A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

Nature Chemical Biology

Volumn 12, Issue 6, 2016, Pages 444-451

  Alagramam, Kumar N ^a,b   Gopal, Suhasini R ^a   Geng, Ruishuang ^a,f   Chen, Daniel H C ^a   Nemet, Ina ^b   Lee, Richard ^b   Tian, Guilian ^b   Miyagi, Masaru ^b   Malagu, Karine F ^c   Lock, Christopher J ^c   Esmieu, William R K ^c   Owens, Andrew P ^c   Lindsay, Nicola A ^c,g   Ouwehand, Krista ^d   Albertus, Faywell ^d   Fischer, David F ^d   Bürli, Roland W ^c,h   MacLeod, Angus M ^c   Harte, William E ^e   Palczewski, Krzysztof ^b   Imanishi, Yoshikazu ^b   more..

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BioFocus DPI   (United Kingdom)

^d Charles River Nederland BV   (Netherlands)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f Canada   (Canada)

^g ASTRAZENECA   (United Kingdom)

^h MEDIMMUNE LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BF 844; CLARIN 1; PEPTIDES AND PROTEINS; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; BF844 COMPOUND; CLRN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MOLECULAR LIBRARY; PYRAZOLE DERIVATIVE; PYRIDAZINE DERIVATIVE; USH3A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENE MUTATION; HEARING ACUITY; HEARING IMPAIRMENT; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MEDICINAL CHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN QUALITY; STRUCTURE ACTIVITY RELATION; USHER SYNDROME; USHER SYNDROME TYPE III; VISUAL IMPAIRMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DISEASE MODEL; GENETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS; THERAPEUTIC USE; USHER SYNDROMES;

ANIMALS; DISEASE MODELS, ANIMAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDAZINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; USHER SYNDROMES;

EID: 84964269941     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2069     Document Type: Article

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