메뉴 건너뛰기




Volumn 40, Issue 5, 2016, Pages 988-999

Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice

Author keywords

Alcoholic Liver Disease; Hepatic Inflammation; Hepatic Lipogenesis; Peroxisome Proliferator Activated Receptor Gamma

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 2; FATTY ACID SYNTHASE; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER PROTEIN 1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; KERATINOCYTE DERIVED CHEMOKINE; LINOLEIC ACID; LIPIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; SHORT HAIRPIN RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; CHEMOKINE; DGAT1 PROTEIN, MOUSE; DGAT2 PROTEIN, MOUSE; DIACYLGLYCEROL ACYLTRANSFERASE; LPIN1 PROTEIN, MOUSE; NUCLEAR PROTEIN; PHOSPHATIDATE PHOSPHATASE; SLC27A1 PROTEIN, MOUSE;

EID: 84963854360     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.13049     Document Type: Article
Times cited : (55)

References (53)
  • 2
    • 0034743328 scopus 로고    scopus 로고
    • Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
    • Bedoucha M, Atzpodien E, Boelsterli UA (2001) Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol 35:17-23.
    • (2001) J Hepatol , vol.35 , pp. 17-23
    • Bedoucha, M.1    Atzpodien, E.2    Boelsterli, U.A.3
  • 7
    • 0028015713 scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation
    • Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA (1994) Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800.
    • (1994) Endocrinology , vol.135 , pp. 798-800
    • Chawla, A.1    Schwarz, E.J.2    Dimaculangan, D.D.3    Lazar, M.A.4
  • 10
    • 1842580431 scopus 로고    scopus 로고
    • A meta-analysis of alcohol consumption and the risk of 15 diseases
    • Corrao G, Bagnardi V, Zambon A, La Vecchia C (2004) A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med 38:613-619.
    • (2004) Prev Med , vol.38 , pp. 613-619
    • Corrao, G.1    Bagnardi, V.2    Zambon, A.3    La Vecchia, C.4
  • 11
    • 77649235913 scopus 로고    scopus 로고
    • How to do successful gene expression analysis using real-time PCR
    • Derveaux S, Vandesompele J, Hellemans J (2010) How to do successful gene expression analysis using real-time PCR. Methods 50:227-230.
    • (2010) Methods , vol.50 , pp. 227-230
    • Derveaux, S.1    Vandesompele, J.2    Hellemans, J.3
  • 18
    • 0034951366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease
    • Guan Y, Breyer MD (2001) Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 60:14-30.
    • (2001) Kidney Int , vol.60 , pp. 14-30
    • Guan, Y.1    Breyer, M.D.2
  • 19
    • 33846360664 scopus 로고    scopus 로고
    • Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha
    • Gui Y, Cai Z, Silha JV, Murphy LJ (2006) Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha. Can J Physiol Pharmacol 84:887-892.
    • (2006) Can J Physiol Pharmacol , vol.84 , pp. 887-892
    • Gui, Y.1    Cai, Z.2    Silha, J.V.3    Murphy, L.J.4
  • 20
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM (2003) Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 100:15712-15717.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6    Nelson, M.7    Ong, E.8    Olefsky, J.M.9    Evans, R.M.10
  • 24
    • 34147180133 scopus 로고    scopus 로고
    • Sex differences in PPARgamma expressions in rat adipose tissues
    • Kadowaki K, Fukino K, Negishi E, Ueno K (2007) Sex differences in PPARgamma expressions in rat adipose tissues. Biol Pharm Bull 30:818-820.
    • (2007) Biol Pharm Bull , vol.30 , pp. 818-820
    • Kadowaki, K.1    Fukino, K.2    Negishi, E.3    Ueno, K.4
  • 25
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
    • Kim JB, Wright HM, Wright M, Spiegelman BM (1998) ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 95:4333-4337.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3    Spiegelman, B.M.4
  • 29
    • 84896988761 scopus 로고    scopus 로고
    • SREBP-1c overexpression induces triglycerides accumulation through increasing lipid synthesis and decreasing lipid oxidation and VLDL assembly in bovine hepatocytes
    • Li X, Li Y, Yang W, Xiao C, Fu S, Deng Q, Ding H, Wang Z, Liu G, Li X (2014) SREBP-1c overexpression induces triglycerides accumulation through increasing lipid synthesis and decreasing lipid oxidation and VLDL assembly in bovine hepatocytes. J Steroid Biochem Mol Biol 143:174-182.
    • (2014) J Steroid Biochem Mol Biol , vol.143 , pp. 174-182
    • Li, X.1    Li, Y.2    Yang, W.3    Xiao, C.4    Fu, S.5    Deng, Q.6    Ding, H.7    Wang, Z.8    Liu, G.9    Li, X.10
  • 30
    • 82455167937 scopus 로고    scopus 로고
    • An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
    • Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D (2011) An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 54:2185-2197.
    • (2011) Hepatology , vol.54 , pp. 2185-2197
    • Mandrekar, P.1    Ambade, A.2    Lim, A.3    Szabo, G.4    Catalano, D.5
  • 34
    • 0037385387 scopus 로고    scopus 로고
    • Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Sponseller CA, Hampton K, Bacon BR (2003) Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis. J Hepatol 38:434-440.
    • (2003) J Hepatol , vol.38 , pp. 434-440
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Sponseller, C.A.4    Hampton, K.5    Bacon, B.R.6
  • 35
    • 79955650290 scopus 로고    scopus 로고
    • Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
    • Pettinelli P, Videla LA (2011) Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction. J Clin Endocrinol Metab 96:1424-1430.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1424-1430
    • Pettinelli, P.1    Videla, L.A.2
  • 36
    • 0034796418 scopus 로고    scopus 로고
    • Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus
    • Rahimian R, Masih-Khan E, Lo M, van Breemen C, McManus BM, Dube GP (2001) Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus. Mol Cell Biochem 224:29-37.
    • (2001) Mol Cell Biochem , vol.224 , pp. 29-37
    • Rahimian, R.1    Masih-Khan, E.2    Lo, M.3    van Breemen, C.4    McManus, B.M.5    Dube, G.P.6
  • 37
    • 58149493049 scopus 로고    scopus 로고
    • IP-10 correlates with hepatitis C viral load, hepatic inflammation and fibrosis and predicts hepatitis C virus relapse or non-response in HIV-HCV coinfection
    • Reiberger T, Aberle JH, Kundi M, Kohrgruber N, Rieger A, Gangl A, Holzmann H, Peck-Radosavljevic M (2008) IP-10 correlates with hepatitis C viral load, hepatic inflammation and fibrosis and predicts hepatitis C virus relapse or non-response in HIV-HCV coinfection. Antivir Ther 13:969-976.
    • (2008) Antivir Ther , vol.13 , pp. 969-976
    • Reiberger, T.1    Aberle, J.H.2    Kundi, M.3    Kohrgruber, N.4    Rieger, A.5    Gangl, A.6    Holzmann, H.7    Peck-Radosavljevic, M.8
  • 39
    • 19444383246 scopus 로고    scopus 로고
    • PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. American journal of physiology
    • Schadinger SE, Bucher NL, Schreiber BM, Farmer SR (2005) PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. American journal of physiology. Endocrinol Metab 288:E1195-E1205.
    • (2005) Endocrinol Metab , vol.288 , pp. E1195-E1205
    • Schadinger, S.E.1    Bucher, N.L.2    Schreiber, B.M.3    Farmer, S.R.4
  • 40
    • 0037973483 scopus 로고    scopus 로고
    • Chronic alcohol exposure sensitizes mice to galactosamine-induced liver injury through enhanced keratinocyte chemoattractant and defective IL-10 production
    • Sermon F, Le Moine O, Gustot T, Quertinmont E, Louis H, Nagy N, Degraef C, Deviere J (2003) Chronic alcohol exposure sensitizes mice to galactosamine-induced liver injury through enhanced keratinocyte chemoattractant and defective IL-10 production. J Hepatol 39:68-76.
    • (2003) J Hepatol , vol.39 , pp. 68-76
    • Sermon, F.1    Le Moine, O.2    Gustot, T.3    Quertinmont, E.4    Louis, H.5    Nagy, N.6    Degraef, C.7    Deviere, J.8
  • 41
    • 0036865166 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism
    • Smith SA (2002) Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism. Biochem Soc Trans 30:1086-1090.
    • (2002) Biochem Soc Trans , vol.30 , pp. 1086-1090
    • Smith, S.A.1
  • 43
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B, Fruchart JC (2005) Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 54:2460-2470.
    • (2005) Diabetes , vol.54 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 45
    • 84863151358 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
    • Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z (2012) Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol 302:G548-G557.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G548-G557
    • Sun, X.1    Tang, Y.2    Tan, X.3    Li, Q.4    Zhong, W.5    Sun, X.6    Jia, W.7    McClain, C.J.8    Zhou, Z.9
  • 46
    • 84866488176 scopus 로고    scopus 로고
    • Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice
    • Tan X, Sun X, Li Q, Zhao Y, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z (2012) Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. Am J Pathol 181:1279-1286.
    • (2012) Am J Pathol , vol.181 , pp. 1279-1286
    • Tan, X.1    Sun, X.2    Li, Q.3    Zhao, Y.4    Zhong, W.5    Sun, X.6    Jia, W.7    McClain, C.J.8    Zhou, Z.9
  • 47
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 48
    • 68949181550 scopus 로고    scopus 로고
    • Specific role for acyl CoA: diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
    • Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr. (2009) Specific role for acyl CoA: diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology 50:434-442.
    • (2009) Hepatology , vol.50 , pp. 434-442
    • Villanueva, C.J.1    Monetti, M.2    Shih, M.3    Zhou, P.4    Watkins, S.M.5    Bhanot, S.6    Farese, R.V.7
  • 49
    • 0037200657 scopus 로고    scopus 로고
    • Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells
    • Wang X, Kilgore MW (2002) Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells. Mol Cell Endocrinol 194:123-133.
    • (2002) Mol Cell Endocrinol , vol.194 , pp. 123-133
    • Wang, X.1    Kilgore, M.W.2
  • 50
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA (2001) Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142:1269-1277.
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1    Harrington, W.W.2    Brown, K.K.3    Gottschalk, W.K.4    Sundseth, S.S.5    Mansfield, T.A.6    Ramachandran, R.K.7    Willson, T.M.8    Kliewer, S.A.9
  • 51
    • 84923837539 scopus 로고    scopus 로고
    • Visceral white adipose tissue is susceptible to alcohol-induced lipodystrophy in rats: role of acetaldehyde
    • Zhang W, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z (2015) Visceral white adipose tissue is susceptible to alcohol-induced lipodystrophy in rats: role of acetaldehyde. Alcohol Clin Exp Res 39:416-423.
    • (2015) Alcohol Clin Exp Res , vol.39 , pp. 416-423
    • Zhang, W.1    Zhong, W.2    Sun, X.3    Sun, Q.4    Tan, X.5    Li, Q.6    Sun, X.7    Zhou, Z.8
  • 52
    • 84885401615 scopus 로고    scopus 로고
    • Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors
    • Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z (2013) Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PLoS One 8:e76522.
    • (2013) PLoS One , vol.8 , pp. e76522
    • Zhong, W.1    Zhao, Y.2    Sun, X.3    Song, Z.4    McClain, C.J.5    Zhou, Z.6
  • 53
    • 84863122866 scopus 로고    scopus 로고
    • Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis
    • Zhong W, Zhao Y, Tang Y, Wei X, Shi X, Sun W, Sun X, Yin X, Sun X, Kim S, McClain CJ, Zhang X, Zhou Z (2012) Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. Am J Pathol 180:998-1007.
    • (2012) Am J Pathol , vol.180 , pp. 998-1007
    • Zhong, W.1    Zhao, Y.2    Tang, Y.3    Wei, X.4    Shi, X.5    Sun, W.6    Sun, X.7    Yin, X.8    Sun, X.9    Kim, S.10    McClain, C.J.11    Zhang, X.12    Zhou, Z.13


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.