Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14610-14615

  Caron, Nicholas Stephane ^a   Desmond, Carly Robyn ^a   Xia, Jianrun ^a   Truant, Ray ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Conformational switching; FLIM FRET; Fluorescence lifetime imaging microscopy; Neurodegeneration; Polyglutamine diseases

Indexed keywords

CASEIN KINASE II; HUNTINGTIN; POLYGLUTAMINE; PROTEIN KINASE C; HTT PROTEIN, HUMAN; NERVE PROTEIN; PACSIN1 PROTEIN, HUMAN; PEPTIDE; POLYPROLINE; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENERGY TRANSFER; GENE SEQUENCE; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; ANIMAL; BINDING SITE; CELL CULTURE; CELL LINE; CHEMISTRY; EXON; FEMALE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; MALE; METABOLISM; MIDDLE AGED; MUTATION; PATHOLOGY; PROTEIN CONFORMATION; TRINUCLEOTIDE REPEAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING SITES; CELL LINE; CELLS, CULTURED; EXONS; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; HUNTINGTON DISEASE; MALE; MICE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MUTATION; NERVE TISSUE PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84883388081     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301342110     Document Type: Article

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