In pulmonary arterial hypertension, reduced bmpr2 promotes endothelial-to-Mesenchymal transition via hmga1 and its target slug

Circulation

Volumn 133, Issue 18, 2016, Pages 1783-1794

  Hopper, Rachel K ^a,b   Moonen, Jan Renier A J ^a,c   Diebold, Isabel ^d   Cao, Aiqin ^a   Rhodes, Christopher J ^a   Tojais, Nancy F ^a   Hennigs, Jan K ^a   Gu, Mingxia ^a   Wang, Lingli ^a   Rabinovitch, Marlene ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d NONE

Author keywords

endothelial to mesenchymal transition; HMGA1 protein; hypertension, pulmonary

Indexed keywords

ACTIN; ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALPONIN; CD31 ANTIGEN; HIGH MOBILITY GROUP AT HOOK 1 PROTEIN; MESSENGER RNA; PROTEIN; SMALL INTERFERING RNA; SMOOTH MUSCLE 22 PROTEIN; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VIMENTIN; VON WILLEBRAND FACTOR; BMPR2 PROTEIN, HUMAN; HIGH MOBILITY GROUP A1A PROTEIN; SNAI1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SNAIL;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CELL TRANSFORMATION; CHILD; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; EXPLANT; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG ALVEOLUS CELL; MALE; MIDDLE AGED; MOUSE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PULMONARY ARTERIAL ENDOTHELIAL CELL; PULMONARY HYPERTENSION; SCHOOL CHILD; YOUNG ADULT; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DEFICIENCY; EPITHELIAL MESENCHYMAL TRANSITION; GENETICS; INFANT; METABOLISM; PATHOLOGY; PHYSIOLOGY; SMOOTH MUSCLE CELL; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELLS, CULTURED; CHILD; ENDOTHELIUM, VASCULAR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HMGA1A PROTEIN; HUMANS; HYPERTENSION, PULMONARY; INFANT; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; SNAIL FAMILY TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84964043382     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.020617     Document Type: Article

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