Prognostic value of HIF-1α expression during fractionated irradiation;Prognostischer Wert der HIF-1α-Expression während der fraktionierten Bestrahlung

Strahlentherapie und Onkologie

Volumn 188, Issue 11, 2012, Pages 1031-1037

  Helbig, L ^a   Yaromina, A ^a   Sriramareddy, S N ^a   Boke S ^a   Koi, L ^a   Thames, H D ^c   Baumann, M ^a,b   Zips, D ^a,d  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Carcinoma, squamous cell; HIF 1 ; Hypoxia; Radiotherapy; Xenograft

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIMONIDAZOLE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PREDICTIVE VALUE; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; TREATMENT RESPONSE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL LINE, TUMOR; DOSE FRACTIONATION; FEMALE; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NITROIMIDAZOLES; OTORHINOLARYNGOLOGIC NEOPLASMS; PROGNOSIS; RADIATION-SENSITIZING AGENTS; STATISTICS AS TOPIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR MARKERS, BIOLOGICAL;

EID: 84867951231     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-012-0150-z     Document Type: Article

References (38)

1. Aebersold DM, Burri P, Beer KT et al (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61:2911-2916
2. Bache M, Kappler M, Said HM et al (2008) Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies. Curr Med Chem 15:322-338
3. Bayer C, Shi K, Astner ST et al (2011) Acute versus chronic hypoxia: why a simplified classification is simply not enough. Int J Radiat Oncol Biol Phys 80:965-968
4. Dewhirst MW, Cao Y, Moeller B (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8:425-437
5. Harada H, Itasaka S, Zhu Y et al (2009) Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. Br J Cancer 100:747-757
6. Horsman M, Wouters BG, Joiner MC, Overgaard J (2009) The oxygen effect and fractionated radiotherapy. In: Joiner MC, Van der Kogel A (eds) Basic clinical radiobiology. 4th ed. Arnold, London, pp 207-216
7. Hui EP, Chan AT, Pezzella F et al (2002) Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin Cancer Res 8:2595-2604
8. Janssen HL, Haustermans KM, Sprong D et al (2002) HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. Int J Radiat Oncol Biol Phys 54:1537-1549
9. Kappler M, Taubert H, Holzhausen HJ et al (2008) Immunohistochemical detection of HIF-1alpha and CAIX in advanced head-and-neck cancer. Prognostic role and correlation with tumor markers and tumor oxygenation parameters. Strahlenther Onkol 184:393-399
10. Kappler MA (2008) Software for rapid prototyping in the pharmaceutical and biotechnology industries. Curr Opin Drug Discov Devel 11:389-392
11. Kessler J, Hahnel A, Wichmann H et al (2010) HIF-1alpha inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 10:605
12. Koukourakis MI, Giatromanolaki A, Danielidis V, Sivridis E (2008) Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy. Int J Radiat Biol 84:47-52
13. Koukourakis MI, Giatromanolaki A, Sivridis E et al (2002) Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 53:1192-1202
14. Li F, Sonveaux P, Rabbani ZN et al (2007) Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell 26:63-74
15. Mayer A, Hockel M, Wree A et al (2008) Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 68:4719-4726
16. Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5:429-441
17. Moeller BJ, Dreher MR, Rabbani ZN et al (2005) Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8:99-110
18. Rademakers SE, Lok J, Kogel AJ van der et al (2011) Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1alpha, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer 11:167
19. Schilling D, Bayer C, Emmerich K et al (2012) Basal HIF-1alpha expression levels are not predictive for radiosensitivity of human cancer cell lines. Strahlenther Onkol 188:353-358
20. Schilling D, Bayer C, Li W et al (2012) Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1alpha. PLoS One 7:e31110
21. Schutze C, Bergmann R, Yaromina A et al (2007) Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice. Radiother Oncol 83:311-315
22. Schwartz DL, Powis G, Thitai-Kumar A et al (2009) The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 8:947-958
23. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732
24. Semenza GL (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634
25. Silva P, Slevin NJ, Sloan P et al (2008) Prognostic significance of tumor hypoxia inducible factor-1alpha expression for outcome after radiotherapy in oropharyngeal cancer. Int J Radiat Oncol Biol Phys 72:1551-1559
26. Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P (2005) Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res 65:7259-7266
27. Staab A, Fleischer M, Loeffler J et al (2011) Small interfering RNA targeting HIF-1alpha reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlenther Onkol 187:252-259
28. Broek GB van den, Wildeman M, Rasch CR et al (2009) Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. Int J Cancer 124:2643-2650
29. Vaupel P, Mayer A (2007) Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26:225-239
30. Vordermark D, Brown JM (2003) Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. Int J Radiat Oncol Biol Phys 56:1184-1193
31. Vordermark D, Katzer A, Baier K et al (2004) Cell type-specific association of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein accumulation and radiobiologic tumor hypoxia. Int J Radiat Oncol Biol Phys 58:1242-1250
32. Williams KJ, Telfer BA, Xenaki D et al (2005) Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother Oncol 75:89-98
33. Wouters BG, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8:851-864
34. Xueguan L, Xiaoshen W, Yongsheng Z et al (2008) Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide. Clin Oncol (R Coll Radiol) 20:606-612
35. Yaromina A, Eckardt A, Zips D et al (2009) Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies. Radiother Oncol 92:460-465
36. Yaromina A, Krause M, Thames H et al (2007) Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation. Radiother Oncol 83:304-310
37. Yaromina A, Kroeber T, Meinzer A et al (2011) Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts. Int J Radiat Oncol Biol Phys 80:1205-1213
38. Zou Y, Cheng C, Omura-Minamisawa M et al (2010) The suppression of hypoxia-inducible factor and vascular endothelial growth factor by siRNA does not affect the radiation sensitivity of multicellular tumor spheroids. J Radiat Res ss51:47-55