Proteasome inhibitors induce auditory hair cell death through peroxisome dysfunction

Biochemical and Biophysical Research Communications

Volumn 456, Issue 1, 2015, Pages 269-274

  Lee, Joon No ^a   Kim, Seul Gi ^a   Lim, Jae Young ^a   Kim, Se Jin ^a   Choe, Seong Kyu ^a   Park, Raekil ^a  

^a Wonkwang University School of Medicine   (South Korea)

Author keywords

Auditory hair cell; Hearing loss; Peroxisome dysfunction; Proteasome inhibitor

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CATALASE; PROTEASOME; ABC TRANSPORTER; ABCD3 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; LIPID; PROTEASOME INHIBITOR; PYRAZINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ADVERSE DRUG REACTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CORTI ORGAN; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; INNER HAIR CELL; NONHUMAN; OUTER HAIR CELL; PEROXISOME; PROTEIN EXPRESSION; RAT; STEREOCILIUM; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; HAIR CELL; HEARING IMPAIRMENT; HUMAN; METABOLISM; PHENOTYPE; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BORONIC ACIDS; CATALASE; CELL LINE; CELL SURVIVAL; HAIR CELLS, AUDITORY; HEARING LOSS; HUMANS; LIPIDS; ORGAN OF CORTI; PEROXISOMES; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84919703757     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.11.070     Document Type: Article

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