Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

FASEB Journal

Volumn 30, Issue 4, 2016, Pages 1599-1609

  Liu, Susan B ^a   Ikenaga, Naoki ^a   Peng, Zhen Wei ^a,b   Sverdlov, Deanna Y ^a   Greenstein, Andrew ^c   Smith, Victoria ^c   Schuppan, Detlef ^a,d   Popov, Yury ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c GILEAD SCIENCES   (United States)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

BAPN; CCl4; Collagen cross linking; Hepatic stellate cells

Indexed keywords

3 AMINOPROPIONITRILE; CARBON TETRACHLORIDE; COLLAGEN; PROTEIN LYSINE 6 OXIDASE; COLLAGEN TYPE 1; COLLAGEN TYPE I, ALPHA 1 CHAIN; COLLAGENASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS; CELL ACTIVATION; CELL INFILTRATION; COLLAGEN FIBRIL; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROGENESIS; HISTOPATHOLOGY; IN VIVO STUDY; LIVER FIBROSIS; LIVER INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; CONFOCAL MICROSCOPY; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; METABOLISM; PATHOLOGY; PROCEDURES;

AMINOPROPIONITRILE; ANIMALS; CARBON TETRACHLORIDE; COLLAGEN; COLLAGEN TYPE I; DISEASE PROGRESSION; FIBROSIS; GENE EXPRESSION; HEPATIC STELLATE CELLS; INJECTIONS, INTRAPERITONEAL; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 13; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; PROTEIN-LYSINE 6-OXIDASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84963978831     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-268425     Document Type: Article

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