BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

Cancer Medicine

Volumn 2, Issue 5, 2013, Pages 611-624

  Ellinghaus, Peter ^a   Heisler, Iring ^a   Unterschemmann, Kerstin ^a   Haerter, Michael ^a   Beck, Hartmut ^a   Greschat, Susanne ^a   Ehrmann, Alexander ^a   Summer, Holger ^a   Flamme, Ingo ^a   Oehme, Felix ^a   Thierauch, Karlheinz ^a   Michels, Martin ^a   Hess Stumpp, Holger ^a   Ziegelbauer, Karl ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ACTIVITY; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR-1; MITOCHONDRIAL COMPLEX 1;

ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CELL HYPOXIA; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ELECTRON TRANSPORT COMPLEX I; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; LUNG NEOPLASMS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; OXADIAZOLES; PYRAZOLES; RNA, SMALL INTERFERING; SMALL MOLECULE LIBRARIES; TUMOR BURDEN; TUMOR CELLS, CULTURED; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84890460358     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.112     Document Type: Article

References (39)