BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

Radiation Oncology

Volumn 9, Issue 1, 2014, Pages

  Helbig, Linda ^a,b   Koi, Lydia ^a,b,c   Brüchner, Kerstin ^b,d   Gurtner, Kristin ^b   Hess Stumpp, Holger ^e   Unterschemmann, Kerstin ^e   Baumann, Michael ^a,b,c,d   Zips, Daniel ^c,f   Yaromina, Ala ^a,b,g  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^e BAYER PHARMA AG   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Cisplatin; Fractionated radiation; HIF pathway inhibition; Human tumor xenograft; Local tumor control; Tumor microenvironment

Indexed keywords

ANTINEOPLASTIC AGENT; BAY 872243; CISPLATIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG; 1-CYCLOPROPYL-4-(4-((5-METHYL-3-(3-(4-(TRIFLUOROMETHOXY)PHENYL)-1,2,4-OXADIAZOL-5-YL)-1H-PYRAZOL-1-YL)METHYL)PYRIDIN-2-YL)PIPERAZINE; HIF1A PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; RADIOSENSITIZING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CONTROL; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENE ACTIVATION; HEAD AND NECK CANCER; HISTOPATHOLOGY; HUMAN; HYPOFRACTIONATED RADIOTHERAPY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIATION DOSE; SOLID TUMOR; TUMOR GROWTH INHIBITION RATE; TUMOR MICROENVIRONMENT; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; CHEMORADIOTHERAPY; DRUG EFFECTS; DRUG SCREENING; HEAD AND NECK TUMOR; NUDE MOUSE; PATHOLOGY; PROCEDURES; RADIATION DOSE FRACTIONATION; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CHEMORADIOTHERAPY; DOSE FRACTIONATION; HEAD AND NECK NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; OXADIAZOLES; PYRAZOLES; RADIATION-SENSITIZING AGENTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84964312767     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-9-207     Document Type: Article

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