Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 305, Issue 11, 2013, Pages

  Sun, Xiuhua ^a   Luo, Weijun ^a,c   Tan, Xiaobing ^a   Li, Qiong ^a   Zhao, Yantao ^d   Zhong, Wei ^a   Sun, Xinguo ^a   Brouwer, Cory ^a,c   Zhou, Zhanxiang ^a,b  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^c University of North Carolina at Charlotte   (United States)

^d NORTH CAROLINA A AND T STATE UNIVERSITY   (United States)

Author keywords

Alcoholic fatty liver; Glucocorticoids; Lipid metabolism

Indexed keywords

ACYL COENZYME A OXIDASE; ADIPONECTIN; ALCOHOL; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL; CORTICOSTERONE; DEXAMETHASONE; DIACYLGLYCEROL ACYLTRANSFERASE 2; GLUCOSE; INSULIN; KETONE BODY; LIPID; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOPLASM; DIET; FATTY ACID OXIDATION; FEEDING; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOGENESIS; LIVER CELL; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WESTERN BLOTTING;

ALCOHOLIC FATTY LIVER; GLUCOCORTICOIDS; LIPID METABOLISM;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CORTICOSTERONE; DEXAMETHASONE; DIACYLGLYCEROL O-ACYLTRANSFERASE; ETHANOL; FATTY LIVER, ALCOHOLIC; LIPID METABOLISM; MICE; MICE, INBRED C57BL; PPAR ALPHA; TRANSCRIPTION, GENETIC;

EID: 84889071909     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00139.2013     Document Type: Article

References (63)

1. Adinoff B, Ruether K, Krebaum S, Iranmanesh A, Williams MJ. Increased salivary cortisol concentrations during chronic alcohol intoxication in a naturalistic clinical sample of men. Alcohol Clin Exp Res 27: 1420-1427, 2003.
2. Badrick E, Bobak M, Britton A, Kirschbaum C, Marmot M, Kumari M. The relationship between alcohol consumption and cortisol secretion in an aging cohort. J Clin Endocrinol Metab 93: 750-757, 2008.
3. Bagdade JD, Yee E, Albers J, Pykalisto OJ. Glucocorticoids and triglyceride transport: effects on triglyceride secretion rates, lipoprotein lipase, and plasma lipoproteins in the rat. Metabolism 25: 533-542, 1976.
4. Beier JI, Arteel GE, McClain CJ. Advances in alcoholic liver disease. Curr Gastroenterol Rep 13: 56-64, 2011.
5. Beresford TP, Arciniegas DB, Alfers J, Clapp L, Martin B, Beresford HF, Du Y, Liu D, Shen D, Davatzikos C, Laudenslager ML. Hypercortisolism in alcohol dependence and its relation to hippocampal volume loss. J Stud Alcohol 67: 861-867, 2006.
6. Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol 86: 1097-1104, 2009.
7. Cederbaum AI. Alcohol metabolism. Clin Liver Dis 16: 667-685, 2012.
8. Collier SD, Wu WJ, Pruett SB. Ethanol suppresses NK cell activation by polyinosinic-polycytidylic acid (poly I:C) in female B6C3F1 mice: role of endogenous corticosterone. Alcohol Clin Exp Res 24: 291-299, 2000.
9. Crabb DW, Galli A, Fischer M, You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol 34: 35-38, 2004.
10. Dolinsky VW, Douglas DN, Lehner R, Vance DE. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J 378: 967-974, 2004.
11. Dong Y, Poellinger L, Okret S, Höög JO, von Bahr-Lindström H, Jörnvall H, Gustafsson JA. Regulation of gene expression of class I alcohol dehydrogenase by glucocorticoids. Proc Natl Acad Sci USA 85: 767-771, 1988.
12. D'Souza El-Guindy NB, de Villiers WJ, Doherty DE. Acute alcohol intake impairs lung inflammation by changing pro- and anti-inflammatory mediator balance. Alcohol 41: 335-345, 2007.
13. Ellis FW. Effect of ethanol on plasma corticosterone levels. J Pharmacol Exp Ther 153: 121-127, 1966.
14. Emanuele N, Emanuele MA. The endocrine system: alcohol alters critical hormonal balance. Alcohol Health Res World 21: 53-64, 1997.
15. Fernandez-Sola J, Preedy VR, Lang CH, Gonzalez-Reimers E, Arno M, Lin JCI, Wiseman H, Zhou S, Emery PW, Nakahara T, Hashimoto K, Hirano M, Santolaria-Fernandez F, Gonzalez-Hernàndez T, Fatjó F, Sacanelia E, Estruch R, Nicolas JM, Urbano-Marquez A. Molecular and cellular events in alcohol-induced muscle disease. Alcohol Clin Exp Res 31: 1953-1962, 2007.
16. Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141: 1572-1585, 2011.
17. Gounarides JS, Korach-André M, Killary K, Argentieri G, Turner O, Laurent D. Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model. Endocrinology 149: 758-766, 2008.
18. Gredilla R, Barja G. Minireview: the role of oxidative stress in relation to caloric restriction and longevity. Endocrinology 146: 3713-3717, 2005.
19. Gursoy E, Cardounel A, Hu Y, Kalimi M. Biological effects of longterm caloric restriction: adaptation with simultaneous administration of caloric stress plus repeated immobilization stress in rats. Exp Biol Med (Maywood) 226: 97-102, 2001.
20. Jiang XC, Qin S, Qiao C, Kawano K, Lin M, Skold A, Xiao X, Tall AR. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med 7: 847-852, 2001.
21. Kang X, Zhong W, Liu J, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferatoractivated receptor-alpha. Hepatology 50: 1241-1250, 2009.
22. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol 50: 538-547, 2009.
23. Kinoshita H, Jessop DS, Finn DP, Coventry TL, Roberts DJ, Ameno K, Jiri I, Harbuz MS. Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat. Alcohol Alcohol 36: 59-64, 2001.
24. Kirkman S, Nelson DH. Alcohol-induced pseudo-Cushing's disease: a study of prevalence with review of the literature. Metabolism 37: 390-394, 1988.
25. Lemberger T, Staels B, Saladin R, Desvergne B, Auwerx J, Wahli W. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J Biol Chem 269: 24527-24530, 1994.
26. Lettéron P, Brahimi-Bourouina N, Robin MA, Moreau A, Feldmann G, Pessayre D. Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation. Am J Physiol Gastrointest Liver Physiol 272: G1141-G1150, 1997.
27. Li T, Matozel M, Boehme S, Kong B, Nilsson LM, Guo G, Ellis E, Chiang JY. Overexpression of cholesterol 7_-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 53: 996-1006, 2011.
28. Li ZZ, Berk M, McIntyre TM, Feldstein AE. Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem 284: 5637-5644, 2009.
29. Lie J, de Crom R, van Gent T, van Haperen R, Scheek L, Lankhuizen I, van Tol A. Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion. J Lipid Res 43: 1875-1880, 2002.
30. Lieber CS. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34: 9-19, 2004.
31. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med 360: 2758-2769, 2009.
32. Luo W, Friedman MS, Shedden K, Hankenson KD, Woolf PJ. GAGE: generally applicable gene set enrichment for pathway analysis. BMC Bioinformatics 10: 161, 2009.
33. Luo W, Brouwer C. Pathview: an R/Bioconductor package for pathwaybased data integration and visualization. Bioinformatics 29: 1830-1831, 2013.
34. Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol 197: 189-204, 2008.
35. McCullough AJ, O'Shea RS, Dasarathy S. Diagnosis and management of alcoholic liver disease. J Dig Dis 12: 257-262, 2011.
36. McDonough AK, Curtis JR, Saag KG. The epidemiology of glucocorticoid- associated adverse events. Curr Opin Rheumatol 20: 131-137, 2008.
37. Meadows GG, Blank SE, Yirmiya R, Taylor AN. Modulation of natural killer cell activity by alcohol. In: Alcohol, Immunity, and Cancer, edited by Yirmiya R, Taylor AN. Boca Raton, FL: CRC, 1993.
38. Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem 279: 35017-35024, 2004.
39. O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Am J Gastroenterol 105: 14-32, 2010.
40. O'Shea RS, Dasarathy S, McCullough AJ, Practice Guideline Committee of the American Association for the Study of Liver Diseases, Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 51: 307-328, 2010.
41. Pandak WM, Schwarz C, Hylemon PB, Mallonee D, Valerie K, Heuman DM, Fisher RA, Redford K, Vlahcevic ZR. Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis. Am J Physiol Gastrointest Liver Physiol 281: G878-G889, 2001.
42. Princen HM, Meijer P, Hofstee B. Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase. Biochem J 262: 341-348, 1989.
43. Pruett SB, Collier SD, Wu WJ. Ethanol-induced activation of the hypothalamic-pituitary-adrenal axis in a mouse model for binge drinking: role of Ro15-4513-sensitive gamma aminobutyric acid receptors, tolerance, and relevance to humans. Life Sci 63: 1137-1146, 1998.
44. Rivier C. Alcohol stimulates ACTH secretion in the rat: mechanisms of action and interactions with other stimuli. Alcohol Clin Exp Res 20: 240-254, 1996.
45. Rivier C, Bruhn T, Vale W. Effect of ethanol on the hypothalamicpituitary- adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther 229: 127-131, 1984.
46. Rosol TJ, Yarrington JT, Latendresse J, Capen CC. Adrenal gland: structure, function, and mechanisms of toxicity. Toxicol Pathol 29: 41-48, 2001.
47. Schaaf MJ, Cidlowski JA. Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol 83: 37-48, 2002.
48. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96: 23-43, 2002.
49. Schoneveld OJ, Gaemers IC, Lamers WH. Mechanisms of glucocorticoid signaling. Biochim Biophys Acta 1680: 114-128, 2004.
50. Sebastian BM, Roychowdhury S, Tang H, Hillian AD, Feldstein AE, Stahl GL, Takahashi K, Nagy LE. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. J Biol Chem 286: 35989-35997, 2011.
51. Sisson JH. Alcohol and airways function in health and disease. Alcohol 41: 293-307, 2007.
52. Stewart PM, Burra P, Shackleton CH, Sheppard MC, Elias E. 11 Beta-hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease. J Clin Endocrinol Metab 76: 748-751, 1993.
53. Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z. Activation of peroxisome proliferator-activated receptor-γby rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol 302: G548-G557, 2012.
54. Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res 33: 220-232, 2009.
55. Tabakoff B, Jafee RC, Ritzmann RF. Corticosterone concentrations in mice during ethanol drinking and withdrawal. J Pharm Pharmacol 30: 371-374, 1978.
56. Tan X, Sun X, Li Q, Zhao Y, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z. Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. Am J Pathol 181: 1279-1286, 2012.
57. Tang H, Sebastian BM, Axhemi A, Chen X, Hillian AD, Jacobsen DW, Nagy LE. Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. Alcohol Clin Exp Res 36: 214-222, 2012.
58. Thayer JF, Hall M, Sollers JJ 3rd, Fischer JE. Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: evidence for impaired inhibitory control of the HPA axis in heavy drinkers. Int J Psychophysiol 59: 244-250, 2006.
59. Tiwari S, Siddiqi SA. Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol 32: 1079-1086, 2012.
60. Wand GS, Dobs AS. Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. J Clin Endocrinol Metab 72: 1290-1295, 1991.
61. Wang CN, McLeod RS, Yao Z, Brindley DN. Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes. Arterioscler Thromb Vasc Biol 15: 1481-1491, 1995.
62. Wolfla CE, Ross RA, Crabb DW. Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone. Arch Biochem Biophys 263: 69-76, 1988.
63. Yazdanyar A, Jiang XC. Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice. Hepatology 56: 576-584, 2012.