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Volumn 285, Issue 1 29-1, 2003, Pages

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Author keywords

G protein; Gene knockout mice

Indexed keywords

ALLERGEN; GUANINE NUCLEOTIDE BINDING PROTEIN; IRRITANT AGENT; METHACHOLINE; MUSCARINIC RECEPTOR; OVALBUMIN;

EID: 17344385550     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00322.2002     Document Type: Article
Times cited : (18)

References (44)
  • 1
    • 0027509977 scopus 로고
    • Muscarinic receptor subtypes in airways
    • Barnes PJ. Muscarinic receptor subtypes in airways. Life Sci 52: 521-527, 1993.
    • (1993) Life Sci , vol.52 , pp. 521-527
    • Barnes, P.J.1
  • 2
    • 0029014409 scopus 로고
    • Nitric oxide and airway disease
    • Barnes PJ. Nitric oxide and airway disease. Ann Med 27: 389-393, 1995.
    • (1995) Ann Med , vol.27 , pp. 389-393
    • Barnes, P.J.1
  • 6
    • 0027208248 scopus 로고
    • Muscarinic receptors - Characterization, coupling and function
    • Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 58: 319-379, 1993.
    • (1993) Pharmacol Ther , vol.58 , pp. 319-379
    • Caulfield, M.P.1
  • 7
    • 0026741825 scopus 로고
    • Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs
    • Eason MG, Kurose H, Holt BD, Raymond JR, and Liggett SB. Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. J Biol Chem 267: 15795-15801, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 15795-15801
    • Eason, M.G.1    Kurose, H.2    Holt, B.D.3    Raymond, J.R.4    Liggett, S.B.5
  • 8
    • 0030442725 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes and smooth muscle function
    • Eglen RM, Hegde SS, and Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48: 531-565, 1996.
    • (1996) Pharmacol Rev , vol.48 , pp. 531-565
    • Eglen, R.M.1    Hegde, S.S.2    Watson, N.3
  • 12
    • 0024467177 scopus 로고
    • Cholinergic bronchomotor tone in COPD. Estimates of its amount in comparison with that in normal subjects
    • Gross NJ, Co E, and Skorodin MS. Cholinergic bronchomotor tone in COPD. Estimates of its amount in comparison with that in normal subjects. Chest 96: 984-987, 1989.
    • (1989) Chest , vol.96 , pp. 984-987
    • Gross, N.J.1    Co, E.2    Skorodin, M.S.3
  • 13
    • 0024400242 scopus 로고
    • Dose response to ipratropium as a nebulized solution in patients with chronic obstructive pulmonary disease. A three-center study
    • Gross NJ, Petty TL, Friedman M, Skorodin MS, Silvers GW, and Donohue JF. Dose response to ipratropium as a nebulized solution in patients with chronic obstructive pulmonary disease. A three-center study. Am Rev Respir Dis 139: 1188-1191, 1989.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 1188-1191
    • Gross, N.J.1    Petty, T.L.2    Friedman, M.3    Skorodin, M.S.4    Silvers, G.W.5    Donohue, J.F.6
  • 16
    • 0028058845 scopus 로고
    • Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells
    • Hepler JR, Kozasa T, and Gilman AG. Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells. Methods Enzymol 237: 191-212, 1994.
    • (1994) Methods Enzymol , vol.237 , pp. 191-212
    • Hepler, J.R.1    Kozasa, T.2    Gilman, A.G.3
  • 18
    • 0032829733 scopus 로고    scopus 로고
    • Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle
    • Kao J, Fortner CN, Liu LH, Shull GE, and Paul RJ. Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol 277: L264-L270, 1999.
    • (1999) Am J Physiol Lung Cell Mol Physiol , vol.277
    • Kao, J.1    Fortner, C.N.2    Liu, L.H.3    Shull, G.E.4    Paul, R.J.5
  • 19
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G12/G13 results in shape change and Rho/Rhokinase-mediated myosin light chain phosphorylation in mouse platelets
    • Klages B, Brandt U, Simon MI, Schultz G, and Offermanns S. Activation of G12/G13 results in shape change and Rho/Rhokinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144: 745-754, 1999.
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 20
    • 0024476743 scopus 로고
    • The role of pirenzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans
    • Lammers JW, Minette P, McCusker M, and Barnes PJ. The role of pirenzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis 139: 446-449, 1989.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 446-449
    • Lammers, J.W.1    Minette, P.2    McCusker, M.3    Barnes, P.J.4
  • 21
    • 0027120839 scopus 로고
    • Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes
    • Lee CH, Park D, Wu D, Rhee SG, and Simon MI. Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes. J Biol Chem 267: 16044-16047, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 16044-16047
    • Lee, C.H.1    Park, D.2    Wu, D.3    Rhee, S.G.4    Simon, M.I.5
  • 22
    • 0034995829 scopus 로고    scopus 로고
    • Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?
    • Lee NA, Gelfand EW, and Lee JJ. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J Allergy Clin Immunol 107: 945-957, 2001.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 945-957
    • Lee, N.A.1    Gelfand, E.W.2    Lee, J.J.3
  • 23
    • 0024414345 scopus 로고
    • Autosomal recessive inheritance of airway reactivity to 5-hydroxytryptamine
    • Levitt RC and Mitzner W. Autosomal recessive inheritance of airway reactivity to 5-hydroxytryptamine. J Appl Physiol 67: 1125-1132, 1989.
    • (1989) J Appl Physiol , vol.67 , pp. 1125-1132
    • Levitt, R.C.1    Mitzner, W.2
  • 24
    • 0014062847 scopus 로고
    • Resistance of central and peripheral airways measured by a retrograde catheter
    • Macklem PT and Mead J. Resistance of central and peripheral airways measured by a retrograde catheter. J Appl Physiol 22: 395-401, 1967.
    • (1967) J Appl Physiol , vol.22 , pp. 395-401
    • Macklem, P.T.1    Mead, J.2
  • 28
    • 0028988310 scopus 로고
    • Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system
    • Nakamura F, Kato M, Kameyama K, Nukada T, Haga T, Kato H, Takenawa T, and Kikkawa U. Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system. J Biol Chem 270: 6246-6253, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 6246-6253
    • Nakamura, F.1    Kato, M.2    Kameyama, K.3    Nukada, T.4    Haga, T.5    Kato, H.6    Takenawa, T.7    Kikkawa, U.8
  • 29
    • 0029993821 scopus 로고    scopus 로고
    • Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma
    • O'Connor BJ, Towse LJ, and Barnes PJ. Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma. Am J Respir Crit Care Med 154: 876-880, 1996.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 876-880
    • O'Connor, B.J.1    Towse, L.J.2    Barnes, P.J.3
  • 31
    • 0032480009 scopus 로고    scopus 로고
    • Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice
    • Offermanns S, Zhao LP, Gohla A, Sarosi I, Simon MI, and Wilkie TM. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J 17: 4304-4312, 1998.
    • (1998) EMBO J , vol.17 , pp. 4304-4312
    • Offermanns, S.1    Zhao, L.P.2    Gohla, A.3    Sarosi, I.4    Simon, M.I.5    Wilkie, T.M.6
  • 32
    • 0025191514 scopus 로고
    • Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle
    • Roffel AF, Elzinga CR, and Zaagsma J. Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle. Pulm Pharmacol 3: 47-51, 1990.
    • (1990) Pulm Pharmacol , vol.3 , pp. 47-51
    • Roffel, A.F.1    Elzinga, C.R.2    Zaagsma, J.3
  • 33
    • 0242570882 scopus 로고    scopus 로고
    • The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling
    • Rumenapp U, Asmus M, Schablowski H, Woznicki M, Han L, Jakobs KH, Fahimi-Vahid M, Michalek C, Wieland T, and Schmidt M. The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. J Biol Chem 276: 2474-2479, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 2474-2479
    • Rumenapp, U.1    Asmus, M.2    Schablowski, H.3    Woznicki, M.4    Han, L.5    Jakobs, K.H.6    Fahimi-Vahid, M.7    Michalek, C.8    Wieland, T.9    Schmidt, M.10
  • 34
    • 0025674079 scopus 로고
    • Clinical dysautonomia in patients with bronchial asthma. Study with seven autonomic function tests
    • Shah PK, Lakhotia M, Mehta S, Jain SK, and Gupta GL. Clinical dysautonomia in patients with bronchial asthma. Study with seven autonomic function tests. Chest 98: 1408-1413, 1990.
    • (1990) Chest , vol.98 , pp. 1408-1413
    • Shah, P.K.1    Lakhotia, M.2    Mehta, S.3    Jain, S.K.4    Gupta, G.L.5
  • 35
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP and Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
    • (2000) J Physiol , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 36
    • 0034885812 scopus 로고    scopus 로고
    • Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung
    • Takeda K, Haczku A, Lee JJ, Irvin CG, and Gelfand EW. Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung. Am J Physiol Lung Cell Mol Physiol 281: L394-L402, 2001.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Takeda, K.1    Haczku, A.2    Lee, J.J.3    Irvin, C.G.4    Gelfand, E.W.5
  • 38
    • 0035166852 scopus 로고    scopus 로고
    • Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes
    • Wettschureck N, Rutten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, and Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med 7: 1236-1240, 2001.
    • (2001) Nat Med , vol.7 , pp. 1236-1240
    • Wettschureck, N.1    Rutten, H.2    Zywietz, A.3    Gehring, D.4    Wilkie, T.M.5    Chen, J.6    Chien, K.R.7    Offermanns, S.8
  • 40
    • 0025836752 scopus 로고
    • Characterization of G-protein alpha subunits in the Gq class: Expression in murine tissues and in stromal and hematopoietic cell lines
    • Wilkie TM, Scherle PA, Strathmann MP, Slepak VZ, and Simon MI. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc Natl Acad Sci USA 88: 10049-10053, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10049-10053
    • Wilkie, T.M.1    Scherle, P.A.2    Strathmann, M.P.3    Slepak, V.Z.4    Simon, M.I.5
  • 41
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 17: 255-281, 1999.
    • (1999) Annu Rev Immunol , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 44
    • 0035830825 scopus 로고    scopus 로고
    • Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. Involvement of Gq but not G11
    • Zywietz A, Gohla A, Schmelz M, Schultz G, and Offermanns S. Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. Involvement of Gq but not G11. J Biol Chem 276: 3840-3845, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 3840-3845
    • Zywietz, A.1    Gohla, A.2    Schmelz, M.3    Schultz, G.4    Offermanns, S.5


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