The influence of bile salts on the distribution of simvastatin in the octanol/buffer system

Drug Development and Industrial Pharmacy

Volumn 42, Issue 4, 2016, Pages 661-667

  Danić, Maja ^a   Pavlović, Nebojša ^a   Stanimirov, Bojan ^a   Vukmirović, Saša ^a   Nikolić, Katarina ^b   Agbaba, Danica ^b   Mikov, Momir ^a,c  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c CURTIN UNIVERSITY   (Australia)

Author keywords

Bile salts; Distribution coefficient; Drug transport; Hydrophilicity; Simvastatin

Indexed keywords

12 MONOKETOCHOLIC ACID; BILE SALT; BUFFER; CHOLIC ACID; CHOLIC ACID DERIVATIVE; DEOXYCHOLIC ACID; HYDROXYACID; LACTONE; OCTANOL; SIMVASTATIN; SODIUM; UNCLASSIFIED DRUG; WATER; BILE ACID; HYPOCHOLESTEROLEMIC AGENT;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; PARTITION COEFFICIENT; PH; PHARMACOKINETIC PARAMETERS; PHYSICAL CHEMISTRY; CHEMISTRY; METABOLISM; SOLUBILITY;

ANTICHOLESTEREMIC AGENTS; BILE ACIDS AND SALTS; BUFFERS; OCTANOLS; SIMVASTATIN; SOLUBILITY;

EID: 84964344080     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2015.1067626     Document Type: Article

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