Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFα and IL-13

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Amrani, Yassine ^b,d   Syed, Farhat ^a   Huang, Chris ^a   Li, Katherine ^a   Liu, Veronica ^a   Jain, Deepika ^b   Keslacy, Stefan ^b   Sims, Michael W ^b   Baidouri, Hasna ^b   Cooper, Philip R ^b   Zhao, Hengjiang ^b   Siddiqui, Salman ^d   Brightling, Christopher E ^d   Griswold, Don ^a   Li, Lily ^c   Panettieri Jr, Reynold A ^b  

^a CENTOCOR INC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Therakos   (United States)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FURA 2; INTERLEUKIN 13; OXYTOCIN; OXYTOCIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; BRONCHODILATING AGENT; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; ASTHMA; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL CULTURE; CONTROLLED STUDY; CYTOSOL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUOROMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; LUNG LAVAGE; LUNG SLICE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; TRACHEA; ADULT; ANIMAL; BAGG ALBINO MOUSE; BRONCHOSPASM; CASE CONTROL STUDY; CHEMISTRY; DRUG EFFECT; FORCED EXPIRATORY VOLUME; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; UPREGULATION; VITAL CAPACITY;

ADULT; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; CALCIUM SIGNALING; CASE-CONTROL STUDIES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUOROMETRY; FORCED EXPIRATORY VOLUME; HUMANS; INTERLEUKIN-13; LUNG; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; OXYTOCIN; RECEPTORS, OXYTOCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VITAL CAPACITY; YOUNG ADULT;

EID: 77956696825     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-104     Document Type: Article

References (56)

1. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001, 81(2):629-683.
2. Kimura T, Takemura M, Nomura S, Nobunaga T, Kubota Y, Inoue T, Hashimoto K, Kumazawa I, Ito Y, Ohashi K, et al. Expression of oxytocin receptor in human pregnant myometrium. Endocrinology 1996, 137(2):780-785. 10.1210/en.137.2.780, 8593830.
3. Barone F, Genazzani AA, Conti A, Churchill GC, Palombi F, Ziparo E, Sorrentino V, Galione A, Filippini A. A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells. Faseb J 2002, 16(7):697-705. 10.1096/fj.01-0749com, 11978734.
4. Holgate ST. The epidemic of allergy and asthma. Nature 1999, 402(6760 Suppl):B2-4. 10.1038/35037000, 10586888.
5. Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 2008, 8(3):183-192. 10.1038/nri2254, 18274560.
6. Lukacs NW, Strieter RM, Chensue SW, Widmer M, Kunkel SL. TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation. J Immunol 1995, 154(10):5411-5417.
7. Busse WW, Coffman RL, Gelfand EW, Kay AB, Rosenwasser LJ. Mechanisms of persistent airway inflammation in asthma. A role for T cells and T-cell products. Am J Respir Crit Care Med 1995, 152(1):388-393.
8. Murphy VE, Gibson P, Talbot PI, Clifton VL. Severe asthma exacerbations during pregnancy. Obstet Gynecol 2005, 106(5 Pt 1):1046-1054. 10.1097/01.AOG.0000185281.21716.02, 16260524.
9. Murphy VE, Gibson PG, Smith R, Clifton VL. Asthma during pregnancy: mechanisms and treatment implications. Eur Respir J 2005, 25(4):731-750. 10.1183/09031936.05.00085704, 15802351.
10. Barr RG, Wentowski CC, Grodstein F, Somers SC, Stampfer MJ, Schwartz J, Speizer FE, Camargo CA. Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease. Arch Intern Med 2004, 164(4):379-386. 10.1001/archinte.164.4.379, 14980988.
11. Troisi RJ, Speizer FE, Willett WC, Trichopoulos D, Rosner B. Menopause, postmenopausal estrogen preparations, and the risk of adult-onset asthma. A prospective cohort study. Am J Respir Crit Care Med 1995, 152(4 Pt 1):1183-1188.
12. Townsend EA, Thompson MA, Pabelick CM, Prakash YS. Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 298(4):L521-530. 10.1152/ajplung.00287.2009, 20097735.
13. Jankowski M, Bissonauth V, Gao L, Gangal M, Wang D, Danalache B, Wang Y, Stoyanova E, Cloutier G, Blaise G, et al. Anti-inflammatory effect of oxytocin in rat myocardial infarction. Basic Res Cardiol 105(2):205-218. 10.1007/s00395-009-0076-5, 20012748.
14. Nation DA, Szeto A, Mendez AJ, Brooks LG, Zaias J, Herderick EE, Gonzales J, Noller CM, Schneiderman N, McCabe PM. Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice. Psychosom Med 72(4):376-382. 10.1097/PSY.0b013e3181d74c48, 20368478.
15. Biyikli NK, Tugtepe H, Sener G, Velioglu-Ogunc A, Cetinel S, Midillioglu S, Gedik N, Yegen BC. Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism. Peptides 2006, 27(9):2249-2257. 10.1016/j.peptides.2006.03.029, 16707192.
16. Pequeux C, Breton C, Hagelstein MT, Geenen V, Legros JJ. Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung. Lung Cancer 2005, 50(2):177-188. 10.1016/j.lungcan.2005.05.027, 16043261.
17. Hirst S. Airway smooth muscle as a target in asthma. Clin Exp Allergy 2000, 30(1):54-59. 10.1046/j.1365-2222.30.s1.1.x, 10849477.
18. Halayko AJ, Amrani Y. Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma. Respir Physiol Neurobiol 2003, 137(2-3):209-222. 10.1016/S1569-9048(03)00148-4, 14516727.
19. Amrani Y, Tliba O, Deshpande DA, Walseth TF, Kannan MS, Panettieri RA. Bronchial hyperresponsiveness: insights into new signaling molecules. Curr Opin Pharmacol 2004, 4(3):230-234. 10.1016/j.coph.2004.02.004, 15140413.
20. Thompson M, Barata da Silva H, Zielinska W, White TA, Bailey JP, Lund FE, Sieck GC, Chini EN. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab 2004, 287(6):E1142-1148. 10.1152/ajpendo.00122.2004, 15339743.
21. Amrani Y. Airway smooth muscle modulation and airway hyper-responsiveness in asthma: new cellular and molecular paradigms. Exp Rev Clin Immunol 2006, 2:353-364.
22. Amrani Y. TNF-alpha and calcium signaling in airway smooth muscle cells: a never-ending story with promising therapeutic relevance. Am J Respir Cell Mol Biol 2007, 36(3):387-388.
23. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003, 9(5):582-588. 10.1038/nm851, 12669034.
24. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998, 282(5397):2261-2263. 10.1126/science.282.5397.2261, 9856950.
25. Venkayya R, Lam M, Willkom M, Grunig G, Corry DB, Erle DJ. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 2002, 26(2):202-208.
26. Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, Umetsu DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001, 167(8):4668-4675.
27. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998, 282(5397):2258-2261. 10.1126/science.282.5397.2258, 9856949.
28. Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, von Mutius E, Martinez FD. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000, 105(3):506-513. 10.1067/mai.2000.104940, 10719301.
29. Amrani Y, Lazaar AL, Panettieri RA. Up-Regulation of ICAM-1 by Cytokines in Human Tracheal Smooth Muscle Cells Involves an NF-{kappa}B-Dependent Signaling Pathway That Is Only Partially Sensitive to Dexamethasone. J Immunol 1999, 163(4):2128-2134.
30. Amrani Y, Magnier C, Enouf J, Wuytack F, Bronner C. Ca2+ increase and Ca(2+)- influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)- ATPase 2 isoform. Br J Pharmacol 1995, 115(7):1204-1210. 1908784, 7582546.
31. Amrani Y, Krymskaya V, Maki C, Panettieri RA. Mechanisms underlying TNF-alpha effects on agonist-mediated calcium homeostasis in human airway smooth muscle cells. Am J Physiol 1997, 273(5):L1020-1028.
32. Chen H, Tliba O, Van Besien CR, Panettieri RA, Amrani Y. Selected Contribution: TNF-{alpha} modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. J Appl Physiol 2003, 95(2):864-872.
33. Kim JH, Jain D, Tliba O, Yang B, Jester WF, Panettieri RA, Amrani Y, Pure E. TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung Cell Mol Physiol 2005, 289(4):L511-520. 10.1152/ajplung.00027.2005, 15923209.
34. Tliba O, Deshpande D, Van Besien C, Chen H, Kannan M, Panettieri RA, Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 2003, 140:1159-1162. 10.1038/sj.bjp.0705558, 1574143, 14597600.
35. Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, Panettieri RA, Haczku A, Amrani Y. Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness. Immunobiology 2008, 213(6):499-509. 10.1016/j.imbio.2007.12.002, 2587232, 18514752.
36. Cooper PR, Panettieri RA. Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol 2008, 122(4):734-740. 10.1016/j.jaci.2008.07.040, 18774166.
37. Cooper PR, Poll CT, Barnes PJ, Sturton RG. Involvement of IL-13 in Tobacco Smoke Induced Changes in the Structure and Function of Rat Intrapulmonary Airways. Am J Respir Cell Mol Biol 2009,
38. Almqvist C, Worm M, Leynaert B. Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 2008, 63(1):47-57.
39. Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, Brightling CE, Busse WW, Castro M, Dahlen B, et al. Severe asthma in adults: what are the important questions?. J Allergy Clin Immunol 2007, 119(6):1337-1348. 10.1016/j.jaci.2006.11.702, 17416409.
40. Bai Y, Zhang M, Sanderson MJ. Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol 2007, 36(1):122-130. 10.1165/rcmb.2006-0036OC, 1899303, 16931808.
41. Bergner A, Sanderson MJ. Airway contractility and smooth muscle Ca(2+) signaling in lung slices from different mouse strains. J Appl Physiol 2003, 95(3):1325-1332.
42. Kimura T, Saji F, Nishimori K, Ogita K, Nakamura H, Koyama M, Murata Y. Molecular regulation of the oxytocin receptor in peripheral organs. J Mol Endocrinol 2003, 30(2):109-115. 10.1677/jme.0.0300109, 12683935.
43. Zingg HH, Laporte SA. The oxytocin receptor. Trends Endocrinol Metab 2003, 14(5):222-227. 10.1016/S1043-2760(03)00080-8, 12826328.
44. Helmer H, Tretzmuller U, Brunbauer M, Kaider A, Husslein P, Knofler M. Production of oxytocin receptor and cytokines in primary uterine smooth muscle cells cultivated under inflammatory conditions. J Soc Gynecol Investig 2002, 9(1):15-21. 10.1016/S1071-5576(01)00142-3, 11839503.
45. Schmid B, Wong S, Mitchell BF. Transcriptional regulation of oxytocin receptor by interleukin-1beta and interleukin-6. Endocrinology 2001, 142(4):1380-1385. 10.1210/en.142.4.1380, 11250916.
46. Jeng YJ, Soloff SL, Anderson GD, Soloff MS. Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. Endocrinology 2003, 144(1):61-68. 10.1210/en.2002-220636, 12488330.
47. Amrani Y, Panettieri RA. Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma. Curr Opin Allergy Clin Immunol 2002, 2(1):39-45. 10.1097/00130832-200202000-00007, 11964749.
48. Deshpande DA, Dogan S, Walseth TF, Miller SM, Amrani Y, Panettieri J, Reynold A, Kannan MS. Modulation of calcium signaling by IL-13 in human airway smooth muscle: role of CD38/cADPR pathway. Am J Respir Cell Mol Biol 2004, 2003-0313OC.
49. Hsu Y, Chiu C, Wang C, Chien C, Luo S, Hsiao L, Liang K, Yang C. Tumour necrosis factor-alpha enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells. Cell Signal 2001, 13(9):633-643. 10.1016/S0898-6568(01)00182-6, 11495721.
50. Yang C, Chien C, Wang C, Hsu Y, Chiu C, Lin C, Luo S, Hsiao L. Interleukin- 1beta enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway. Biochem J 2001, 354(2):439-446. 10.1042/0264-6021:3540439, 1221673, 11171124.
51. Hotta K, Emala CW, Hirshman CA. TNF-alpha upregulates Gialpha and Gqalpha protein expression and function in human airway smooth muscle cells. Am J Physiol 1999, 276(3 Pt 1):L405-L411.
52. Amrani Y, Martinet N, Bronner C. Potentiation by tumour necrosis factor-alpha of calcium signals induced by bradykinin and carbachol in human tracheal smooth muscle cells. Br J Pharmacol 1995, 114(1):4-5. 1510165, 7712026.
53. Deshpande DA, Walseth TF, Panettieri RA, Kannan MS. CD38-cyclic ADP ribosemediated Ca2+ signaling contributes to airway smooth muscle hyperresponsiveness. Faseb J 2003, FASEB Journal Express Article 10.1096/fj.1002-0450fje.
54. Deshpande DA, White TA, Guedes AG, Milla C, Walseth TF, Lund FE, Kannan MS. Altered Airway Responsiveness in CD38-Deficient Mice. Am J Respir Cell Mol Biol 2005, 32(2):149-156. 10.1165/rcmb.2004-0243OC, 15557017.
55. Tliba O, Cidlowski JA, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol Pharmacol 2006, 69(2):588-596. 10.1124/mol.105.019679, 16291871.
56. Tliba O, Panettieri RA, Tliba S, Walseth TF, Amrani Y. Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway. Mol Pharmacol 2004, 66(2):322-329. 10.1124/mol.104.001040, 15266023.