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Volumn 7, Issue , 2016, Pages

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALKALINE PHOSPHATASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ERYTHROMYCIN; GAMMA SECRETASE INHIBITOR; GLUCOSE; INSULIN; NEUROGENIN 3; PRISTINAMYCIN; TETRACYCLINE; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; VANA 1 PROTEIN; VANILLIC ACID; YELLOW FLUORESCENT PROTEIN; TRANSCRIPTION FACTOR;

EID: 84964335447     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11247     Document Type: Article
Times cited : (106)

References (70)
  • 1
    • 14244266611 scopus 로고    scopus 로고
    • Minireview: Transcriptional regulation in pancreatic development
    • Habener, J. F., Kemp, D. M. and Thomas, M. K. Minireview: transcriptional regulation in pancreatic development. Endocrinology 146, 1025-1034 (2005).
    • (2005) Endocrinology , vol.146 , pp. 1025-1034
    • Habener, J.F.1    Kemp, D.M.2    Thomas, M.K.3
  • 2
    • 84899800252 scopus 로고    scopus 로고
    • In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes
    • Li, W. et al. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. eLife 3, e01846 (2014).
    • (2014) ELife , vol.3 , pp. e01846
    • Li, W.1
  • 3
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. and Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 (2008).
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 4
    • 84897030116 scopus 로고    scopus 로고
    • De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts
    • Chen, Y. J. et al. De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep. 6, 1046-1058 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 1046-1058
    • Chen, Y.J.1
  • 5
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371, 606-609 (1994).
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 6
    • 0031253820 scopus 로고    scopus 로고
    • Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
    • Stoffers, D. A., Ferrer, J., Clarke, W. L. and Habener, J. F. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nature Genet. 17, 138-139 (1997).
    • (1997) Nature Genet. , vol.17 , pp. 138-139
    • Stoffers, D.A.1    Ferrer, J.2    Clarke, W.L.3    Habener, J.F.4
  • 7
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl, G., Dierich, A., LeMeur, M. and Guillemot, F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl Acad. Sci. USA 97, 1607-1611 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 8
    • 84863088235 scopus 로고    scopus 로고
    • A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
    • Shih, H. P. et al. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139, 2488-2499 (2012).
    • (2012) Development , vol.139 , pp. 2488-2499
    • Shih, H.P.1
  • 9
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson, K. A. et al. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev. Cell 12, 457-465 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1
  • 10
    • 0033825383 scopus 로고    scopus 로고
    • Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    • Schwitzgebel, V. M. et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127, 3533-3542 (2000).
    • (2000) Development , vol.127 , pp. 3533-3542
    • Schwitzgebel, V.M.1
  • 11
    • 68349146403 scopus 로고    scopus 로고
    • Expression of MafA in pancreatic progenitors is detrimental for pancreatic development
    • Nishimura, W., Bonner-Weir, S. and Sharma, A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev. Biol. 333, 108-120 (2009).
    • (2009) Dev. Biol. , vol.333 , pp. 108-120
    • Nishimura, W.1    Bonner-Weir, S.2    Sharma, A.3
  • 12
    • 34447521981 scopus 로고    scopus 로고
    • The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
    • Nelson, S. B., Schaffer, A. E. and Sander, M. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development 134, 2491-2500 (2007).
    • (2007) Development , vol.134 , pp. 2491-2500
    • Nelson, S.B.1    Schaffer, A.E.2    Sander, M.3
  • 13
    • 84922465037 scopus 로고    scopus 로고
    • Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant
    • Folcher, M. et al. Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant. Nat. Commun. 5, 5392 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5392
    • Folcher, M.1
  • 14
    • 77950676224 scopus 로고    scopus 로고
    • Self-sufficient control of urate homeostasis in mice by a synthetic circuit
    • Kemmer, C. et al. Self-sufficient control of urate homeostasis in mice by a synthetic circuit. Nature Biotechnol. 28, 355-360 (2010).
    • (2010) Nature Biotechnol. , vol.28 , pp. 355-360
    • Kemmer, C.1
  • 15
    • 84889260345 scopus 로고    scopus 로고
    • A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice
    • Rossger, K., Charpin-El-Hamri, G. and Fussenegger, M. A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. Nat. Commun. 4, 2825 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2825
    • Rossger, K.1    Charpin-El-Hamri, G.2    Fussenegger, M.3
  • 16
    • 79959514813 scopus 로고    scopus 로고
    • A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice
    • Ye, H., Daoud-El Baba, M., Peng, R. W. and Fussenegger, M. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332, 1565-1568 (2011).
    • (2011) Science , vol.332 , pp. 1565-1568
    • Ye, H.1    Daoud-El Baba, M.2    Peng, R.W.3    Fussenegger, M.4
  • 17
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 18
    • 84904722292 scopus 로고    scopus 로고
    • Revealing transcription factors during human pancreatic beta cell development
    • Conrad, E., Stein, R. and Hunter, C. S. Revealing transcription factors during human pancreatic beta cell development. Trends Endocrinol. Metab. 25, 407-414 (2014).
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 407-414
    • Conrad, E.1    Stein, R.2    Hunter, C.S.3
  • 19
    • 84876351067 scopus 로고    scopus 로고
    • Gene regulatory networks governing pancreas development
    • Arda, H. E., Benitez, C. M. and Kim, S. K. Gene regulatory networks governing pancreas development. Dev. Cell 25, 5-13 (2013).
    • (2013) Dev. Cell , vol.25 , pp. 5-13
    • Arda, H.E.1    Benitez, C.M.2    Kim, S.K.3
  • 20
    • 84954555664 scopus 로고    scopus 로고
    • Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
    • Guye, P. et al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat. Commun. 7, 10243 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10243
    • Guye, P.1
  • 21
    • 84870061237 scopus 로고    scopus 로고
    • Diabetes: Long-acting insulin analogues-are benefits worth the cost?
    • Nathan, D. M. Diabetes: long-acting insulin analogues-are benefits worth the cost? Nat. Rev. Endocrinol. 8, 699-700 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 699-700
    • Nathan, D.M.1
  • 22
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson, M. A. and Eisenbarth, G. S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358, 221-229 (2001).
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 23
    • 0027253061 scopus 로고
    • Long-term complications of diabetes mellitus
    • Nathan, D. M. Long-term complications of diabetes mellitus. N. Engl. J. Med. 328, 1676-1685 (1993).
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1676-1685
    • Nathan, D.M.1
  • 24
  • 25
    • 78650843724 scopus 로고    scopus 로고
    • Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade
    • Posselt, A. M. et al. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation 90, 1595-1601.
    • Transplantation , vol.90 , pp. 1595-1601
    • Posselt, A.M.1
  • 26
    • 77956145092 scopus 로고    scopus 로고
    • Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation
    • Turgeon, N. A. et al. Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation. Am. J. Transplant. 10, 2082-2091 (2010).
    • (2010) Am. J. Transplant. , vol.10 , pp. 2082-2091
    • Turgeon, N.A.1
  • 27
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro, A. M. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230-238 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 230-238
    • Shapiro, A.M.1
  • 28
    • 84878890508 scopus 로고    scopus 로고
    • Sustained function of alginateencapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
    • Jacobs-Tulleneers-Thevissen, D. et al. Sustained function of alginateencapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient. Diabetologia 56, 1605-1614 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1605-1614
    • Jacobs-Tulleneers-Thevissen, D.1
  • 29
    • 84954270762 scopus 로고    scopus 로고
    • Replacing and safeguarding pancreatic beta cells for diabetes
    • 316ps323
    • Bruin, J. E., Rezania, A. and Kieffer, T. J. Replacing and safeguarding pancreatic beta cells for diabetes. Sci. Transl. Med. 7, 316ps323 (2015).
    • (2015) Sci. Transl. Med. , vol.7
    • Bruin, J.E.1    Rezania, A.2    Kieffer, T.J.3
  • 30
    • 1842731851 scopus 로고    scopus 로고
    • Clinical islet transplantation: Advances and immunological challenges
    • Ricordi, C. and Strom, T. B. Clinical islet transplantation: advances and immunological challenges. Nat. Rev. Immunol. 4, 259-268 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 259-268
    • Ricordi, C.1    Strom, T.B.2
  • 32
    • 84910673362 scopus 로고    scopus 로고
    • Generation of functional human pancreatic beta cells in vitro
    • Pagliuca, F. W. et al. Generation of functional human pancreatic beta cells in vitro. Cell 159, 428-439 (2014).
    • (2014) Cell , vol.159 , pp. 428-439
    • Pagliuca, F.W.1
  • 33
    • 84983134468 scopus 로고    scopus 로고
    • Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
    • Rezania, A. et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol. 32, 1121-1133 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 1121-1133
    • Rezania, A.1
  • 34
    • 84933674159 scopus 로고    scopus 로고
    • Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro
    • Russ, H. A. et al. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J. 34, 1759-1772 (2015).
    • (2015) EMBO J. , vol.34 , pp. 1759-1772
    • Russ, H.A.1
  • 36
    • 84942920867 scopus 로고    scopus 로고
    • Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells
    • Rostovskaya, M., Bredenkamp, N. and Smith, A. Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20140365 (2015).
    • (2015) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.370 , pp. 20140365
    • Rostovskaya, M.1    Bredenkamp, N.2    Smith, A.3
  • 37
    • 84871869282 scopus 로고    scopus 로고
    • Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells
    • Thatava, T. et al. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol. Ther. 21, 228-239 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 228-239
    • Thatava, T.1
  • 39
    • 84858389998 scopus 로고    scopus 로고
    • The food additive vanillic acid controls transgene expression in mammalian cells and mice
    • Gitzinger, M. et al. The food additive vanillic acid controls transgene expression in mammalian cells and mice. Nucleic Acids Res. 40, e37 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. e37
    • Gitzinger, M.1
  • 40
    • 58249123661 scopus 로고    scopus 로고
    • Monomeric fluorescent timers that change color from blue to red report on cellular trafficking
    • Subach, F. V. et al. Monomeric fluorescent timers that change color from blue to red report on cellular trafficking. Nat. Chem. Biol. 5, 118-126 (2009).
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 118-126
    • Subach, F.V.1
  • 41
    • 84875249890 scopus 로고    scopus 로고
    • Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment
    • Qu, X. et al. Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. Dev. Biol. 376, 1-12 (2013).
    • (2013) Dev. Biol. , vol.376 , pp. 1-12
    • Qu, X.1
  • 42
    • 0033800896 scopus 로고    scopus 로고
    • Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression
    • Marshak, S. et al. Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression. Mol. Cell Biol. 20, 7583-7590 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 7583-7590
    • Marshak, S.1
  • 43
    • 33746507174 scopus 로고    scopus 로고
    • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site
    • Raum, J. C. et al. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol. Cell Biol. 26, 5735-5743 (2006).
    • (2006) Mol. Cell Biol. , vol.26 , pp. 5735-5743
    • Raum, J.C.1
  • 44
    • 34547793553 scopus 로고    scopus 로고
    • A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts
    • Chepurny, O. G. and Holz, G. G. A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts. J. Biomol. Screen. 12, 740-746 (2007).
    • (2007) J. Biomol. Screen. , vol.12 , pp. 740-746
    • Chepurny, O.G.1    Holz, G.G.2
  • 45
    • 84888291757 scopus 로고    scopus 로고
    • Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA
    • Hu He, K. et al. Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. Dev. Biol. 385, 2-12 (2014).
    • (2014) Dev. Biol. , vol.385 , pp. 2-12
    • Hu He, K.1
  • 46
    • 53049099470 scopus 로고    scopus 로고
    • MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells
    • Vanhoose, A. M. et al. MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells. J. Biol. Chem. 283, 22612-22619 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 22612-22619
    • Vanhoose, A.M.1
  • 47
    • 77949870524 scopus 로고    scopus 로고
    • Identification of markers for newly formed beta-cells in the perinatal period: A time of recognized beta-cell immaturity
    • Aye, T., Toschi, E., Sharma, A., Sgroi, D. and Bonner-Weir, S. Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J. Histochem. Cytochem. 58, 369-376 (2010).
    • (2010) J. Histochem. Cytochem. , vol.58 , pp. 369-376
    • Aye, T.1    Toschi, E.2    Sharma, A.3    Sgroi, D.4    Bonner-Weir, S.5
  • 48
    • 84896889356 scopus 로고    scopus 로고
    • Differentiated human stem cells resemble fetal, not adult, beta cells
    • Hrvatin, S. et al. Differentiated human stem cells resemble fetal, not adult, beta cells. Proc. Natl Acad. Sci. USA 111, 3038-3043 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 3038-3043
    • Hrvatin, S.1
  • 49
    • 84943743452 scopus 로고    scopus 로고
    • MAFA and T3 drive maturation of both fetal human islets and insulin-producing cells differentiated from hESC
    • Aguayo-Mazzucato, C. et al. MAFA and T3 drive maturation of both fetal human islets and insulin-producing cells differentiated from hESC. J. Clin. Endocrinol. Metab. 100, 3651-3659 (2015).
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. 3651-3659
    • Aguayo-Mazzucato, C.1
  • 50
    • 77954999528 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell
    • Gao, N. et al. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol. Endocrinol. 24, 1594-1604 (2010).
    • (2010) Mol. Endocrinol. , vol.24 , pp. 1594-1604
    • Gao, N.1
  • 51
    • 84867303343 scopus 로고    scopus 로고
    • A dynamical-systems view of stem cell biology
    • Furusawa, C. and Kaneko, K. A dynamical-systems view of stem cell biology. Science 338, 215-217 (2012).
    • (2012) Science , vol.338 , pp. 215-217
    • Furusawa, C.1    Kaneko, K.2
  • 52
    • 84884594497 scopus 로고    scopus 로고
    • The use of stem cells for pancreatic regeneration in diabetes mellitus
    • Bouwens, L., Houbracken, I. and Mfopou, J. K. The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat. Rev. Endocrinol. 9, 598-606 (2013).
    • (2013) Nat. Rev. Endocrinol. , vol.9 , pp. 598-606
    • Bouwens, L.1    Houbracken, I.2    Mfopou, J.K.3
  • 53
    • 75749109851 scopus 로고    scopus 로고
    • Converting human pluripotent stem cells into beta-cells: Recent advances and future challenges
    • Mayhew, C. N. and Wells, J. M. Converting human pluripotent stem cells into beta-cells: recent advances and future challenges. Curr. Opin. Organ Transplant. 15, 54-60 (2010).
    • (2010) Curr. Opin. Organ Transplant , vol.15 , pp. 54-60
    • Mayhew, C.N.1    Wells, J.M.2
  • 54
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon, E. et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nature Biotechnol. 26, 443-452 (2008).
    • (2008) Nature Biotechnol. , vol.26 , pp. 443-452
    • Kroon, E.1
  • 55
    • 79551580013 scopus 로고    scopus 로고
    • Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
    • Nostro, M. C. et al. Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 138, 861-871 (2011).
    • (2011) Development , vol.138 , pp. 861-871
    • Nostro, M.C.1
  • 56
    • 0035221762 scopus 로고    scopus 로고
    • Human embryonic stem cell research: Ethical and legal issues
    • Robertson, J. A. Human embryonic stem cell research: ethical and legal issues. Nat. Rev. Genet. 2, 74-78 (2001).
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 74-78
    • Robertson, J.A.1
  • 57
    • 70349437501 scopus 로고    scopus 로고
    • Generation of pluripotent stem cells from patients with type 1 diabetes
    • Maehr, R. et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc. Natl Acad. Sci. USA 106, 15768-15773 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15768-15773
    • Maehr, R.1
  • 58
    • 64149118087 scopus 로고    scopus 로고
    • Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
    • Zhang, D. et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 19, 429-438 (2009).
    • (2009) Cell Res. , vol.19 , pp. 429-438
    • Zhang, D.1
  • 59
    • 84877130503 scopus 로고    scopus 로고
    • mRNA Transfection-Based, Feeder-Free, Induced Pluripotent Stem Cells from Adipose Tissue of a 50 Year-Old Patient
    • Heng, B. C. et al. mRNA Transfection-Based, Feeder-Free, Induced Pluripotent Stem Cells From Adipose Tissue of a 50 Year-Old Patient. Metab. Eng. 18, 9-24 (2013).
    • (2013) Metab. Eng. , vol.18 , pp. 9-24
    • Heng, B.C.1
  • 60
    • 84933677431 scopus 로고    scopus 로고
    • Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines
    • Nostro, M. C. et al. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Rep. 4, 591-604 (2015).
    • (2015) Stem Cell Rep. , vol.4 , pp. 591-604
    • Nostro, M.C.1
  • 61
    • 84956702282 scopus 로고    scopus 로고
    • Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves disease
    • Saxena, P., Charpin-El Hamri, G., Folcher, M., Zulewski, H. and Fussenegger, M. Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves disease. Proc. Natl Acad. Sci. USA 113, 1244-1249 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 1244-1249
    • Saxena, P.1    Charpin-El Hamri, G.2    Folcher, M.3    Zulewski, H.4    Fussenegger, M.5
  • 62
    • 84954290530 scopus 로고    scopus 로고
    • Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis
    • 318ra201
    • Schukur, L., Geering, B., Charpin-El Hamri, G. and Fussenegger, M. Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis. Sci. Transl. Med. 7, 318ra201 (2015).
    • (2015) Sci. Transl. Med. , vol.7
    • Schukur, L.1    Geering, B.2    Charpin-El Hamri, G.3    Fussenegger, M.4
  • 63
    • 79955572417 scopus 로고    scopus 로고
    • Harnessing the potential of induced pluripotent stem cells for regenerative medicine
    • Wu, S. M. and Hochedlinger, K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat. Cell Biol. 13, 497-505 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 497-505
    • Wu, S.M.1    Hochedlinger, K.2
  • 64
    • 0021873134 scopus 로고
    • Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases
    • Sibley, R. K., Sutherland, D. E., Goetz, F. and Michael, A. F. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest. 53, 132-144 (1985).
    • (1985) Lab Invest. , vol.53 , pp. 132-144
    • Sibley, R.K.1    Sutherland, D.E.2    Goetz, F.3    Michael, A.F.4
  • 65
    • 84924977469 scopus 로고    scopus 로고
    • Tolerance induction and reversal of diabetes in mice transplanted with human embryonic-stem-cell-derived pancreatic endoderm
    • Szot, G. L. et al. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic-stem-cell-derived pancreatic endoderm. Cell Stem Cell 16, 148-157 (2015).
    • (2015) Cell Stem Cell , vol.16 , pp. 148-157
    • Szot, G.L.1
  • 66
    • 84860492238 scopus 로고    scopus 로고
    • Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival
    • Nosov, M. et al. Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival. Am. J. Transpl. 12, 1313-1322 (2012).
    • (2012) Am. J. Transpl. , vol.12 , pp. 1313-1322
    • Nosov, M.1
  • 67
    • 84955615077 scopus 로고    scopus 로고
    • Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice
    • Vegas, A. J. et al. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nature Med. 22, 306-311 (2016).
    • (2016) Nature Med. , vol.22 , pp. 306-311
    • Vegas, A.J.1
  • 68
    • 0035984714 scopus 로고    scopus 로고
    • Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    • Simonsen, J. L. et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotechnol. 20, 592-596 (2002).
    • (2002) Nature Biotechnol. , vol.20 , pp. 592-596
    • Simonsen, J.L.1
  • 69
    • 0037045403 scopus 로고    scopus 로고
    • SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase
    • Schlatter, S., Rimann, M., Kelm, J. and Fussenegger, M. SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase. Gene 282, 19-31 (2002).
    • (2002) Gene , vol.282 , pp. 19-31
    • Schlatter, S.1    Rimann, M.2    Kelm, J.3    Fussenegger, M.4
  • 70
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen, T. D. and Livak, K. J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3, 1101-1108 (2008).
    • (2008) Nat. Protoc. , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.