MTOR inhibition enhances NVP-AUY922-induced autophagymediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors

Oncotarget

Volumn 5, Issue 22, 2014, Pages 11711-11724

  Hsueh, Yuan Shuo ^a   Chang, Hui Hua ^b   Chiang, Nai Jung ^a,c   Yen, Chueh Chuan ^d,e   Li, Chien Feng ^a,f,g,h   Chen, Li Tzong ^a,b,c,i  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

^f CHI MEI MEDICAL CENTER   (Taiwan)

^g SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^h KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

ⁱ KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Autophagy; Gastrointestinal stromal tumor; Heat shock protein 90 inhibitor; KIT; MTOR inhibitor

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; IMATINIB; LUMINESPIB; RAPAMYCIN; SMALL INTERFERING RNA; 5-(2,4-DIHYDROXY-5-ISOPROPYLPHENYL)-4-(4-MORPHOLIN-4-YLMETHYLPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; HEAT SHOCK PROTEIN 90; ISOXAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RESORCINOL DERIVATIVE; STEM CELL FACTOR RECEPTOR; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CELL DEATH; CELL KILLING; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG MEGADOSE; DRUG POTENTIATION; GASTROINTESTINAL STROMAL TUMOR; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; MUTANT; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TUMOR NECROSIS; TUMOR RESISTANCE; TUMOR VOLUME; ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; DRUG RESISTANCE; GASTROINTESTINAL STROMAL TUMORS; HUMAN; IC50; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; NECROSIS; NONOBESE DIABETIC MOUSE; RNA INTERFERENCE; SCID MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BENZAMIDES; CELL DEATH; CELL SURVIVAL; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; GASTROINTESTINAL STROMAL TUMORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMATINIB MESYLATE; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MICE; MICE, INBRED NOD; MICE, SCID; MUTATION; NECROSIS; NEOPLASM TRANSPLANTATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RESORCINOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84964314384     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2607     Document Type: Article

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