M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 49, 2010, Pages 21181-21186

  Kong, Kok Choi ^a   Butcher, Adrian J ^a   McWilliams, Phillip ^a   Jones, David ^b   Wess, Jürgen ^c   Hamdan, Fadi F ^d   Werry, Tim ^e   Rosethorne, Elizabeth M ^f   Charlton, Steven J ^f   Munson, Sarah E ^g   Cragg, Hannah A ^h   Smart, Alison D ^h   Tobin, Andrew B ^a  

^a Department of Cell Physiology and Pharmacology ^*  (United Kingdom)

^b Biomedical Joint Workshop   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF MONTREAL   (Canada)

^e GLAXOSMITHKLINE   (United Kingdom)

^f NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^g Geneta Centre for Core Biotechnology Services   (United Kingdom)

^h UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

G protein coupled receptor; Ligand bias

Indexed keywords

INSULIN; MUSCARINIC M3 RECEPTOR; MUTANT PROTEIN; PROTEIN KINASE D; PROTEIN KINASE D1; RETINA S ANTIGEN; UNCLASSIFIED DRUG; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GLUCOSE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE HOMEOSTASIS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; ANIMAL; GENETICS; HOMEOSTASIS; METABOLISM; PANCREAS ISLET; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; SECRETION; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; ARRESTINS; ENZYME ACTIVATION; GLUCOSE; HOMEOSTASIS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, MUTANT STRAINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN TRANSPORT; RECEPTOR, MUSCARINIC M3; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 78650508127     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011651107     Document Type: Article

References (29)

1. Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639-650.
2. Premont RT, Gainetdinov RR (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69:511-534.
3. Tobin AB, Butcher AJ, Kong KC (2008) Location, location, location. Site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci 29:413-420.
4. Bockaert J, et al. (2004) GPCR-interacting proteins (GIPs): Nature and functions. Biochem Soc Trans 32:851-855.
5. Kreienkamp HJ (2002) Organisation of G-protein-coupled receptor signalling complexes by scaffolding proteins. Curr Opin Pharmacol 2:581-586.
6. Lefkowitz RJ, Rajagopal K, Whalen EJ (2006) New roles for beta-arrestins in cell signaling: Not just for seven-transmembrane receptors. Mol Cell 24:643-652.
7. Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17(4):159-165.
8. Caulfield MP (1993) Muscarinic receptors-Characterization, coupling and function. Pharmacol Ther 58:319-379.
9. Wess J, Eglen RM, Gautam D (2007) Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721-733.
10. Budd DC, McDonald JE, Tobin AB (2000) Phosphorylation and regulation of a Gq/11- coupled receptor by casein kinase 1alpha. J Biol Chem 275:19667-19675.
11. Luo J, Busillo JM, Benovic JL (2008) M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol Pharmacol 74:338-347.
12. Torrecilla I, et al. (2007) Phosphorylation and regulation of a G protein-coupled receptor by protein kinase CK2. J Cell Biol 177(1):127-137.
13. Willets JM, Challiss RA, Nahorski SR (2002) Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. J Biol Chem 277:15523-15529.
14. Poulin B, et al. (2010) TheM3-muscarinic receptor regulates learning andmemory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci USA 107:9440-9445.
15. Ahrén B (2000) Autonomic regulation of islet hormone secretion-Implications for health and disease. Diabetologia 43:393-410.
16. Gautam D, et al. (2007) Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis. Diabetes Obes Metab 9 (Suppl 2):158-169.
17. GautamD, et al. (2006) Acritical role for beta cellM3muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab 3:449-461.
18. DuttaroyA, et al. (2004) Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes 53:1714-1720.
19. Sumara G, et al. (2009) Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136:235-248.
20. Oancea E, Bezzerides VJ, Greka A, Clapham DE (2003) Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell 4:561-574.
21. Wang QJ (2006) PKD at the crossroads of DAG and PKC signaling. Trends Pharmacol Sci 27:317-323.
22. Rybin VO, Guo J, Steinberg SF (2009) Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916. J Biol Chem 284:2332-2343.
23. Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci 28:416-422.
24. Gilon P, Henquin JC (2001) Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev 22:565-604.
25. Gromada J, Hughes TE (2006) Ringing the dinner bell for insulin: Muscarinic M3 receptor activity in the control of pancreatic beta cell function. Cell Metab 3:390-392.
26. Xiao K, et al. (2007) Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci USA 104:12011-12016.
27. Sonoda N, et al. (2008) Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Proc Natl Acad SciUSA105:6614-6619.
28. Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seventransmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9:1540-1553.
29. Davalli AM, et al. (1995) Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 44(1):104-111.