-
1
-
-
0035197291
-
Ebola virus: The search for vaccines and treatments
-
J. A. Wilson, C. M. Bosio, M. K. Hart, Ebola virus: The search for vaccines and treatments. Cell. Mol. Life Sci. 58, 1826-1841 (2001).
-
(2001)
Cell. Mol. Life Sci.
, vol.58
, pp. 1826-1841
-
-
Wilson, J.A.1
Bosio, C.M.2
Hart, M.K.3
-
2
-
-
84859462127
-
Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
-
J. M. Dye, A. S. Herbert, A. I. Kuehne, J. F. Barth, M. A. Muhammad, S. E. Zak, R. A. Ortiz, L. I. Prugar, W. D. Pratt, Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease. Proc. Natl. Acad. Sci. U.S.A. 109, 5034-5039 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 5034-5039
-
-
Dye, J.M.1
Herbert, A.S.2
Kuehne, A.I.3
Barth, J.F.4
Muhammad, M.A.5
Zak, S.E.6
Ortiz, R.A.7
Prugar, L.I.8
Pratt, W.D.9
-
3
-
-
84860456246
-
Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever
-
A. Marzi, R. Yoshida, H. Miyamoto, M. Ishijima, Y. Suzuki, M. Higuchi, Y. Matsuyama, M. Igarashi, E. Nakayama, M. Kuroda, M. Saijo, F. Feldmann, D. Brining, H. Feldmann, A. Takada, Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever. PLoS One 7, e36192 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Marzi, A.1
Yoshida, R.2
Miyamoto, H.3
Ishijima, M.4
Suzuki, Y.5
Higuchi, M.6
Matsuyama, Y.7
Igarashi, M.8
Nakayama, E.9
Kuroda, M.10
Saijo, M.11
Feldmann, F.12
Brining, D.13
Feldmann, H.14
Takada, A.15
-
4
-
-
84868149422
-
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques
-
G. G. Olinger Jr., J. Pettitt, D. Kim, C. Working, O. Bohorov, B. Bratcher, E. Hiatt, S. D. Hume, A. K. Johnson, J. Morton, M. Pauly, K. J. Whaley, C. M. Lear, J. E. Biggins, C. Scully, L. Hensley, L. Zeitlin, Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques. Proc. Natl. Acad. Sci. U.S.A. 109, 18030-18035 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 18030-18035
-
-
Olinger Jr., G.G.1
Pettitt, J.2
Kim, D.3
Working, C.4
Bohorov, O.5
Bratcher, B.6
Hiatt, E.7
Hume, S.D.8
Johnson, A.K.9
Morton, J.10
Pauly, M.11
Whaley, K.J.12
Lear, C.M.13
Biggins, J.E.14
Scully, C.15
Hensley, L.16
Zeitlin, L.17
-
5
-
-
84862525229
-
Successful treatment of Ebola virus-infected cynomolgus macaques with monoclonal antibodies
-
X. Qiu, J. Audet, G. Wong, S. Pillet, A. Bello, T. Cabral, J. E. Strong, F. Plummer, C. R. Corbett, J. B. Alimonti, G. P. Kobinger, Successful treatment of Ebola virus-infected cynomolgus macaques with monoclonal antibodies. Sci. Transl. Med. 4, 138ra81 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Qiu, X.1
Audet, J.2
Wong, G.3
Pillet, S.4
Bello, A.5
Cabral, T.6
Strong, J.E.7
Plummer, F.8
Corbett, C.R.9
Alimonti, J.B.10
Kobinger, G.P.11
-
6
-
-
35748957479
-
Pre- and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha
-
J. Q. Wu, N. D. Barabé, Y. M. Huang, G. A. Rayner, M. E. Christopher, F. L. Schmaltz, Pre- and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha. Virology 369, 206-213 (2007).
-
(2007)
Virology
, vol.369
, pp. 206-213
-
-
Wu, J.Q.1
Barabé, N.D.2
Huang, Y.M.3
Rayner, G.A.4
Christopher, M.E.5
Schmaltz, F.L.6
-
7
-
-
84874240722
-
Evaluation of different strategies for post-exposure treatment of Ebola virus infection in rodents
-
J. S. Richardson, G. Wong, S. Pillet, S. Schindle, J. Ennis, J. Turner, J. E. Strong, G. P. Kobinger, Evaluation of different strategies for post-exposure treatment of Ebola virus infection in rodents. J. Bioterror. Biodef. (S1), 007 (2011).
-
(2011)
J. Bioterror. Biodef.
, Issue.S1
, pp. 007
-
-
Richardson, J.S.1
Wong, G.2
Pillet, S.3
Schindle, S.4
Ennis, J.5
Turner, J.6
Strong, J.E.7
Kobinger, G.P.8
-
8
-
-
84880348349
-
Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs
-
X. Qiu, G. Wong, L. Fernando, J. Ennis, J. D. Turner, J. B. Alimonti, X. Yao, G. P. Kobinger, Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs. J. Virol. 87, 7754-7757 (2013).
-
(2013)
J. Virol.
, vol.87
, pp. 7754-7757
-
-
Qiu, X.1
Wong, G.2
Fernando, L.3
Ennis, J.4
Turner, J.D.5
Alimonti, J.B.6
Yao, X.7
Kobinger, G.P.8
-
9
-
-
0033037010
-
An analysis of features of pathogenesis in two animal models of Ebola virus infection
-
E. I. Ryabchikova, L. V. Kolesnikova, S. V. Luchko, An analysis of features of pathogenesis in two animal models of Ebola virus infection. J. Infect. Dis. 179 (Suppl. 1), S199-S202 (1999).
-
(1999)
J. Infect. Dis.
, vol.179
, Issue.SUPPL. 1
-
-
Ryabchikova, E.I.1
Kolesnikova, L.V.2
Luchko, S.V.3
-
10
-
-
0024669532
-
Clinical aspects of African viral hemorrhagic fevers
-
J. H. Gear, Clinical aspects of African viral hemorrhagic fevers. Rev. Infect. Dis. 11 (Suppl. 4), S777-S782 (1989).
-
(1989)
Rev. Infect. Dis.
, vol.11
, Issue.SUPPL. 4
-
-
Gear, J.H.1
-
11
-
-
0026597119
-
Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates
-
T. G. Ksiazek, P. E. Rollin, P. B. Jahrling, E. Johnson, D. W. Dalgard, C. J. Peters, Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates. J. Clin. Microbiol. 30, 947-950 (1992).
-
(1992)
J. Clin. Microbiol.
, vol.30
, pp. 947-950
-
-
Ksiazek, T.G.1
Rollin, P.E.2
Jahrling, P.B.3
Johnson, E.4
Dalgard, D.W.5
Peters, C.J.6
-
12
-
-
0034003159
-
Diagnosis of Ebola haemorrhagic fever by RT-PCR in an epidemic setting
-
E. M. Leroy, S. Baize, C. Y. Lu, J. B. McCormick, A. J. Georges, M. C. Georges-Courbot, J. Lansoud-Soukate, S. P. Fisher-Hoch, Diagnosis of Ebola haemorrhagic fever by RT-PCR in an epidemic setting. J. Med. Virol. 60, 463-467 (2000).
-
(2000)
J. Med. Virol.
, vol.60
, pp. 463-467
-
-
Leroy, E.M.1
Baize, S.2
Lu, C.Y.3
McCormick, J.B.4
Georges, A.J.5
Georges-Courbot, M.C.6
Lansoud-Soukate, J.7
Fisher-Hoch, S.P.8
-
13
-
-
84878907971
-
Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever
-
L. M. Smith, L. E. Hensley, T. W. Geisbert, J. Johnson, A. Stossel, A. Honko, J. Y. Yen, J. Geisbert, J. Paragas, E. Fritz, G. Olinger, H. A. Young, K. H. Rubins, C. L. Karp, Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever. J. Infect. Dis. 208, 310-318 (2013).
-
(2013)
J. Infect. Dis.
, vol.208
, pp. 310-318
-
-
Smith, L.M.1
Hensley, L.E.2
Geisbert, T.W.3
Johnson, J.4
Stossel, A.5
Honko, A.6
Yen, J.Y.7
Geisbert, J.8
Paragas, J.9
Fritz, E.10
Olinger, G.11
Young, H.A.12
Rubins, K.H.13
Karp, C.L.14
-
14
-
-
33846500073
-
Effective post-exposure treatment of Ebola infection
-
H. Feldmann, S. M. Jones, K. M. Daddario-DiCaprio, J. B. Geisbert, U. Ströher, A. Grolla, M. Bray, E. A. Fritz, L. Fernando, F. Feldmann, L. E. Hensley, T. W. Geisbert, Effective post-exposure treatment of Ebola infection. PLoS Pathog. 3, e2 (2007).
-
(2007)
PLoS Pathog.
, vol.3
-
-
Feldmann, H.1
Jones, S.M.2
Daddario-DiCaprio, K.M.3
Geisbert, J.B.4
Ströher, U.5
Grolla, A.6
Bray, M.7
Fritz, E.A.8
Fernando, L.9
Feldmann, F.10
Hensley, L.E.11
Geisbert, T.W.12
-
15
-
-
77952680862
-
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: A proof-of-concept study
-
T. W. Geisbert, A. C. Lee, M. Robbins, J. B. Geisbert, A. N. Honko, V. Sood, J. C. Johnson, S. de Jong, I. Tavakoli, A. Judge, L. E. Hensley, I. Maclachlan, Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: A proof-of-concept study. Lancet 375, 1896-1905 (2010).
-
(2010)
Lancet
, vol.375
, pp. 1896-1905
-
-
Geisbert, T.W.1
Lee, A.C.2
Robbins, M.3
Geisbert, J.B.4
Honko, A.N.5
Sood, V.6
Johnson, J.C.7
De Jong, S.8
Tavakoli, I.9
Judge, A.10
Hensley, L.E.11
Maclachlan, I.12
-
16
-
-
77956436149
-
Advanced antisense therapies for postexposure protection against lethal filovirus infections
-
T. K. Warren, K. L. Warfield, J. Wells, D. L. Swenson, K. S. Donner, S. A. Van Tongeren, N. L. Garza, L. Dong, D. V. Mourich, S. Crumley, D. K. Nichols, P. L. Iversen, S. Bavari, Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat. Med. 16, 991-994 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 991-994
-
-
Warren, T.K.1
Warfield, K.L.2
Wells, J.3
Swenson, D.L.4
Donner, K.S.5
Van Tongeren, S.A.6
Garza, N.L.7
Dong, L.8
Mourich, D.V.9
Crumley, S.10
Nichols, D.K.11
Iversen, P.L.12
Bavari, S.13
-
17
-
-
10744222633
-
Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: A study in rhesus monkeys
-
T. W. Geisbert, L. E. Hensley, P. B. Jahrling, T. Larsen, J. B. Geisbert, J. Paragas, H. A. Young, T. M. Fredeking, W. E. Rote, G. P. Vlasuk, Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: A study in rhesus monkeys. Lancet 362, 1953-1958 (2003).
-
(2003)
Lancet
, vol.362
, pp. 1953-1958
-
-
Geisbert, T.W.1
Hensley, L.E.2
Jahrling, P.B.3
Larsen, T.4
Geisbert, J.B.5
Paragas, J.6
Young, H.A.7
Fredeking, T.M.8
Rote, W.E.9
Vlasuk, G.P.10
-
18
-
-
84876982494
-
Pathology of experimental aerosol Zaire ebolavirus infection in rhesus macaques
-
N. A. Twenhafel, M. E. Mattix, J. C. Johnson, C. G. Robinson, W. D. Pratt, K. A. Cashman, V. Wahl-Jensen, C. Terry, G. G. Olinger, L. E. Hensley, A. N. Honko, Pathology of experimental aerosol Zaire ebolavirus infection in rhesus macaques. Vet. Pathol. 50, 514-529 (2013).
-
(2013)
Vet. Pathol.
, vol.50
, pp. 514-529
-
-
Twenhafel, N.A.1
Mattix, M.E.2
Johnson, J.C.3
Robinson, C.G.4
Pratt, W.D.5
Cashman, K.A.6
Wahl-Jensen, V.7
Terry, C.8
Olinger, G.G.9
Hensley, L.E.10
Honko, A.N.11
-
19
-
-
56149115867
-
Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice
-
M. A. Croyle, A. Patel, K. N. Tran, M. Gray, Y. Zhang, J. E. Strong, H. Feldmann, G. P. Kobinger, Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice. PLoS One 3, e3548 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Croyle, M.A.1
Patel, A.2
Tran, K.N.3
Gray, M.4
Zhang, Y.5
Strong, J.E.6
Feldmann, H.7
Kobinger, G.P.8
-
20
-
-
84875525572
-
Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates
-
J. S. Richardson, S. Pillet, A. J. Bello, G. P. Kobinger, Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates. J. Virol. 87, 3668-3677 (2013).
-
(2013)
J. Virol.
, vol.87
, pp. 3668-3677
-
-
Richardson, J.S.1
Pillet, S.2
Bello, A.J.3
Kobinger, G.P.4
-
21
-
-
84868265780
-
Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates
-
G. Wong, J. S. Richardson, S. Pillet, A. Patel, X. Qiu, J. Alimonti, J. Hogan, Y. Zhang, A. Takada, H. Feldmann, G. P. Kobinger, Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates. Sci. Transl. Med. 4, 158ra146 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Wong, G.1
Richardson, J.S.2
Pillet, S.3
Patel, A.4
Qiu, X.5
Alimonti, J.6
Hogan, J.7
Zhang, Y.8
Takada, A.9
Feldmann, H.10
Kobinger, G.P.11
-
22
-
-
19344366513
-
Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever
-
M. Bray, T. W. Geisbert, Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever. Int. J. Biochem. Cell Biol. 37, 1560-1566 (2005).
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 1560-1566
-
-
Bray, M.1
Geisbert, T.W.2
-
23
-
-
38449101458
-
Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus
-
T. Larsen, E. L. Stevens, K. J. Davis, J. B. Geisbert, K. M. Daddario-DiCaprio, P. B. Jahrling, L. E. Hensley, T. W. Geisbert, Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus. J. Infect. Dis. 196 (Suppl. 2), S323-S328 (2007).
-
(2007)
J. Infect. Dis.
, vol.196
, Issue.SUPPL. 2
-
-
Larsen, T.1
Stevens, E.L.2
Davis, K.J.3
Geisbert, J.B.4
Daddario-DiCaprio, K.M.5
Jahrling, P.B.6
Hensley, L.E.7
Geisbert, T.W.8
-
24
-
-
12344273726
-
The blood-brain barrier: Bottleneck in brain drug development
-
W. M. Pardridge, The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2, 3-14 (2005).
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
25
-
-
79957452852
-
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
-
J. K. Atwal, Y. Chen, C. Chiu, D. L. Mortensen, W. J. Meilandt, Y. Liu, C. E. Heise, K. Hoyte, W. Luk, Y. Lu, K. Peng, P. Wu, L. Rouge, Y. Zhang, R. A. Lazarus, K. Scearce-Levie, W. Wang, Y. Wu, M. Tessier-Lavigne, R. J. Watts, A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Sci. Transl. Med. 3, 84ra43 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Atwal, J.K.1
Chen, Y.2
Chiu, C.3
Mortensen, D.L.4
Meilandt, W.J.5
Liu, Y.6
Heise, C.E.7
Hoyte, K.8
Luk, W.9
Lu, Y.10
Peng, K.11
Wu, P.12
Rouge, L.13
Zhang, Y.14
Lazarus, R.A.15
Scearce-Levie, K.16
Wang, W.17
Wu, Y.18
Tessier-Lavigne, M.19
Watts, R.J.20
more..
-
26
-
-
4544228226
-
Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels
-
A. Sanchez, M. Lukwiya, D. Bausch, S. Mahanty, A. J. Sanchez, K. D. Wagoner, P. E. Rollin, Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels. J. Virol. 78, 10370-10377 (2004).
-
(2004)
J. Virol.
, vol.78
, pp. 10370-10377
-
-
Sanchez, A.1
Lukwiya, M.2
Bausch, D.3
Mahanty, S.4
Sanchez, A.J.5
Wagoner, K.D.6
Rollin, P.E.7
-
27
-
-
0033066490
-
Evaluation of immune globulin and recombinant interferon-α2b for treatment of experimental Ebola virus infections
-
P. B. Jahrling, T. W. Geisbert, J. B. Geisbert, J. R. Swearengen, M. Bray, N. K. Jaax, J. W. Huggins, J. W. LeDuc, C. J. Peters, Evaluation of immune globulin and recombinant interferon-α2b for treatment of experimental Ebola virus infections. J. Infect. Dis. 179 (Suppl. 1), S224-S234 (1999).
-
(1999)
J. Infect. Dis.
, vol.179
, Issue.SUPPL. 1
-
-
Jahrling, P.B.1
Geisbert, T.W.2
Geisbert, J.B.3
Swearengen, J.R.4
Bray, M.5
Jaax, N.K.6
Huggins, J.W.7
LeDuc, J.W.8
Peters, C.J.9
-
28
-
-
80054837546
-
Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies
-
X. Qiu, J. B. Alimonti, P. L. Melito, L. Fernando, U. Ströher, S. M. Jones, Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies. Clin. Immunol. 141, 218-227 (2011).
-
(2011)
Clin. Immunol.
, vol.141
, pp. 218-227
-
-
Qiu, X.1
Alimonti, J.B.2
Melito, P.L.3
Fernando, L.4
Ströher, U.5
Jones, S.M.6
-
29
-
-
84859206023
-
Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection
-
X. Qiu, L. Fernando, P. L. Melito, J. Audet, H. Feldmann, G. Kobinger, J. B. Alimonti, S. M. Jones, Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection. PLoS Negl. Trop. Dis. 6, e1575 (2012).
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
-
-
Qiu, X.1
Fernando, L.2
Melito, P.L.3
Audet, J.4
Feldmann, H.5
Kobinger, G.6
Alimonti, J.B.7
Jones, S.M.8
-
30
-
-
65849373288
-
Mucosal immunization of cynomolgus macaques with the VSVD G/ZEBOVGP vaccine stimulates strong Ebola GP-specific immune responses
-
X. Qiu, L. Fernando, J. B. Alimonti, P. L. Melito, F. Feldmann, D. Dick, U. Ströher, H. Feldmann, S. M. Jones, Mucosal immunization of cynomolgus macaques with the VSVD G/ZEBOVGP vaccine stimulates strong Ebola GP-specific immune responses. PLoS One 4, e5547 (2009).
-
(2009)
PLoS One
, vol.4
-
-
Qiu, X.1
Fernando, L.2
Alimonti, J.B.3
Melito, P.L.4
Feldmann, F.5
Dick, D.6
Ströher, U.7
Feldmann, H.8
Jones, S.M.9
-
31
-
-
33745158157
-
A simple method of estimating fifty per cent endpoints
-
L. J. Reed, H. Muench, A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27, 493-497 (1938).
-
(1938)
Am. J. Hyg.
, vol.27
, pp. 493-497
-
-
Reed, L.J.1
Muench, H.2
-
32
-
-
0024444791
-
Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA
-
U. Edwards, T. Rogall, H. Blöcker, M. Emde, E. C. Böttger, Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acids Res. 17, 7843-7853 (1989).
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 7843-7853
-
-
Edwards, U.1
Rogall, T.2
Blöcker, H.3
Emde, M.4
Böttger, E.C.5
|