Improvement of catechin production in Escherichia coli through combinatorial metabolic engineering

Metabolic Engineering

Volumn 28, Issue , 2015, Pages 43-53

  Zhao, Shujuan ^a,c   Jones, J Andrew ^a   Lachance, Daniel M ^b   Bhan, Namita ^a   Khalidi, Omar ^a   Venkataraman, Sylesh ^d   Wang, Zhengtao ^c   Koffas, Mattheos A G ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d Chromadex Inc   (United States)

Author keywords

Catechin; Copy number balancing; EPathBrick; NADPH availability; Pathway optimization; Protein scaffolds

Indexed keywords

BATCH CELL CULTURE; BIOCHEMISTRY; BIOSYNTHESIS; ESCHERICHIA COLI; METABOLIC ENGINEERING; METABOLITES; MICROORGANISMS; ORGANIC COMPOUNDS; PHENOLS; PROTEINS; SCAFFOLDS (BIOLOGY); VITAMINS;

CATECHIN; COPY NUMBER; EPATHBRICK; NADPH AVAILABILITY; PROTEIN SCAFFOLDS;

FLAVONOIDS;

AVANONE 3 BETA HYDROXYLASE; AVONOL 4 REDUCTASE; CATECHIN; ERIODICTYOL; LEUCOANTHOCYANIDIN REDUCTASE; NARINGENIN; OXIDOREDUCTASE; OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; MIXED FUNCTION OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; VEGETABLE PROTEIN;

ANTHURIUM ANDRAEANUM; ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; CAMELLIA SINENSIS; DESMODIUM UNCINATUM; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE DOSAGE; GENE MUTATION; GENETIC SCREENING; METABOLIC ENGINEERING; NONHUMAN; PLANT GENE; PROCESS OPTIMIZATION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRAWBERRY; SYNTHETIC BIOLOGY; GENETICS; METABOLISM;

ANTHURIUM ANDRAEANUM; CAMELLIA SINENSIS; DESMODIUM UNCINATUM; ESCHERICHIA COLI; FRAGARIA;

CATECHIN; ESCHERICHIA COLI; METABOLIC ENGINEERING; MIXED FUNCTION OXYGENASES; NADP; PLANT PROTEINS;

EID: 84920161546     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.12.002     Document Type: Article

References (23)

1. Anderson J.C., Dueber J.E., Leguia M., Wu G.C., Goler J.A., Arkin A.P., Keasling J.D. BglBricks: a flexible standard for biological part assembly. J. Biol. Eng. 2010, 4:1. 10.1186/1754-1611-4-1.
2. Anthony J.R., Anthony L.C., Nowroozi F., Kwon G., Newman J.D., Keasling J.D. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metab. Eng. 2009, 11:13-19. 10.1016/j.ymben.2008.07.007.
3. Bokinsky G., Peralta-Yahya P.P., George A., Holmes B.M., Steen E.J., Dietrich J., Lee T.S., Tullman-Ercek D., Voigt C.A., Simmons B.A., Keasling J.D. Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli. Proc. Natl. Acad. Sci. U.S.A 2011, 108:19949-19954. 10.1073/pnas.1106958108.
4. Chemler J.A., Fowler Z.L., McHugh K.P., Koffas M.A.G. Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering. Metab. Eng. 2010, 12:96-104. 10.1016/j.ymben.2009.07.003.
5. Chemler J.A., Lock L.T., Koffas M.A.G., Tzanakakis E.S. Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion. Appl. Microbiol. Biotechnol. 2007, 77:797-807. 10.1007/s00253-007-1227-y.
6. Dueber J.E., Wu G.C., Malmirchegini G.R., Moon T.S., Petzold C.J., Ullal A.V., Prather K.L.J., Keasling J.D. Synthetic protein scaffolds provide modular control over metabolic flux. Nat. Biotechnol. 2009, 27:753-759. 10.1038/nbt.1557.
7. Johnson E.T., Ryu S., Yi H., Shin B., Cheong H., Choi G. Alteration of a single amino acid changes the substrate specificity of dihydroflavonol 4-reductase. Plant J. 2001, 25:325-333. 10.1046/j.1365-313x.2001.00962.x.
8. Jones J.A., Toparlak O.D., Koffas M.A.G. Metabolic pathway balancing and its role in the production of biofuels and chemicals. Curr. Opin. Biotechnol. 2015, 33:52-59. 10.1016/j.copbio.2014.11.013.
9. Juminaga D., Baidoo E.E.K., Redding-Johanson A.M., Batth T.S., Burd H., Mukhopadhyay A., Petzold C.J., Keasling J.D. Modular engineering of l-tyrosine production in Escherichia coli. Appl. Environ. Microbiol. 2012, 78:89-98. 10.1128/AEM.06017-11.
10. Lee T.S., Krupa R.A., Zhang F., Hajimorad M., Holtz W.J., Prasad N., Lee S.K., Keasling J.D. BglBrick vectors and datasheets: a synthetic biology platform for gene expression. J. Biol. Eng. 2011, 5:12. 10.1186/1754-1611-5-12.
11. Leonard E., Yan Y., Chemler J., Matern U., Martens S., Koffas Characterization of dihydroflavonol 4-reductases for recombinant plant pigment biosynthesis applications. Biocatal. Biotransform. 2008, 26:243-251. 10.1080/10242420701685635.
12. Moon T.S., Dueber J.E., Shiue E., Prather K.L.J. Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli. Metab. Eng. 2010, 12:298-305. 10.1016/j.ymben.2010.01.003.
13. Petit P., Granier T., d'Estaintot B.L., Manigand C., Bathany K., Schmitter J.-M., Lauvergeat V., Hamdi S., Gallois B. Crystal structure of grape dihydroflavonol 4-reductase, a key enzyme in flavonoid biosynthesis. J. Mol. Biol. 2007, 368:1345-1357. 10.1016/j.jmb.2007.02.088.
14. Paddon C.J., Westfall P.J., Pitera D.J., Benjamin K., Fisher K., McPhee D., Leavell M.D., Tai A., Main A., Eng D., Polichuk D.R., Teoh K.H., Reed D.W., Treynor T., Lenihan J., Fleck M., Bajad S., Dang G., Dengrove D., Diola D., Dorin G., Ellens K.W., Fickes S., Galazzo J., Gaucher S.P., Geistlinger T., Henry R., Hepp M., Horning T., Iqbal T., Jiang H., Kizer L., Lieu B., Melis D., Moss N., Regentin R., Secrest S., Tsuruta H., Vazquez R., Westblade L.F., Xu L., Yu M., Zhang Y., Zhao L., Lievense J., Covello P.S., Keasling J.D., Reiling K.K., Renninger N.S., Newman J.D. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 2013, 496:528-532. 10.1038/nature12051.
15. Punyasiri P.A.N., Abeysinghe I.S.B., Kumar V., Treutter D., Duy D., Gosch C., Martens S., Forkmann G., Fischer T.C. Flavonoid biosynthesis in the tea plant Camellia sinensis: properties of enzymes of the prominent epicatechin and catechin pathways. Arch. Biochem. Biophys. 2004, 431:22-30. 10.1016/j.abb.2004.08.003.
16. Umar K.M., Abdulkarim S.M., Radu S., Abdul Hamid A., Saari N. Engineering the production of major catechins by Escherichia coli carrying metabolite genes of Camellia sinensis. ScientificWorldJournal 2012, 2012:529031. 10.1100/2012/529031.
17. Wang Y., Yu O. Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells. J. Biotechnol. 2012, 157:258-260. 10.1016/j.jbiotec.2011.11.003.
18. Way J.C., Collins J.J., Keasling J.D., Silver P.A. Integrating biological redesign: where synthetic biology came from and where it needs to go. Cell 2014, 157:151-161. 10.1016/j.cell.2014.02.039.
19. Xu P., Gu Q., Wang W., Wong L., Bower A.G.W., Collins C.H., Koffas M.A.G. Modular optimization of multi-gene pathways for fatty acids production in E. coli. Nat. Commun. 2013, 4:1409. 10.1038/ncomms2425.
20. Xu P., Ranganathan S., Fowler Z.L., Maranas C.D., Koffas M.a.G. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab. Eng. 2011, 13:578-587. 10.1016/j.ymben.2011.06.008.
21. Xu P., Vansiri A., Bhan N., Koffas M.A.G. ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli. ACS Synth. Biol. 2012, 1:256-266. 10.1021/sb300016b.
22. Zhang H., Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Appl. Microbiol. Biotechnol. 2013, 97:3333-3341. 10.1007/s00253-012-4544-8.
23. Zhu S., Wu J., Du G., Zhou J., Chen J. Efficient synthesis of eriodictyol from l-tyrosine in Escherichia coli. Appl. Environ. Microbiol. 2014, 80:3072-3080. 10.1128/AEM.03986-13.