Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

eLife

Volumn 5, Issue MARCH2016, 2016, Pages

  Vijayvargia, Ravi ^a,b,i   Epand, Raquel ^c   Leitner, Alexander ^d   Jung, Tae Yang ^e,f,g   Shin, Baehyun ^a,b   Jung, Roy ^a,b   Lloret, Alejandro ^a,b,j   Atwal, Randy Singh ^a,b   Lee, Hyeongseok ^e   Lee, Jong Min ^a,b   Aebersold, Ruedi ^d,h   Hebert, Hans ^f,g   Song, Ji Joon ^e   Seong, Ihn Sik ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d ETH ZURICH   (Switzerland)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^f KAROLINSKA INSTITUTE   (Sweden)

^g ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^h UNIVERSITY OF ZURICH   (Switzerland)

ⁱ M S UNIVERSITY OF BARODA   (India)

^j UNIVERSIDAD AUTÓNOMA DE QUERÉTARO   (Mexico)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DICHOLINE SUBERATE; HUNTINGTIN; POLYGLUTAMINE; HTT PROTEIN, HUMAN; PEPTIDE;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DNA SEQUENCE; ELECTRON MICROSCOPY; EXPRESSION VECTOR; HUMAN; HUNTINGTON DISEASE LIKE SYNDROME; HYDROPHOBICITY; IMMUNOBLOTTING; MASS SPECTROMETRY; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RESTRICTION SITE; SIZE EXCLUSION CHROMATOGRAPHY; SOLID PHASE EXTRACTION; BIOPHYSICS; CHEMISTRY; METABOLISM; PROTEIN CONFORMATION;

BIOPHYSICAL PHENOMENA; CIRCULAR DICHROISM; HUNTINGTIN PROTEIN; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; PEPTIDES; PROTEIN CONFORMATION;

EID: 84964285135     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.11184     Document Type: Article

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