CHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody

mAbs

Volumn 8, Issue 2, 2016, Pages 347-357

  Pettit, Dean K ^a   Rogers, Richard S ^a   Arthur, Kelly ^b   Brodsky, Yan ^b   Clark, Rutilio H ^a   Crowell, Chris ^b   Ennis, Jane ^c   Gillespie, Alison ^a   Gillespie, Ron ^a   Livingston, Brittney ^a   Nalbandian, Edith ^b   Pace, Danielle ^a   Smidt, Pauline ^a   Pauly, Michael ^c   Timmons, Ken ^a   Trentalange, Michael ^b   Whaley, Kevin J ^c   Zeitlin, Larry ^c   Thomas, James N ^a  

^a Just Biotherapeutics   (United States)

^b AMGEN INC   (United States)

^c Mapp Biopharmaceutical Inc   (United States)

Author keywords

Anti viral; Ebola; Manufacturability; Thermal stability; ZMapp

Indexed keywords

13C6FR1; UNCLASSIFIED DRUG; VIRUS ANTIBODY; ZMAPP; HYBRID PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; BIOREACTOR; CHINESE HAMSTER; CHO CELL LINE; COMPUTER MODEL; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DOWNSTREAM PROCESSING; EBOLAVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HYBRIDOMA; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR BIOLOGY; MURINE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIZE EXCLUSION CHROMATOGRAPHY; THERMOSTABILITY; ANIMAL; BIOSYNTHESIS; CRICETULUS; GENE EXPRESSION; GENETICS; HAMSTER; MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODIES, VIRAL; CHO CELLS; CRICETINAE; CRICETULUS; EBOLAVIRUS; GENE EXPRESSION; MICE; RECOMBINANT FUSION PROTEINS;

EID: 84964425104     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2015.1127492     Document Type: Article

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