MAFA and T3 drive maturation of both fetal human islets and insulin-producing cells differentiated from hESC

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 10, 2015, Pages 3651-3659

  Aguayo Mazzucato, Cristina ^a   Dilenno, Amanda ^b   Hollister Lock, Jennifer ^a   Cahill, Christopher ^a   Sharma, Arun ^a   Weir, Gordon ^a   Colton, Clark ^b   Bonner Weir, Susan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; THYROID HORMONE; TRANSCRIPTION FACTOR MAFA; LIOTHYRONINE; MAFA PROTEIN, HUMAN; TRANSCRIPTION FACTOR MAF;

ADULT; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; EMBRYONIC STEM CELL; FETUS; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INSULIN RELEASE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RODENT; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS ISLET; PHYSIOLOGY;

CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MAF TRANSCRIPTION FACTORS, LARGE; TRIIODOTHYRONINE;

EID: 84943743452     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2632     Document Type: Article

References (23)

1. Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008;26(4):443-452.
2. Rezania A, Bruin JE, Riedel MJ, et al. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes. 2012; 61(8):2016-2029.
3. Aynsley-Green A, Bloom SR, Williamson DH, Turner RC. Endocrine and metabolic response in the human newborn to first feed of breast milk. Arch Dis Childh. 1977;52(4):291-295.
4. Hrvatin S, O'Donnell CW, Deng F, et al. Differentiated human stem cells resemble fetal, not adult, beta cells. Proc Natl Acad Sci USA. 2014;111(8):3038-3043.
5. Mitanchez-Mokhtari D, Lahlou N, Kieffer F, Magny JF, Roger M, Voyer M. Both relative insulin resistance and defective islet-cell processing of proinsulin are responsible for transient hyperglycemia in extremely preterm infants. Pediatrics. 2004;113(3 Pt 1):537-541.
6. Baetge EE. Production of-cells from human embryonic stem cells. Diabetes Obesity Metab. 2008;10(suppl 4):186-194.
7. Bliss CR, Sharp GW. Glucose-induced insulin release in islets of young rats: time-dependent potentiation and effects of 2-bromostearate. Am J Physiol. 1992;263(5 Pt 1):E890-E896.
8. Aguayo-Mazzucato C, Koh A, El Khattabi I, et al. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat cells. Diabetologia. 2011;54(3):583-593.
9. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, et al. Thyroid hormone promotes postnatal rat pancreatic beta-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013;62(5):1569-1580.
10. Rezania A, Bruin JE, Arora P, et al. Reversal of diabetes with insulinproducing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol. 2014;32(11):1121-1133.
11. Pagliuca FW, Millman JR, GurtlerM,et al. Generation of functional human pancreatic cells in vitro. Cell. 2014;159(2):428-439.
12. Gotoh M, Maki T, Satomi S, et al. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation. 1987;43(5): 725-730.
13. D'Amour KA, Bang AG, Eliazer S, et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006;24(11):1392-1401.
14. Samuels HH, Stanley F, Casanova J. Relationship of receptor affinity to the modulation of thyroid hormone nuclear receptor levels and growth hormone synthesis by L-triiodothyronine and iodothyronine analogues in cultured GH1 cells. J Clin Invest. 1979;63(6): 1229-1240.
15. Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir GC. Replication of adult pancreatic-cells cultured on bovine corneal endothelial cell extracellular matrix. In Vitro Cell Dev Biol Animal. 1993;29A(4):339-344.
16. Nishimura W, Kondo T, Salameh T, et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic-cells. Dev Biol. 2006;293(2):526-539.
17. Ling Z, Pipeleers DG. Prolonged exposure of human cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest. 1996;98(12):2805-2812.
18. Aguayo-Mazzucato CM, Ramados P, Scanlan T, Hollenberg A, Sharma A, Bonner-Weir S. T3 has dual effects upon pancreatic beta cells inducing markers of both maturation and aging. Diabetes. 2014;63(suppl 1):A54.
19. Blum B, Hrvatin SS, Schuetz C, Bonal C, Rezania A, Melton DA. Functional-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol. 2012; 30(3):261-264.
20. Leahy JL, Cooper HE, Weir GC. Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions. Diabetes. 1987;36(4):459-464.
21. Leahy JL, Bonner-Weir S, Weir GC. Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment. Diabetes. 1985;34(7):660-666.
22. Hostens K, Pavlovic D, Zambre Y, et al. Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J Clin Invest. 1999;104(1):67-72.
23. Clark AR, Wilson ME, London NJ, James RF, Docherty K. Identification and characterization of a functional retinoic acid/thyroid hormone-response element upstream of the human insulin gene enhancer. Biochem J. 1995;309(Pt 3):863-870.