Liquid formulations for stabilizing IgMs during physical stress and long-term storage

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 735-750

  Mueller, Monika ^a   Loh, Maybelle Q T ^a   Tscheliessnig, Rupert ^b,c   Tee, Doris H Y ^a   Tan, Eddy ^a   Bardor, Muriel ^a   Jungbauer, Alois ^c,d  

^a AGENCY FOR SCIENCE   (Singapore)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^d UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

conformational stability; DSC; formulation; IgM; protein aggregation

Indexed keywords

GLYCINE; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14; MONOCLONAL ANTIBODY 432; MONOCLONAL ANTIBODY 5; MONOCLONAL ANTIBODY 529; MONOCLONAL ANTIBODY 63; MONOCLONAL ANTIBODY 84; MONOCLONAL ANTIBODY 85; MONOCLONAL ANTIBODY 95; SORBITOL; SUCROSE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CONFORMATION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FLUORESCENCE ACTIVATED CELL SORTING; FRAGMENTATION REACTION; FREEZE THAWING; GEL PERMEATION CHROMATOGRAPHY; IMMUNOGLOBULIN AGGREGATE; IMMUNOREACTIVITY; ISOELECTRIC POINT; LIQUID; MOUSE; NONHUMAN; PH; PHYSICAL STRESS; PRIORITY JOURNAL; SHEAR STRESS; STRUCTURE ANALYSIS; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; DRUG STORAGE; EXCIPIENTS; GLYCINE; IMMUNOGLOBULIN M; MICE; PROTEIN CONFORMATION; PROTEIN STABILITY; SCATTERING, SMALL ANGLE; SORBITOL; SUCROSE; X-RAY DIFFRACTION;

EID: 84878865779     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0914-2     Document Type: Article

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