Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1)

Journal of Chromatography A

Volumn 1251, Issue , 2012, Pages 101-110

  Gillespie, Ron ^a   Nguyen, Thao ^a   Macneil, Sean ^a   Jones, Laurie ^a   Crampton, Shon ^a   Vunnum, Suresh ^a  

^a AMGEN INC   (United States)

Author keywords

Aglycosylated IgG1; Atypical peak shapes; Cation exchange chromatography; Hydrogen deuterium exchange; Monoclonal antibody purification; Surface induced denaturation

Indexed keywords

AGLYCOSYLATED IGG1; CATION EXCHANGE CHROMATOGRAPHY; HYDROGEN-DEUTERIUM EXCHANGE; MONOCLONAL ANTIBODY PURIFICATION; PEAK SHAPES;

AMINO ACIDS; CHROMATOGRAPHY; DEUTERIUM; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDROGEN; IONIC STRENGTH; MONOCLONAL ANTIBODIES; POSITIVE IONS; PURIFICATION;

DENATURATION;

ACETIC ACID; AGLYCOSYLATED IMMUNOGLOBULIN G1 ANTIBODY; ARGININE; BUFFER; CITRATE SODIUM; DEUTERIUM; GLYCINE; HYDROGEN; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; RESIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ELUTION; GLYCOSYLATION; IMMUNOGLOBULIN AGGREGATE; INFRARED SPECTROSCOPY; ION EXCHANGE CHROMATOGRAPHY; IONIC STRENGTH; MOLECULAR WEIGHT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TEMPERATURE SENSITIVITY;

ANIMALS; ANTIBODIES, MONOCLONAL; ARGININE; CATIONS; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; DEUTERIUM EXCHANGE MEASUREMENT; EXCIPIENTS; GLYCOSYLATION; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MOLECULAR WEIGHT; OSMOLAR CONCENTRATION; PROTEIN DENATURATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE;

EID: 84864052659     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.037     Document Type: Article

References (45)

1. Shukla A.A., Hubbard B., Tressel T., Guhan S., Low D. J. Chromatogr. B 2007, 848:28.
2. Yigzaw Y., Hinkley P., Hewig A., Vedantham G. Curr. Pharm. Biotechnol. 2009, 10:421.
3. Pabst T.M., Suda E.J., Thomas K.E., Mensah P., Ramasubramanyan N., Gustafson M.E., Hunter A.K. J. Chromatogr. A 2009, 1216:7950.
4. Gagnon P. Purification Tools for Monoclonal Antibodies 1996, Validated Biosystems, Inc.
5. Voitl A., Butte A., Morbidelli M. J. Chromatogr. A 2010, 1217:5484.
6. Voitl A., Butte A., Morbidelli M. J. Chromatogr. A 2010, 1217:5492.
7. Azevedo A., Rosa P., Ferreira I., de Vries J., Visser T.J., Aries-Barros M. J. Chromatogr. B 2009, 50.
8. Arakawa T., Tsumoto K., Nagase K., Ejima D. Protein Expr. Purif. 2007, 54:110.
9. Ejima D., Yumioka R., Tsumoto K., Arakawa T. Anal. Biochem. 2005, 345:250.
10. McNay J.L., Fernandez E.J. J. Chromatogr. A 1999, 849:135.
11. Lu X.M., Benedek K., Karger B.L. J. Chromatogr. 1986, 359:19.
12. Jungbauer A., Machold C., Hahn R. J. Chromatogr. A 2005, 1079:221.
13. Tibbs Jones T., Fernandez E.J. J. Colloid Interface Sci. 2003, 259:27.
14. Xiao Y., Rathore A., O'Connell J., Fernandez E.J. J. Chromatogr. A 2007, 1157:197.
15. Fogle J.L., O'Connell J.P., Fernandez E.J. J. Chromatogr. A 2006, 1121:209.
16. Steadman B.L., Thompson K.C., Middaugh C.R., Matsuno K., Vrons S., Lawson E.Q., Lewis R.V. Biotechnol. Bioeng. 1992, 40:8.
17. Arakawa T., Philo J.S., Tsumoto K., Yumioka R., Ejima D. Protein Expr. Purif. 2004, 36:244.
18. Arakawa T., Tsumoto K. Biochem. Biophys. Res. Commun. 2003, 304:148.
19. Tsumoto K., Umetsu M., Kumagai I., Ejima D., Arakawa T. Biochem. Biophys. Res. Commun. 2003, 312:1383.
20. Tsumoto K., Umetsu M., Kumagai I., Ejima D., Philo J.S., Arakawa T. Biotechnol. Prog. 2004, 20:1301.
21. Das U., Hariprasad G., Ethayathulla A.S., Manral P., Das T.K., Pasha S., Mann A., Ganguli M., Verma A.K., Bhat R., Chandrayan S.K., Ahmed S., Sharma S., Kaur P., Singh T.P., Srinivasan A. PLoS One 2007, e1176.
22. Arakawa T., Ejima D., Tsumoto K., Obeyama N., Tanaka Y., Kita Y., Timasheff S.N. Biophys. Chem. 2007, 127:1.
23. Shukla D., Trout B.L. J. Phys. Chem. B 2010, 114:13426.
24. Wang W., Singh S., Zeng D.L., King K., Nema S. J. Pharm. Sci. 2006, 96:1.
25. Walker M.R., Lund J., Thomson K.M., Jefferis R. Biochem. J. 1989, 259:347.
26. Jefferis R. Nat. Rev. Drug Discov. 2009, 8:226.
27. R. Jefferis, patent WO2008030564.
28. Wen J., Jiang Y., Narhi L. Am. Pharm. Rev. 2007, 10:10.
29. Lewis J.D., Nail S.L. Process Biochem. 1997, 32:279.
30. Hunter A.K., Carta G. J. Chromatogr. A 2001, 937:13.
31. Fogle J.L., Fernandez E.J. LCGC North Am. 2006, 24:158.
32. van de Weert M., Haris P.I., Hennink W.E., Crommelin D. J. Anal. Biochem. 2001, 297:160.
33. Dong A., Kendrick B., Kreilgard L., Matsuura J., Manning M.C., Carpenter J.F. Arch. Biochem. Biophys. 1997, 347:213.
34. Houde D., Arndt J., Domeier W., Berkowitz S., Engen J.R. Anal. Chem. 2009, 81:2644.
35. Sun J., et al. Immunol. Lett. 2006, 106:144.
36. He F., Hogan S., Latypov R.F., Narhi L.O., Razinkov V.I. J. Pharm. Sci. 2010, 99:1707.
37. Ghose S., McNerney T.M., Hubbard B. Biotechnol. Prog. 2002, 18:530.
38. Hardin A.M., Ivory C.F. J. Colloid Interface Sci. 2006, 302:560.
39. Wu S., Figueroa A., Karger B. J. Chromatogr. 1986, 371:3.
40. Sane S.U., Cramer S.M., Przybycien T.M. J. Chromatogr. A 1999, 849:149.
41. DePhillips P., Lenhoff A.M. J. Chromatogr. A 2001, 933:57.
42. Urmann M., Graalfs H., Joehnck M., Jacob L., Frech R.C. mAbs 2010, 2:395.
43. Gorkarn Y.R., Fesinmeyer R.M., Saluja A., Razinkov V., Chase S.F., Laue T.M., Brems D.N. Protein Sci. 2010, 20:580.
44. de Lencastre Novaes L.C., Mazzola P.G., Pessao A., Vessoni Penna T.C. Biotechnol. Prog. 2011, 27:269.
45. Kaushik J.K., Bhat R. Protein Sci. 1999, 8:222.