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Volumn 66, Issue 22, 2015, Pages 7211-7226

Enhancing diterpenoid concentration in Salvia miltiorrhiza hairy roots through pathway engineering with maize C1 transcription factor

Author keywords

Hairy roots; regulation; Salvia miltiorrhiza Bunge; salvianolic acids; tanshinones; ZmC1

Indexed keywords

C1 PROTEIN, ZEA MAYS; DITERPENE; DNA BINDING PROTEIN; PLANT PROTEIN; TRANSCRIPTION FACTOR;

EID: 84963959899     PISSN: 00220957     EISSN: 14602431     Source Type: Journal    
DOI: 10.1093/jxb/erv418     Document Type: Article
Times cited : (43)

References (52)
  • 1
    • 77956603386 scopus 로고    scopus 로고
    • Subgroup 4 R2R3-MYBs in conifer trees: Gene family expansion and contribution to the isoprenoidand flavonoid-oriented responses
    • Bedon F, Bomal C, Caron S, et aL.2010. Subgroup 4 R2R3-MYBs in conifer trees: gene family expansion and contribution to the isoprenoidand flavonoid-oriented responses. Journal of Experimental Botany 61, 3847-3864.
    • (2010) Journal of Experimental Botany , vol.61 , pp. 3847-3864
    • Bedon, F.1    Bomal, C.2    Caron, S.3
  • 2
    • 0036801705 scopus 로고    scopus 로고
    • High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1
    • Bovy A, de Vos R, Kemper M, et aL.2002. High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and C1. The Plant Cell 14, 2509-2526.
    • (2002) The Plant Cell , vol.14 , pp. 2509-2526
    • Bovy, A.1    De Vos, R.2    Kemper, M.3
  • 3
    • 1542351251 scopus 로고    scopus 로고
    • Transcription factors as tools for metabolic engineering in plants
    • Broun P. 2004. Transcription factors as tools for metabolic engineering in plants. Current Opinion in Plant Biology 7, 202-209.
    • (2004) Current Opinion in Plant Biology , vol.7 , pp. 202-209
    • Broun, P.1
  • 4
    • 33746893789 scopus 로고    scopus 로고
    • An in vivo, luciferase-based, Agrobacterium-infiltration assay system: Implications for posttranscriptional gene silencing
    • Cazzonelli CI, Velten J. 2006. An in vivo, luciferase-based, Agrobacterium-infiltration assay system: implications for posttranscriptional gene silencing. Planta 224, 582-597.
    • (2006) Planta , vol.224 , pp. 582-597
    • Cazzonelli, C.I.1    Velten, J.2
  • 5
    • 60549111213 scopus 로고    scopus 로고
    • PlantPAN: Plant promoter analysis navigator, for identifying combinatorial cis-regulatory elements with distance constraint in plant gene groups
    • Chang W-C, Lee T-Y, Huang H-D, Huang H-Y, Pan R-L.2008. PlantPAN: Plant promoter analysis navigator, for identifying combinatorial cis-regulatory elements with distance constraint in plant gene groups. BMC Genomics 9, 561.
    • (2008) BMC Genomics , vol.9 , pp. 561
    • Chang, W.-C.1    Lee, T.-Y.2    Huang, H.-D.3    Huang, H.-Y.4    Pan, R.-L.5
  • 6
    • 84880543753 scopus 로고    scopus 로고
    • 13C tracer reveals phenolic acids biosynthesis in hairy root cultures of Salvia miltiorrhiza
    • Di P, Zhang L, Chen J, Tan H, Xiao Y, Dong X, Zhou X, Chen W. 2013. 13C tracer reveals phenolic acids biosynthesis in hairy root cultures of Salvia miltiorrhiza. ACS Chemical Biology 8, 1537-1548.
    • (2013) ACS Chemical Biology , vol.8 , pp. 1537-1548
    • Di, P.1    Zhang, L.2    Chen, J.3    Tan, H.4    Xiao, Y.5    Dong, X.6    Zhou, X.7    Chen, W.8
  • 7
    • 58549119938 scopus 로고    scopus 로고
    • CDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis
    • Eberle D, Ullmann P, Werck-Reichhart D, Petersen M. 2009. cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis. Plant Molecular Biology 69, 239-53.
    • (2009) Plant Molecular Biology , vol.69 , pp. 239-253
    • Eberle, D.1    Ullmann, P.2    Werck-Reichhart, D.3    Petersen, M.4
  • 8
    • 77952492353 scopus 로고    scopus 로고
    • Anthocyanin biosynthesis in pears is regulated by a R2R3-MYB transcription factor PyMYB10
    • Feng S, Wang Y, Yang S, Xu Y, Chen X. 2010. Anthocyanin biosynthesis in pears is regulated by a R2R3-MYB transcription factor PyMYB10. Planta 232, 245-255.
    • (2010) Planta , vol.232 , pp. 245-255
    • Feng, S.1    Wang, Y.2    Yang, S.3    Xu, Y.4    Chen, X.5
  • 9
    • 0036890833 scopus 로고    scopus 로고
    • Transcription factors: Tools to engineer the production of pharmacologically active plant metabolites
    • Gantet P, Memelink J. 2002. Transcription factors: tools to engineer the production of pharmacologically active plant metabolites. Trends in Pharmacological Sciences 23, 563-569.
    • (2002) Trends in Pharmacological Sciences , vol.23 , pp. 563-569
    • Gantet, P.1    Memelink, J.2
  • 10
    • 84892945451 scopus 로고    scopus 로고
    • Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
    • Gao W, Sun H-X, Xiao H, et aL.2014. Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. BMC Genomics 15, 73.
    • (2014) BMC Genomics , vol.15 , pp. 73
    • Gao, W.1    Sun, H.-X.2    Xiao, H.3
  • 11
    • 10344249948 scopus 로고    scopus 로고
    • Tanshinone production and isoprenoid pathways in Salvia miltiorrhiza hairy roots induced by Ag+ and yeast elicitor
    • Ge X, Wu J. 2005. Tanshinone production and isoprenoid pathways in Salvia miltiorrhiza hairy roots induced by Ag+ and yeast elicitor. Plant Science 168, 487-491.
    • (2005) Plant Science , vol.168 , pp. 487-491
    • Ge, X.1    Wu, J.2
  • 12
    • 42249096763 scopus 로고    scopus 로고
    • Transcription factors for predictive plant metabolic engineering: Are we there yet
    • Grotewold E. 2008. Transcription factors for predictive plant metabolic engineering: are we there yet? Current Opinion in Biotechnology 19, 138-144.
    • (2008) Current Opinion in Biotechnology , vol.19 , pp. 138-144
    • Grotewold, E.1
  • 14
    • 84860817547 scopus 로고    scopus 로고
    • Gibberellin biosynthesis and its regulation
    • Hedden P, Thomas SG. 2012. Gibberellin biosynthesis and its regulation. Biochemical Journal 444, 11-25.
    • (2012) Biochemical Journal , vol.444 , pp. 11-25
    • Hedden, P.1    Thomas, S.G.2
  • 17
    • 43949174969 scopus 로고
    • Diterpenoid production in hairy root cultures of Salvia miltiorrhiza
    • Hu ZB, Alfermann AW. 1993. Diterpenoid production in hairy root cultures of Salvia miltiorrhiza. Phytochemistry 32, 699-703.
    • (1993) Phytochemistry , vol.32 , pp. 699-703
    • Hu, Z.B.1    Alfermann, A.W.2
  • 18
    • 21144444351 scopus 로고    scopus 로고
    • Quantitative determination of four diterpenoids in Radix Salviae miltiorrhizae using LC-MS-MS
    • Hu P, Luo GA, Zhao ZZ, Jiang ZH. 2005. Quantitative determination of four diterpenoids in Radix Salviae miltiorrhizae using LC-MS-MS. Chemical and Pharmaceutical Bulletin 53, 705-709.
    • (2005) Chemical and Pharmaceutical Bulletin , vol.53 , pp. 705-709
    • Hu, P.1    Luo, G.A.2    Zhao, Z.Z.3    Jiang, Z.H.4
  • 19
    • 21344471138 scopus 로고    scopus 로고
    • Real-time RT-PCR normalisation; Strategies and considerations
    • Huggett J, Dheda K, Bustin S, Zumla A. 2005. Real-time RT-PCR normalisation; strategies and considerations. Genes &Immunity 6, 279-284.
    • (2005) Genes &Immunity , vol.6 , pp. 279-284
    • Huggett, J.1    Dheda, K.2    Bustin, S.3    Zumla, A.4
  • 20
    • 79955161144 scopus 로고    scopus 로고
    • Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
    • Kai G, Xu H, Zhou C, Liao P, Xiao J, Luo X, You L, Zhang L.2011. Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. Metabolic Engineering 13, 319-327.
    • (2011) Metabolic Engineering , vol.13 , pp. 319-327
    • Kai, G.1    Xu, H.2    Zhou, C.3    Liao, P.4    Xiao, J.5    Luo, X.6    You, L.7    Zhang, L.8
  • 21
  • 22
    • 84963991762 scopus 로고    scopus 로고
    • Beijing: People's Medical Publishing House
    • Li L, Luo H (eds). 2008. Phytochemistry of danshen. Beijing: People's Medical Publishing House.
    • (2008) Phytochemistry of Danshen
    • Li, L.1    Luo, H.2
  • 23
    • 33846459430 scopus 로고    scopus 로고
    • Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn
    • Liu AH, Lin YH, Guo H, Guan SH, Sun JH, Guo DA. 2007. Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn. Journal of Chromatography B 846, 32-41.
    • (2007) Journal of Chromatography B , vol.846 , pp. 32-41
    • Liu, A.H.1    Lin, Y.H.2    Guo, H.3    Guan, S.H.4    Sun, J.H.5    Guo, D.A.6
  • 24
    • 53649093517 scopus 로고    scopus 로고
    • AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: Expression in fruit results in very high levels of both types of polyphenoL
    • Luo J, Butelli E, Hill L, Parr A, Niggeweg R, Bailey P, Weisshaar B, Martin C. 2008. AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: expression in fruit results in very high levels of both types of polyphenoL.The Plant Journal 56, 316-326.
    • (2008) The Plant Journal , vol.56 , pp. 316-326
    • Luo, J.1    Butelli, E.2    Hill, L.3    Parr, A.4    Niggeweg, R.5    Bailey, P.6    Weisshaar, B.7    Martin, C.8
  • 25
    • 84879883454 scopus 로고    scopus 로고
    • Regulation of water-soluble phenolic acid biosynthesis in Salvia miltiorrhiza Bunge
    • Ma P, Liu J, Zhang C, Liang Z. 2013. Regulation of water-soluble phenolic acid biosynthesis in Salvia miltiorrhiza Bunge. Applied Biochemistry and Biotechnology 170, 1253-1262.
    • (2013) Applied Biochemistry and Biotechnology , vol.170 , pp. 1253-1262
    • Ma, P.1    Liu, J.2    Zhang, C.3    Liang, Z.4
  • 26
    • 84861060144 scopus 로고    scopus 로고
    • Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza
    • Ma Y, Yuan L, Wu B, Li X, Chen S, Lu S. 2012. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. Journal of Experimental Botany 63, 2809-2823.
    • (2012) Journal of Experimental Botany , vol.63 , pp. 2809-2823
    • Ma, Y.1    Yuan, L.2    Wu, B.3    Li, X.4    Chen, S.5    Lu, S.6
  • 27
    • 67349159345 scopus 로고    scopus 로고
    • Overexpression of a grapevine R2R3-MYB factor in tomato affects vegetative development, flower morphology and flavonoid and terpenoid metabolism
    • Mahjoub A, Hernould M, Joubès J, Decendit A, Mars M, Barrieu F, Hamdi S, Delrot S. 2009. Overexpression of a grapevine R2R3-MYB factor in tomato affects vegetative development, flower morphology and flavonoid and terpenoid metabolism. Plant Physiology and Biochemistry 47, 551-561.
    • (2009) Plant Physiology and Biochemistry , vol.47 , pp. 551-561
    • Mahjoub, A.1    Hernould, M.2    Joubès, J.3    Decendit, A.4    Mars, M.5    Barrieu, F.6    Hamdi, S.7    Delrot, S.8
  • 28
    • 26944450940 scopus 로고    scopus 로고
    • The Arabidopsis transcription factor MYB12 is a flavonol-specific regulator of phenylpropanoid biosynthesis
    • Mehrtens F, Kranz H, Bednarek P, Weisshaar B. 2005. The Arabidopsis transcription factor MYB12 is a flavonol-specific regulator of phenylpropanoid biosynthesis. Plant Physiology 138, 1083-1096.
    • (2005) Plant Physiology , vol.138 , pp. 1083-1096
    • Mehrtens, F.1    Kranz, H.2    Bednarek, P.3    Weisshaar, B.4
  • 29
    • 0034932991 scopus 로고    scopus 로고
    • The pathway of biosynthesis of abscisic acid in vascular plants: A review of the present state of knowledge of ABA biosynthesis
    • Milborrow BV. 2001. The pathway of biosynthesis of abscisic acid in vascular plants: a review of the present state of knowledge of ABA biosynthesis. Journal of Experimental Botany 52, 1145-1164.
    • (2001) Journal of Experimental Botany , vol.52 , pp. 1145-1164
    • Milborrow, B.V.1
  • 30
    • 79960807863 scopus 로고    scopus 로고
    • The biosynthesis of isoprenoids and the mechanisms regulating it in plants
    • Okada K. 2011. The biosynthesis of isoprenoids and the mechanisms regulating it in plants. Bioscience, Biotechnology, and Biochemistry 75, 1219-1225.
    • (2011) Bioscience, Biotechnology, and Biochemistry , vol.75 , pp. 1219-1225
    • Okada, K.1
  • 31
    • 67349100690 scopus 로고    scopus 로고
    • A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening
    • Palapol Y, Ketsa S, Lin-Wang K, Ferguson IB, Allan AC. 2009. A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening. Planta 229, 1323-1334.
    • (2009) Planta , vol.229 , pp. 1323-1334
    • Palapol, Y.1    Ketsa, S.2    Lin-Wang, K.3    Ferguson, I.B.4    Allan, A.C.5
  • 32
    • 84876667455 scopus 로고    scopus 로고
    • Rosmarinic acid: New aspects
    • Petersen M. 2013. Rosmarinic acid: new aspects. Phytochemistry Reviews 12, 207-227.
    • (2013) Phytochemistry Reviews , vol.12 , pp. 207-227
    • Petersen, M.1
  • 33
    • 70350717066 scopus 로고    scopus 로고
    • Evolution of rosmarinic acid biosynthesis
    • Petersen M, Abdullah Y, Benner J, et aL.2009. Evolution of rosmarinic acid biosynthesis. Phytochemistry 70, 1663-1679.
    • (2009) Phytochemistry , vol.70 , pp. 1663-1679
    • Petersen, M.1    Abdullah, Y.2    Benner, J.3
  • 34
    • 0031127329 scopus 로고    scopus 로고
    • Evidence for direct activation of an anthocyanin promoter by the maize C1 protein and comparison of DNA binding by related Myb domain proteins
    • Sainz MB, Grotewold E, Chandler VL, Chandleragl VL.1997. Evidence for direct activation of an anthocyanin promoter by the maize C1 protein and comparison of DNA binding by related Myb domain proteins. The Plant Cell 9, 611-625.
    • (1997) The Plant Cell , vol.9 , pp. 611-625
    • Sainz, M.B.1    Grotewold, E.2    Chandler, V.L.3    Chandleragl, V.L.4
  • 37
    • 78650519832 scopus 로고    scopus 로고
    • RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis
    • Song J, Wang Z. 2011. RNAi-mediated suppression of the phenylalanine ammonia-lyase gene in Salvia miltiorrhiza causes abnormal phenotypes and a reduction in rosmarinic acid biosynthesis. Journal of Plant Research 124, 183-192.
    • (2011) Journal of Plant Research , vol.124 , pp. 183-192
    • Song, J.1    Wang, Z.2
  • 38
    • 34248365134 scopus 로고    scopus 로고
    • Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling
    • Stracke R, Ishihara H, Huep G, Barsch A, Mehrtens F, Niehaus K, Weisshaar B. 2007. Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. The Plant Journal 50, 660-677.
    • (2007) The Plant Journal , vol.50 , pp. 660-677
    • Stracke, R.1    Ishihara, H.2    Huep, G.3    Barsch, A.4    Mehrtens, F.5    Niehaus, K.6    Weisshaar, B.7
  • 39
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • research
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 3, research 0034. 1-0034. 11.
    • (2002) Genome Biology , vol.3 , pp. 00341-003411
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 40
    • 80053316627 scopus 로고    scopus 로고
    • De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients
    • Wenping H, Yuan Z, Jie S, Lijun Z, Zhezhi W. 2011. De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients. Genomics 98, 272-279.
    • (2011) Genomics , vol.98 , pp. 272-279
    • Wenping, H.1    Yuan, Z.2    Jie, S.3    Lijun, Z.4    Zhezhi, W.5
  • 42
    • 84855272650 scopus 로고    scopus 로고
    • The c4h, tat, hppr and hppd genes prompted engineering of rosmarinic acid biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
    • Xiao Y, Zhang L, Gao S, Saechao S, Di P, Chen J, Chen W. 2011. The c4h, tat, hppr and hppd genes prompted engineering of rosmarinic acid biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. PloS One 6, e29713.
    • (2011) PloS One , vol.6 , pp. e29713
    • Xiao, Y.1    Zhang, L.2    Gao, S.3    Saechao, S.4    Di, P.5    Chen, J.6    Chen, W.7
  • 43
    • 42549133432 scopus 로고    scopus 로고
    • A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes
    • Xie Z, Kapteyn J, Gang DR. 2008. A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes. The lant Journal 54, 349-361.
    • (2008) The Lant Journal , vol.54 , pp. 349-361
    • Xie, Z.1    Kapteyn, J.2    Gang, D.R.3
  • 45
    • 84874978130 scopus 로고    scopus 로고
    • Engineering plant metabolism into microbes: From systems biology to synthetic biology
    • Xu P, Bhan N, Koffas MA. 2013. Engineering plant metabolism into microbes: from systems biology to synthetic biology. Current Opinion in Biotechnology 24, 291-299.
    • (2013) Current Opinion in Biotechnology , vol.24 , pp. 291-299
    • Xu, P.1    Bhan, N.2    Koffas, M.A.3
  • 46
    • 79251568292 scopus 로고    scopus 로고
    • Metabolic regulation and genetic engineering of pharmaceutical component tanshinone biosynthesis in Salvia miltiorrhiza
    • Xu H, Zhang L, Zhou C, Xiao J, Liao P, Kai G. 2010. Metabolic regulation and genetic engineering of pharmaceutical component tanshinone biosynthesis in Salvia miltiorrhiza. Journal of Medicinal Plants Research 4, 2591-2597.
    • (2010) Journal of Medicinal Plants Research , vol.4 , pp. 2591-2597
    • Xu, H.1    Zhang, L.2    Zhou, C.3    Xiao, J.4    Liao, P.5    Kai, G.6
  • 47
    • 84894207903 scopus 로고    scopus 로고
    • Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis
    • Yang L, Ding G, Lin H, et aL.2013. Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis. PLoS One 8, 1-13.
    • (2013) PLoS One , vol.8 , pp. 1-13
    • Yang, L.1    Ding, G.2    Lin, H.3
  • 48
    • 70049085259 scopus 로고    scopus 로고
    • Phenolic composition and antioxidant activities of two Phlomis species: A correlation study
    • Zhang Y, Wang Z. 2009. Phenolic composition and antioxidant activities of two Phlomis species: a correlation study. Comptes Rendus Biologies 332, 816-826.
    • (2009) Comptes Rendus Biologies , vol.332 , pp. 816-826
    • Zhang, Y.1    Wang, Z.2
  • 49
    • 78649683731 scopus 로고    scopus 로고
    • The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza
    • Zhang Y, Yan YP, Wang ZZ. 2010. The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza. Journal of Agricultural and Food Chemistry 58, 12168-12175.
    • (2010) Journal of Agricultural and Food Chemistry , vol.58 , pp. 12168-12175
    • Zhang, Y.1    Yan, Y.P.2    Wang, Z.Z.3
  • 50
    • 84889637548 scopus 로고    scopus 로고
    • Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation
    • Zhang Y, Yan YP, Wu YC, Hua WP, Chen C, Ge Q, Wang ZZ. 2014. Pathway engineering for phenolic acid accumulations in Salvia miltiorrhiza by combinational genetic manipulation. Metabolic Engineering 21, 71-80.
    • (2014) Metabolic Engineering , vol.21 , pp. 71-80
    • Zhang, Y.1    Yan, Y.P.2    Wu, Y.C.3    Hua, W.P.4    Chen, C.5    Ge, Q.6    Wang, Z.Z.7
  • 52
    • 77952890134 scopus 로고    scopus 로고
    • Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures
    • Zhao J-L, Zhou L-G, Wu J-Y. 2010. Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures. Applied Microbiology and Biotechnology 87, 137-144.
    • (2010) Applied Microbiology and Biotechnology , vol.87 , pp. 137-144
    • Zhao, J.-L.1    Zhou, L.-G.2    Wu, J.-Y.3


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