe Malaria
-
Xie, L. H.; Li, Q.; Lin, A. J.; Smith, K.; Zhang, J.; Skillman, D. New Potential Antimalarial Agents: Therapeutic-Index Evaluation of Pyrroloquinazolinediamine and Its Prodrugs in a Rat Model of Severe Malaria. Antimicrob. Agents Chemother. 2006, 50, 1649-1655.
-
(2006)
Antimicrob. Agents Chemother
, vol.50
, pp. 1649-1655
-
-
Xie, L.H.1
Li, Q.2
Lin, A.J.3
Smith, K.4
Zhang, J.5
Skillman, D.6
-
164
-
-
9344236530
-
Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines
-
Weller, T.; Alig, L.; Beresini, M.; Blackburn, B.; Bunting, S.; Hadvary, P.; Muller, M. H.; Knopp, D.; Levet-Trafit, B.; Lipari, M. T.; Modi, N. B.; Muller, M.; Refino, C. J.; Schmitt, M.; Schonholzer, P.; Weiss, S.; Steiner, B. Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines. J. Med. Chem. 1996, 39, 3139-3147.
-
(1996)
J. Med. Chem
, vol.39
, pp. 3139-3147
-
-
Weller, T.1
Alig, L.2
Beresini, M.3
Blackburn, B.4
Bunting, S.5
Hadvary, P.6
Muller, M.H.7
Knopp, D.8
Levet-Trafit, B.9
Lipari, M.T.10
Modi, N.B.11
Muller, M.12
Refino, C.J.13
Schmitt, M.14
Schonholzer, P.15
Weiss, S.16
Steiner, B.17
-
165
-
-
0036845742
-
Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl) Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug
-
Zhou, L.; Lee, K.; Thakker, D. R.; Boykin, D. W.; Tiwell, R. R.; Hall, J. E. Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl) Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug. Pharm. Res. 2002, 19, 1689-1685.
-
(2002)
Pharm. Res
, vol.19
, pp. 1689-1685
-
-
Zhou, L.1
Lee, K.2
Thakker, D.R.3
Boykin, D.W.4
Tiwell, R.R.5
Hall, J.E.6
-
166
-
-
0035087137
-
-
Kitamura, S. F. H.; Miyawaki, T.; Kawamura, M.; Terashita, Z-I.; Naka, T. Orally Active GPIIb/IIIa Antagonists: Synthesis and Biological Activities of Masked Amidines as Prodrugs of 2-[(3S)-4-[(2S)-2-(4- Amidinobenzoylamino)-3-(4-methoxyphenyl)propanoyl]-3-(2-methoxy-2-oxoethyl) -2-oxopiperazinyl]acetic Acid. Chem. Pharm. Bull. 2001, 49, 268-277.
-
Kitamura, S. F. H.; Miyawaki, T.; Kawamura, M.; Terashita, Z-I.; Naka, T. Orally Active GPIIb/IIIa Antagonists: Synthesis and Biological Activities of Masked Amidines as Prodrugs of 2-[(3S)-4-[(2S)-2-(4- Amidinobenzoylamino)-3-(4-methoxyphenyl)propanoyl]-3-(2-methoxy-2-oxoethyl) -2-oxopiperazinyl]acetic Acid. Chem. Pharm. Bull. 2001, 49, 268-277.
-
-
-
-
167
-
-
0031468133
-
New NO-Donors with Antithrombotic and Vasodilating Activities, Part 17. Arylazoamidoximes and 3-Arylazo-1,2,4-oxadiazol-5-ones
-
Rehse, K.; Bade, S.; Harsdorf, A.; Clement, B. New NO-Donors with Antithrombotic and Vasodilating Activities, Part 17. Arylazoamidoximes and 3-Arylazo-1,2,4-oxadiazol-5-ones. Arch. Pharm. 1997, 330, 392-398.
-
(1997)
Arch. Pharm
, vol.330
, pp. 392-398
-
-
Rehse, K.1
Bade, S.2
Harsdorf, A.3
Clement, B.4
-
168
-
-
0030591850
-
Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs
-
Boykin, D. W.; Kumar, A.; Hall, J. E.; Bender, B. C.; Tidwell, R. R. Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs Bioorg. Med. Chem. Lett. 1996, 6, 3017-3020.
-
(1996)
Bioorg. Med. Chem. Lett
, vol.6
, pp. 3017-3020
-
-
Boykin, D.W.1
Kumar, A.2
Hall, J.E.3
Bender, B.C.4
Tidwell, R.R.5
-
169
-
-
0024988192
-
Metabolic N-hydroxylation of pentamidine in vitro
-
Berger, B. J.; Lombardy, R. J.; Marbury, G. D.; Bell, C. A.; Dykstra, C. C.; Hall, J. E.; Tidwell, R. R. Metabolic N-hydroxylation of pentamidine in vitro. Antimicrob. Agents Chemother. 1990, 34, 1678-1684.
-
(1990)
Antimicrob. Agents Chemother
, vol.34
, pp. 1678-1684
-
-
Berger, B.J.1
Lombardy, R.J.2
Marbury, G.D.3
Bell, C.A.4
Dykstra, C.C.5
Hall, J.E.6
Tidwell, R.R.7
-
171
-
-
33846343962
-
Synthesis and antimalarial activity of new 1,12-bis- (N,N)-acetamidinyl)dodecane derivatives
-
Outtara, M.; Wein, S.; Calas, M.; Hoang, Y. V.; Vial, H.; Escale, R. Synthesis and antimalarial activity of new 1,12-bis- (N,N)-acetamidinyl)dodecane derivatives Bioorg. Med. Chem. Lett. 2007, 17, 593-596.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 593-596
-
-
Outtara, M.1
Wein, S.2
Calas, M.3
Hoang, Y.V.4
Vial, H.5
Escale, R.6
-
172
-
-
0026795458
-
The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites
-
Cerami, C.; Frevert, U.; Sinnis, P.; Takacs, B.; Clavijo, P.; Santos, M. J.; Nussenzweig, V. The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites. Cell. 1992, 70, 1021-1033.
-
(1992)
Cell
, vol.70
, pp. 1021-1033
-
-
Cerami, C.1
Frevert, U.2
Sinnis, P.3
Takacs, B.4
Clavijo, P.5
Santos, M.J.6
Nussenzweig, V.7
-
173
-
-
0028954476
-
Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured
-
Ding, Z. M.; Cristiano, R. J.; Roth, J. A.; Takacs, B.; Kuo, M. T. Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured. J. Biol. Chem. 1995, 270, 3667-3676.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 3667-3676
-
-
Ding, Z.M.1
Cristiano, R.J.2
Roth, J.A.3
Takacs, B.4
Kuo, M.T.5
-
174
-
-
0036560015
-
Prolonged stability and sustained prodrug cell killing activity using receptor-mediated delivery of malarial circumsporozoite-cytosine deaminase fusion protein into liver cancer cells
-
Lin-Lee, Y-C.; Nakamura, S.; Gandhi, V.; Curley, S. A.; Stüber, D.; Burkot, T. R.; Kuo, M. T. Prolonged stability and sustained prodrug cell killing activity using receptor-mediated delivery of malarial circumsporozoite-cytosine deaminase fusion protein into liver cancer cells. Mol. Cancer Ther. 2002, 1, 461-467.
-
(2002)
Mol. Cancer Ther
, vol.1
, pp. 461-467
-
-
Lin-Lee, Y.-C.1
Nakamura, S.2
Gandhi, V.3
Curley, S.A.4
Stüber, D.5
Burkot, T.R.6
Kuo, M.T.7
-
175
-
-
0031086191
-
Malaria sporozoites and chylomicron remnants compete for binding sites in the liver
-
Nussenzweig, V. Malaria sporozoites and chylomicron remnants compete for binding sites in the liver. Behring Inst. Mitt. 1997, 99, 85-89.
-
(1997)
Behring Inst. Mitt
, vol.99
, pp. 85-89
-
-
Nussenzweig, V.1
-
176
-
-
33845956330
-
Design, synthesis, and in vivo evaluation of oxamniquine methacrylate and acrylamide prodrugs
-
Parise Filho, R.; Menezes, C.M.S.; Pinto, P.L.S.; Paula, G.A.; Brandt, C.A.; Siveira, M.A.B. Design, synthesis, and in vivo evaluation of oxamniquine methacrylate and acrylamide prodrugs. Bioorg. Med. Chem. 2007, 15, 1229-1236.
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 1229-1236
-
-
Parise Filho, R.1
Menezes, C.M.S.2
Pinto, P.L.S.3
Paula, G.A.4
Brandt, C.A.5
Siveira, M.A.B.6
-
177
-
-
33644881973
-
Synthesis and thermal study of prodrug of oxamniquine
-
Almeida, A.E.; Ferreira, A.G.; Crespi, M.S.; Andrade, Z.A.; Man-Chin, C. Synthesis and thermal study of prodrug of oxamniquine. J. Therm. Anal. Cal., 2006, 83, 277-281.
-
(2006)
J. Therm. Anal. Cal
, vol.83
, pp. 277-281
-
-
Almeida, A.E.1
Ferreira, A.G.2
Crespi, M.S.3
Andrade, Z.A.4
Man-Chin, C.5
-
178
-
-
0023729075
-
Studies on some derivatives of oxamniquine
-
El-Hamouly, W.; Pica-Mattocia, L.; Cioli, D.; Schwartz, H.M.; Archer, S. Studies on some derivatives of oxamniquine. J. Med. Chem. 1988, 31, 1629-1631.
-
(1988)
J. Med. Chem
, vol.31
, pp. 1629-1631
-
-
El-Hamouly, W.1
Pica-Mattocia, L.2
Cioli, D.3
Schwartz, H.M.4
Archer, S.5
-
179
-
-
31044454267
-
Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
-
Shaohong, L.; Kumagai, T.; Qinghua, A., Xiaolan, Y.; Ohmae, H.; Yabu, Y.; Siwen, L.; Liyong, W.; Maruyama, H.; Ohta, N. Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols. Parasitol. Int. 2006, 55, 63-68
-
(2006)
Parasitol. Int
, vol.55
, pp. 63-68
-
-
Shaohong, L.1
Kumagai, T.2
Qinghua, A.3
Xiaolan, Y.4
Ohmae, H.5
Yabu, Y.6
Siwen, L.7
Liyong, W.8
Maruyama, H.9
Ohta, N.10
-
180
-
-
0036064218
-
Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice
-
Utzinger, J.; Chollet, J.; Tu, Z.; Shuhua,X.; Tanner, M. Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice. Trans. R. Soc. Trop. Med. Hy. 2002, 96, 318-323.
-
(2002)
Trans. R. Soc. Trop. Med. Hy
, vol.96
, pp. 318-323
-
-
Utzinger, J.1
Chollet, J.2
Tu, Z.3
Shuhua, X.4
Tanner, M.5
-
181
-
-
21544479736
-
Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice
-
Jiraungkoorskul, W.; Sahaphong, S.; Sobhon, P.; Riengrojpitak, S.; Kangwanrangsan, N. Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice. Parasitol. Int. 2005, 54, 177-183.
-
(2005)
Parasitol. Int
, vol.54
, pp. 177-183
-
-
Jiraungkoorskul, W.1
Sahaphong, S.2
Sobhon, P.3
Riengrojpitak, S.4
Kangwanrangsan, N.5
-
182
-
-
0032936728
-
Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide
-
Zhang, Y.; Scorpio, A.; Nikaido, H. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J. Bacteriol. 1999, 181, 2044-9.
-
(1999)
J. Bacteriol
, vol.181
, pp. 2044-2049
-
-
Zhang, Y.1
Scorpio, A.2
Nikaido, H.3
-
183
-
-
13844319812
-
The magic bullets and tuberculosis drug targets
-
Zhang, Y. The magic bullets and tuberculosis drug targets. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 529-64.
-
(2005)
Annu. Rev. Pharmacol. Toxicol
, vol.45
, pp. 529-564
-
-
Zhang, Y.1
-
184
-
-
0029954860
-
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
-
Scorpio, A.; Zhang, Y. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat. Med. 1996, 2, 662-667.
-
(1996)
Nat. Med
, vol.2
, pp. 662-667
-
-
Scorpio, A.1
Zhang, Y.2
-
185
-
-
33748681705
-
Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria
-
Hanoulle, X.; Wieruszeski, J-M.; Rousselot-Pailley, P.; Landrieu, I.; Locht, C.; Lippens, G.; Baulard, A. R. Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria. J. Antimicrob. Chemother. 2006, 58, 768-772.
-
(2006)
J. Antimicrob. Chemother
, vol.58
, pp. 768-772
-
-
Hanoulle, X.1
Wieruszeski, J.-M.2
Rousselot-Pailley, P.3
Landrieu, I.4
Locht, C.5
Lippens, G.6
Baulard, A.R.7
-
186
-
-
0034662963
-
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis
-
DeBarber, A. E.; Mdluli, K.; Bosman, M.; Bekker, L. G.; Barry III, C. E. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 9677-9682.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A
, vol.97
, pp. 9677-9682
-
-
DeBarber, A.E.1
Mdluli, K.2
Bosman, M.3
Bekker, L.G.4
Barry III, C.E.5
-
187
-
-
0026705772
-
The catalase peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
-
Zhang, Y.; Heym, B.; Allen, B.; Young, D.; Cole, S. The catalase peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature. 1992, 358, 591-593.
-
(1992)
Nature
, vol.358
, pp. 591-593
-
-
Zhang, Y.1
Heym, B.2
Allen, B.3
Young, D.4
Cole, S.5
-
188
-
-
0027248433
-
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis
-
Heym, B.; Zhang, Y.; Poulet, S.; Young, D.; Cole, S. T. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J. Bacteriol. 1993, 175, 4255-4259.
-
(1993)
J. Bacteriol
, vol.175
, pp. 4255-4259
-
-
Heym, B.1
Zhang, Y.2
Poulet, S.3
Young, D.4
Cole, S.T.5
-
189
-
-
25444522967
-
Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis katg
-
Ghiladi, R. A.; Medzihardsky, K. F.; Rusnak, F. M.; de Montellano, P. R. O. Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis katg. J. Am. Chem. Soc. 2005, 127, 13428-13442.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 13428-13442
-
-
Ghiladi, R.A.1
Medzihardsky, K.F.2
Rusnak, F.M.3
de Montellano, P.R.O.4
-
190
-
-
0037066702
-
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
-
Vannelli, T. A.; Dykman, A.; de Montellano, P. R. O. The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J. Biol. Chem. 2002, 277, 12824-12829.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12824-12829
-
-
Vannelli, T.A.1
Dykman, A.2
de Montellano, P.R.O.3
-
191
-
-
0942287234
-
The prodrug activator etaa from Mycobacterium tuberculosis is a baeyer-villiger monooxygenase
-
Fraaije, M. W.; Kamerbeek, N. M.; Heidekamp, A. J.; Fortin, R.; Janssen, D. B. The prodrug activator etaa from Mycobacterium tuberculosis is a baeyer-villiger monooxygenase. J. Biol. Chem. 2004, 279, 3354-3360.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 3354-3360
-
-
Fraaije, M.W.1
Kamerbeek, N.M.2
Heidekamp, A.J.3
Fortin, R.4
Janssen, D.B.5
-
192
-
-
0034622924
-
Activation of the pro-drug ethionamide is regulated in mycobacteria
-
Baulard, A. R.; Betts, J. C.; Engohang-Ndong, J.; Quan, S.; McAdam, R. A.; Brennan, P. J.; Locht, C.; Besra, G. S. Activation of the pro-drug ethionamide is regulated in mycobacteria. J. Biol. Chem. 2000, 275, 28326-28331.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 28326-28331
-
-
Baulard, A.R.1
Betts, J.C.2
Engohang-Ndong, J.3
Quan, S.4
McAdam, R.A.5
Brennan, P.J.6
Locht, C.7
Besra, G.S.8
-
193
-
-
0032930265
-
Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis
-
Phetsuksiri, B.; Baulard, A. R.; Cooper, A. M.; Minnikin, D. E.; Douglas, J. D.; Besra, G. S.; Brennan, P. J. Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis. Antimicrob. Agents Chemother. 1999, 43, 1042-1051.
-
(1999)
Antimicrob. Agents Chemother
, vol.43
, pp. 1042-1051
-
-
Phetsuksiri, B.1
Baulard, A.R.2
Cooper, A.M.3
Minnikin, D.E.4
Douglas, J.D.5
Besra, G.S.6
Brennan, P.J.7
-
194
-
-
33645471799
-
Oxidative activation of thiacetazone by the mycobacterium tuberculosis flavin monooxygenase etaa and human fmo1 and fmo3
-
Qian, L; de Montellano, P. R. O. Oxidative activation of thiacetazone by the mycobacterium tuberculosis flavin monooxygenase etaa and human fmo1 and fmo3. Chem. Res. Toxicol. 2006, 19, 443-449.
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 443-449
-
-
Qian, L.1
de Montellano, P.R.O.2
-
196
-
-
0018772113
-
Toxic effects of isoniazid in tuberculosis chemoprophylaxis. Role of biochemical monitoring in 1,000 patients
-
Byrd, R. B.; Horn, B. R.; Solomon, D. A.; Griggs, G. W. Toxic effects of isoniazid in tuberculosis chemoprophylaxis. Role of biochemical monitoring in 1,000 patients. JAMA. 1979, 241, 1239-1241.
-
(1979)
JAMA
, vol.241
, pp. 1239-1241
-
-
Byrd, R.B.1
Horn, B.R.2
Solomon, D.A.3
Griggs, G.W.4
-
197
-
-
0018374181
-
Clinical importance of the interaction of phenytoin and isoniazid: A report from the Boston Collaborative Drug Surveillance Program
-
Miller, R. R.; Porter, J.; Greenblatt, D. J. Clinical importance of the interaction of phenytoin and isoniazid: a report from the Boston Collaborative Drug Surveillance Program. Chest. 1979, 75, 356-8.
-
(1979)
Chest
, vol.75
, pp. 356-358
-
-
Miller, R.R.1
Porter, J.2
Greenblatt, D.J.3
-
198
-
-
34247574645
-
Synthesis and evaluation of mutual prodrugs of isoniazid, p-amino salicylic acid and ethambutol
-
Prateek, J. R.; Jaim, K.; Ravichandran, V.; Agrawal, R. K. Synthesis and evaluation of mutual prodrugs of isoniazid, p-amino salicylic acid and ethambutol. Arkivoc 2007, 1, 105-118.
-
(2007)
Arkivoc
, vol.1
, pp. 105-118
-
-
Prateek, J.R.1
Jaim, K.2
Ravichandran, V.3
Agrawal, R.K.4
-
199
-
-
0028603583
-
Dormancy of Mycobacterium tuberculosis and latency of disease
-
Wayne, L. G. Dormancy of Mycobacterium tuberculosis and latency of disease. Eur. J. Clin. Microbiol. Infect. Dis. 1994, 13, 908-914.
-
(1994)
Eur. J. Clin. Microbiol. Infect. Dis
, vol.13
, pp. 908-914
-
-
Wayne, L.G.1
-
200
-
-
0029976980
-
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
-
Wayne, L. G.; Hayes, L. G. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 1996, 64, 2062-2069.
-
(1996)
Infect. Immun
, vol.64
, pp. 2062-2069
-
-
Wayne, L.G.1
Hayes, L.G.2
-
201
-
-
0032780258
-
Why metronidazole is active against both bacteria and parasites
-
Samuelson, J. Why metronidazole is active against both bacteria and parasites. Antimicrob. Agents Chemother. 1999, 43, 1533-1541.
-
(1999)
Antimicrob. Agents Chemother
, vol.43
, pp. 1533-1541
-
-
Samuelson, J.1
-
202
-
-
0032930277
-
Metronidazole therapy in mice infected with tuberculosis
-
Brooks, J. V.; Furney, S. K.; Orme, I. M. Metronidazole therapy in mice infected with tuberculosis. Antimicrob. Agents Chemother. 1999, 43, 1285-1288.
-
(1999)
Antimicrob. Agents Chemother
, vol.43
, pp. 1285-1288
-
-
Brooks, J.V.1
Furney, S.K.2
Orme, I.M.3
-
203
-
-
19544364888
-
-
Lenaerts, A. J.; Gruppo, V.; Marietta, K. S.; Johnson, C. M.; Driscoll, D. K.; Tompkins, N. M.; Rose, J. D.; Reynolds, R. C.; Orme, I. M. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob. Agents Chemother. 2005, 49, 2294-2301.
-
Lenaerts, A. J.; Gruppo, V.; Marietta, K. S.; Johnson, C. M.; Driscoll, D. K.; Tompkins, N. M.; Rose, J. D.; Reynolds, R. C.; Orme, I. M. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob. Agents Chemother. 2005, 49, 2294-2301.
-
-
-
-
204
-
-
31044452898
-
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
-
Manjunatha, U. H.; Boshoff, H.; Dowd, C. S.; Zhang, L.; Albert, T. J.; Norton, J. E.; Daniels, L.; Dick, T.; Pang, S. S.; Barry, C. E. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 2006, 103, 431-436.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 431-436
-
-
Manjunatha, U.H.1
Boshoff, H.2
Dowd, C.S.3
Zhang, L.4
Albert, T.J.5
Norton, J.E.6
Daniels, L.7
Dick, T.8
Pang, S.S.9
Barry, C.E.10
-
205
-
-
0034702247
-
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
-
Stover, C. K.; Warrener, P.; Vandevanter, D. R.; Sherman, D. R.; Arain, T. M.; Langhorne, M. H.; Anderson, S. W.; Towell, J. A.; Yuan, Y.; McMurray, D. N.; Kreiswirth, B. N.; Barry, C. E.; Baker, W. R. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 2000, 405, 962-966.
-
(2000)
Nature
, vol.405
, pp. 962-966
-
-
Stover, C.K.1
Warrener, P.2
Vandevanter, D.R.3
Sherman, D.R.4
Arain, T.M.5
Langhorne, M.H.6
Anderson, S.W.7
Towell, J.A.8
Yuan, Y.9
McMurray, D.N.10
Kreiswirth, B.N.11
Barry, C.E.12
Baker, W.R.13
-
206
-
-
34248144307
-
NLCQ-1 and NLCQ-2, two new agents with activity against dormant Mycobacterium tuberculosis
-
Papadopoulou, M. V.; Bloomer, W. D.; McNeil, M. R. NLCQ-1 and NLCQ-2, two new agents with activity against dormant Mycobacterium tuberculosis. Int. J. Antimicrob. Agents. 2007, 29, 724-727.
-
(2007)
Int. J. Antimicrob. Agents
, vol.29
, pp. 724-727
-
-
Papadopoulou, M.V.1
Bloomer, W.D.2
McNeil, M.R.3
-
207
-
-
0034577002
-
4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin
-
Papadopoulou, M. V.; Ji, M.; Rao, M. K.; Bloomer, W. D. 4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin. Oncol. Res. 2000, 12,185-192.
-
(2000)
Oncol. Res
, vol.12
, pp. 185-192
-
-
Papadopoulou, M.V.1
Ji, M.2
Rao, M.K.3
Bloomer, W.D.4
-
208
-
-
0345356572
-
Reductive metabolism of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257)
-
Papadopoulou, M. V.; Ji, M.; Rao, M. K.; Bloomer, W. D. Reductive metabolism of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257). Oncol. Res. 2003, 14, 21-29.
-
(2003)
Oncol. Res
, vol.14
, pp. 21-29
-
-
Papadopoulou, M.V.1
Ji, M.2
Rao, M.K.3
Bloomer, W.D.4
-
209
-
-
0042924152
-
Towards the design and development of agents with broad spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS
-
Sriram, D.; Yogeeswari, P. Towards the design and development of agents with broad spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS. Curr. Med. Chem. 2003, 10, 1909-1915.
-
(2003)
Curr. Med. Chem
, vol.10
, pp. 1909-1915
-
-
Sriram, D.1
Yogeeswari, P.2
-
210
-
-
1242316935
-
Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS
-
Sriram, D.; Yogeeswari, P.; Narasimharaghavan, S.; Bai, T. R. Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. Bioorg. Med. Chem. Lett. 2004, 14, 1085-1087.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 1085-1087
-
-
Sriram, D.1
Yogeeswari, P.2
Narasimharaghavan, S.3
Bai, T.R.4
-
211
-
-
6344240339
-
Design, synthesis and biological evaluation of novel nonnucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties
-
Sriram, D.; Bal, T. R.; Yogeeswari, P. Design, synthesis and biological evaluation of novel nonnucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties. Bioorg. Med. Chem. 2004, 12, 5865-5873.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 5865-5873
-
-
Sriram, D.1
Bal, T.R.2
Yogeeswari, P.3
-
212
-
-
25644443315
-
-
Sriram, D.; Srichakravarthy, N.; Bal, T. R.; Yogeeswari, P. Dossier: HIV/AIDS: New approaches in chemotherapy and Immunotherapy. Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. Biomed. Pharmacother. 2005, 59, 452-455.
-
Sriram, D.; Srichakravarthy, N.; Bal, T. R.; Yogeeswari, P. Dossier: HIV/AIDS: New approaches in chemotherapy and Immunotherapy. Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. Biomed. Pharmacother. 2005, 59, 452-455.
-
-
-
-
213
-
-
27744493324
-
Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs
-
Sriram, D.; Yogeeswari, P.; Gopal, G. Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs. Eur. J. Med. Chem. 2005, 40, 1373-1376.
-
(2005)
Eur. J. Med. Chem
, vol.40
, pp. 1373-1376
-
-
Sriram, D.1
Yogeeswari, P.2
Gopal, G.3
-
214
-
-
0028007124
-
Cellular transport of drugs
-
Steinberg, T. H. Cellular transport of drugs. Clin. Infect. Dis. 1994, 19, 916-921.
-
(1994)
Clin. Infect. Dis
, vol.19
, pp. 916-921
-
-
Steinberg, T.H.1
-
215
-
-
0027944130
-
Tissue-directed antibiotics and intracellular parasites: Complex interaction of phagocytes, pathogens, and drugs
-
Donowitz, G. R. Tissue-directed antibiotics and intracellular parasites: complex interaction of phagocytes, pathogens, and drugs. Clin. Infect. Dis. 1994, 19, 926-930.
-
(1994)
Clin. Infect. Dis
, vol.19
, pp. 926-930
-
-
Donowitz, G.R.1
-
216
-
-
0024424627
-
Macrophages as targets for drug delivery
-
Gordon, S.; Rabinowitz, S. Macrophages as targets for drug delivery. Adv. Drug Deliv. Rev. 1989, 4, 27-47.
-
(1989)
Adv. Drug Deliv. Rev
, vol.4
, pp. 27-47
-
-
Gordon, S.1
Rabinowitz, S.2
-
217
-
-
10744229900
-
Synthesis, Degradation, and Antimicrobial Properties of Targeted Macromolecular Prodrugs of Norfloxacin
-
Roseeuw, E.; Coessens, V.; Balazuc, A-M.; Lagranderie, M.; Chavarot, P.; Pessina, A.; Néri, M. G.; Schacht, E.; Marchal, G.; Domurado, D. Synthesis, Degradation, and Antimicrobial Properties of Targeted Macromolecular Prodrugs of Norfloxacin. Antimicrob. Agents Chemother. 2003, 47, 3435-3441.
-
(2003)
Antimicrob. Agents Chemother
, vol.47
, pp. 3435-3441
-
-
Roseeuw, E.1
Coessens, V.2
Balazuc, A.-M.3
Lagranderie, M.4
Chavarot, P.5
Pessina, A.6
Néri, M.G.7
Schacht, E.8
Marchal, G.9
Domurado, D.10
-
218
-
-
0033374561
-
Polymeric prodrugs of antibiotics with improved efficiency
-
Roseeuw, E.; Coessens, V.; Schat, E.; Vrooman, B.; Domurado, D.; Marchal, G. Polymeric prodrugs of antibiotics with improved efficiency. J. Mater. Sci. Mater. Med. 1999, 10, 743-746.
-
(1999)
J. Mater. Sci. Mater. Med
, vol.10
, pp. 743-746
-
-
Roseeuw, E.1
Coessens, V.2
Schat, E.3
Vrooman, B.4
Domurado, D.5
Marchal, G.6
-
219
-
-
0027185687
-
Influence of barrier-crossing limitations on the amount of macromolecular drug taken up by its target
-
Aubrée-Lecat, A., Duban, M-C.; Demignot, S.; Domurado, M.; Fournié, P.; Domurado. D. Influence of barrier-crossing limitations on the amount of macromolecular drug taken up by its target. J. Pharmacokinet. Biopharm. 1993, 21, 75-98.
-
(1993)
J. Pharmacokinet. Biopharm
, vol.21
, pp. 75-98
-
-
Aubrée-Lecat, A.1
Duban, M.-C.2
Demignot, S.3
Domurado, M.4
Fournié, P.5
Domurado, D.6
-
220
-
-
22144469468
-
In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, Mycobacterium bovis BCG present in the physiologically hypoxic mouse liver
-
Balazuc, A. M.; Lagranderie, M.; Chavarot, P.; Pescher, P.; Roseeuw, E.; Schacht, E.; Domurado, D.; Marchal, G. In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, Mycobacterium bovis BCG present in the physiologically hypoxic mouse liver. Microbes Infect. 2005, 7, 969-975.
-
(2005)
Microbes Infect
, vol.7
, pp. 969-975
-
-
Balazuc, A.M.1
Lagranderie, M.2
Chavarot, P.3
Pescher, P.4
Roseeuw, E.5
Schacht, E.6
Domurado, D.7
Marchal, G.8
-
221
-
-
0034952920
-
Potential tuberculostatic agents: Micelleforming copolymer poly(ethyleneglycol)- poly(aspartic acid) prodrug with isoniazid
-
Silva, M. ; Lara, A. S. ; Leite, C. Q. F. ; Ferreira, E. I. . Potential tuberculostatic agents: micelleforming copolymer poly(ethyleneglycol)- poly(aspartic acid) prodrug with isoniazid. Arch. Pharm. Pharm. Med. Chem. 2001, 334, 189-193.
-
(2001)
Arch. Pharm. Pharm. Med. Chem
, vol.334
, pp. 189-193
-
-
Silva, M.1
Lara, A.S.2
Leite, C.Q.F.3
Ferreira, E.I.4
-
222
-
-
33745531638
-
Potential Tuberculostatic Agent: Micelle-forming Pyrazinamide Prodrug
-
Silva, M.; Ricelli, N. L.; Seoud, O. E.; Valentim, C. S.; Ferreira, A.; Sato, D. N.; Leite, C. Q. F.; Ferreira, E. I. Potential Tuberculostatic Agent: Micelle-forming Pyrazinamide Prodrug. Arch. Pharm. Chem. Life Sci. 2006, 339, 283-290.
-
(2006)
Arch. Pharm. Chem. Life Sci
, vol.339
, pp. 283-290
-
-
Silva, M.1
Ricelli, N.L.2
Seoud, O.E.3
Valentim, C.S.4
Ferreira, A.5
Sato, D.N.6
Leite, C.Q.F.7
Ferreira, E.I.8
-
223
-
-
0025015189
-
Polymer micelles as novel drug carriers: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
-
Anderson, J. M, Kim, S. W, Knutson, K, Eds, Elsevier: Amsterdam
-
Yokoyama, M.; Miyauchi, M.; Yamada, N.; Okano, T.; Sakurai, Y.; Kataoka, K.; Inoue, S. Polymer micelles as novel drug carriers: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. In Advances in Drug Delivery Systems; Anderson, J. M., Kim, S. W.; Knutson, K.; Eds.: Elsevier: Amsterdam, 1990;Vol. 4, pp. 269-278.
-
(1990)
Advances in Drug Delivery Systems
, vol.4
, pp. 269-278
-
-
Yokoyama, M.1
Miyauchi, M.2
Yamada, N.3
Okano, T.4
Sakurai, Y.5
Kataoka, K.6
Inoue, S.7
-
224
-
-
0035816145
-
Development of the polymer micelle carrier system for doxorubicin
-
Nakanishi, T.; Fukushima, S.; Okamoto, K.; Suzuki, M.; Matsumura, Y.; Yokoyama, M.; Okano, T.; Sakurai, Y.; Kataoka, K. Development of the polymer micelle carrier system for doxorubicin. J. Control Release. 2001, 74, 295-302.
-
(2001)
J. Control Release
, vol.74
, pp. 295-302
-
-
Nakanishi, T.1
Fukushima, S.2
Okamoto, K.3
Suzuki, M.4
Matsumura, Y.5
Yokoyama, M.6
Okano, T.7
Sakurai, Y.8
Kataoka, K.9
-
225
-
-
11144267731
-
N-methylene phosphonic chitosan to obtain an isoniazid prodrug
-
Rando, D. G. ; Brandt, C. A. ; Ferreira, E. I. Use of N-methylene phosphonic chitosan to obtain an isoniazid prodrug. Rev. Bras. Ciên. Farm. 2004, 40, 335-344.
-
(2004)
Rev. Bras. Ciên. Farm
, vol.40
, pp. 335-344
-
-
Rando, D.1
Brandt, G.2
Ferreira, C.A.3
Use of, E.I.4
-
226
-
-
0031225516
-
Chitin particle-induced cell- mediated immunity is inhibited by soluble mannan: Mannose receptor-mediated phagocytosis initiates IL-12 production
-
Shibata, Y.; Metzger, W. J.; Myrvik, Q. N. Chitin particle-induced cell- mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. J. Immunol. 1997, 159, 2462-2467.
-
(1997)
J. Immunol
, vol.159
, pp. 2462-2467
-
-
Shibata, Y.1
Metzger, W.J.2
Myrvik, Q.N.3
-
227
-
-
0343288985
-
N-methylene phosphonic chitosan: A novel soluble derivative
-
Heras, A,; Rodríguez, N.M.; Ramos, V.M.; Agulló, E. N-methylene phosphonic chitosan: a novel soluble derivative. Carbohydr. Polym. 2001, 44, 1-8.
-
(2001)
Carbohydr. Polym
, vol.44
, pp. 1-8
-
-
Heras, A.1
Rodríguez, N.M.2
Ramos, V.M.3
Agulló, E.4
-
228
-
-
31544471208
-
J. Oxazolidinone susceptibility patterns in 2004: Report from the Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) program assessing isolates from 16 nations
-
Jones, R. N.; Ross, J. E.; Fritsche, T. R.; Sader, H. S. J. Oxazolidinone susceptibility patterns in 2004: report from the Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) program assessing isolates from 16 nations. Antimicrob. Chemother. 2006, 57, 279-287.
-
(2006)
Antimicrob. Chemother
, vol.57
, pp. 279-287
-
-
Jones, R.N.1
Ross, J.E.2
Fritsche, T.R.3
Sader, H.S.4
-
229
-
-
1442324636
-
In vitro activities of new quinolones and oxazolidinones against Actinomadura madurae
-
Vera-Cabrera, L.; Ochoa-Felix, E. Y.; Gonzalez, G.; Tijerina, R.; Choi, S. H.; Welsh, O. In vitro activities of new quinolones and oxazolidinones against Actinomadura madurae. Antimicrob. Agents Chemother. 2004, 48, 1037-1039.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 1037-1039
-
-
Vera-Cabrera, L.1
Ochoa-Felix, E.Y.2
Gonzalez, G.3
Tijerina, R.4
Choi, S.H.5
Welsh, O.6
-
230
-
-
25844516661
-
In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867
-
Vera-Cabrera, L.; Castro-Garza, J.; Rendon, A.; Ocampo-Candiani, J.; Welsh, O.; Choi, S. H.; Blackwood, K.; Molina-Torres, C. In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867. Antimicrob. Agents Chemother. 2005, 49, 4351-4353.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 4351-4353
-
-
Vera-Cabrera, L.1
Castro-Garza, J.2
Rendon, A.3
Ocampo-Candiani, J.4
Welsh, O.5
Choi, S.H.6
Blackwood, K.7
Molina-Torres, C.8
-
231
-
-
0942279621
-
In vitro activities of new antimicrobials against Nocardia brasiliensis
-
Vera-Cabrera, L.; Gonzalez, E.; Choi, S. H.; Welsh; O. In vitro activities of new antimicrobials against Nocardia brasiliensis. Antimicrob. Agents Chemother. 2004, 48, 602-604.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 602-604
-
-
Vera-Cabrera, L.1
Gonzalez, E.2
Choi, S.H.3
Welsh, O.4
-
232
-
-
1442300143
-
In vitro and in vivo activities of antimicrobials against Nocardia brasiliensis
-
Gomez-Flores, A.; Welsh, O.; Said-Fernandez, S.; Lozano-Garza, G.; Tavarez-Alejandro, R. E.; Vera-Cabrera, L. In vitro and in vivo activities of antimicrobials against Nocardia brasiliensis. Antimicrob. Agents Chemother. 2004, 48, 832-837.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 832-837
-
-
Gomez-Flores, A.1
Welsh, O.2
Said-Fernandez, S.3
Lozano-Garza, G.4
Tavarez-Alejandro, R.E.5
Vera-Cabrera, L.6
-
233
-
-
24044461782
-
Linezolid for the treatment of multidrug-resistant tuberculosis
-
Fortun, J.; Martin-Davila, P.; Navas, E.; Perez-Elias, M. J.; Cobo, J.; Tato, M.; De la Pedrosa, E. G.; Gomez-Mampaso, E.; Moreno S. Linezolid for the treatment of multidrug-resistant tuberculosis. J. Antimicrob. Chemother. 2005, 56, 180-185.
-
(2005)
J. Antimicrob. Chemother
, vol.56
, pp. 180-185
-
-
Fortun, J.1
Martin-Davila, P.2
Navas, E.3
Perez-Elias, M.J.4
Cobo, J.5
Tato, M.6
De la Pedrosa, E.G.7
Gomez-Mampaso, E.8
Moreno, S.9
-
234
-
-
0032846686
-
Mechanism of action of the oxazolidinone antibacterial agents
-
Shinabarger, D. Mechanism of action of the oxazolidinone antibacterial agents. Expert Opin. Investig. Drugs. 1999, 8, 1195-1202.
-
(1999)
Expert Opin. Investig. Drugs
, vol.8
, pp. 1195-1202
-
-
Shinabarger, D.1
-
235
-
-
33748680963
-
In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis
-
Vera-Cabrera, L.; Gonzalez, E.; Rendon, A.; Ocampo-Candiani, J.; Welsh, O.; Velazquez-Moreno, V. M.; Choi, S. H.; Molina-Torres, C. In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis. Antimicrob. Agents Chemother. 2006, 50, 3170-3172.
-
(2006)
Antimicrob. Agents Chemother
, vol.50
, pp. 3170-3172
-
-
Vera-Cabrera, L.1
Gonzalez, E.2
Rendon, A.3
Ocampo-Candiani, J.4
Welsh, O.5
Velazquez-Moreno, V.M.6
Choi, S.H.7
Molina-Torres, C.8
-
236
-
-
0019838759
-
Short chain fatty acids in the human colon
-
Cummings, J.H. Short chain fatty acids in the human colon. Gut 1981, 22, 763-779.
-
(1981)
Gut
, vol.22
, pp. 763-779
-
-
Cummings, J.H.1
-
237
-
-
0020025385
-
Effects of sodium butyrate, a new pharmacological agent, on cells in culture
-
Kruh, J. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol. Cell Biochem. 1982, 42, 65-82.
-
(1982)
Mol. Cell Biochem
, vol.42
, pp. 65-82
-
-
Kruh, J.1
-
238
-
-
0035111343
-
Prodrugs of butyric acid. Novel derivatives possessing increased aqueous solubility and potential for treating cancer and blood diseases
-
Nudelman, A.; Gnizi, E.; Katz, Y.; Azulai, R.; Cohen-Ohana, M.; Zhuk, R.; Sampson, S.R.; Langzam, L.; Fibach, E.; Prus, E.; Pugach, V.; Rephaeli, A. Prodrugs of butyric acid. Novel derivatives possessing increased aqueous solubility and potential for treating cancer and blood diseases. Eur. J. Med. Chem. 2001, 36, 63-74.
-
(2001)
Eur. J. Med. Chem
, vol.36
, pp. 63-74
-
-
Nudelman, A.1
Gnizi, E.2
Katz, Y.3
Azulai, R.4
Cohen-Ohana, M.5
Zhuk, R.6
Sampson, S.R.7
Langzam, L.8
Fibach, E.9
Prus, E.10
Pugach, V.11
Rephaeli, A.12
-
239
-
-
0026710710
-
Increased fetal hemoglobin in patients receiving sodium 4-Phenylbutyrate
-
Dover, G.J.; Brusilow, S.; Samid, D. Increased fetal hemoglobin in patients receiving sodium 4-Phenylbutyrate. New Engl. J. Med. 1992, 327, 569-570.
-
(1992)
New Engl. J. Med
, vol.327
, pp. 569-570
-
-
Dover, G.J.1
Brusilow, S.2
Samid, D.3
-
240
-
-
0029025475
-
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
-
Charache, S.; Terrin, M.L.; Moore, R.D.; Dover, G.J.; Barton, F.B.; Eckert, S.V.; McMahon, R.P.; Bonds, D.R. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia N. Engl. J. Med. 1995, 332, 1317-1322.
-
(1995)
N. Engl. J. Med
, vol.332
, pp. 1317-1322
-
-
Charache, S.1
Terrin, M.L.2
Moore, R.D.3
Dover, G.J.4
Barton, F.B.5
Eckert, S.V.6
McMahon, R.P.7
Bonds, D.R.8
-
241
-
-
0033559320
-
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease
-
Atweh, G.F.; Sutton, M.; Nassif, I.; Boosalis, V.; Dover, G.J.; Wallenstei, S.; Wright, E.; McMahon, L.; Stamatoyannopoulos, G.; Faller, D.V.; Perrine, S.P. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood 1999, 93, 1790-1797.
-
(1999)
Blood
, vol.93
, pp. 1790-1797
-
-
Atweh, G.F.1
Sutton, M.2
Nassif, I.3
Boosalis, V.4
Dover, G.J.5
Wallenstei, S.6
Wright, E.7
McMahon, L.8
Stamatoyannopoulos, G.9
Faller, D.V.10
Perrine, S.P.11
-
242
-
-
4444233550
-
Structural basis for the potent antisickiling effects of a novel class of five membered heterocyclic aldehydic compounds
-
Safo, M.K.; Abdulmalik, O.; Danso-Danquat, R.; Burnett, J.C.; Nokuri, S.; Joshi, G.S.; Musayev, F.N.; Asakura, T.; Abraham, D.J. Structural basis for the potent antisickiling effects of a novel class of five membered heterocyclic aldehydic compounds. J. Med. Chem. 2004, 47, 4665-4676
-
(2004)
J. Med. Chem
, vol.47
, pp. 4665-4676
-
-
Safo, M.K.1
Abdulmalik, O.2
Danso-Danquat, R.3
Burnett, J.C.4
Nokuri, S.5
Joshi, G.S.6
Musayev, F.N.7
Asakura, T.8
Abraham, D.J.9
-
243
-
-
0017661802
-
Schiff base adducts of hemoglobin. Modifications that inhibit erythrocyte sickling
-
Zaugg, R.H.; Walder, J.A.; Klotz, I.M. Schiff base adducts of hemoglobin. Modifications that inhibit erythrocyte sickling. J. Biol. Chem. 1977, 252, 8542-8548.
-
(1977)
J. Biol. Chem
, vol.252
, pp. 8542-8548
-
-
Zaugg, R.H.1
Walder, J.A.2
Klotz, I.M.3
-
244
-
-
0025855331
-
-
Abraham, D.J.; Mehanna, A.S.; Wireko, F.C.; Whitney, J.; Thomas, R.P.; Orringer, E.P. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood. 1991, 77, 1334-1341.
-
Abraham, D.J.; Mehanna, A.S.; Wireko, F.C.; Whitney, J.; Thomas, R.P.; Orringer, E.P. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood. 1991, 77, 1334-1341.
-
-
-
-
245
-
-
41649096860
-
Antisickling agents
-
Safo, M,K.; Danso-Danquat, R.; Joshi, G.S.; Abraham, D.J. Antisickling agents. US2005/0209199 A1, 2005.
-
(2005)
US2005/0209199 A1
-
-
Safo, M.K.1
Danso-Danquat, R.2
Joshi, G.S.3
Abraham, D.J.4
-
246
-
-
3042601100
-
Antisickling effect of MX-1520, a prodrug of vanillin: An in vivo study using rodents
-
Zhang, C.; Li, X.; Lian, L.; Chen, Q.; Abdulmalik, O.; Vassilev, V.; Lai, C.S.; Asakura, T.; Antisickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents. Br. J. Haematol. 2004, 125, 788-795.
-
(2004)
Br. J. Haematol
, vol.125
, pp. 788-795
-
-
Zhang, C.1
Li, X.2
Lian, L.3
Chen, Q.4
Abdulmalik, O.5
Vassilev, V.6
Lai, C.S.7
Asakura, T.8
-
247
-
-
0026778383
-
Mechanism of action oh hydroxyurea
-
Yarbro, J.M. Mechanism of action oh hydroxyurea. Semin. Oncol. 1992, 19, 1-10.
-
(1992)
Semin. Oncol
, vol.19
, pp. 1-10
-
-
Yarbro, J.M.1
-
248
-
-
0034210238
-
Acquired DNA mutations associated with in vivo hydroxyurea exposure
-
Hanft, V.N.; Fruchtman, S.R.; Pickens, C.V.; Rosse, W.F.; Howard, T.A.; Ware, R.E. Acquired DNA mutations associated with in vivo hydroxyurea exposure. Blood 2000, 95, 3589-3593.
-
(2000)
Blood
, vol.95
, pp. 3589-3593
-
-
Hanft, V.N.1
Fruchtman, S.R.2
Pickens, C.V.3
Rosse, W.F.4
Howard, T.A.5
Ware, R.E.6
-
249
-
-
0037414164
-
Effect Of Hydroxyurea On Mortality And Morbidity In Adult Sickle Cell anemia: Risks and benefits up to nine years of treatment
-
Steinberg, M.H.; Barton, F.; Castro, O.; Pegelow, C.H.; Balas, S.K.; Kutlar, A.; Orringer, E.; Bellevie, R.; Olivieri, N.; Eckman, J.; Varma, M.; Ramirez, G.; Adler, B.; Smith, W.; Carlos, T.; Ataga, K.; Decastro, L.; Bjelow, C.; Sauntharajah, Y.; Telfer, M.; Bonds, D.; Terrin, M. Effect Of Hydroxyurea On Mortality And Morbidity In Adult Sickle Cell anemia: risks and benefits up to nine years of treatment. JAMA 2003, 289, 1645-1651.
-
(2003)
JAMA
, vol.289
, pp. 1645-1651
-
-
Steinberg, M.H.1
Barton, F.2
Castro, O.3
Pegelow, C.H.4
Balas, S.K.5
Kutlar, A.6
Orringer, E.7
Bellevie, R.8
Olivieri, N.9
Eckman, J.10
Varma, M.11
Ramirez, G.12
Adler, B.13
Smith, W.14
Carlos, T.15
Ataga, K.16
Decastro, L.17
Bjelow, C.18
Sauntharajah, Y.19
Telfer, M.20
Bonds, D.21
Terrin, M.22
more..
-
250
-
-
0030464953
-
Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive "switching" agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia
-
Charache, S.; Barton, F.B.; Moore, R.D.; Terrin, M.L.; Steinberg, M.H.; Dover, G.J.; Ballas, S.K.; Mcmahon, R.P.; Castro, O.; Orringer, E.P. Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive "switching" agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Medicine 1996, 75, 300-326.
-
(1996)
Medicine
, vol.75
, pp. 300-326
-
-
Charache, S.1
Barton, F.B.2
Moore, R.D.3
Terrin, M.L.4
Steinberg, M.H.5
Dover, G.J.6
Ballas, S.K.7
Mcmahon, R.P.8
Castro, O.9
Orringer, E.P.10
-
251
-
-
0034102968
-
-
Space, S.L.; Lane, P.A.; Pickett, C.K.; Weil, J.L. nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium. Am. J. Hematol. 2000, 63, 200-204.
-
Space, S.L.; Lane, P.A.; Pickett, C.K.; Weil, J.L. nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium. Am. J. Hematol. 2000, 63, 200-204.
-
-
-
-
252
-
-
1242315424
-
Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients
-
Conran, N.; Oresco-Santos, C.; Acosta, H.C.; Fattori, A.; Saad, S.T.; Costa, F.F. Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients. Br. J. Haematol. 2004, 124, 547-554.
-
(2004)
Br. J. Haematol
, vol.124
, pp. 547-554
-
-
Conran, N.1
Oresco-Santos, C.2
Acosta, H.C.3
Fattori, A.4
Saad, S.T.5
Costa, F.F.6
-
253
-
-
33846561976
-
Nicorandil Elevates Tissue cGMP Levels in a Nitric-Oxide-Independent Manner
-
Minamiyama, Y.; Takemura, S.; Hai, S.; Suehiro, S.; Okada, S.; Funae, Y. Nicorandil Elevates Tissue cGMP Levels in a Nitric-Oxide-Independent Manner. J. Pharmacol. Sci. 2007, 103, 33-39.
-
(2007)
J. Pharmacol. Sci
, vol.103
, pp. 33-39
-
-
Minamiyama, Y.1
Takemura, S.2
Hai, S.3
Suehiro, S.4
Okada, S.5
Funae, Y.6
-
254
-
-
0037237980
-
Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase
-
Cokic, V.P.; Smith, R.D.; Beleslin-cokic, B.B.; Njoroge, J.M.; Miller, J.L.; Gladwin, M.T.; Schechter, A.N. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J. Clin. Invest. 2003, 111, 231-239.
-
(2003)
J. Clin. Invest
, vol.111
, pp. 231-239
-
-
Cokic, V.P.1
Smith, R.D.2
Beleslin-cokic, B.B.3
Njoroge, J.M.4
Miller, J.L.5
Gladwin, M.T.6
Schechter, A.N.7
-
255
-
-
41649111166
-
-
Unpublished results
-
Unpublished results
-
-
-
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