Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 16, 2016, Pages 4524-4529

  Bradley, Sophie J ^a,b   Wiegman, Coen H ^c   Iglesias, Max Maza ^a   Kong, Kok Choi ^d   Butcher, Adrian J ^a,b   Plouffe, Bianca ^e   Goupil, Eugénie ^f   Bourgognon, Julie Myrtille ^a   Macedo Hatch, Timothy ^a   Legouill, Christian ^e   Russell, Kirsty ^c   Laporte, Stéphane A ^f   König, Gabriele M ^g   Kostenis, Evi ^g   Bouvier, Michel ^e   Chung, Kian Fan ^c   Amrani, Yassine ^a   Tobin, Andrew B ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d UNIVERSITY OF BRIGHTON   (United Kingdom)

^e INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^f MCGILL UNIVERSITY   (Canada)

^g UNIVERSITY OF BONN   (Germany)

Author keywords

Asthma; G protein coupled receptor; Ligand bias; Muscarinic; Signaling

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M3 RECEPTOR;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOCONSTRICTION; BRONCHUS MUSCLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; GENETICALLY ENGINEERED MOUSE STRAIN; LUNG FUNCTION; LUNG RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT ALLERGY; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; ANIMAL; BRONCHUS; CYTOLOGY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SMOOTH MUSCLE;

ANIMALS; BRONCHI; HUMANS; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH; PHOSPHORYLATION; RECEPTOR, MUSCARINIC M3; SIGNAL TRANSDUCTION;

EID: 84964355260     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1521706113     Document Type: Article

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