Chikusetsusaponin V inhibits inflammatory responses via NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages

Immunopharmacology and Immunotoxicology

Volumn 36, Issue 6, 2014, Pages 404-411

  Wang, Ting ^a   Dai, Yanwen ^a   Dun, Yaoyan ^a   Zhang, Changcheng ^a   Wan, Jingzhi ^a   Deng, Lili ^a   Zhou, Zhiyong ^a   Liu, Chaoqi ^a   Yuan, Ding ^a  

^a CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

Chikusetsusaponin V; Inflammatory; LPS; MAPK; NF BKW

Indexed keywords

CD14 ANTIGEN; CHIKUSETSU SAPONIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; INFLAMMATION; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

PANAX JAPONICUS;

EID: 84964292216     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2014.960088     Document Type: Article

References (35)

1. Rietschel ET, Brade H. Bacterial endotoxins. Sci Am 1992;267: 54-61
2. Lawrence T, Willoughby DA, Gilroy DW. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2002;2:787-795
3. Szabo G, Lippai D. Molecular hepatic carcinogenesis: impact of inflammation. Dig Dis 2012;30:243-248
4. Kim TW, Joh EH, Kim B, Kim DH. Ginsenoside Rg5 ameliorates lung inflammation in mice by inhibiting the binding of LPS to tolllike receptor-4 on macrophages. Int Immunopharmacol 2012;12: 110-116
5. Joh EH, Gu W, Kim DH. Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-kB and mapk pathways. Biochem Pharmacol 2012;84:331-340
6. Jung HW, Mahesh R, Park JH, et al. Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells. Int Immunopharmacol 2010;10:155-162
7. He H, Xu J, Xu Y, et al. Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. J Ethnopharmacol 2012;140:73-82
8. Zhao H, Zhang QX, Mu Y. [Effects of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury]. Zhong Guo Zhong Yao Aa Zhi 2008;33:557-559
9. Li YG, Ji DF, Zhong S, et al. Saponins from Panax japonicus protect against alcohol-induced hepatic injury in mice by up-regulating the expression of GPX3, SOD1 and SOD3. Alcohol Alcohol 2010;45:320-331
10. Rhule A, Navarro S, Smith JR, Shepherd DM. Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW264.7 cells. J Ethnopharmacol 2006;106:121-128
11. Peng Q, Liu H, Shi S, Li M. Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NF-kB signaling pathway. Int J Biol Macromol 2014;67:330-335
12. Yuan F, Chen J, Sun PP, et al. Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells. J Biomed Sci 2013;20:84
13. Yang X-L, Guo T-K, Wang Y-H, et al. Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis. Int Immunopharmacol 2012;12:408-414
14. Wang S, Hibberd ML, Pettersson S, Lee YK. Enterococcus faecalis from healthy infants modulates inflammation through mapk signaling pathways. PLoS One 2014;9:e97523
15. Andreakos E, Foxwell B, Feldmann M. Is targeting toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?. Immunol Rev 2004; 202:250-265
16. Davis KL, Martin E, Turko IV, Murad F. Novel effects of nitric oxide. Ann Rev Pharmacol Toxicol 2001;41:203-236
17. Trinh MDL, Dinh M-H, Ngo D-H, et al. Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells. Int J Biol Macromol 2014;66:1-6
18. Fan H, Cook JA. Molecular mechanisms of endotoxin tolerance. J Endotoxin Res 2004;10:71-84
19. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002;13:413-421
20. Hoesel B, Schmid JA. The complexity of NF-kB signaling in inflammation and cancer. Mol Cancer 2013;12:86
21. Abraham E. Nuclear factor-kappaB and its role in sepsis-associated organ failure. J Infect Dis 2003;15:364-369
22. Park JS, Park EM, Kim DH, et al. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009; 209:40-49
23. Kim Y-H, Yoon D-W, Kim J-H, et al. Effect of remote ischemic post-conditioning on systemic inflammatory response and survival rate in lipopolysaccharide-induced systemic inflammation model. J Inflamm 2014;11:16
24. Arthur JS, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol 2013;13:679-692
25. Bak MJ, Truong VL, Kang HS, et al. Anti-inflammatory effect of procyanidins from wild grape (Vitis amurensis) seeds in LPSinduced RAW 264.7 cells. Oxid Med Cell Longe 2013;2013: 409321
26. Park H-M, Kim S-J, Mun A-R, et al. Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the mapk pathway in TIB-73 cells. J Ethnopharmacol 2012;141:1071-1076
27. Han S, Lee JH, Kim C, et al. Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-kB activation. Immunopharmacol Immunotoxicol 2013;35: 34-42
28. Munshi A, Ramesh A. Mitogen-activated protein kinases and their role in radiation response. Genes Cancer 2013;4: 401-408
29. Kong Y, Le Y. Toll-like receptors in inflammation of the central nervous system. Int Immunopharmacol 2011;11:1407-1414
30. Fang H, Wang PF, Zhou Y, et al. Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury. J Neuroinflamm 2013;10:27
31. Miller YI, Choi SH, Wiesner P, Bae YS. The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. Br J Pharmacol 2012;167:990-999
32. Zanoni I, Granucci F. Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol 2013;3:32
33. Wu J, Zhou J, Chen X, et al. Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes. Int Immunopharmacol 2012;12:74-79
34. Fu Y, Liu B, Zhang N, et al. Magnolol inhibits lipopolysaccharideinduced inflammatory response by interfering with TLR4 mediated NF-kB and MAPKs signaling pathways. J Ethnopharmacol 2013; 145:193-199
35. Wang JX, Hou LF, Yang Y, et al. SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing mapk and NF-kappaB pathways in RAW 264.7 macrophages. Acta Pharmacol Sin 2009;30: 1428-1435