메뉴 건너뛰기




Volumn 362, Issue 9400, 2003, Pages 1953-1958

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: A study in rhesus monkeys

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT PROTEIN; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; D DIMER; FIBRIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT NEMATODE ANTICOAGULANT PROTEIN C2; RECOMBINANT PROTEIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

EID: 10744222633     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)15012-X     Document Type: Article
Times cited : (356)

References (20)
  • 1
    • 0002858305 scopus 로고    scopus 로고
    • Filoviridae: Marburg and Ebola viruses
    • D.M. Knipe, & P.M. Howley. Philadelphia: Lippincott Williams and Wilkins
    • Sanchez A., Khan A.S., Zaki S.R., et al. Filoviridae: Marburg and Ebola viruses. Knipe D.M., Howley P.M. Fields virology. 2001;1279-1304 Lippincott Williams and Wilkins, Philadelphia.
    • (2001) Fields Virology , pp. 1279-1304
    • Sanchez, A.1    Khan, A.S.2    Zaki, S.R.3
  • 3
    • 0033066490 scopus 로고    scopus 로고
    • Evaluation of immune globulin and recombinant interferon α-2b for treatment of experimental Ebola virus infections
    • Jahrling P.B., Geisbert T.W., Geisbert J.B., et al. Evaluation of immune globulin and recombinant interferon α-2b for treatment of experimental Ebola virus infections. J Infect Dis. 179 (suppl 1):1999;S224-S234.
    • (1999) J Infect Dis , vol.1791
    • Jahrling, P.B.1    Geisbert, T.W.2    Geisbert, J.B.3
  • 4
    • 0033026484 scopus 로고    scopus 로고
    • Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model
    • Huggins J., Zhang Z.X., Bray M. Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J Infect Dis. 179 (suppl 1):1999;S240-S247.
    • (1999) J Infect Dis , vol.1791
    • Huggins, J.1    Zhang, Z.X.2    Bray, M.3
  • 5
    • 0034096583 scopus 로고    scopus 로고
    • Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor
    • Bray M., Driscoll J., Huggins J.W. Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. Antiviral Res. 45:2000;135-147.
    • (2000) Antiviral Res , vol.45 , pp. 135-147
    • Bray, M.1    Driscoll, J.2    Huggins, J.W.3
  • 6
    • 0346791564 scopus 로고
    • Inhibition of Ebola virus by S-adenosylhomocysteine hydrolase inhibitors
    • Huggins J.W., Zhang Z.X., Davis K., Coulombe R.A. Inhibition of Ebola virus by S-adenosylhomocysteine hydrolase inhibitors. Antiviral Res. 26:1995;A301.
    • (1995) Antiviral Res , vol.26 , pp. 301
    • Huggins, J.W.1    Zhang, Z.X.2    Davis, K.3    Coulombe, R.A.4
  • 7
    • 0035666691 scopus 로고    scopus 로고
    • Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus
    • Bray M., Hatfill S., Hensley L.E., Huggins J.W. Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus. J Comp Pathol. 125:2001;243-253.
    • (2001) J Comp Pathol , vol.125 , pp. 243-253
    • Bray, M.1    Hatfill, S.2    Hensley, L.E.3    Huggins, J.W.4
  • 8
    • 0348053693 scopus 로고    scopus 로고
    • Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: Overexpression of tissue factor in primate monocytes/macrophages is a key event
    • Geisbert T.W., Young H.A., Jahrling P.B., Davis K.J., Kagan E., Hensley L.E. Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis. 188:2003;1618-1629.
    • (2003) J Infect Dis , vol.188 , pp. 1618-1629
    • Geisbert, T.W.1    Young, H.A.2    Jahrling, P.B.3    Davis, K.J.4    Kagan, E.5    Hensley, L.E.6
  • 10
    • 0033957378 scopus 로고    scopus 로고
    • Detection of mononuclear cells as the source of the increased tissue factor mRNA in the liver from lipopolysaccharide-treated rats
    • Arai A., Hirano H., Ueta Y., Hamada T., Mita T., Shirahata A. Detection of mononuclear cells as the source of the increased tissue factor mRNA in the liver from lipopolysaccharide-treated rats. Thromb Res. 97:2000;153-162.
    • (2000) Thromb Res , vol.97 , pp. 153-162
    • Arai, A.1    Hirano, H.2    Ueta, Y.3    Hamada, T.4    Mita, T.5    Shirahata, A.6
  • 11
    • 0036873001 scopus 로고    scopus 로고
    • Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: From unique mechanism to a promising new clinical anticoagulant
    • Vlasuk G.P., Rote W.E. Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: from unique mechanism to a promising new clinical anticoagulant. Trends Cardiovasc Med. 12:2002;325-331.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 325-331
    • Vlasuk, G.P.1    Rote, W.E.2
  • 12
    • 0035800075 scopus 로고    scopus 로고
    • Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
    • Lee A., Agnelli G., Buller H., et al. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation. 104:2001;74-78.
    • (2001) Circulation , vol.104 , pp. 74-78
    • Lee, A.1    Agnelli, G.2    Buller, H.3
  • 13
    • 0037971568 scopus 로고    scopus 로고
    • Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty
    • Moons A.H., Peters R.J., Bijsterveld N.R., et al. Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty. J Am Coll Cardiol. 41:2003;2147-2153.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2147-2153
    • Moons, A.H.1    Peters, R.J.2    Bijsterveld, N.R.3
  • 14
    • 0031881324 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation: Pathophysiological mechanisms and manifestations
    • Bick R.L. Disseminated intravascular coagulation: pathophysiological mechanisms and manifestations. Semin Thromb Hemost. 24:1998;3-18.
    • (1998) Semin Thromb Hemost , vol.24 , pp. 3-18
    • Bick, R.L.1
  • 15
    • 0033761834 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor (TFPI) in disseminated intravascular coagulation: Low levels of the activated factor X-TFPI complex
    • Iversen N., Strekerud F.G., Abildgaard U. Tissue factor pathway inhibitor (TFPI) in disseminated intravascular coagulation: low levels of the activated factor X-TFPI complex. Blood Coagul Fibrinolysis. 11:2000;591-598.
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 591-598
    • Iversen, N.1    Strekerud, F.G.2    Abildgaard, U.3
  • 16
    • 0021017848 scopus 로고
    • Features of DIC in dengue hemorrhagic fever
    • Funahara Y., Sumarmo, Wirawan R. Features of DIC in dengue hemorrhagic fever. Bibl Haematol. 49:1983;201-211.
    • (1983) Bibl Haematol , vol.49 , pp. 201-211
    • Funahara, Y.1    Sumarmo2    Wirawan, R.3
  • 17
    • 0028363702 scopus 로고
    • Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, IL-6 and plasminogen activator inhibitors from monocytes in vitro
    • Robson S.C., Shephard E.G., Kirsch R.E. Fibrin degradation product D-dimer induces the synthesis and release of biologically active IL-1 beta, IL-6 and plasminogen activator inhibitors from monocytes in vitro. Br J Haematol. 86:1994;322-326.
    • (1994) Br J Haematol , vol.86 , pp. 322-326
    • Robson, S.C.1    Shephard, E.G.2    Kirsch, R.E.3
  • 18
    • 0032525041 scopus 로고    scopus 로고
    • Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
    • Johnson K., Choi Y., DeGroot E., Samuels I., Creasey A., Aarden L. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J Immunol. 160:1998;5130-5135.
    • (1998) J Immunol , vol.160 , pp. 5130-5135
    • Johnson, K.1    Choi, Y.2    Degroot, E.3    Samuels, I.4    Creasey, A.5    Aarden, L.6
  • 19
    • 0038633316 scopus 로고    scopus 로고
    • Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects
    • de Jonge E., Friederich P.W., Vlasuk G.P., et al. Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects. Clin Diag Lab Immunol. 10:2003;495-497.
    • (2003) Clin Diag Lab Immunol , vol.10 , pp. 495-497
    • De Jonge, E.1    Friederich, P.W.2    Vlasuk, G.P.3
  • 20
    • 0141737821 scopus 로고    scopus 로고
    • Recombinant nematode anticoagulant protein c2 (rNAPc2), an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the IL-10 response in human endotoxemia
    • de Pont A-C, Moons A.H., de Jonge E., et al. Recombinant nematode anticoagulant protein c2 (rNAPc2), an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the IL-10 response in human endotoxemia. Blood. 100:2002;487a.
    • (2002) Blood , vol.100
    • De Pont, A.-C.1    Moons, A.H.2    De Jonge, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.